Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0342 | 0.0467 | 0.5 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0342 | 0.0467 | 0.0755 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0205 | 0.0214 | 0.0214 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Plasmodium falciparum | plasmepsin IX | 0.0342 | 0.0467 | 0.5 |
Plasmodium falciparum | plasmepsin VII | 0.0342 | 0.0467 | 0.5 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0176 | 0.0161 | 0.042 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0431 | 0.0632 | 0.1021 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0867 | 0.1435 | 0.2319 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0205 | 0.0214 | 0.0346 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0342 | 0.0467 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0867 | 0.1435 | 1 |
Plasmodium vivax | plasmepsin IV, putative | 0.0342 | 0.0467 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0107 | 0.0033 | 0.0107 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0431 | 0.0632 | 0.4271 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Plasmodium vivax | aspartyl protease, putative | 0.0342 | 0.0467 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1757 | 0.3078 | 1 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0342 | 0.0467 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0867 | 0.1435 | 0.4661 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0205 | 0.0214 | 0.0696 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0342 | 0.0467 | 0.0755 |
Plasmodium falciparum | plasmepsin II | 0.0342 | 0.0467 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0342 | 0.0467 | 0.0755 |
Plasmodium falciparum | plasmepsin III | 0.0342 | 0.0467 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0107 | 0.0033 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.0632 | 0.1021 |
Toxoplasma gondii | aspartyl protease | 0.0342 | 0.0467 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0867 | 0.1435 | 0.2319 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0089 | 0 | 0.5 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.3442 | 0.6187 | 1 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0342 | 0.0467 | 0.0755 |
Plasmodium falciparum | plasmepsin I | 0.0342 | 0.0467 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0431 | 0.0632 | 0.0632 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Brugia malayi | Choline O-acetyltransferase | 0.0431 | 0.0632 | 0.1021 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0431 | 0.0632 | 0.1021 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.0342 | 0.0467 | 1 |
Onchocerca volvulus | 0.0342 | 0.0467 | 0.7396 | |
Plasmodium vivax | aspartyl protease, putative | 0.0342 | 0.0467 | 0.5 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Plasmodium falciparum | plasmepsin IV | 0.0342 | 0.0467 | 0.5 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0342 | 0.0467 | 0.0755 |
Plasmodium falciparum | plasmepsin VI | 0.0342 | 0.0467 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0867 | 0.1435 | 0.4661 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0342 | 0.0467 | 1 |
Echinococcus granulosus | choline O acetyltransferase | 0.0431 | 0.0632 | 0.2052 |
Brugia malayi | MAP kinase sur-1 | 0.0107 | 0.0033 | 0.0053 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1757 | 0.3078 | 1 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0176 | 0.0161 | 0.026 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0431 | 0.0632 | 0.1021 |
Giardia lamblia | Kinase, AGC AKT | 0.0176 | 0.0161 | 1 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Onchocerca volvulus | 0.0342 | 0.0467 | 0.7396 | |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0205 | 0.0214 | 0.0696 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0107 | 0.0033 | 0.0107 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0342 | 0.0467 | 0.1518 |
Brugia malayi | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0342 | 0.0467 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1757 | 0.3078 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3442 | 0.6187 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0867 | 0.1435 | 0.4603 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0342 | 0.0467 | 1 |
Brugia malayi | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.0033 | 0.0033 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0867 | 0.1435 | 0.4603 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0431 | 0.0632 | 0.2052 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0091 | 0.0003 | 0.001 |
Schistosoma mansoni | choline o-acyltransferase | 0.0431 | 0.0632 | 0.0632 |
Plasmodium vivax | aspartyl protease, putative | 0.0342 | 0.0467 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0431 | 0.0632 | 0.4271 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0342 | 0.0467 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1757 | 0.3078 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0431 | 0.0632 | 0.4271 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0342 | 0.0467 | 0.0755 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0107 | 0.0033 | 0.0107 |
Plasmodium vivax | plasmepsin V, putative | 0.0342 | 0.0467 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Brugia malayi | Pepsin A precursor | 0.0342 | 0.0467 | 0.0755 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0342 | 0.0467 | 0.1518 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0107 | 0.0033 | 0.0107 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Plasmodium falciparum | plasmepsin X | 0.0342 | 0.0467 | 0.5 |
Plasmodium falciparum | plasmepsin V | 0.0342 | 0.0467 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.4271 |
Brugia malayi | Choline O-acetyltransferase | 0.0431 | 0.0632 | 0.1021 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1757 | 0.3078 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.