Detailed information for compound 1805008

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 324.412 | Formula: C18H28O5
  • H donors: 0 H acceptors: 0 LogP: 2.99 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOC[C@@]1(C)O[C@H]2[C@@]34[C@H]1CC[C@H](C4CC[C@@](O2)(OO3)C)C
  • InChi: 1S/C18H28O5/c1-5-10-19-11-16(3)14-7-6-12(2)13-8-9-17(4)21-15(20-16)18(13,14)23-22-17/h5,12-15H,1,6-11H2,2-4H3/t12-,13?,14+,15-,16-,17+,18-/m1/s1
  • InChiKey: LOVQCYAEOLPIBZ-KIPGADRNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0061 0.0061
Mycobacterium tuberculosis Conserved protein 0.1104 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0241 0.0863
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0791 0.396
Echinococcus multilocularis dual specificity 0.021 0.1837 0.1837
Trypanosoma brucei Sphingosine kinase 0.0043 0.0313 0.1269
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0183 0.0536
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0791 0.396
Schistosoma mansoni cpg binding protein 0.003 0.0191 0.0131
Trypanosoma brucei diacylglycerol kinase, putative 0.0043 0.0313 0.1269
Plasmodium vivax glutathione reductase, putative 0.0083 0.0679 0.3326
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0183 0.0536
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0241 0.0241
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0241 0.0863
Mycobacterium ulcerans hypothetical protein 0.0035 0.0241 0.0154
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0406 0.0406
Plasmodium falciparum diacylglycerol kinase, putative 0.0043 0.0313 0.1269
Loa Loa (eye worm) hypothetical protein 0.0043 0.0313 0.0313
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0114 0.0106
Brugia malayi beta-lactamase 0.0035 0.0241 0.0364
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0183 0.0123
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0114 0.0965 0.0965
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0241 0.0154
Entamoeba histolytica hypothetical protein 0.021 0.1837 0.1764
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0189 0.1649 0.8795
Brugia malayi beta-lactamase family protein 0.0035 0.0241 0.0364
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0791 1
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0406 0.0347
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.0241
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.021 0.1837 0.9854
Leishmania major hypothetical protein, conserved 0.0043 0.0313 0.1269
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.021 0.1837 0.1837
Plasmodium vivax diacylglycerol kinase, putative 0.0043 0.0313 0.1269
Echinococcus multilocularis thioredoxin glutathione reductase 0.0083 0.0683 0.0683
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0461 0.0376
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0241 0.0241
Leishmania major protein kinase, putative 0.0213 0.1863 1
Plasmodium vivax thioredoxin reductase, putative 0.0083 0.0679 0.3326
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0367 0.1567
Leishmania major trypanothione reductase 0.0083 0.0679 0.3326
Trichomonas vaginalis hypothetical protein 0.0024 0.0142 0.0305
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0183 0.0536
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0461 0.0461
Echinococcus multilocularis GPCR, family 2 0.0015 0.0061 0.0061
Trichomonas vaginalis bmru protein, putative 0.0043 0.0313 0.1269
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0406 0.1789
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0241 0.0241
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0461 0.2102
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0241 0.0181
Loa Loa (eye worm) diacylglycerol kinase 2 0.0043 0.0313 0.0313
Leishmania major hypothetical protein, conserved 0.0035 0.0241 0.0863
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0791 0.396
Entamoeba histolytica protein kinase, putative 0.021 0.1837 0.1764
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0083 0.0679 0.0595
Giardia lamblia Tenascin precursor 0.0024 0.0142 0.0305
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0183 0.0536
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.0241
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0043 0.0313 0.1269
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0213 0.1863 1
Schistosoma mansoni integrin beta subunit 0.0443 0.3967 0.393
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0791 0.1474
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0183 0.0536
Entamoeba histolytica protein kinase domain containing protein 0.021 0.1837 0.1764
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0213 0.1863 1
Loa Loa (eye worm) glutathione reductase 0.0083 0.0679 0.0679
Echinococcus granulosus fibrillin 1 0.0024 0.0142 0.0142
Giardia lamblia Tenascin-37 0.0024 0.0142 0.0305
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0791 0.396
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0213 0.1863 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0061 0.0061
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.0406 0.1789
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0043 0.0313 0.1269
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.0406 0.1789
Schistosoma mansoni sphingosine kinase A B 0.1104 1 1
Loa Loa (eye worm) hypothetical protein 0.0209 0.1831 0.1831
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.0406 0.0406
Echinococcus granulosus dnaJ subfamily B 0.0399 0.3562 0.3562
Echinococcus multilocularis protein jagged 2 0.0024 0.0142 0.0142
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0241 0.0863
Entamoeba histolytica diacylglycerol kinase, putative 0.0043 0.0313 0.0227
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0367 0.1567
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.0406 0.1789
Loa Loa (eye worm) hypothetical protein 0.0049 0.0365 0.0365
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0461 0.2102
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0043 0.0313 0.0313
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0183 0.0536
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0183 0.0536
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0224 0.0329
Giardia lamblia Kinase, PLK 0.0095 0.0791 0.396
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0183 0.0096
Giardia lamblia Neurogenic locus Notch protein precursor 0.0024 0.0142 0.0305
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0088 0.0088
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0406 0.1789
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0183 0.0536
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0189 0.1649 0.1575
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0183 0.0536
Echinococcus granulosus GPCR family 2 0.0015 0.0061 0.0061
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.021 0.1837 0.9854
Mycobacterium tuberculosis Conserved protein 0.0035 0.0241 0.0154
Trichomonas vaginalis diacylglycerol kinase, putative 0.0043 0.0313 0.1269
Schistosoma mansoni cpg binding protein 0.0028 0.0177 0.0116
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0241 0.0154
Brugia malayi hypothetical protein 0.0114 0.0965 0.1826
Toxoplasma gondii thioredoxin reductase 0.0083 0.0679 0.3326
Brugia malayi Thioredoxin reductase 0.0083 0.0679 0.1247
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0043 0.0313 0.0254
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0183 0.0096
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0461 0.0461
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0177 0.0177
Echinococcus granulosus thioredoxin glutathione reductase 0.0083 0.0683 0.0683
Mycobacterium tuberculosis Probable dehydrogenase 0.0189 0.1649 0.1575
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0241 0.0863
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0183 0.0536
Loa Loa (eye worm) integrin beta-2 0.0558 0.5011 0.5011
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0406 0.1789
Giardia lamblia High cysteine protein 0.0024 0.0142 0.0305
Plasmodium falciparum thioredoxin reductase 0.0029 0.0183 0.0536
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0183 0.0183
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0241 0.0863
Echinococcus granulosus Diacylglycerol kinase theta 0.0043 0.0313 0.0313
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0183 0.0536
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0043 0.0313 0.1269
Schistosoma mansoni serine/threonine protein kinase 0.021 0.1837 0.1787
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0189 0.1649 0.1575
Brugia malayi cell division control protein 2 homolog 0.0053 0.0406 0.0696
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0241 0.0863
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0406 0.032
Schistosoma mansoni hypothetical protein 0.0033 0.0224 0.0164
Mycobacterium ulcerans hypothetical protein 0.1104 1 1
Schistosoma mansoni kinase 0.005 0.0378 0.0318
Entamoeba histolytica hypothetical protein 0.0035 0.0241 0.0154
Echinococcus multilocularis ceramide kinase 0.0043 0.0313 0.0313
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0183 0.0536
Mycobacterium tuberculosis Probable reductase 0.0189 0.1649 0.1575
Leishmania major diacylglycerol kinase, putative 0.0043 0.0313 0.1269
Trypanosoma brucei polo-like protein kinase 0.0095 0.0791 0.396
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0043 0.0313 0.0313
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.6064 0.6064
Echinococcus granulosus cpg binding protein 0.003 0.0191 0.0191
Echinococcus granulosus Diacylglycerol kinase zeta 0.0043 0.0313 0.0313
Brugia malayi glutathione reductase 0.0083 0.0679 0.1247
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0241 0.0154
Echinococcus multilocularis fibrillin 2 0.0024 0.0142 0.0142
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0114 0.0106
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0183 0.0536
Trypanosoma cruzi Sphingosine kinase 0.0043 0.0313 0.1269
Schistosoma mansoni diacylglycerol kinase theta 0.0043 0.0313 0.0254
Brugia malayi diacylglycerol kinase 0.0043 0.0313 0.0509
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0461 0.0403
Giardia lamblia High cysteine protein 0.0024 0.0142 0.0305
Loa Loa (eye worm) hypothetical protein 0.0033 0.0224 0.0224
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0406 0.1789
Loa Loa (eye worm) hypothetical protein 0.0043 0.0313 0.0313
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0183 0.5
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0183 0.0536
Giardia lamblia Kinase, CMGC CLK 0.0213 0.1863 1
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0043 0.0313 0.0254
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0142
Schistosoma mansoni hypothetical protein 0.0043 0.0313 0.0254
Schistosoma mansoni hypothetical protein 0.0399 0.3562 0.3522
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0313 0.1269
Brugia malayi EGF-like domain containing protein 0.0024 0.0142 0.0164
Brugia malayi beta-lactamase family protein 0.0035 0.0241 0.0364
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0241 0.0364
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0791 0.396
Leishmania major hypothetical protein, conserved 0.0043 0.0313 0.1269
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0142
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0088 0.0055
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.6064 0.604
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0183 0.0536
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0183 0.0536
Onchocerca volvulus 0.0035 0.0241 0.1527
Trypanosoma cruzi diacylglycerol kinase, putative 0.0043 0.0313 0.1269
Plasmodium vivax protein kinase Crk2 0.0053 0.0406 0.1789
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0365 0.0613
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0406 0.1789
Echinococcus multilocularis adam 0.0024 0.0142 0.0142
Echinococcus multilocularis integrin beta 2 0.0558 0.5011 0.5011
Schistosoma mansoni cpg binding protein 0.003 0.0191 0.0131
Brugia malayi EGF-like domain containing protein 0.0024 0.0142 0.0164
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0043 0.0313 0.1269
Loa Loa (eye worm) thioredoxin reductase 0.0083 0.0679 0.0679
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0791 0.396
Giardia lamblia Tenascin-like 0.0024 0.0142 0.0305
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0183 0.0536
Trichomonas vaginalis sphingosine kinase, putative 0.0043 0.0313 0.1269
Toxoplasma gondii ABC1 family protein 0.0035 0.0241 0.0863
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1969 0.1897
Entamoeba histolytica diacylglycerol kinase, putative 0.0043 0.0313 0.0227
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0213 0.1863 1
Brugia malayi Protein kinase domain containing protein 0.021 0.1837 0.3588
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0061 0.0061
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0183 0.0536
Treponema pallidum NADH oxidase 0.0029 0.0183 1
Trichomonas vaginalis sphingosine kinase, putative 0.0043 0.0313 0.1269
Echinococcus granulosus integrin beta 2 0.0558 0.5011 0.5011
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.0406 0.0406
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0183 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0791 0.396
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.021 0.1842 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0406 0.0406
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0189 0.1649 0.1575
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0365 0.0613
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.1863 0.1813
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.0406 0.1789
Onchocerca volvulus 0.0035 0.0241 0.1527
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.0241
Mycobacterium tuberculosis Probable oxidoreductase 0.021 0.1842 0.1769
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.0406 0.0406
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.021 0.1842 0.1769
Entamoeba histolytica hypothetical protein 0.0035 0.0241 0.0154
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0406 0.0406
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0061 0.0061
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0183 0.0536
Brugia malayi hypothetical protein 0.0035 0.0241 0.0363
Mycobacterium ulcerans lipase LipD 0.0035 0.0241 0.0154
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0183 0.0536
Echinococcus multilocularis sphingosine kinase 1 0.1104 1 1
Plasmodium vivax diacylglycerol kinase, putative 0.0043 0.0313 0.1269
Leishmania major diacylglycerol kinase-like protein 0.0043 0.0313 0.1269
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0213 0.1863 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.021 0.1837 0.9854
Toxoplasma gondii hypothetical protein 0.0024 0.0142 0.0305
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.0406 0.0406
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0024 0.0142 0.0305
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.3562 0.3562
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0406 0.0347
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0241 0.0863
Onchocerca volvulus Ceramide kinase 1 homolog 0.0043 0.0313 0.2638
Trichomonas vaginalis bmru protein, putative 0.0043 0.0313 0.1269
Plasmodium falciparum glutathione reductase 0.0029 0.0183 0.0536
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0405 0.1786
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0241 0.0181
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0142
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0213 0.1863 0.1863
Echinococcus granulosus fibrillin 2 0.0024 0.0142 0.0142
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0791 0.0791
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0043 0.0313 0.1269
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0791 0.396
Leishmania major protein kinase, putative 0.0213 0.1863 1
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0043 0.0313 0.1269
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0241 0.0181
Loa Loa (eye worm) ceramide kinase 0.0043 0.0313 0.0313
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0406 0.1789
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0461 0.0376
Brugia malayi hypothetical protein 0.0043 0.0313 0.0509
Entamoeba histolytica diacylglycerol kinase, putative 0.0043 0.0313 0.0227
Echinococcus granulosus ceramide kinase 0.0043 0.0313 0.0313
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0791 0.0791
Giardia lamblia Neurogenic locus notch-like protein 0.0024 0.0142 0.0305
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0406 0.1789
Entamoeba histolytica hypothetical protein, conserved 0.1104 1 1
Brugia malayi diacylglycerol kinase 0.0043 0.0313 0.0509
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0406 0.0406
Mycobacterium ulcerans beta-lactamase 0.0035 0.0241 0.0154
Loa Loa (eye worm) hypothetical protein 0.0206 0.1805 0.1805
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0791 0.0791
Echinococcus multilocularis cpg binding protein 0.003 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0043 0.0313 0.0313
Entamoeba histolytica protein kinase, putative 0.021 0.1837 0.1764
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0406 0.032
Schistosoma mansoni ap endonuclease 0.0018 0.0088 0.0027
Entamoeba histolytica hypothetical protein 0.0035 0.0241 0.0154
Plasmodium falciparum protein kinase 5 0.0053 0.0406 0.1789
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.021 0.1837 0.9854
Trichomonas vaginalis CMGC family protein kinase 0.0213 0.1863 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0241 0.0241
Schistosoma mansoni hypothetical protein 0.0035 0.0241 0.0181
Echinococcus granulosus cyclin dependent kinase 0.0053 0.0406 0.0406
Echinococcus multilocularis 0.0209 0.1831 0.1831
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0406 0.1789
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0241 0.0154
Schistosoma mansoni sphingoid long chain base kinase 0.1104 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.1104 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0142
Mycobacterium tuberculosis Conserved protein 0.0035 0.0241 0.0154
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0061 0.0061
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0406 0.1789
Brugia malayi Eye-specific diacylglycerol kinase 0.0043 0.0313 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0313 0.1269
Loa Loa (eye worm) beta-lactamase 0.0035 0.0241 0.0241
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0365 0.0365
Toxoplasma gondii diacylglycerol kinase, putative 0.0043 0.0313 0.1269
Echinococcus multilocularis dual specificity protein kinase clk2 0.0213 0.1863 0.1863
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0183 0.0096
Loa Loa (eye worm) hypothetical protein 0.0206 0.1805 0.1805
Entamoeba histolytica hypothetical protein 0.0035 0.0241 0.0154
Brugia malayi CXXC zinc finger family protein 0.0028 0.0177 0.0233
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0241 0.0154
Trichomonas vaginalis diacylglycerol kinase, putative 0.0043 0.0313 0.1269
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0241 0.0154
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0241 0.0863
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0183 0.0536
Brugia malayi EGF-like domain containing protein 0.0024 0.0142 0.0164
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.0241
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0461 0.0376
Brugia malayi Kelch motif family protein 0.0114 0.0965 0.1826
Trypanosoma brucei trypanothione reductase 0.0083 0.0679 0.3326
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0088 0.0088
Onchocerca volvulus 0.0028 0.0177 0.0527
Mycobacterium tuberculosis Diacylglycerol kinase 0.0043 0.0313 0.0227
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0183 0.0536
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0241 0.0154
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0183 0.0536
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0791 0.396
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0183 1
Echinococcus granulosus hypothetical protein 0.0209 0.1831 0.1831
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0183 0.0247
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.021 0.1842 0.1769
Mycobacterium ulcerans diacylglycerol kinase 0.0043 0.0313 0.0227
Trypanosoma cruzi Sphingosine kinase 0.0043 0.0313 0.1269
Brugia malayi Ceramide kinase 0.0043 0.0313 0.0509
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0213 0.1863 1
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0043 0.0313 0.1269
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0183 0.0536
Echinococcus granulosus dual specificity 0.021 0.1837 0.1837
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0791 0.0734
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.0406 0.0406
Brugia malayi Diacylglycerol kinase protein 2 0.0043 0.0313 0.0509
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.0406 0.0406
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0241 0.0154
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0791 0.396
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0213 0.1863 1
Plasmodium falciparum thioredoxin reductase 0.0083 0.0679 0.3326
Giardia lamblia Tenascin-X 0.0024 0.0142 0.0305
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0183 0.0536
Brugia malayi Protein kinase domain containing protein 0.0053 0.0406 0.0696
Plasmodium falciparum diacylglycerol kinase, putative 0.0043 0.0313 0.1269
Plasmodium falciparum glutathione reductase 0.0083 0.0679 0.3326
Plasmodium vivax serine/threonine kinase-1, putative 0.0213 0.1863 1
Plasmodium falciparum protein serine/threonine kinase-1 0.0213 0.1863 1
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0043 0.0313 0.0313
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0313 0.1269
Echinococcus multilocularis fibrillin 1 0.0024 0.0142 0.0142
Mycobacterium tuberculosis Conserved protein 0.0035 0.0241 0.0154
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0183 0.0536
Loa Loa (eye worm) hypothetical protein 0.0114 0.0965 0.0965
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0043 0.0313 0.1269
Trypanosoma cruzi trypanothione reductase, putative 0.0083 0.0679 0.3326
Trypanosoma cruzi diacylglycerol kinase, putative 0.0043 0.0313 0.1269
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0463 0.0404
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0043 0.0313 0.1269
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0791 0.0709
Echinococcus granulosus adam 0.0024 0.0142 0.0142
Giardia lamblia hypothetical protein 0.0024 0.0142 0.0305
Trichomonas vaginalis esterase, putative 0.0035 0.0241 0.0863
Echinococcus granulosus microtubule associated protein 2 0.0673 0.6064 0.6064
Schistosoma mansoni ap endonuclease 0.0018 0.0088 0.0027
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0183 0.0183
Onchocerca volvulus 0.0035 0.0241 0.1527
Schistosoma mansoni diacylglycerol kinase theta 0.0043 0.0313 0.0254
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0461 0.0403
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0241 0.0241
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0461 0.0376
Leishmania major sphingosine kinase A, B, putative 0.0043 0.0313 0.1269
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0241 0.0863
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.0241
Brugia malayi Integrin beta pat-3 precursor 0.0558 0.5011 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0061 0.0061
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0189 0.1649 0.1575
Brugia malayi Protein kinase domain containing protein 0.0213 0.1863 0.364
Echinococcus multilocularis Diacylglycerol kinase theta 0.0043 0.0313 0.0313
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0241 0.0154
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0043 0.0313 0.0313
Echinococcus granulosus dual specificity protein kinase clk2 0.0213 0.1863 0.1863
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.0406 0.1789
Brugia malayi EGF-like domain containing protein 0.0024 0.0142 0.0164
Loa Loa (eye worm) hypothetical protein 0.005 0.0374 0.0374
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0183 0.0096
Entamoeba histolytica diacylglycerol kinase, putative 0.0043 0.0313 0.0227
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.1863 0.1813
Onchocerca volvulus 0.0043 0.0313 0.2638

Activities

Activity type Activity value Assay description Source Reference
Cured/treated (functional) = 0 Antimalarial activity was determined by Blood schizonticidal activity in mouse infected with Plasmodium berghei(K-173 strain) at 2.5 (mg/kgx5) subcutaneous dosage; Cured/treated = 0/6 on day 7 ChEMBL. 7783124
Cured/treated (functional) = 0 Antimalarial activity was determined by Blood schizonticidal activity in mouse infected with Plasmodium berghei(K-173 strain) at 25 (mg/kgx5) per oral dosage; Cured/treated = 0/6 ChEMBL. 7783124
Cured/treated (functional) = 10 Antimalarial activity was determined by Blood schizonticidal activity in mouse infected with Plasmodium berghei (NS strain) at 5 (mg/kg x5) subcutaneous dosage; Cured/treated = 10/10 ChEMBL. 7783124

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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