TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 459.494 | Formula: C21H22FN5O4S
H donors: 1 H acceptors: 4 LogP: 2.06 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)/C=C/c1cn(c2nccs2)c2c(c1=O)cc(c(n2)N1C[C@@H]([C@H](C1)NC)OC)F
InChi: 1S/C21H22FN5O4S/c1-23-15-10-26(11-16(15)30-2)20-14(22)8-13-18(29)12(4-5-17(28)31-3)9-27(19(13)25-20)21-24-6-7-32-21/h4-9,15-16,23H,10-11H2,1-3H3/b5-4+/t15-,16-/m0/s1
InChiKey: RNPPZKFAYFQRPP-SWJNODNISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	glucose transporter, putative	0.0058	0.0656	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Brugia malayi	Cathepsin L-like precursor	0.001	0.0045	0.0181
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0027	0.0263	0.1146
Leishmania major	hypothetical protein, conserved	0.0026	0.0254	0.3381
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0058	0.0647	0.0647
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0058	0.0647	0.0647
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0056	0.0632	0.9772
Plasmodium vivax	glycine--tRNA ligase, putative	0.0011	0.0053	0.0053
Onchocerca volvulus		0.0026	0.0254	0.8651
Leishmania major	glucose transporter, lmgt2	0.0058	0.0656	0.8747
Echinococcus multilocularis	survival motor neuron protein 1	0.0145	0.1748	0.7617
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0026	0.0254	0.1106
Brugia malayi	major facilitator superfamily protein	0.0026	0.0254	0.1091
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0038	0.0504
Onchocerca volvulus		0.0026	0.0254	0.8651
Trichomonas vaginalis	glucose transporter, putative	0.0058	0.0656	0.286
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0035	0.0357	0.4756
Echinococcus multilocularis	lysyl tRNA synthetase	0.0042	0.045	0.196
Schistosoma mansoni	cathepsin F (C01 family)	0.001	0.0045	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1748	0.7617
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0045	0.0198
Loa Loa (eye worm)	cysteine protease	0.001	0.0045	0.0198
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Brugia malayi	Major Facilitator Superfamily protein	0.0026	0.0254	0.1091
Trypanosoma cruzi	cysteine peptidase, putative	0.001	0.0045	0.0605
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.0647	0.2819
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0038	0.0398	0.531
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0058	0.0647	0.0976
Trichomonas vaginalis	sugar transporter, putative	0.0058	0.0656	0.286
Trypanosoma cruzi	major cysteine proteinase, putative	0.003	0.0296	0.3945
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Echinococcus granulosus	cathepsin l1	0.0007	0.0004	0.0017
Leishmania major	cathepsin L-like protease	0.001	0.0045	0.0605
Toxoplasma gondii	glycyl-tRNA synthetase	0.0011	0.0053	0.008
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0042	0.045	0.6932
Leishmania major	hypothetical protein, conserved	0.0009	0.0038	0.0504
Onchocerca volvulus		0.001	0.0045	0.1438
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0632	0.2755
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0011	0.0053	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0254	0.1106
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0024	0.0223	0.0972
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0058	0.0647	0.0647
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0056	0.0632	1
Giardia lamblia	Sugar-proton symporter	0.0026	0.0254	0.346
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.001	0.0045	0.0045
Mycobacterium ulcerans	sugar transporter	0.0026	0.0254	0.5639
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Onchocerca volvulus		0.003	0.0293	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0045	0.0198
Trypanosoma cruzi	hexose transporter	0.0058	0.0656	0.8747
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0499	0.2173
Echinococcus granulosus	cathepsin L cysteine proteinase	0.001	0.0045	0.0198
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0045	0.0198
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.003	0.0293	0.1261
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0799	1	1
Brugia malayi	hypothetical protein	0.0145	0.1748	0.7613
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0045	0.0198
Onchocerca volvulus		0.0026	0.0254	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0254	0.1106
Plasmodium vivax	vivapain-2	0.001	0.0045	0.0045
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0026	0.0254	0.1106
Schistosoma mansoni	glucose transport protein	0.0188	0.2295	1
Schistosoma mansoni	sugar transporter	0.0026	0.0254	0.1106
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0045	0.0198
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0058	0.0647	0.0647
Echinococcus multilocularis	General substrate transporter	0.0162	0.1961	0.8545
Echinococcus granulosus	solute carrier family 22	0.0026	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0011	0.0053	0.0233
Toxoplasma gondii	sugar transporter ST1	0.0026	0.0254	0.0383
Entamoeba histolytica	cysteine proteinase, putative	0.0007	0.0004	0.006
Trichomonas vaginalis	conserved hypothetical protein	0.0188	0.2295	1
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0011	0.0053	0.0216
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0045	0.0198
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0042	0.045	0.5996
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0004	0.0017
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0058	0.0656	0.8747
Onchocerca volvulus	Cathepsin F homolog	0.001	0.0045	0.1438
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0254	0.1106
Echinococcus multilocularis	cathepsin L cysteine protease	0.001	0.0045	0.0198
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0024	0.0223	0.0972
Leishmania major	cathepsin L-like protease	0.0038	0.0398	0.531
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0038	0.0398	0.531
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0254	0.1106
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0011	0.0053	0.0825
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0011	0.0053	0.0233
Plasmodium vivax	threonine--tRNA ligase, putative	0.0011	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0254	0.1106
Onchocerca volvulus		0.001	0.0045	0.1438
Leishmania major	lysyl-tRNA synthetase, putative	0.0042	0.045	0.5996
Mycobacterium ulcerans	hypothetical protein	0.0009	0.0038	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0254	0.1106
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0304	0.3758	0.5667
Schistosoma mansoni	cathepsin F (C01 family)	0.0007	0.0004	0.0017
Schistosoma mansoni	glycyl-tRNA synthetase	0.0011	0.0053	0.0233
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0045	0.0198
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0058	0.0647	0.0647
Plasmodium falciparum	cysteine proteinase falcipain 3	0.001	0.0045	0.0045
Trypanosoma brucei	glucose transporter, putative	0.0058	0.0656	0.8747
Plasmodium vivax	sugar transporter, putative	0.0026	0.0254	0.0254
Trichomonas vaginalis	sugar transporter, putative	0.0058	0.0656	0.286
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0011	0.0053	0.0711
Trypanosoma cruzi	glucose transporter, putative	0.0026	0.0254	0.3381
Leishmania major	protein kinase, putative	0.0058	0.0647	0.8623
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0036	0.037	0.5587
Loa Loa (eye worm)	sugar transporter	0.0026	0.0254	0.1106
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0188	0.2295	1
Schistosoma mansoni	hypothetical protein	0.0024	0.0223	0.0972
Schistosoma mansoni	hypothetical protein	0.0024	0.0223	0.0972
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0027	0.0263	0.1146
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Brugia malayi	lysyl-tRNA synthetase	0.0042	0.045	0.1947
Schistosoma mansoni	survival motor neuron protein	0.003	0.0293	0.1275
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0045	0.0198
Trypanosoma brucei	glucose transporter, putative	0.0058	0.0656	0.8747
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0304	0.3758	0.3758
Plasmodium falciparum	threonine--tRNA ligase	0.0011	0.0053	0.0053
Trichomonas vaginalis	CAMK family protein kinase	0.0058	0.0647	0.2819
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0058	0.0647	0.2819
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0066	0.075	1
Trichomonas vaginalis	glucose transporter, putative	0.0026	0.0254	0.1106
Toxoplasma gondii	sugar transporter ST2	0.0026	0.0254	0.0383
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0011	0.0053	0.0233
Schistosoma mansoni	hypothetical protein	0.0188	0.2295	1
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0011	0.0053	0.0711
Trypanosoma cruzi	cysteine peptidase, putative	0.0038	0.0398	0.531
Schistosoma mansoni	sugar transporter	0.0026	0.0254	0.1106
Echinococcus granulosus	synaptic vesicle 2 protein	0.0026	0.0254	0.1106
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0045	0.0198
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0011	0.0053	0.0233
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0058	0.0647	0.2819
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0026	0.0254	0.5639
Plasmodium vivax	lysine--tRNA ligase, putative	0.0042	0.045	0.045
Echinococcus granulosus	calcium dependent protein kinase	0.0054	0.0602	0.2623
Leishmania major	cathepsin L-like protease	0.001	0.0045	0.0605
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.001	0.0045	0.0198
Treponema pallidum	prolyl-tRNA synthetase	0.002	0.0171	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0076	0.0878	0.3827
Brugia malayi	Cam kinase protein 1	0.0058	0.0647	0.2807
Schistosoma mansoni	lysyl-tRNA synthetase	0.0042	0.045	0.196
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0076	0.0878	0.3817
Trypanosoma cruzi	sugar transporter, putative	0.0026	0.0254	0.3381
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0036	0.037	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0045	0.0198
Brugia malayi	Cathepsin L-like precursor	0.001	0.0045	0.0181
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0038	0.0398	0.531
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0045	0.0198
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0011	0.0053	0.0825
Trypanosoma brucei	glucose transporter 2A	0.0058	0.0656	0.8747
Echinococcus granulosus	geminin	0.0101	0.1191	0.5191
Toxoplasma gondii	transporter, major facilitator family protein	0.0026	0.0254	0.0383
Echinococcus granulosus	solute carrier family 22	0.0026	0.0254	0.1106
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0038	0.0398	0.531
Entamoeba histolytica	hypothetical protein	0.0042	0.045	0.6953
Brugia malayi	latrophilin 2 splice variant baaae	0.0052	0.0575	0.2493
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.001	0.0045	0.0045
Schistosoma mansoni	cathepsin F (C01 family)	0.001	0.0045	0.0198
Trypanosoma cruzi	hexose transporter, putative	0.0026	0.0254	0.3381
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0188	0.2295	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.001	0.0045	0.0198
Onchocerca volvulus		0.0026	0.0254	0.8651
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0045	0.0198
Trypanosoma cruzi	cysteine peptidase, putative	0.0038	0.0398	0.531
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0045	0.0198
Mycobacterium ulcerans	integral membrane transport protein	0.0026	0.0254	0.5639
Toxoplasma gondii	cathepsin CPL	0.001	0.0045	0.0068
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Entamoeba histolytica	cysteine proteinase, putative	0.001	0.0045	0.0701
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0058	0.0647	0.0647
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0304	0.3758	0.3758
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0058	0.0647	0.2819
Echinococcus granulosus	survival motor neuron protein 1	0.0145	0.1748	0.7617
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0026	0.0254	0.3381
Brugia malayi	hypothetical protein	0.0026	0.0254	0.1091
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Echinococcus granulosus	General substrate transporter	0.0162	0.1961	0.8545
Brugia malayi	Latrophilin receptor protein 2	0.0024	0.0223	0.0957
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0038	0.0398	0.531
Leishmania major	cathepsin L-like protease	0.0038	0.0398	0.531
Plasmodium falciparum	hexose transporter	0.0188	0.2295	0.2295
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0027	0.0263	0.1146
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0009	0.0038	0.0504
Plasmodium falciparum	proline--tRNA ligase	0.0066	0.075	0.075
Toxoplasma gondii	YbaK/proline-tRNA ligase associated domain-containing protein	0.0009	0.0038	0.0057
Trichomonas vaginalis	sugar transport protein, putative	0.0026	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Brugia malayi	Cathepsin L-like precursor	0.001	0.0045	0.0181
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0042	0.045	0.5996
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0656	0.286
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0011	0.0053	0.0216
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0011	0.0053	0.1186
Toxoplasma gondii	protein kinase, putative	0.0532	0.663	1
Schistosoma mansoni	hypothetical protein	0.0024	0.0223	0.0972
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0011	0.0053	0.0262
Schistosoma mansoni	hypothetical protein	0.003	0.0293	0.1275
Brugia malayi	Sugar transporter family protein	0.0026	0.0254	0.1091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0045	0.0198
Trypanosoma brucei	glucose transporter, putative	0.0058	0.0656	0.8747
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0011	0.0053	0.008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0045	0.0198
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0027	0.0263	0.1146
Trypanosoma brucei	glucose transporter, putative	0.0058	0.0656	0.8747
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0045	0.0198
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0026	0.0254	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0058	0.0647	0.2819
Leishmania major	hypothetical protein, conserved	0.0009	0.0038	0.0504
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0042	0.045	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0056	0.0632	0.2743
Echinococcus granulosus	cathepsin l1	0.001	0.0045	0.0198
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0045	0.0198
Echinococcus granulosus	GPCR family 2	0.0024	0.0223	0.0972
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0042	0.045	1
Trypanosoma cruzi	hexose transporter, putative	0.0058	0.0656	0.8747
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0026	0.0254	0.5639
Onchocerca volvulus	Putative transporter	0.0026	0.0254	0.8651
Echinococcus multilocularis	GPCR, family 2	0.0024	0.0223	0.0972
Brugia malayi	Cathepsin L-like precursor	0.001	0.0045	0.0181
Leishmania major	cathepsin L-like protease	0.001	0.0045	0.0605
Echinococcus granulosus	lysyl tRNA synthetase	0.0042	0.045	0.196
Schistosoma mansoni	hypothetical protein	0.0052	0.0575	0.2506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.001	0.0045	0.0198
Leishmania major	cathepsin L-like protease	0.001	0.0045	0.0605
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Onchocerca volvulus		0.001	0.0045	0.1438
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Entamoeba histolytica	cysteine protease, putative	0.001	0.0045	0.0701
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0026	0.0254	0.1106
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0045	0.0181
Trypanosoma brucei	glucose transporter 1E	0.0058	0.0656	0.8747
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0024	0.0223	0.0972
Chlamydia trachomatis	proline--tRNA ligase	0.002	0.0171	0.3811
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0038	0.0398	0.531
Echinococcus multilocularis	solute carrier family 22	0.0026	0.0254	0.1106
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0058	0.0647	0.2819
Plasmodium vivax	vivapain-2	0.001	0.0045	0.0045
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0066	0.075	1
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0322	0.4296
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0026	0.0254	0.1106
Entamoeba histolytica	protein kinase, putative	0.0058	0.0647	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0188	0.2295	1
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0058	0.0647	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0254	0.1106
Leishmania major	cathepsin L-like protease	0.0038	0.0398	0.531
Leishmania major	cathepsin L-like protease	0.001	0.0045	0.0605
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Trypanosoma cruzi	hexose transporter, putative	0.0058	0.0656	0.8747
Leishmania major	myo-inositol/proton symporter (MIT)	0.0026	0.0254	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0254	0.1106
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0038	0.0398	0.531
Trypanosoma cruzi	cruzipain precursor, putative	0.0038	0.0398	0.531
Onchocerca volvulus		0.0026	0.0254	0.8651
Onchocerca volvulus		0.0026	0.0254	0.8651
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0038	0.0504
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.001	0.0045	0.0198
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0056	0.0632	0.2755
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0058	0.0656	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0058	0.0647	0.2807
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0066	0.075	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0056	0.0632	0.2743
Onchocerca volvulus		0.0026	0.0254	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.002	0.0171	0.3811
Onchocerca volvulus		0.0026	0.0254	0.8651
Onchocerca volvulus		0.001	0.0045	0.1438
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0009	0.0038	0.0504
Echinococcus multilocularis	solute carrier family 22	0.0026	0.0254	0.1106
Brugia malayi	hypothetical protein	0.0026	0.0254	0.1091
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0076	0.0878	0.3817
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0254	0.1106
Echinococcus granulosus	solute carrier family 22	0.0026	0.0254	0.1106
Giardia lamblia	Lysyl-tRNA synthetase	0.0042	0.045	0.6849
Echinococcus multilocularis	cathepsin L cysteine protease	0.001	0.0045	0.0198
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0026	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0004	0.0017
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0026	0.0254	0.6499
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0575	0.2506
Chlamydia trachomatis	threonine--tRNA ligase	0.0011	0.0053	0.1186
Brugia malayi	Major Facilitator Superfamily protein	0.0026	0.0254	0.1091
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0027	0.0263	0.1146
Brugia malayi	hypothetical protein	0.0026	0.0254	0.1091
Onchocerca volvulus		0.0026	0.0254	0.8651
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0042	0.045	0.196
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0647	0.2819
Trypanosoma brucei	sugar transporter, putative	0.0026	0.0254	0.3381
Echinococcus multilocularis	solute carrier family 22	0.0026	0.0254	0.1106
Schistosoma mansoni	protein kinase	0.0058	0.0647	0.2819
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0027	0.0263	0.1146
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0038	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Trichomonas vaginalis	myo-inositol transporter, putative	0.0026	0.0254	0.1106
Schistosoma mansoni	sugar transporter	0.0026	0.0254	0.1106
Loa Loa (eye worm)	ctsf protein	0.001	0.0045	0.0198
Brugia malayi	major facilitator superfamily protein	0.0026	0.0254	0.1091
Echinococcus multilocularis	cysteine protease	0.001	0.0045	0.0198
Toxoplasma gondii	facilitative glucose transporter GT1	0.0188	0.2295	0.3461
Plasmodium vivax	proline--tRNA ligase, putative	0.0066	0.075	0.075
Giardia lamblia	Prolyl-tRNA synthetase	0.0056	0.0632	1
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0254	0.1106
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0058	0.0647	0.2819
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0058	0.0647	0.0976
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0007	0.0004	0.0017
Onchocerca volvulus		0.0026	0.0254	0.8651
Trypanosoma cruzi	cysteine peptidase, putative	0.0038	0.0398	0.531
Schistosoma mansoni	lysyl-tRNA synthetase	0.0042	0.045	0.196
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0254	0.1106
Entamoeba histolytica	protein kinase, putative	0.0058	0.0647	1
Wolbachia endosymbiont of Brugia malayi	prolyl-tRNA synthetase	0.0011	0.0053	0.2103
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0037	0.0385	0.1676
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0036	0.037	1
Onchocerca volvulus		0.0026	0.0254	0.8651
Echinococcus multilocularis	calcium dependent protein kinase	0.0054	0.0602	0.2623
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0056	0.0632	0.2755
Loa Loa (eye worm)	hypothetical protein	0.001	0.0045	0.0198
Onchocerca volvulus		0.0026	0.0254	0.8651
Leishmania major	cysteine peptidase A (CPA)	0.001	0.0045	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0254	0.1106
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0027	0.0263	0.1146
Wolbachia endosymbiont of Brugia malayi	threonyl-tRNA synthetase	0.0011	0.0053	0.2103
Echinococcus multilocularis	cysteine protease	0.001	0.0045	0.0198
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0026	0.0254	0.6499
Toxoplasma gondii	sugar transporter ST3	0.0026	0.0254	0.0383
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Loa Loa (eye worm)	sugar transporter	0.0188	0.2295	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0024	0.0223	0.0972
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0188	0.2295	1
Schistosoma mansoni	protein kinase	0.0058	0.0647	0.2819
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0038	0.0398	0.531
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0056	0.0632	0.2755
Schistosoma mansoni	hypothetical protein	0.0024	0.0223	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0053	0.0233
Echinococcus granulosus	glycyl tRNA synthetase	0.0011	0.0053	0.0233
Leishmania major	glucose transporter, lmgt1	0.0058	0.0656	0.8747
Brugia malayi	Sugar transporter family protein	0.0188	0.2295	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0066	0.075	1
Onchocerca volvulus		0.0026	0.0254	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0254	0.1106
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0027	0.0263	0.1131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0045	0.0198
Schistosoma mansoni	sugar transporter	0.0026	0.0254	0.1106
Schistosoma mansoni	protein kinase	0.0058	0.0647	0.2819
Schistosoma mansoni	hypothetical protein	0.0101	0.1191	0.5191
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0056	0.0632	0.2755
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0007	0.0004	0.0017
Trypanosoma brucei	glucose transporter, putative	0.0058	0.0656	0.8747
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0058	0.0656	0.8747
Trypanosoma brucei	Aminoacyl-tRNA editing domain containing protein, putative	0.0009	0.0038	0.0504
Giardia lamblia	Hexose transporter	0.0026	0.0254	0.346
Leishmania major	glucose transporter, lmgt3	0.0058	0.0656	0.8747
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.001	0.0045	0.0198
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0058	0.0647	0.2819
Trypanosoma brucei	glucose transporter, putative	0.0058	0.0656	0.8747
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0045	0.0198
Trichomonas vaginalis	glucose transporter, putative	0.0058	0.0656	0.286
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0024	0.0223	0.0972
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0188	0.2295	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0045	0.0198
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0058	0.0647	0.8623
Echinococcus granulosus	cathepsin l cysteine peptidase	0.001	0.0045	0.0198
Brugia malayi	glycyl-tRNA synthetase	0.0011	0.0053	0.0216
Onchocerca volvulus	Cathepsin L homolog	0.001	0.0045	0.1438
Trichomonas vaginalis	sugar transporter, putative	0.0058	0.0656	0.286
Schistosoma mansoni	glucose transporter	0.0026	0.0254	0.1106
Leishmania major	threonyl-tRNA synthetase, putative	0.0011	0.0053	0.0711
Schistosoma mansoni	hypothetical protein	0.0101	0.1191	0.5191
Onchocerca volvulus		0.0026	0.0254	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0254	0.1106
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0027	0.0263	0.1146
Toxoplasma gondii	lysine-tRNA ligase	0.0042	0.045	0.0679
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0038	0.0165
Treponema pallidum	threonyl-tRNA synthetase	0.0011	0.0053	0.3113
Brugia malayi	Sugar transporter family protein	0.0026	0.0254	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0223	0.0972
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.001	0.0045	0.0198
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0026	0.0254	0.1106
Echinococcus granulosus	solute carrier family 22	0.0026	0.0254	0.1106
Plasmodium falciparum	lysine--tRNA ligase	0.0042	0.045	0.045
Echinococcus multilocularis	geminin	0.0101	0.1191	0.5191
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0045	0.0198
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0045	0.0198
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0188	0.2295	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0056	0.0632	0.2755
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0058	0.0647	0.0647
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0011	0.0053	0.0468
Onchocerca volvulus		0.0026	0.0254	0.8651
Echinococcus multilocularis	glycyl tRNA synthetase	0.0011	0.0053	0.0233
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0058	0.0647	0.2819
Entamoeba histolytica	cysteine proteinase, putative	0.001	0.0045	0.0701
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0011	0.0053	0.0711
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0066	0.075	0.1132
Schistosoma mansoni	glucose transport protein	0.0188	0.2295	1
Plasmodium falciparum	protein kinase 7	0.0532	0.663	0.663
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0004	0.0017
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0058	0.0647	0.2819
Onchocerca volvulus		0.0026	0.0254	0.8651
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0011	0.0053	0.0233
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0011	0.0053	0.0711
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0024	0.0223	0.0957
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0878	0.3827
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0066	0.075	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0058	0.0647	0.0976
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0254	0.1106
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0188	0.2295	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0188	0.2295	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0038	0.0398	0.531
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Loa Loa (eye worm)	fibroinase	0.001	0.0045	0.0198
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0058	0.0656	0.8747
Brugia malayi	Major Facilitator Superfamily protein	0.0026	0.0254	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0632	0.2755
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0038	0.0398	0.531
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0026	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0254	0.1106
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0058	0.0647	0.2819
Schistosoma mansoni	glucose transport protein	0.0188	0.2295	1
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0058	0.0647	0.0647
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0023	0.0212	0.0925
Brugia malayi	Cathepsin L-like precursor	0.001	0.0045	0.0181
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0038	0.0165
Trypanosoma brucei	glucose transporter, putative	0.0058	0.0656	0.8747
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0045	0.0198
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0656	0.286
Onchocerca volvulus		0.001	0.0045	0.1438
Onchocerca volvulus		0.001	0.0045	0.1438
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0038	0.0398	0.531
Onchocerca volvulus		0.001	0.0045	0.1438
Echinococcus multilocularis	solute carrier family 22	0.0026	0.0254	0.1106
Brugia malayi	Cathepsin L-like precursor	0.001	0.0045	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0042	0.045	0.196
Plasmodium vivax	hexose transporter	0.0188	0.2295	0.2295
Chlamydia trachomatis	lysine--tRNA ligase	0.0042	0.045	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0254	0.1106
Trypanosoma cruzi	hexose transporter, putative	0.0058	0.0656	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0026	0.0254	0.1106
Onchocerca volvulus	Cathepsin L homolog	0.001	0.0045	0.1438

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.0947 ug ml-1	In vitro cytotoxicity of the compound was measured towards murine lymphocytic leukemia P388 cells	ChEMBL.	15149673
IC50 (functional)	= 0.09470000000000003 ug ml-1	In vitro cytotoxicity of the compound was measured towards murine lymphocytic leukemia P388 cells	ChEMBL.	15149673
MIC (functional)	> 100 ug ml-1	In vitro antibacterial activity of the compound towards Staphylococcus aureus 209 JC-1	ChEMBL.	15149673
MIC (functional)	> 100 ug ml-1	In vitro antibacterial activity of compound towards Escherichia coli NIHJ JC-2	ChEMBL.	15149673
MIC (functional)	> 100 ug ml-1	In vitro antibacterial activity of compound towards Escherichia coli NIHJ JC-2	ChEMBL.	15149673

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23	15149673

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL108081

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 180226