Detailed information for compound 1810564

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 400.817 | Formula: C22H13ClN4O2
  • H donors: 0 H acceptors: 3 LogP: 4.54 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1nnc(o1)n1c(nc2c(c1=O)cccc2)c1ccccc1
  • InChi: 1S/C22H13ClN4O2/c23-16-12-10-15(11-13-16)20-25-26-22(29-20)27-19(14-6-2-1-3-7-14)24-18-9-5-4-8-17(18)21(27)28/h1-13H
  • InChiKey: LQQVTHLMEQJKFN-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum importin beta, putative 0.0029 0.0294 0.027
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.2198 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0159 0.2198 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0219 0.0822
Giardia lamblia Kinase, PLK 0.0095 0.1258 0.5333
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0159 0.2198 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0495 0.2101
Brugia malayi NADH-dependent xylose reductase 0.0046 0.0545 0.1266
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0458 0.0456
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0458 0.1929
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0054 0.0663 0.154
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0161 0.0375
Brugia malayi Matrixin family protein 0.0102 0.1366 0.3173
Onchocerca volvulus 0.0009 0.0008 0.0015
Brugia malayi PAN domain containing protein 0.0014 0.0079 0.0184
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.007 0.0892 0.089
Echinococcus multilocularis aldo keto reductase 0.0159 0.2198 0.2197
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0014 0.0079 0.0125
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0025 0.0024
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.2198 0.2197
Onchocerca volvulus 0.0159 0.2198 0.5102
Echinococcus multilocularis snurportin 1 0.0308 0.4389 0.4388
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0431 0.6187 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0161 0.016
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.2198 0.2197
Schistosoma mansoni nuclear receptor 0.0009 0.0008 0.0006
Toxoplasma gondii aldo-keto reductase 0.0046 0.0545 0.0879
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.0495 0.2101
Echinococcus granulosus expressed conserved protein 0.0093 0.1229 0.1227
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0458 0.1929
Echinococcus multilocularis aldo keto reductase 0.0159 0.2198 0.2197
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0159 0.2198 1
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.1936 0.1935
Loa Loa (eye worm) hypothetical protein 0.0054 0.0663 0.1508
Toxoplasma gondii malate dehydrogenase MDH 0.0018 0.0134 0.0213
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0219 0.0145
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0161 0.0371
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0934 0.0933
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0495 0.2101
Brugia malayi lactate dehydrogenase. 0.0018 0.0134 0.031
Echinococcus multilocularis protein C ets 2 0.0011 0.0025 0.0024
Brugia malayi N-terminal motif family protein 0.0181 0.2521 0.5853
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0025 0.0054
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.035 0.1513
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0491 0.049
Echinococcus granulosus lactate dehydrogenase a 0.0018 0.0134 0.0132
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0008 0.0015
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0431 0.6187 1
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0046 0.0545 0.0879
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0161 0.016
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0051 0.0624 0.2438
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0491 0.1116
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0495 0.2101
Entamoeba histolytica alcohol dehydrogenase, putative 0.0046 0.0545 0.2334
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0079 0.0125
Loa Loa (eye worm) hypothetical protein 0.002 0.0161 0.0364
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1258 0.5638
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0008 0.0019
Schistosoma mansoni rotamase 0.0033 0.0362 0.036
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.1258 0.5681
Schistosoma mansoni flap endonuclease-1 0.0024 0.0217 0.0215
Schistosoma mansoni zinc finger protein 0.0009 0.0008 0.0006
Echinococcus multilocularis voltage gated potassium channel subunit 0.0046 0.0545 0.0544
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0219 0.0509
Toxoplasma gondii microneme protein MIC17B 0.0014 0.0079 0.0125
Brugia malayi Fli-1 protein 0.022 0.3098 0.7193
Schistosoma mansoni thyroid hormone receptor 0.002 0.0161 0.016
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0495 0.2101
Loa Loa (eye worm) hypothetical protein 0.0042 0.049 0.1112
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0153 0.212 0.2118
Trypanosoma cruzi malate dehydrogenase, putative 0.0018 0.0134 0.052
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0042 0.0099
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0219 0.0491
Trichomonas vaginalis aldo/keto reductase, putative 0.0159 0.2198 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.2198 0.2197
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0161 0.016
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0193 0.0791
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0054 0.0663 0.0662
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0207 0.0125
Schistosoma mansoni microtubule-associated protein tau 0.0691 1 1
Brugia malayi PAN domain containing protein 0.0014 0.0079 0.0184
Loa Loa (eye worm) hypothetical protein 0.0014 0.0079 0.0177
Echinococcus multilocularis lactate dehydrogenase a 0.0018 0.0134 0.0132
Loa Loa (eye worm) hypothetical protein 0.0014 0.0079 0.0177
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.2198 0.2197
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0207 0.0125
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0207 0.0302
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0024 0.0219 0.0496
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0008 0.0006
Brugia malayi ecdysteroid receptor 0.002 0.0161 0.0375
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0025 0.0024
Mycobacterium tuberculosis Conserved protein 0.0046 0.0545 0.2058
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0161 0.016
Schistosoma mansoni ran 0.0021 0.0183 0.0181
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.2198 0.2197
Trichomonas vaginalis aldo/keto reductase, putative 0.0159 0.2198 1
Brugia malayi PAN domain containing protein 0.0014 0.0079 0.0184
Echinococcus granulosus cpg binding protein 0.003 0.0317 0.0315
Mycobacterium tuberculosis Probable oxidoreductase 0.0159 0.2198 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.2198 0.2197
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0153 0.212 0.2118
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.1316 0.1315
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0052
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0253 0.0407
Schistosoma mansoni importin beta-1 0.0029 0.0294 0.0293
Onchocerca volvulus 0.0042 0.049 0.1133
Echinococcus multilocularis protein patched 0.0042 0.0491 0.049
Brugia malayi DIX domain containing protein 0.0009 0.0002 0.0004
Entamoeba histolytica hypothetical protein 0.0023 0.0207 0.0764
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0219 0.0913
Onchocerca volvulus 0.0014 0.0079 0.018
Entamoeba histolytica hypothetical protein 0.0023 0.0214 0.08
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0079 0.0177
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0046 0.0545 0.241
Echinococcus granulosus voltage gated potassium channel subunit 0.0046 0.0545 0.0544
Echinococcus granulosus lactate dehydrogenase protein 0.0018 0.0134 0.0132
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0018 0.0134 0.052
Schistosoma mansoni hypothetical protein 0.0041 0.0469 0.0467
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0008 0.0006
Echinococcus multilocularis malate dehydrogenase 0.0018 0.0134 0.0132
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0008 0.0019
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0018 0.0134 0.052
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0024 0.0023
Trypanosoma cruzi malate dehydrogenase, putative 0.0018 0.0134 0.052
Echinococcus granulosus malate dehydrogenase 0.0018 0.0134 0.0132
Schistosoma mansoni malate dehydrogenase 0.0018 0.0134 0.0132
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0458 0.1365
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0042 0.0099
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.035 0.1513
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0015
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0294 0.1259
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0219 0.0145
Loa Loa (eye worm) matrixin family protein 0.0102 0.1366 0.3111
Toxoplasma gondii PAN/Apple domain-containing protein 0.0014 0.0079 0.0125
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.2198 1
Plasmodium falciparum malate dehydrogenase 0.0018 0.0134 0.0004
Schistosoma mansoni hypothetical protein 0.0409 0.5875 0.5874
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0161 0.0371
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0008 0.0006
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.2198 1
Trypanosoma brucei cytosolic malate dehydrogenase 0.0043 0.0495 0.2179
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.4389 1
Leishmania major prostaglandin f synthase, putative 0.0159 0.2198 1
Brugia malayi Matrixin family protein 0.0042 0.049 0.1137
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0161 0.016
Schistosoma mansoni ran 0.0021 0.0183 0.0181
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0008 0.0006
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0458 0.0456
Echinococcus multilocularis lactate dehydrogenase a 0.0018 0.0134 0.0132
Schistosoma mansoni hypothetical protein 0.0054 0.0663 0.0662
Brugia malayi Flap endonuclease-1 0.0026 0.0253 0.0589
Mycobacterium ulcerans hypothetical protein 0.0046 0.0545 0.0684
Schistosoma mansoni malate dehydrogenase 0.0043 0.0495 0.0493
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.5875 0.5874
Brugia malayi Protein kinase domain containing protein 0.0022 0.0193 0.0447
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.002 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0052
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0042 0.0099
Echinococcus multilocularis aldo keto reductase 0.0159 0.2198 0.2197
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0183 0.0293
Brugia malayi nuclear hormone receptor 0.002 0.0161 0.0375
Echinococcus granulosus hypothetical protein 0.0159 0.2198 0.2197
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0025 0.0054
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0219 0.0913
Echinococcus multilocularis microtubule associated protein 2 0.0691 1 1
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0043 0.0495 0.2179
Loa Loa (eye worm) hypothetical protein 0.0042 0.049 0.1112
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0219 0.0145
Brugia malayi Ets-domain containing protein 0.0072 0.0934 0.2169
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0046 0.0545 0.0684
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0193 0.0191
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0161 0.0364
Onchocerca volvulus 0.0159 0.2198 0.5102
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.1258 0.292
Onchocerca volvulus 0.0046 0.0545 0.1263
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0008 0.0006
Brugia malayi PAN domain containing protein 0.0014 0.0079 0.0184
Loa Loa (eye worm) hypothetical protein 0.0029 0.0294 0.0667
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0558 0.2391
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0161 0.016
Schistosoma mansoni coup transcription factor 0.002 0.0161 0.016
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0008 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0161 0.0364
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0079 0.0177
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0025 0.0024
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.2198 0.2197
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0219 0.0509
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0495 0.2101
Brugia malayi PAN domain containing protein 0.0014 0.0079 0.0184
Entamoeba histolytica aldose reductase, putative 0.0159 0.2198 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0134 0.0301
Loa Loa (eye worm) matrixin family protein 0.0094 0.1243 0.2829
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0025 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0042 0.0099
Echinococcus multilocularis lactate dehydrogenase a 0.0018 0.0134 0.0132
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0193 0.0101
Schistosoma mansoni hypothetical protein 0.0041 0.0469 0.0467
Schistosoma mansoni ets 0.0011 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0042 0.049 0.1112
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0008 0.0006
Onchocerca volvulus 0.0159 0.2198 0.5102
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.2521 0.5852
Echinococcus granulosus snurportin 1 0.0308 0.4389 0.4388
Schistosoma mansoni nuclear receptor 0.0009 0.0008 0.0006
Trypanosoma brucei malate dehydrogenase-related 0.0018 0.0134 0.052
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0046 0.0545 0.1239
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0161 0.016
Entamoeba histolytica malate dehydrogenase, putative 0.0018 0.0134 0.0425
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.00000055984
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0024 0.0023
Onchocerca volvulus 0.0014 0.0079 0.018
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0161 0.016
Trypanosoma brucei glycosomal malate dehydrogenase 0.0018 0.0134 0.052
Trichomonas vaginalis rotamase, putative 0.0033 0.035 0.1428
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0253 0.1071
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0042 0.0099
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0219 0.0822
Onchocerca volvulus 0.0014 0.0079 0.018
Brugia malayi hypothetical protein 0.0009 0.0002 0.0004
Schistosoma mansoni ets-related 0.022 0.3098 0.3097
Schistosoma mansoni hypothetical protein 0.006 0.0748 0.0747
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0159 0.2198 0.5104
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0161 0.0375
Loa Loa (eye worm) hypothetical protein 0.0159 0.2198 0.5006
Brugia malayi Matrixin family protein 0.0042 0.049 0.1137
Onchocerca volvulus 0.0303 0.4307 1
Trypanosoma cruzi aldo-keto reductase 0.0159 0.2198 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0458 0.2009
Loa Loa (eye worm) hypothetical protein 0.0024 0.0219 0.0496
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0161 0.016
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0159 0.2198 0.5104
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0219 0.0145
Brugia malayi PAN domain containing protein 0.0014 0.0079 0.0184
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0183 0.0085
Brugia malayi Ets-domain containing protein 0.0011 0.0025 0.0059
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.2198 0.2197
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0219 0.0021
Brugia malayi CXXC zinc finger family protein 0.0029 0.0293 0.068
Echinococcus multilocularis aldehyde reductase 0.0113 0.1524 0.1523
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0183 0.0746
Brugia malayi hypothetical protein 0.001 0.0024 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0161 0.0364
Giardia lamblia Aldose reductase 0.0159 0.2198 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0024 0.0052
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0161 0.0375
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0161 0.0375
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0046 0.0545 0.0879
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0677 0.9794 0.9794
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0161 0.0375
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0431 0.6187 1
Toxoplasma gondii microneme protein, putative 0.0014 0.0079 0.0125
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1258 0.5638
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0015
Mycobacterium ulcerans hypothetical protein 0.0024 0.0219 0.0145
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0015
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0198 0.0814
Echinococcus multilocularis malate dehydrogenase 0.0018 0.0134 0.0132
Echinococcus granulosus tumor susceptibility gene 101 protein 0.007 0.0892 0.089
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0214 0.0891
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0018 0.0134 0.0132
Loa Loa (eye worm) hypothetical protein 0.0081 0.1064 0.2422
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0362 0.1482
Toxoplasma gondii lactate dehydrogenase LDH1 0.0018 0.0134 0.0213
Echinococcus granulosus aldo keto reductase 0.0159 0.2198 0.2197
Trypanosoma brucei polo-like protein kinase 0.0095 0.1258 0.5681
Toxoplasma gondii aldose reductase, putative 0.0159 0.2198 0.3551
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.0295
Brugia malayi hypothetical protein 0.007 0.0892 0.2071
Loa Loa (eye worm) hypothetical protein 0.002 0.0161 0.0364
Brugia malayi PAN domain containing protein 0.0014 0.0079 0.0184
Leishmania major malate dehydrogenase, putative 0.0018 0.0134 0.052
Schistosoma mansoni elf1 0.0011 0.0025 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1258 0.1256
Echinococcus granulosus dnaJ subfamily B 0.0409 0.5875 0.5874
Onchocerca volvulus 0.0009 0.0008 0.0015
Toxoplasma gondii lactate dehydrogenase LDH2 0.0018 0.0134 0.0213
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0008 0.0006
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0018 0.0134 0.0184
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0431 0.6187 1
Mycobacterium ulcerans oxidoreductase 0.0159 0.2198 0.3413
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0161 0.0375
Leishmania major cytosolic malate dehydrogenase 0.0043 0.0495 0.2179
Leishmania major malate dehydrogenase, putative 0.0018 0.0134 0.052
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0161 0.016
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0015
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0207 0.0332
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0043 0.0495 0.1149
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0024 0.0057
Onchocerca volvulus 0.0014 0.0079 0.018
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0219 0.0822
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0161 0.016
Loa Loa (eye worm) hypothetical protein 0.0062 0.078 0.1774
Leishmania major aldo-keto reductase-like protein 0.0159 0.2198 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0008 0.0006
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0025 0.0059
Chlamydia trachomatis malate dehydrogenase 0.0043 0.0495 0.0601
Onchocerca volvulus 0.0014 0.0079 0.018
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.2198 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.0295
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0008 0.0019
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.1936 0.1935
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0362 0.082
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0008 0.0006
Brugia malayi transcription factor E74 isoform 0.0011 0.0025 0.0059
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.035 0.0563
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.1316 0.591
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0043 0.0495 0.0493
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0025 0.0024
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0495 0.2101
Onchocerca volvulus 0.0081 0.1064 0.2468
Loa Loa (eye worm) apoptosis regulator protein 0.0054 0.0663 0.1508
Brugia malayi nuclear receptor NHR-67 0.0009 0.0008 0.0019
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0018 0.0134 0.052
Schistosoma mansoni hypothetical protein 0.0054 0.0663 0.0662
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0458 0.1063
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0495 0.2101
Schistosoma mansoni hypothetical protein 0.0105 0.1417 0.1416
Loa Loa (eye worm) hypothetical protein 0.004 0.0458 0.104
Onchocerca volvulus Matrix metalloproteinase homolog 0.0094 0.1243 0.2883
Onchocerca volvulus 0.0159 0.2198 0.5102
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0008 0.0015
Brugia malayi Hemopexin family protein 0.006 0.0748 0.1737
Onchocerca volvulus 0.002 0.0161 0.0371
Trypanosoma brucei prostaglandin f synthase 0.0159 0.2198 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.2198 1
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0104 0.139 0.6117
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0362 0.0839
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0219 0.0491
Echinococcus multilocularis protein dispatched 1 0.0048 0.0579 0.0577
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.2198 0.2197
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0458 0.2009
Loa Loa (eye worm) fli-1 protein 0.022 0.3098 0.7057
Loa Loa (eye worm) oxidoreductase 0.0159 0.2198 0.5006
Brugia malayi CHE-14 protein 0.0042 0.0491 0.1141
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0253 0.1071
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0431 0.6187 1
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0253 0.0981
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.2198 0.2197
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0193 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0161 0.0364
Loa Loa (eye worm) hypothetical protein 0.0303 0.4307 0.9812
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0018 0.0134 0.031
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0219 0.0509
Loa Loa (eye worm) hypothetical protein 0.0024 0.0219 0.0496
Onchocerca volvulus 0.0014 0.0079 0.018
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0024 0.0057
Echinococcus multilocularis cpg binding protein 0.003 0.0317 0.0315
Schistosoma mansoni apoptosis regulator bax 0.0054 0.0663 0.0662
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.067 0.108
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0207 0.0125
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0025 0.0054
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0207 0.0856
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0002 0.0000012757
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0024 0.0023
Loa Loa (eye worm) oxidoreductase 0.0159 0.2198 0.5006
Schistosoma mansoni tsg101-related 0.0058 0.0721 0.072
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0161 0.016
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0047 0.0566 0.2428
Loa Loa (eye worm) hypothetical protein 0.002 0.0161 0.0364
Plasmodium vivax malate dehydrogenase, putative 0.0018 0.0134 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0219 0.0145
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0161 0.0375
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0765 0.0764
Brugia malayi hypothetical protein 0.0303 0.4307 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0161 0.016
Schistosoma mansoni hypothetical protein 0.0054 0.0663 0.0662
Plasmodium vivax importin-beta 2, putative 0.0029 0.0294 0.027
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0042 0.0099
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0495 0.2101
Plasmodium falciparum aldehyde reductase, putative 0.0046 0.0545 0.0684
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0008 0.0006
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0495 0.2101
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.2198 0.2197
Echinococcus granulosus cytosolic malate dehydrogenase 0.0043 0.0495 0.0493
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1258 0.5638
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0161 0.016
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0159 0.2198 0.5104
Leishmania major hypothetical protein, conserved 0.0022 0.0193 0.0791
Toxoplasma gondii hypothetical protein 0.0014 0.0079 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0161 0.0375
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0043 0.0495 0.0482
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0161 0.016
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0161 0.016
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0008 0.0006
Echinococcus granulosus lactate dehydrogenase a 0.0018 0.0134 0.0132
Schistosoma mansoni tsg101-related 0.0058 0.0721 0.072
Plasmodium falciparum lactate dehydrogenase, putative 0.0018 0.0134 0.0004
Brugia malayi nuclear receptor NHR-88 0.002 0.0161 0.0375
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0458 0.0456
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.1258 0.1256
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0161 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0491 0.2084
Brugia malayi nuclear receptor RXR 0.001 0.0024 0.0057
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0015
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.2198 1
Echinococcus granulosus L lactate dehydrogenase B chain 0.0018 0.0134 0.0132
Onchocerca volvulus 0.0159 0.2198 0.5102
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0025 0.0024
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0293 0.0663
Loa Loa (eye worm) oxidoreductase 0.0159 0.2198 0.5006
Schistosoma mansoni hypothetical protein 0.0041 0.0469 0.0467
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0025 0.0024
Echinococcus multilocularis ets variant gene 4 0.0011 0.0025 0.0024
Trichomonas vaginalis malate dehydrogenase, putative 0.0033 0.036 0.1477
Schistosoma mansoni kinase 0.0048 0.0576 0.0574
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0161 0.0375
Plasmodium falciparum flap endonuclease 1 0.0026 0.0253 0.0202
Onchocerca volvulus 0.0014 0.0079 0.018
Leishmania major glycosomal malate dehydrogenase 0.0018 0.0134 0.052
Loa Loa (eye worm) hypothetical protein 0.0014 0.0079 0.0177
Trichomonas vaginalis aldo-keto reductase, putative 0.0046 0.0545 0.2334
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0495 0.2101
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.0495 0.2101
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.1258 0.1256
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0161 0.016
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0025 0.0054
Brugia malayi tailless protein 0.0009 0.0008 0.0019
Trichomonas vaginalis aldo/keto reductase, putative 0.0159 0.2198 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1258 0.5638
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0043 0.0495 0.2101
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.0295
Trypanosoma cruzi aldo/keto reductase, putative 0.0046 0.0545 0.241
Loa Loa (eye worm) hypothetical protein 0.0014 0.0079 0.0177
Loa Loa (eye worm) hypothetical protein 0.0014 0.0079 0.0177
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0193 0.0435
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0018 0.0134 0.052
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.1258 0.2917
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.1339 0.1337
Mycobacterium leprae PROBABLE HYDROLASE 0.0051 0.0624 0.0698
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0207 0.0125
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0159 0.2198 0.5104
Loa Loa (eye worm) hypothetical protein 0.0014 0.0079 0.0177
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0046 0.0545 0.0544
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.1064 0.1063
Loa Loa (eye worm) hypothetical protein 0.002 0.0161 0.0364
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0161 0.0371
Schistosoma mansoni hypothetical protein 0.0022 0.0193 0.0191
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0161 0.016
Onchocerca volvulus 0.0029 0.0293 0.0676
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0161 0.016
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0214 0.08
Loa Loa (eye worm) oxidoreductase 0.0159 0.2198 0.5006
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0046 0.0545 0.1266
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0008 0.0006
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.2198 0.2197
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.0431 0.6187 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0294 0.0684
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0183 0.0181
Onchocerca volvulus Matrilysin homolog 0.0094 0.1243 0.2883
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0161 0.0375
Onchocerca volvulus 0.0014 0.0079 0.018
Leishmania major malate dehydrogenase 0.0018 0.0134 0.052
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0042 0.0099
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0491 0.1116
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0046 0.0545 0.2334
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0677 0.9794 0.9794
Entamoeba histolytica aldose reductase, putative 0.0159 0.2198 1
Echinococcus granulosus aldo keto reductase 0.0159 0.2198 0.2197
Loa Loa (eye worm) matrix metalloproteinase 0.0042 0.049 0.1112
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.2198 1
Schistosoma mansoni patched 1 0.0042 0.0491 0.049
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.2198 0.2197
Entamoeba histolytica alcohol dehydrogenase, putative 0.0046 0.0545 0.2334
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0458 0.0456
Trypanosoma brucei aldo/keto reductase, putative 0.0046 0.0545 0.241
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0253 0.0202
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.035 0.1513
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0042 0.0099
Brugia malayi Kringle domain containing protein 0.0022 0.0193 0.0447
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.2198 0.2197
Leishmania major GTP-binding protein, putative 0.0021 0.0183 0.0746
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.2198 0.2197
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.0295
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0161 0.016
Loa Loa (eye worm) malate dehydrogenase 0.0018 0.0134 0.0301
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0161 0.016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0161 0.0375
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0079 0.0177
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0008 0.0006
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0934 0.2125
Echinococcus granulosus aldo keto reductase 0.0159 0.2198 0.2197
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0161 0.0375
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0008 0.0006
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0079 0.0125
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0008 0.0019
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.1258 0.5638
Brugia malayi nuclear hormone receptor 0.0009 0.0008 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0161 0.0375
Plasmodium falciparum L-lactate dehydrogenase 0.0018 0.0134 0.0004
Echinococcus multilocularis expressed protein 0.0033 0.0362 0.036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0161 0.016
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1258 0.5638
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0015
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0159 0.2198 1
Mycobacterium leprae Conserved hypothetical protein 0.0113 0.1524 0.2203
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0042 0.0099
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0008 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0219 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0015
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0159 0.2198 0.333
Schistosoma mansoni pol-related 0.0159 0.2198 0.2197
Mycobacterium ulcerans hydrolase 0.0051 0.0624 0.0814
Echinococcus granulosus malate dehydrogenase 0.0018 0.0134 0.0132
Schistosoma mansoni hypothetical protein 0.0041 0.0469 0.0467
Onchocerca volvulus 0.006 0.0748 0.1734
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0042 0.0099
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0042 0.0099
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0008 0.0006
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0431 0.6187 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0253 0.1071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0015
Schistosoma mansoni malate dehydrogenase 0.0018 0.0134 0.0132
Schistosoma mansoni cpg binding protein 0.003 0.0317 0.0315
Plasmodium vivax lactate dehydrogenase 0.0018 0.0134 0.0004
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.2198 0.2197
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0043 0.0495 0.0493
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0018 0.0134 0.0004
Onchocerca volvulus 0.0022 0.0193 0.0444
Loa Loa (eye worm) hypothetical protein 0.0051 0.0624 0.1419
Trichomonas vaginalis aldo-keto reductase, putative 0.0046 0.0545 0.2334
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0042 0.0099
Brugia malayi hypothetical protein 0.0009 0.0008 0.0019
Brugia malayi hypothetical protein 0.0009 0.0008 0.0019
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0161 0.016
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0458 0.2009
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.2198 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0161 0.0364
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1258 0.5681
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0079 0.0125
Entamoeba histolytica malate dehydrogenase, putative 0.0043 0.0495 0.2101
Brugia malayi ecdysone receptor 0.0009 0.0008 0.0019
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.2198 0.2197
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0052
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0219 0.0145
Mycobacterium leprae Possible oxidoreductase 0.0046 0.0545 0.0566
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0491 0.049
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0161 0.0364
Leishmania major importin beta-1 subunit, putative 0.0023 0.0214 0.0891
Echinococcus multilocularis expressed conserved protein 0.0093 0.1229 0.1227
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0042 0.049 0.0488
Schistosoma mansoni aldo-keto reductase 0.0159 0.2198 0.2197
Loa Loa (eye worm) hypothetical protein 0.002 0.0161 0.0364
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.035 0.1428
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.2198 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1258 0.5681
Schistosoma mansoni L-lactate dehydrogenase 0.0018 0.0134 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1258 0.5638
Brugia malayi PAN domain containing protein 0.0014 0.0079 0.0184
Brugia malayi steroid hormone receptor 0.002 0.0161 0.0375
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.2198 0.2197
Loa Loa (eye worm) hypothetical protein 0.002 0.0161 0.0364
Loa Loa (eye worm) hypothetical protein 0.0181 0.2521 0.5742
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0008 0.0006
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0495 0.2101
Brugia malayi Matrixin family protein 0.0042 0.049 0.1137
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0161 0.016
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.1064 0.1063
Loa Loa (eye worm) malate dehydrogenase 0.0043 0.0495 0.1124
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0159 0.2198 1
Schistosoma mansoni hypothetical protein 0.0011 0.0025 0.0024
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0008 0.0015
Schistosoma mansoni L-lactate dehydrogenase 0.0018 0.0134 0.0132
Trichomonas vaginalis hypothetical protein 0.0034 0.0368 0.1514
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0015
Toxoplasma gondii microneme protein MIC4 0.0014 0.0079 0.0125
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.2198 1
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0253 0.0574
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0025 0.0024
Echinococcus granulosus expressed protein 0.0033 0.0362 0.036
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0207 0.0125
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0054 0.0663 0.0662
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.1064 0.1063
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0253 0.0252
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0043 0.0495 0.2179
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0545 0.2334
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0161 0.0364
Toxoplasma gondii microneme protein MIC17A 0.0014 0.0079 0.0125
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.1258 0.2863
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0079 0.0125
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0131 0.0068
Schistosoma mansoni potassium channel beta 0.0046 0.0545 0.0544
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0042 0.0099
Onchocerca volvulus 0.0159 0.2198 0.5102
Schistosoma mansoni hypothetical protein 0.0308 0.4389 0.4388
Onchocerca volvulus 0.0014 0.0079 0.018
Mycobacterium ulcerans malate dehydrogenase 0.0043 0.0495 0.0601
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0024 0.0023
Brugia malayi RNA, U transporter 1 0.0082 0.1075 0.2495
Onchocerca volvulus Matrilysin homolog 0.0042 0.049 0.1133
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0054
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0008 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0161 0.0375
Toxoplasma gondii hypothetical protein 0.0014 0.0079 0.0125
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0183 0.0413
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.0295
Toxoplasma gondii microneme protein MIC17C 0.0014 0.0079 0.0125
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0015
Onchocerca volvulus 0.0024 0.0219 0.0505
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0458 0.2009
Echinococcus granulosus flap endonuclease 1 0.0026 0.0253 0.0252
Plasmodium falciparum aldo-keto reductase, putative 0.0046 0.0545 0.0684
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0161 0.016
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0253 0.0981
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0294 0.0293
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1258 0.5638
Loa Loa (eye worm) DR-78 0.0009 0.0008 0.0015
Onchocerca volvulus 0.0014 0.0079 0.018
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0431 0.6187 1
Echinococcus multilocularis lactate dehydrogenase protein 0.0018 0.0134 0.0132
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0193 0.0101
Trypanosoma brucei aldo-keto reductase, putative 0.0159 0.2198 1
Brugia malayi nuclear receptor RXR 0.0009 0.0008 0.0019
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0042 0.0099
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0079 0.0177
Loa Loa (eye worm) hypothetical protein 0.007 0.0892 0.2029
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0458 0.0456
Trichomonas vaginalis malate dehydrogenase, putative 0.0018 0.0134 0.0425
Echinococcus granulosus FTZ F1 alpha 0.002 0.0161 0.016
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.1064 0.2471
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0198 0.0814
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0015
Brugia malayi hypothetical protein 0.001 0.0024 0.0057
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.1316 0.3056
Trichomonas vaginalis ran, putative 0.0021 0.0183 0.0653
Echinococcus granulosus importin subunit beta 1 0.0029 0.0294 0.0293
Schistosoma mansoni tsg101-related 0.0047 0.0566 0.0564
Loa Loa (eye worm) oxidoreductase 0.0159 0.2198 0.5006
Trypanosoma cruzi aldo/keto reductase, putative 0.0159 0.2198 1
Brugia malayi hypothetical protein 0.0009 0.0002 0.0004
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0025 0.0024
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0183 0.0746
Trichomonas vaginalis rotamase, putative 0.0033 0.0362 0.1482
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0207 0.0856
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0207 0.0431
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0002 0.0004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.00000055984
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0054
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0219 0.0145
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0207 0.0332
Echinococcus granulosus protein C ets 2 0.0011 0.0025 0.0024
Schistosoma mansoni ets-related 0.0011 0.0025 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0458 0.1929
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0079 0.0177
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0043 0.0495 0.1816
Schistosoma mansoni cpg binding protein 0.0029 0.0293 0.0291
Plasmodium vivax aldehyde reductase, putative 0.0046 0.0545 0.0684
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0183 0.0424
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0079 0.0125
Onchocerca volvulus 0.0014 0.0079 0.018
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0294 0.1259
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0054 0.0663 0.0662
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0294 0.0473
Toxoplasma gondii subtilisin SUB12 0.0014 0.0079 0.0125
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0193 0.0309
Trypanosoma brucei RNA helicase, putative 0.0105 0.1417 0.6414
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0491 0.049
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0051 0.0624 0.145
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0161 0.016
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0008 0.0015
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0934 0.0933
Brugia malayi Ets-domain containing protein 0.0072 0.0934 0.2169
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0002 0.0004
Entamoeba histolytica Ran family GTPase 0.0021 0.0183 0.0653
Entamoeba histolytica aldose reductase, putative 0.0159 0.2198 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0183 0.0085
Loa Loa (eye worm) hypothetical protein 0.0014 0.0079 0.0177
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0161 0.0375
Giardia lamblia Malate dehydrogenase 0.0043 0.0495 0.1549
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0253 0.0351
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0193 0.0435
Schistosoma mansoni thyroid hormone receptor 0.002 0.0161 0.016
Schistosoma mansoni gabp alpha 0.0072 0.0934 0.0933
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.0495 0.2101
Schistosoma mansoni cpg binding protein 0.003 0.0317 0.0315
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0558 0.2391
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0183 0.0181
Loa Loa (eye worm) hypothetical protein 0.002 0.0161 0.0364
Loa Loa (eye worm) hypothetical protein 0.0052 0.0631 0.1434
Schistosoma mansoni malate dehydrogenase 0.0043 0.0495 0.0493
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0183 0.0746
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0458 0.0456
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0219 0.0913
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0008 0.0015
Brugia malayi PAN domain containing protein 0.0014 0.0079 0.0184
Leishmania major mitochondrial malate dehydrogenase 0.0018 0.0134 0.052
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.035 0.1513
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0161 0.0364
Schistosoma mansoni aldo-keto reductase 0.0159 0.2198 0.2197
Echinococcus granulosus cytosolic malate dehydrogenase 0.0043 0.0495 0.0493
Brugia malayi PAN domain containing protein 0.0014 0.0079 0.0184
Echinococcus multilocularis aldo keto reductase 0.0159 0.2198 0.2197
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0161 0.0375
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0458 0.0456
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.0495 0.2101
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0458 0.0456
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0458 0.1929
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0015
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0214 0.08
Leishmania major hypothetical protein, conserved 0.0022 0.0198 0.0814
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.2198 1
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0079 0.0125
Trichomonas vaginalis aldo-keto reductase, putative 0.0159 0.2198 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0046 0.0545 0.2334
Echinococcus granulosus aldehyde reductase 0.0113 0.1524 0.1523
Loa Loa (eye worm) hypothetical protein 0.0099 0.1316 0.2996
Brugia malayi Matrixin family protein 0.0042 0.049 0.1137
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0161 0.016
Schistosoma mansoni hypothetical protein 0.0011 0.0025 0.0024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0214 0.08
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.1316 0.1315
Giardia lamblia Aldose reductase 0.0159 0.2198 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0159 0.2198 0.2197
Brugia malayi nuclear receptor NHR-88 0.0009 0.0008 0.0019
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0159 0.2198 0.2197
Brugia malayi conserved hypotetical protein 0.0009 0.0008 0.0019

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Neurotoxicity in Mus musculus albino (mouse) assessed as minimal motor impairment at 300 mg/kg, ip after 4 hr by rotarod test LITERATURE. No reference
Activity (ADMET) Neurotoxicity in Mus musculus albino (mouse) assessed as minimal motor impairment at 300 mg/kg, ip after 0 LITERATURE. No reference
Activity (functional) Anticonvulsant activity in Mus musculus albino (mouse) assessed as protection against subcutaneous metrazole-induced seizure at 300 mg/kg, ip after 4 hr LITERATURE. No reference
Activity (functional) Anticonvulsant activity in Mus musculus albino (mouse) assessed as protection against maximal electroshock-induced seizure at 300 mg/kg, ip after 4 hr LITERATURE. No reference
Activity (functional) Anticonvulsant activity in Mus musculus albino (mouse) assessed as protection against maximal electroshock-induced seizure at 300 mg/kg, ip after 0 LITERATURE. No reference
Activity (functional) Anticonvulsant activity in Mus musculus albino (mouse) assessed as protection against subcutaneous metrazole-induced seizure at 300 mg/kg, ip after 0 LITERATURE. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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