Detailed information for compound 1810042

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 416.469 | Formula: C25H24N2O4
  • H donors: 1 H acceptors: 3 LogP: 4.79 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@H](n1cccc1)Cc1ccc(cc1)OCCc1nc(oc1C)c1ccccc1
  • InChi: 1S/C25H24N2O4/c1-18-22(26-24(31-18)20-7-3-2-4-8-20)13-16-30-21-11-9-19(10-12-21)17-23(25(28)29)27-14-5-6-15-27/h2-12,14-15,23H,13,16-17H2,1H3,(H,28,29)/t23-/m1/s1
  • InChiKey: OCWDFPOKWYMLGH-HSZRJFAPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peroxisome proliferator-activated receptor gamma Starlite/ChEMBL No references
Homo sapiens peroxisome proliferator-activated receptor alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative Get druggable targets OG5_137778 All targets in OG5_137778
Schistosoma japonicum IPR008946,Nuclear receptor, ligand-binding,domain-containing Get druggable targets OG5_137778 All targets in OG5_137778
Schistosoma mansoni nuclear hormone receptor superfamily protein-related Get druggable targets OG5_137778 All targets in OG5_137778
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor alpha 468 aa 397 aa 25.4 %
Echinococcus granulosus ecdysone induced protein 78C peroxisome proliferator-activated receptor gamma 477 aa 447 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0252 0.0438 0.0421
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0292 0.0558 0.0542
Loa Loa (eye worm) phosphatidylinositol 3 0.0232 0.0379 0.0362
Loa Loa (eye worm) phosphatidylinositol 3 0.3438 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1876 0.5312 0.5312
Trichomonas vaginalis PIKK family atypical protein kinase 0.2568 0.7389 0.7389
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0489 0.1149 0.1134
Onchocerca volvulus 0.0232 0.0379 0.5
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0669 0.1689 0.1675
Entamoeba histolytica hypothetical protein 0.0669 0.1689 0.1675
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0232 0.0379 0.0362
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0595 0.147 0.1455
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0292 0.0558 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.1876 0.5312 0.5312
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0252 0.0438 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.2743 0.7915 0.7915
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0232 0.0379 0.0362
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0669 0.1689 0.1675
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0232 0.0379 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.1192 0.3259 0.3259
Leishmania major phosphatidylinositol kinase related protein, putative 0.0232 0.0379 0.0362
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0252 0.0438 0.0085
Leishmania major phosphatidylinositol 3-kinase, putative 0.0252 0.0438 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.2926 0.8462 0.8462
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1192 0.3259 0.3247
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0252 0.0438 0.0421
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0252 0.0438 0.0438
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3438 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0232 0.0379 0.0362
Loa Loa (eye worm) hypothetical protein 0.0353 0.0743 0.0727
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0422 0.0951 0.0935
Mycobacterium tuberculosis Conserved hypothetical protein 0.0232 0.0379 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.2743 0.7915 0.7915
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1619 0.4541 0.4531
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0252 0.0438 0.0421
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3438 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0669 0.1689 0.1689
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1192 0.3259 0.3247
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0292 0.0558 0.0558
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0292 0.0558 0.0542
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3438 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2051 0.5838 0.5838
Entamoeba histolytica hypothetical protein 0.0232 0.0379 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0924 0.2456 0.2456
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0252 0.0438 0.0438
Entamoeba histolytica hypothetical protein 0.0382 0.083 0.0814
Schistosoma mansoni voltage-gated potassium channel 0.0123 0.0054 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.1181 0.3227 0.3227
Loa Loa (eye worm) hypothetical protein 0.0512 0.122 0.1205
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0113 0.0022 0.0005
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0252 0.0438 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0232 0.0379 0.0362
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0437 0.0993 0.0978
Loa Loa (eye worm) hypothetical protein 0.0692 0.176 0.1745
Trichomonas vaginalis PIKK family atypical protein kinase 0.2231 0.6377 0.6377
Echinococcus granulosus serine protein kinase ATM 0.0669 0.1689 0.1675
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0232 0.0379 0.0362
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1231 0.3378 0.3367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0232 0.0379 0.0379
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0669 0.1689 0.1675
Trichomonas vaginalis PIKK family atypical protein kinase 0.2743 0.7915 0.7915
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3438 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.1181 0.3227 0.3215
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1231 0.3378 0.3367
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0512 0.122 0.1205
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0252 0.0438 0.0421
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0353 0.0743 0.0727
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1231 0.3378 0.3367
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0232 0.0379 0.859
Trichomonas vaginalis conserved hypothetical protein 0.0744 0.1916 0.1916
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3438 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0232 0.0379 0.0362
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0321 0.0646 0.0629
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0113 0.0022 0.0005
Loa Loa (eye worm) hypothetical protein 0.0232 0.0379 0.0362
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0361 0.0766 0.0766
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3438 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0292 0.0558 0.0542
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0292 0.0558 0.0558
Echinococcus multilocularis serine protein kinase ATM 0.0669 0.1689 0.1675
Trichomonas vaginalis PIKK family atypical protein kinase 0.2055 0.5851 0.5851
Trichomonas vaginalis PIKK family atypical protein kinase 0.1181 0.3227 0.3227
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1231 0.3378 0.3367
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0113 0.0022 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1231 0.3378 0.3367
Loa Loa (eye worm) hypothetical protein 0.0437 0.0993 0.0978
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0382 0.083 0.0814
Trichomonas vaginalis PIKK family atypical protein kinase 0.1873 0.5304 0.5304
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0173 0.0202 0.0185
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0113 0.0022 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.2051 0.5838 0.5838
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0232 0.0379 0.859
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0232 0.0379 0.0362
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0292 0.0558 0.0558
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0422 0.0951 0.0935
Trypanosoma brucei target of rapamycin kinase 3, putative 0.2746 0.7923 0.792
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0252 0.0438 0.0085
Brugia malayi FAT domain containing protein 0.0512 0.122 0.1205
Echinococcus multilocularis Zinc finger, PHD finger 0.0252 0.0438 0.0421
Loa Loa (eye worm) phosphatidylinositol 3 0.0555 0.1349 0.1334
Trichomonas vaginalis PIKK family atypical protein kinase 0.2055 0.5851 0.5851
Trichomonas vaginalis PIKK family atypical protein kinase 0.2743 0.7915 0.7915
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0232 0.0379 0.0379
Schistosoma mansoni hypothetical protein 0.0232 0.0379 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0669 0.1689 0.1689
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0292 0.0558 0.0542
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0422 0.0951 0.0951
Leishmania major phosphatidylinositol kinase, putative 0.0232 0.0379 0.0362
Toxoplasma gondii FATC domain-containing protein 0.0669 0.1689 0.1869
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0232 0.0379 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.2568 0.7389 0.7389
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0232 0.0379 0.859
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0422 0.0951 0.0935
Trichomonas vaginalis PIKK family atypical protein kinase 0.3438 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0252 0.0438 0.0421
Giardia lamblia Hypothetical protein 0.0232 0.0379 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.0437 0.0993 0.0993
Trichomonas vaginalis PIKK family atypical protein kinase 0.1876 0.5312 0.5312
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0669 0.1689 0.1675
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0232 0.0379 0.0362
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0232 0.0379 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.2568 0.7389 0.7389
Trichomonas vaginalis fk506-binding protein, putative 0.0111 0.0017 0.0017
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0669 0.1689 0.1675
Trichomonas vaginalis PIKK family atypical protein kinase 0.2306 0.6604 0.6604
Entamoeba histolytica hypothetical protein 0.0232 0.0379 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.2568 0.7389 0.7389
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0232 0.0379 0.0362
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.2746 0.7923 0.792
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0595 0.147 0.1455
Trichomonas vaginalis PIKK family atypical protein kinase 0.0679 0.1721 0.1721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0232 0.0379 0.0379
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0422 0.0951 0.0951
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0232 0.0379 0.0362
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0232 0.0379 0.0362
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0595 0.147 0.1455
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0111 0.0017 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0744 0.1916 0.2193
Trichomonas vaginalis PIKK family atypical protein kinase 0.3438 1 1
Giardia lamblia GTOR 0.3438 1 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3438 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0313 0.0623 0.0606
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0252 0.0438 0.0421
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0353 0.0743 0.0727
Plasmodium vivax hypothetical protein, conserved 0.0232 0.0379 0.859
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0191 0.0255 0.0238
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0422 0.0951 0.0935
Schistosoma mansoni hypothetical protein 0.0512 0.122 0.1205
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0232 0.0379 0.859
Entamoeba histolytica protein kinase rad3, putative 0.0669 0.1689 0.1675
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0422 0.0951 0.0951
Giardia lamblia Phosphatidylinositol 4-kinase 0.0232 0.0379 0.0362
Loa Loa (eye worm) hypothetical protein 0.0744 0.1916 0.1902
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3438 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.2746 0.7923 0.792
Trichomonas vaginalis PIKK family atypical protein kinase 0.2568 0.7389 0.7389
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0232 0.0379 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.1873 0.5304 0.5304
Onchocerca volvulus 0.0232 0.0379 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.2055 0.5851 0.5851
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0232 0.0379 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.2568 0.7389 0.7389
Schistosoma mansoni fkbp-rapamycin associated protein 0.0669 0.1689 0.1675
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0232 0.0379 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.2568 0.7389 0.7389
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1231 0.3378 0.3367
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0272 0.0499 0.0483
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0252 0.0438 0.0438
Mycobacterium leprae conserved hypothetical protein 0.0232 0.0379 0.5
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3438 1 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0252 0.0438 0.0421
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0252 0.0438 0.0421
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0232 0.0379 0.0362
Loa Loa (eye worm) phosphatidylinositol 3 0.0232 0.0379 0.0362
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0252 0.0438 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.1181 0.3227 0.3227
Trichomonas vaginalis PIKK family atypical protein kinase 0.3438 1 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0512 0.122 0.1205
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0232 0.0379 0.0379
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0679 0.1721 0.1707
Trichomonas vaginalis PIKK family atypical protein kinase 0.1181 0.3227 0.3227
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0252 0.0438 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.0512 0.122 0.122
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0232 0.0379 0.859
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1439 0.4001 0.3991
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0361 0.0766 0.0766
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0252 0.0438 0.0421
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3438 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0292 0.0558 0.0542
Echinococcus multilocularis 0.0232 0.0379 0.0362
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0669 0.1689 0.1675
Loa Loa (eye worm) phosphatidylinositol 3 0.1192 0.3259 0.3247
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0232 0.0379 0.0362
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0669 0.1689 0.1675
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0232 0.0379 0.0362
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0232 0.0379 0.0362
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1181 0.3227 0.3215
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0111 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.1876 0.5312 0.5312
Trichomonas vaginalis PIKK family atypical protein kinase 0.2743 0.7915 0.7915
Leishmania major hypothetical protein, unknown function 0.0232 0.0379 0.0362
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0489 0.1149 0.1134
Leishmania major phosphatidylinositol 4-kinase, putative 0.0232 0.0379 0.0362
Loa Loa (eye worm) phosphatidylinositol 3 0.0232 0.0379 0.0362
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3438 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1873 0.5304 0.5304
Plasmodium vivax hypothetical protein 0.0232 0.0379 0.859
Leishmania major hypothetical protein, conserved 0.0323 0.0652 0.0636
Entamoeba histolytica hypothetical protein 0.0232 0.0379 0.0362
Schistosoma mansoni voltage-gated potassium channel 0.0123 0.0054 0.0036
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0432 0.0981 0.0965
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0353 0.0743 0.0727
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0111 0.0017 0.5
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0111 0.0017 0.0017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0669 0.1689 0.1675
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0252 0.0438 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0437 0.0993 0.0993
Loa Loa (eye worm) hypothetical protein 0.0669 0.1689 0.1675
Toxoplasma gondii target of rapamycin (TOR), putative 0.2568 0.7389 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0252 0.0438 0.0421
Trichomonas vaginalis immunophilin, putative 0.0111 0.0017 0.0017

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 5.89 Transactivation of Homo sapiens (human) PPARalpha assessed as luciferase activity by reporter gene assay ChEMBL. No reference
EC50 (binding) = 7.7 Transactivation of Homo sapiens (human) PPARgamma assessed as luciferase activity by reporter gene assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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