Detailed information for compound 1810250

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 305.759 | Formula: C15H16ClN3O2
  • H donors: 2 H acceptors: 2 LogP: 2.03 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)C)C[n+]1cccc(c1)C(=O)N.[Cl-]
  • InChi: 1S/C15H15N3O2.ClH/c1-11-4-2-6-13(8-11)17-14(19)10-18-7-3-5-12(9-18)15(16)20;/h2-9H,10H2,1H3,(H2-,16,17,19,20);1H
  • InChiKey: IRAKGZXIAQZHRX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis aminopeptidase P 0.006 0.0797 0.5
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0177 0.0157
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0631
Echinococcus granulosus xaa Pro dipeptidase 0.006 0.0797 0.0631
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.006 0.0797 0.0631
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0352 0.0352
Mycobacterium ulcerans dipeptidase 0.006 0.0797 1
Trypanosoma cruzi Metallopeptidase family M24, putative 0.006 0.0797 0.0797
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Echinococcus multilocularis xaa pro aminopeptidase 0.006 0.0797 0.0631
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0631
Plasmodium falciparum methionine aminopeptidase 2 0.048 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.048 1 1
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.006 0.0797 0.0461
Entamoeba histolytica peptidase, putative 0.006 0.0797 0.0461
Echinococcus granulosus heat shock protein 0.0039 0.0352 0.0178
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0461
Leishmania major transcription factor-like protein 0.006 0.0797 0.0631
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0797
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Plasmodium falciparum aminopeptidase P 0.006 0.0797 0.0779
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.006 0.0797 1
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.006 0.0797 0.0461
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Plasmodium vivax FACT complex subunit SPT16, putative 0.006 0.0797 0.0461
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Echinococcus multilocularis methionyl aminopeptidase 2 0.048 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Loa Loa (eye worm) DNA-binding protein 0.006 0.0797 0.0461
Loa Loa (eye worm) hypothetical protein 0.006 0.0797 0.0461
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Trypanosoma cruzi aminopeptidase P, putative 0.006 0.0797 0.0797
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0352 0.0352
Echinococcus multilocularis methionine aminopeptidase, type I 0.006 0.0797 0.0631
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0352 0.0178
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.006 0.0797 0.0461
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.006 0.0797 0.0461
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Echinococcus granulosus Proliferation associated protein 2G4 0.006 0.0797 0.0631
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0352 0.0352
Treponema pallidum aminopeptidase P 0.006 0.0797 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Loa Loa (eye worm) methionine aminopeptidase type I 0.006 0.0797 0.0461
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.006 0.0797 0.0461
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.006 0.0797 0.0461
Giardia lamblia Xaa-Pro dipeptidase 0.006 0.0797 0.0631
Entamoeba histolytica hypothetical protein, conserved 0.006 0.0797 0.0461
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.006 0.0797 0.0461
Echinococcus multilocularis heat shock protein 90 0.0039 0.0352 0.0178
Echinococcus multilocularis Proliferation associated protein 2G4 0.006 0.0797 0.0631
Plasmodium vivax proliferation-associated protein 2g4, putative 0.006 0.0797 0.0461
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.048 1 1
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.006 0.0797 0.0779
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.006 0.0797 0.0461
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.006 0.0797 0.0797
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Echinococcus granulosus xaa pro aminopeptidase 0.006 0.0797 0.0631
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Loa Loa (eye worm) initiation factor 2-associated protein 0.048 1 1
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0631
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.006 0.0797 0.0631
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.048 1 1
Leishmania major methionine aminopeptidase 2, putative 0.048 1 1
Plasmodium vivax methionine aminopeptidase 1a, putative 0.006 0.0797 0.0461
Trypanosoma brucei methionine aminopeptidase 2, putative 0.048 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Toxoplasma gondii creatinase domain-containing protein 0.006 0.0797 0.0461
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.006 0.0797 0.0797
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.006 0.0797 1
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.006 0.0797 1
Echinococcus granulosus methionyl aminopeptidase 2 0.048 1 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.006 0.0797 0.0631
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0352 0.0352
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0352 0.0352
Brugia malayi Methionine aminopeptidase protein type I 0.006 0.0797 0.0461
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Schistosoma mansoni peptidase 0.006 0.0797 0.0461
Trypanosoma cruzi Metallopeptidase family M24, putative 0.006 0.0797 0.0797
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.006 0.0797 1
Treponema pallidum methionine aminopeptidase (map) 0.006 0.0797 1
Trypanosoma cruzi aminopeptidase P1, putative 0.006 0.0797 0.0797
Entamoeba histolytica methionine aminopeptidase, putative 0.048 1 1
Plasmodium vivax peptidase, putative 0.006 0.0797 0.0461
Echinococcus granulosus xaa Pro dipeptidase 0.006 0.0797 0.0631
Echinococcus multilocularis xaa Pro dipeptidase 0.006 0.0797 0.0631
Echinococcus multilocularis heat shock protein 0.0039 0.0352 0.0178
Mycobacterium ulcerans aminopeptidase 0.006 0.0797 1
Trypanosoma brucei methionine aminopeptidase, putative 0.006 0.0797 0.0461
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.006 0.0797 0.0631
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0177 0.0157
Toxoplasma gondii methionine aminopeptidase 0.006 0.0797 0.0461
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0631
Leishmania major hypothetical protein, conserved 0.006 0.0797 0.0631
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0461
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.006 0.0797 1
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0177 0.0177
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0177 0.0157
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Entamoeba histolytica aminopeptidase, putative 0.006 0.0797 0.0461
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0797
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.006 0.0797 0.0797
Toxoplasma gondii methionine aminopeptidase 0.006 0.0797 0.0461
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0631
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.048 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0797 0.0461
Brugia malayi metallopeptidase family M24 containing protein 0.006 0.0797 0.0461
Plasmodium vivax methionine aminopeptidase 1b, putative 0.006 0.0797 0.0461
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.006 0.0797 0.0797
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0352 0.0333
Echinococcus multilocularis xaa Pro dipeptidase 0.006 0.0797 0.0631
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.048 1 1
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.048 1 1
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.006 0.0797 0.0461
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.006 0.0797 0.0461
Giardia lamblia Xaa-Pro dipeptidase 0.006 0.0797 0.0631
Echinococcus granulosus methionine aminopeptidase type I 0.006 0.0797 0.0631
Plasmodium falciparum FACT complex subunit SPT16, putative 0.006 0.0797 0.0779
Giardia lamblia Methionine aminopeptidase 0.048 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Mycobacterium ulcerans methionine aminopeptidase MapB 0.006 0.0797 1
Echinococcus multilocularis FACT complex subunit SPT16 0.006 0.0797 0.0631
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.006 0.0797 1
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Plasmodium vivax methionine aminopeptidase 2, putative 0.048 1 1
Trypanosoma brucei Metallopeptidase family M24, putative 0.006 0.0797 0.0461
Echinococcus granulosus heat shock protein 90 0.0039 0.0352 0.0178
Mycobacterium tuberculosis Dipeptidase PepE 0.006 0.0797 1
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.006 0.0797 0.0461
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.006 0.0797 0.0631
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.006 0.0797 0.0461
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.006 0.0797 0.0779
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.006 0.0797 0.0461
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.006 0.0797 0.0797
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.006 0.0797 1
Mycobacterium ulcerans methionine aminopeptidase 0.006 0.0797 1
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.006 0.0797 0.0461
Toxoplasma gondii transcriptional elongation factor FACT140 0.006 0.0797 0.0461
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.006 0.0797 0.0461
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.048 1 1
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.006 0.0797 0.0779
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.006 0.0797 0.0461
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.006 0.0797 0.0461
Chlamydia trachomatis methionine aminopeptidase 0.006 0.0797 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Toxoplasma gondii peptidase D, putative 0.006 0.0797 0.0461
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.048 1 1
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.006 0.0797 0.0461
Mycobacterium ulcerans dipeptidase PepE 0.006 0.0797 1
Plasmodium falciparum heat shock protein 90 0.0039 0.0352 0.0333
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.006 0.0797 0.0779
Toxoplasma gondii methionine aminopeptidase 2, putative 0.048 1 1
Brugia malayi metallopeptidase family M24 containing protein 0.006 0.0797 0.0461
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.006 0.0797 1
Brugia malayi metallopeptidase family M24 containing protein 0.006 0.0797 0.0461
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0631
Echinococcus granulosus FACT complex subunit SPT16 0.006 0.0797 0.0631
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.006 0.0797 1
Plasmodium vivax methionine aminopeptidase 1c, putative 0.006 0.0797 0.0461
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.048 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 13.2 uM Inhibition of recombinant Homo sapiens (human) Hsp90 alpha ATPase activity assessed as inorganic phosphate release by malachite green colorimetric method ChEMBL. No reference
Inhibition (binding) = 34 % Inhibition of recombinant Homo sapiens (human) Hsp90 alpha ATPase activity assessed as inorganic phosphate release at 10 uM by malachite green colorimetric method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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