Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0059 | 0.0076 | 0.0076 | |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.0046 | 0.0379 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.002 | 0.119 |
Brugia malayi | Beta-glucuronidase precursor | 0.0698 | 0.1084 | 0.2635 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0.0039 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0013 | 0.0107 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.01 | 0.0141 | 0.0343 |
Schistosoma mansoni | lamin | 0.0059 | 0.0076 | 0.0185 |
Schistosoma mansoni | hypothetical protein | 0.0265 | 0.04 | 0.0973 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0031 | 0.0075 |
Onchocerca volvulus | 0.0025 | 0.0023 | 0.0023 | |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0031 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.01 | 0.0141 | 0.0343 |
Schistosoma mansoni | hypothetical protein | 0.0121 | 0.0173 | 0.0421 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0313 | 0.0477 | 0.3965 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0031 | 0.0075 |
Brugia malayi | Inositol-1 | 0.004 | 0.0046 | 0.0112 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0029 | 0.4196 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0017 | 0.0041 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0023 | 0.0025 |
Schistosoma mansoni | hypothetical protein | 0.2618 | 0.4114 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0031 | 0.0075 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0029 | 0.9089 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0191 | 0.1582 |
Entamoeba histolytica | hypothetical protein | 0.0121 | 0.0173 | 0.2034 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0128 | 0.0185 | 0.1538 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0121 | 0.0173 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0031 | 0.0256 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0871 | 0.1357 | 0.33 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0023 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0023 | 0.0191 |
Schistosoma mansoni | beta-mannosidase | 0.0244 | 0.0368 | 0.0895 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0774 | 0.1204 | 0.2927 |
Brugia malayi | hypothetical protein | 0.0121 | 0.0173 | 0.0421 |
Onchocerca volvulus | 0.0241 | 0.0363 | 0.0363 | |
Entamoeba histolytica | hypothetical protein | 0.0121 | 0.0173 | 0.2034 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0774 | 0.1204 | 0.2927 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0029 | 0.4196 |
Brugia malayi | hypothetical protein | 0.0774 | 0.1204 | 0.2927 |
Mycobacterium ulcerans | glutaminase | 0.0297 | 0.0451 | 0.1068 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0121 | 0.0173 | 0.0421 |
Loa Loa (eye worm) | glutaminase | 0.0297 | 0.0451 | 0.3745 |
Echinococcus granulosus | Transglutaminase | 0.2618 | 0.4114 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0023 | 0.0025 |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 0.0191 | 0.0191 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0029 | 0.0071 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0212 | 0.0317 | 0.2635 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.01 | 0.0141 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.0774 | 0.1204 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0059 | 0.0076 | 0.0631 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0023 | 0.0029 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0023 | 0.0079 |
Brugia malayi | Thioredoxin family protein | 0.2618 | 0.4114 | 1 |
Giardia lamblia | Hypothetical protein | 0.2618 | 0.4114 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 2 | 0.0718 | 0.1116 | 0.9271 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0029 | 0.0071 |
Echinococcus granulosus | lamin | 0.0059 | 0.0076 | 0.0185 |
Trichomonas vaginalis | beta-galactosidase, putative | 0.0753 | 0.1171 | 0.2818 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0013 | 0.0004 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0023 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0023 | 0.0191 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.0232 | 0.0564 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0022 | 0.0017 | 0.0041 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0031 | 0.0075 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0032 | 0.0033 | 0.008 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.002 | 0.0008 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0023 | 0.0056 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0036 | 0.0039 | 0.0069 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0128 | 0.0185 | 0.1538 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0023 | 0.0025 |
Mycobacterium ulcerans | hypothetical protein | 0.2618 | 0.4114 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.2618 | 0.4114 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.2618 | 0.4114 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.2618 | 0.4114 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0023 | 0.0025 |
Mycobacterium leprae | Conserved hypothetical protein | 0.2618 | 0.4114 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.0046 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0032 | 0.0033 | 0.0272 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0029 | 0.0071 |
Entamoeba histolytica | hypothetical protein | 0.0121 | 0.0173 | 0.2034 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0046 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0013 | 0.0107 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0059 | 0.0076 | 0.0185 |
Brugia malayi | manba-prov protein | 0.0244 | 0.0368 | 0.0895 |
Echinococcus granulosus | snurportin 1 | 0.0313 | 0.0477 | 0.116 |
Mycobacterium ulcerans | transglutaminase family protein | 0.2618 | 0.4114 | 1 |
Trichomonas vaginalis | beta-mannosidase, putative | 0.0244 | 0.0368 | 0.0858 |
Onchocerca volvulus | 0.0059 | 0.0076 | 0.0076 | |
Echinococcus multilocularis | snurportin 1 | 0.0313 | 0.0477 | 0.116 |
Trichomonas vaginalis | glycoside hydrolase, putative | 0.0753 | 0.1171 | 0.2818 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.2618 | 0.4114 | 1 |
Echinococcus multilocularis | musashi | 0.0059 | 0.0076 | 0.0185 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0023 | 0.0025 |
Entamoeba histolytica | beta-galactosidase, putative | 0.0509 | 0.0786 | 1 |
Brugia malayi | hypothetical protein | 0.0132 | 0.0191 | 0.0463 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0023 | 0.0029 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0022 | 0.0017 | 0.2267 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0013 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0028 | 0.0231 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.0046 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0191 | 0.1582 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 0.0023 | 0.0079 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0017 | 0.0141 |
Schistosoma mansoni | ran | 0.0022 | 0.0017 | 0.0041 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.0141 | 0.0343 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0031 | 0.0075 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0074 | 0.0617 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0753 | 0.1171 | 0.2818 |
Mycobacterium tuberculosis | Hypothetical protein | 0.2618 | 0.4114 | 1 |
Brugia malayi | intermediate filament protein | 0.0059 | 0.0076 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0454 | 0.0699 | 0.5803 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.0046 | 0.0071 |
Brugia malayi | MH2 domain containing protein | 0.0128 | 0.0185 | 0.045 |
Schistosoma mansoni | lamin | 0.0059 | 0.0076 | 0.0185 |
Echinococcus multilocularis | Transglutaminase | 0.2618 | 0.4114 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0076 | 0.0631 |
Brugia malayi | RNA, U transporter 1 | 0.0083 | 0.0115 | 0.0279 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.002 | 0.0008 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0059 | 0.0076 | 0.0631 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0046 | 0.0112 |
Brugia malayi | glutaminase DH11.1 | 0.0297 | 0.0451 | 0.1096 |
Echinococcus multilocularis | lamin dm0 | 0.0059 | 0.0076 | 0.0185 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0023 | 0.0025 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0017 | 0.2494 |
Mycobacterium tuberculosis | Conserved protein | 0.2618 | 0.4114 | 1 |
Onchocerca volvulus | 0.003 | 0.0031 | 0.0031 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0013 | 0.0107 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0031 | 0.0075 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0023 | 0.0056 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 0.0046 | 0.0081 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0031 | 0.0075 |
Giardia lamblia | Transglutaminase/protease, putative | 0.2618 | 0.4114 | 1 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0022 | 0.0017 | 0.0041 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 0.0046 | 0.0071 |
Brugia malayi | Glycosyl hydrolases family 2, sugar binding domain containing protein | 0.0718 | 0.1116 | 0.2713 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.0141 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0026 | 0.0217 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0023 | 0.0025 |
Schistosoma mansoni | intermediate filament proteins | 0.0059 | 0.0076 | 0.0185 |
Onchocerca volvulus | 0.0158 | 0.0232 | 0.0232 | |
Loa Loa (eye worm) | glutaminase 2 | 0.0297 | 0.0451 | 0.3745 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0046 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0028 | 0.0028 | 0.0068 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0031 | 0.4756 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0023 | 0.2091 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0029 | 0.4196 |
Schistosoma mansoni | glutaminase | 0.0297 | 0.0451 | 0.1096 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0013 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.01 | 0.0141 | 0.1173 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0023 | 0.2091 |
Echinococcus granulosus | lamin dm0 | 0.0059 | 0.0076 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0023 | 0.0191 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.01 | 0.0141 | 0.0343 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0046 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0028 | 0.0028 | 0.0068 |
Schistosoma mansoni | ran | 0.0022 | 0.0017 | 0.0041 |
Schistosoma mansoni | survival motor neuron protein | 0.0158 | 0.0232 | 0.0564 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.2618 | 0.4114 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.0046 | 0.0071 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0046 | 1 |
Mycobacterium tuberculosis | Long conserved protein | 0.2618 | 0.4114 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0241 | 0.0363 | 0.0846 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0158 | 0.0232 | 0.0564 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0121 | 0.0173 | 0.0421 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.0046 | 0.0383 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0029 | 0.0071 |
Echinococcus multilocularis | lamin | 0.0059 | 0.0076 | 0.0185 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0023 | 0.2091 |
Schistosoma mansoni | hypothetical protein | 0.0313 | 0.0477 | 0.116 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.01 | 0.0141 | 0.0343 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.002 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0026 | 0.0217 |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 0.0191 | 0.0191 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.002 | 0.0008 |
Loa Loa (eye worm) | beta-glucuronidase | 0.0698 | 0.1084 | 0.9004 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.0046 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.2618 | 0.4114 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0029 | 0.0242 |
Brugia malayi | Pre-SET motif family protein | 0.0212 | 0.0317 | 0.0771 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0046 | 0.0112 |
Trichomonas vaginalis | glutaminase, putative | 0.0297 | 0.0451 | 0.1059 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.002 | 0.119 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0023 | 0.0025 |
Echinococcus granulosus | intermediate filament protein | 0.0059 | 0.0076 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0013 | 0.0107 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.0046 | 0.0112 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0029 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.0141 | 0.0343 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0031 | 0.0075 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0029 | 0.0071 |
Entamoeba histolytica | hypothetical protein | 0.0121 | 0.0173 | 0.2034 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.