Detailed information for compound 1810250

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 305.759 | Formula: C15H16ClN3O2
  • H donors: 2 H acceptors: 2 LogP: 2.03 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)C)C[n+]1cccc(c1)C(=O)N.[Cl-]
  • InChi: 1S/C15H15N3O2.ClH/c1-11-4-2-6-13(8-11)17-14(19)10-18-7-3-5-12(9-18)15(16)20;/h2-9H,10H2,1H3,(H2-,16,17,19,20);1H
  • InChiKey: IRAKGZXIAQZHRX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi metallopeptidase family M24 containing protein 0.006 0.0797 0.0461
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0461
Echinococcus multilocularis Proliferation associated protein 2G4 0.006 0.0797 0.0631
Trypanosoma cruzi aminopeptidase P1, putative 0.006 0.0797 0.0797
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.006 0.0797 0.0797
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0352 0.0352
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.006 0.0797 1
Brugia malayi Methionine aminopeptidase protein type I 0.006 0.0797 0.0461
Echinococcus multilocularis methionine aminopeptidase, type I 0.006 0.0797 0.0631
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Leishmania major transcription factor-like protein 0.006 0.0797 0.0631
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.006 0.0797 0.0461
Echinococcus multilocularis FACT complex subunit SPT16 0.006 0.0797 0.0631
Trypanosoma brucei methionine aminopeptidase 2, putative 0.048 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.006 0.0797 0.0779
Plasmodium falciparum FACT complex subunit SPT16, putative 0.006 0.0797 0.0779
Echinococcus granulosus FACT complex subunit SPT16 0.006 0.0797 0.0631
Leishmania major methionine aminopeptidase 2, putative 0.048 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0797
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.048 1 1
Mycobacterium ulcerans methionine aminopeptidase 0.006 0.0797 1
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.006 0.0797 0.0461
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.006 0.0797 0.0461
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.006 0.0797 0.0461
Trypanosoma cruzi Metallopeptidase family M24, putative 0.006 0.0797 0.0797
Echinococcus multilocularis xaa pro aminopeptidase 0.006 0.0797 0.0631
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.006 0.0797 0.0461
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.006 0.0797 0.0461
Treponema pallidum aminopeptidase P 0.006 0.0797 1
Entamoeba histolytica hypothetical protein, conserved 0.006 0.0797 0.0461
Echinococcus granulosus xaa pro aminopeptidase 0.006 0.0797 0.0631
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.006 0.0797 0.0461
Echinococcus multilocularis methionyl aminopeptidase 2 0.048 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0352 0.0352
Loa Loa (eye worm) hypothetical protein 0.006 0.0797 0.0461
Echinococcus granulosus methionine aminopeptidase type I 0.006 0.0797 0.0631
Chlamydia trachomatis methionine aminopeptidase 0.006 0.0797 0.5
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0352 0.0352
Echinococcus multilocularis xaa Pro dipeptidase 0.006 0.0797 0.0631
Toxoplasma gondii creatinase domain-containing protein 0.006 0.0797 0.0461
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.006 0.0797 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.006 0.0797 0.0797
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.006 0.0797 0.0461
Mycobacterium ulcerans methionine aminopeptidase MapB 0.006 0.0797 1
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.006 0.0797 0.0631
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Brugia malayi metallopeptidase family M24 containing protein 0.006 0.0797 0.0461
Loa Loa (eye worm) initiation factor 2-associated protein 0.048 1 1
Giardia lamblia Xaa-Pro dipeptidase 0.006 0.0797 0.0631
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.006 0.0797 0.0797
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.048 1 1
Schistosoma mansoni peptidase 0.006 0.0797 0.0461
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0461
Echinococcus granulosus xaa Pro dipeptidase 0.006 0.0797 0.0631
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.006 0.0797 0.0631
Loa Loa (eye worm) hypothetical protein 0.006 0.0797 0.0461
Entamoeba histolytica methionine aminopeptidase, putative 0.048 1 1
Plasmodium vivax FACT complex subunit SPT16, putative 0.006 0.0797 0.0461
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0631
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Trypanosoma cruzi Metallopeptidase family M24, putative 0.006 0.0797 0.0797
Leishmania major hypothetical protein, conserved 0.006 0.0797 0.0631
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.006 0.0797 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.048 1 1
Toxoplasma gondii transcriptional elongation factor FACT140 0.006 0.0797 0.0461
Toxoplasma gondii methionine aminopeptidase 0.006 0.0797 0.0461
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.006 0.0797 0.0779
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0797
Treponema pallidum methionine aminopeptidase (map) 0.006 0.0797 1
Plasmodium falciparum methionine aminopeptidase 2 0.048 1 1
Toxoplasma gondii methionine aminopeptidase 0.006 0.0797 0.0461
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Echinococcus granulosus heat shock protein 90 0.0039 0.0352 0.0178
Plasmodium vivax methionine aminopeptidase 1a, putative 0.006 0.0797 0.0461
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.006 0.0797 1
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0631
Plasmodium falciparum aminopeptidase P 0.006 0.0797 0.0779
Plasmodium vivax proliferation-associated protein 2g4, putative 0.006 0.0797 0.0461
Mycobacterium ulcerans dipeptidase 0.006 0.0797 1
Echinococcus granulosus Proliferation associated protein 2G4 0.006 0.0797 0.0631
Toxoplasma gondii methionine aminopeptidase 2, putative 0.048 1 1
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0177 0.0157
Trypanosoma cruzi aminopeptidase P, putative 0.006 0.0797 0.0797
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Trypanosoma brucei Metallopeptidase family M24, putative 0.006 0.0797 0.0461
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.048 1 1
Mycobacterium ulcerans dipeptidase PepE 0.006 0.0797 1
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.006 0.0797 0.0461
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.006 0.0797 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.006 0.0797 0.0797
Entamoeba histolytica peptidase, putative 0.006 0.0797 0.0461
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0177 0.0177
Chlamydia trachomatis aminopeptidase P 0.006 0.0797 0.5
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.006 0.0797 0.0779
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0177 0.0157
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.006 0.0797 0.0631
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.048 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0177 0.0177
Echinococcus granulosus xaa Pro dipeptidase 0.006 0.0797 0.0631
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.048 1 1
Loa Loa (eye worm) methionine aminopeptidase type I 0.006 0.0797 0.0461
Echinococcus multilocularis heat shock protein 0.0039 0.0352 0.0178
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.006 0.0797 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0631
Giardia lamblia Methionine aminopeptidase 0.048 1 1
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.006 0.0797 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.006 0.0797 0.0631
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.006 0.0797 0.0461
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.006 0.0797 0.0461
Loa Loa (eye worm) DNA-binding protein 0.006 0.0797 0.0461
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0631
Entamoeba histolytica aminopeptidase, putative 0.006 0.0797 0.0461
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Toxoplasma gondii peptidase D, putative 0.006 0.0797 0.0461
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.006 0.0797 0.0779
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.006 0.0797 0.0461
Giardia lamblia Xaa-Pro dipeptidase 0.006 0.0797 0.0631
Echinococcus multilocularis heat shock protein 90 0.0039 0.0352 0.0178
Trypanosoma brucei methionine aminopeptidase, putative 0.006 0.0797 0.0461
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.006 0.0797 0.0461
Echinococcus granulosus heat shock protein 0.0039 0.0352 0.0178
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.048 1 1
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.006 0.0797 0.0461
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.006 0.0797 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.006 0.0797 0.0779
Plasmodium vivax peptidase, putative 0.006 0.0797 0.0461
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0631
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0177 0.0157
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.048 1 1
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.006 0.0797 1
Plasmodium falciparum heat shock protein 90 0.0039 0.0352 0.0333
Plasmodium vivax methionine aminopeptidase 2, putative 0.048 1 1
Echinococcus granulosus methionyl aminopeptidase 2 0.048 1 1
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.006 0.0797 0.0797
Mycobacterium tuberculosis Dipeptidase PepE 0.006 0.0797 1
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.006 0.0797 0.0631
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0352 0.0333
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0352 0.0352
Brugia malayi metallopeptidase family M24 containing protein 0.006 0.0797 0.0461
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.006 0.0797 0.0461
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.006 0.0797 0.0631
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.006 0.0797 0.0461
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0352 0.0352
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.006 0.0797 0.0461
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.048 1 1
Echinococcus multilocularis xaa Pro dipeptidase 0.006 0.0797 0.0631
Mycobacterium ulcerans aminopeptidase 0.006 0.0797 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0797 0.0461
Plasmodium vivax methionine aminopeptidase 1c, putative 0.006 0.0797 0.0461
Plasmodium vivax methionine aminopeptidase 1b, putative 0.006 0.0797 0.0461
Leishmania major heat shock protein 83-1 0.0039 0.0352 0.0178
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0352 0.0178

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 13.2 uM Inhibition of recombinant Homo sapiens (human) Hsp90 alpha ATPase activity assessed as inorganic phosphate release by malachite green colorimetric method ChEMBL. No reference
Inhibition (binding) = 34 % Inhibition of recombinant Homo sapiens (human) Hsp90 alpha ATPase activity assessed as inorganic phosphate release at 10 uM by malachite green colorimetric method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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