TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 421.532 | Formula: C25H31N3O3
H donors: 2 H acceptors: 3 LogP: 3.62 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCCNC[C@H](Cn1c(C)c(c(=O)n1c1ccccc1)C(=O)CCc1ccccc1)O
InChi: 1S/C25H31N3O3/c1-3-16-26-17-22(29)18-27-19(2)24(23(30)15-14-20-10-6-4-7-11-20)25(31)28(27)21-12-8-5-9-13-21/h4-13,22,26,29H,3,14-18H2,1-2H3/t22-/m1/s1
InChiKey: MVBHWZHXSXDVEV-JOCHJYFZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATP-binding cassette, sub-family B (MDR/TAP), member 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Multidrug resistance protein 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-5	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium falciparum	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium yoelii	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Candida albicans	potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export	Get druggable targets OG5_126596	All targets in OG5_126596
Onchocerca volvulus		Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ATP-binding cassette sub-family B member 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	ABC transporter family protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium parvum	ATP-binding cassette transporter	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Neospora caninum	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Bile salt export pump, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glyco protein 6, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium vivax	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Neospora caninum	ATP-binding cassette, sub-family B (MDR/TAP), member 4, related	Get druggable targets OG5_126596	All targets in OG5_126596
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium hominis	ATP-binding cassette protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania braziliensis	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	smdr2	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium berghei	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	taga, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-1	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania donovani	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium knowlesi	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania donovani	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0028	0.0029
Plasmodium vivax	hypothetical protein, conserved	0.0016	0.0432	0.1353
Trichomonas vaginalis	abcb9, putative	0.0013	0.0262	0.2423
Onchocerca volvulus		0.0013	0.0262	0.0866
Toxoplasma gondii	hypothetical protein	0.0018	0.0515	0.1614
Leishmania major	p-glycoprotein	0.0013	0.0262	0.0821
Echinococcus granulosus	multidrug resistance protein 1	0.0013	0.0262	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0256	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0262	0.0271
Trichomonas vaginalis	penicillin-binding protein, putative	0.0016	0.0432	0.3992
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0008	0.0028	0.0028
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0025	0.0839	0.7759
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0016	0.0432	0.0446
Brugia malayi	Probable ClpP-like protease	0.0036	0.1317	0.1317
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0008	0.0028	0.0028
Brugia malayi	DNA topoisomerase I	0.0041	0.1555	0.1555
Echinococcus multilocularis	jun protein	0.0085	0.3569	0.3569
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0025	0.0839	0.2629
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0008	0.0028	0.0028
Echinococcus multilocularis	neuropeptide s receptor	0.0203	0.9013	0.9013
Echinococcus multilocularis	multidrug resistance protein 1	0.0009	0.0085	0.0085
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0025	0.0839	0.7759
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0025	0.0839	0.7759
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0432	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0028	0.0029
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0008	0.0028	0.0087
Echinococcus multilocularis	multidrug resistance protein 1	0.0013	0.0262	0.0262
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0262	0.2423
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0025	0.0839	0.7759
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0432	0.0446
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0036	0.1317	0.4049
Brugia malayi	photoreceptor-specific nuclear receptor	0.0008	0.0028	0.0028
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0013	0.0262	0.0271
Echinococcus multilocularis	inositol monophosphatase 1	0.0016	0.0409	0.0409
Loa Loa (eye worm)	TOPoisomerase family member	0.0031	0.1081	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0028	0.0029
Entamoeba histolytica	DNA topoisomerase II, putative	0.0031	0.1081	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0248	0.0256
Trypanosoma brucei	beta lactamase	0.0028	0.0962	0.3015
Echinococcus multilocularis	JmjC domain containing protein 4	0.0007	0.0005	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0008	0.0028	0.0028
Toxoplasma gondii	GAF domain-containing protein	0.0018	0.0515	0.1614
Trypanosoma brucei	DNA topoisomerase IB, large subunit	0.0041	0.1555	0.4873
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0029	0.1005	0.3151
Schistosoma mansoni	1-acyl-sn-glycerol-3-phosphate o-acyltransferase	0.0076	0.3191	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0025	0.0839	0.7759
Mycobacterium ulcerans	putative regulatory protein	0.0018	0.0515	0.0383
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.0262	0.2423
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0025	0.0839	0.0839
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.0262	0.0262
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0018	0.0488	0.1528
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0036	0.1317	0.4127
Brugia malayi	beta-lactamase	0.0016	0.0432	0.0432
Brugia malayi	jmjC domain containing protein	0.0027	0.091	0.091
Mycobacterium tuberculosis	Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoseri	0.0073	0.3046	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0028	0.0029
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0031	0.1081	0.1081
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0027	0.091	0.091
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.0262	0.2423
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0036	0.1317	0.1317
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.0262	0.0262
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0018	0.0495	0.0312
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0262	0.2423
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0025	0.0839	0.7759
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0008	0.0028	0.0028
Schistosoma mansoni	coup transcription factor	0.0008	0.0028	0.0087
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0029	0.1005	0.3151
Echinococcus granulosus	beta LACTamase domain containing family member	0.0016	0.0432	0.0432
Loa Loa (eye worm)	jmjC domain-containing protein	0.0007	0.0005	0.0006
Brugia malayi	MH2 domain containing protein	0.0042	0.1599	0.1599
Trypanosoma brucei	DNA topoisomerase ii	0.0034	0.1253	0.3927
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0262	0.2423
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0036	0.1317	0.4127
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0007	0.0005	0.0017
Schistosoma mansoni	nuclear hormone receptor	0.0008	0.0028	0.0087
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0012	0.0241	0.0757
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0432	0.0446
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0013	0.0256	0.0256
Schistosoma mansoni	jun-related protein	0.0069	0.284	0.8901
Loa Loa (eye worm)	hypothetical protein	0.0076	0.3191	0.3297
Mycobacterium tuberculosis	Conserved protein	0.0016	0.0432	0.04
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0027	0.091	0.2852
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.0262	0.2423
Mycobacterium ulcerans	esterase/lipase LipP	0.0016	0.0432	0.0083
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0007	0.0005	0.0017
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0036	0.1317	0.3646
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0025	0.0839	0.0839
Leishmania major	mitochondrial DNA topoisomerase II	0.0034	0.1253	0.3927
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	0.0058	0.2355	0.4937
Schistosoma mansoni	multidrug resistance protein	0.0013	0.0262	0.0821
Mycobacterium ulcerans	1-acylglycerol-3-phosphate O-acyltransferase	0.0076	0.3191	1
Brugia malayi	nuclear hormone receptor	0.0008	0.0028	0.0028
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0016	0.0409	0.3779
Schistosoma mansoni	inositol monophosphatase	0.0016	0.0409	0.128
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0262	0.2423
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0008	0.0028	0.0087
Trichomonas vaginalis	taga, putative	0.0013	0.0262	0.2423
Trichomonas vaginalis	abcb9, putative	0.0013	0.0262	0.2423
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0262	0.2423
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0005	0.0006
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0262	0.2423
Brugia malayi	Acyltransferase family protein	0.0076	0.3191	0.3191
Loa Loa (eye worm)	steroid hormone receptor	0.0008	0.0028	0.0029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0008	0.0028	0.0029
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0262	0.2423
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0248	0.0256
Loa Loa (eye worm)	multidrug resistance protein 3	0.0013	0.0262	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1317	0.1361
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0008	0.0028	0.0028
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0008	0.0028	0.0028
Leishmania major	1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative	0.0076	0.3191	1
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0029	0.1005	0.3151
Echinococcus granulosus	inositol monophosphatase 1	0.0016	0.0409	0.0409
Echinococcus multilocularis	1 acyl sn glycerol 3 phosphate acyltransferase	0.0076	0.3191	0.3191
Echinococcus granulosus	neuropeptide s receptor	0.0203	0.9013	0.9013
Trichomonas vaginalis	D-aminoacylase, putative	0.0016	0.0432	0.3992
Onchocerca volvulus		0.0066	0.2733	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0042	0.1599	0.1652
Echinococcus granulosus	DNA topoisomerase 1	0.0041	0.1555	0.1555
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0016	0.0409	0.128
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0008	0.0028	0.0028
Toxoplasma gondii	ABC1 family protein	0.0016	0.0432	0.1353
Onchocerca volvulus		0.0016	0.0432	0.1493
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0025	0.0839	0.2629
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0008	0.0028	0.0028
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0013	0.0262	0.0821
Trichomonas vaginalis	D-aminoacylase, putative	0.0016	0.0432	0.3992
Plasmodium falciparum	topoisomerase I	0.0041	0.1555	0.4873
Echinococcus granulosus	multidrug resistance protein 1	0.0013	0.0262	0.0262
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0262	0.2423
Loa Loa (eye worm)	beta-lactamase	0.0016	0.0432	0.0446
Schistosoma mansoni	inositol monophosphatase	0.0016	0.0409	0.128
Brugia malayi	beta-lactamase family protein	0.0016	0.0432	0.0432
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0025	0.0839	0.7759
Loa Loa (eye worm)	jmjC domain-containing protein	0.0007	0.0005	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0028	0.0029
Plasmodium vivax	topoisomerase I, putative	0.0041	0.1555	0.4873
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0018	0.0488	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0076	0.3191	0.3297
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.0028	0.0962	0.1652
Echinococcus granulosus	jumonji domain containing 1A	0.0007	0.0005	0.0005
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0008	0.0028	0.0028
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0013	0.0262	0.0821
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0014	0.0332	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0028	0.0029
Schistosoma mansoni	jumonji domain containing protein	0.0007	0.0005	0.0017
Echinococcus multilocularis	neuropeptide receptor A26	0.0203	0.9013	0.9013
Mycobacterium leprae	POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI	0.0076	0.3191	1
Echinococcus granulosus	lysine specific demethylase 6a	0.0007	0.0005	0.0005
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0008	0.0028	0.0028
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0008	0.0028	0.0028
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.002	0.0588	0.077
Mycobacterium tuberculosis	Conserved protein	0.0016	0.0432	0.04
Trypanosoma brucei	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	0.0076	0.3191	1
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0016	0.0409	0.128
Schistosoma mansoni	retinoic acid receptor RXR	0.0008	0.0028	0.0087
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0012	0.0241	0.0635
Plasmodium falciparum	DNA topoisomerase 2	0.0031	0.1081	0.3388
Leishmania major	DNA topoisomerase IB, large subunit	0.0041	0.1555	0.4873
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0008	0.0028	0.0029
Trichomonas vaginalis	inositol monophosphatase, putative	0.0016	0.0409	0.3779
Trypanosoma cruzi	DNA topoisomerase IB, large subunit, putative	0.0041	0.1555	0.4873
Schistosoma mansoni	RAR-like nuclear receptor	0.0008	0.0028	0.0087
Mycobacterium tuberculosis	Conserved protein	0.0016	0.0432	0.04
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0008	0.0028	0.0028
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.0262	0.0262
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.0058	0.2355	0.6996
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0008	0.0028	0.0028
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0031	0.1081	1
Trichomonas vaginalis	esterase, putative	0.0016	0.0432	0.3992
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0008	0.0028	0.0028
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0432	0.1353
Brugia malayi	Probable DNA topoisomerase II	0.0031	0.1081	0.1081
Plasmodium falciparum	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	0.0076	0.3191	1
Echinococcus granulosus	Phospholipid glycerol acyltransferase	0.0076	0.3191	0.3191
Schistosoma mansoni	thyroid hormone receptor	0.0008	0.0028	0.0087
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0262	0.2423
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0028	0.0029
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0008	0.0028	0.0028
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0432	0.1353
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0036	0.1317	0.3601
Schistosoma mansoni	DNA topoisomerase type I	0.0041	0.1555	0.4873
Schistosoma mansoni	phosphatidylserine receptor	0.0007	0.0005	0.0017
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0432	0.0083
Plasmodium vivax	DNA gyrase subunit B, putative	0.0018	0.0495	0.1553
Loa Loa (eye worm)	jmjC domain-containing protein	0.0007	0.0005	0.0006
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0025	0.0839	0.7759
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0627	0.0648
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0025	0.0839	0.2629
Brugia malayi	jmjC domain containing protein	0.0007	0.0005	0.0005
Trichomonas vaginalis	penicillin-binding protein, putative	0.0016	0.0432	0.3992
Mycobacterium leprae	conserved hypothetical protein	0.0018	0.0515	0.1504
Mycobacterium ulcerans	beta-lactamase	0.0016	0.0432	0.0083
Loa Loa (eye worm)	acyltransferase	0.0076	0.3191	0.3297
Echinococcus granulosus	lysine specific demethylase 5A	0.0027	0.091	0.091
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Onchocerca volvulus		0.0016	0.0432	0.1493
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.0262	0.0262
Schistosoma mansoni	multidrug resistance protein	0.0013	0.0262	0.0821
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0016	0.0432	0.0432
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0515	0.4765
Echinococcus multilocularis	ATP binding cassette sub family B	0.0013	0.0256	0.0256
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0034	0.1253	0.3927
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0034	0.1253	0.3927
Brugia malayi	Steroid receptor seven-up type 2	0.0008	0.0028	0.0028
Echinococcus granulosus	multidrug resistance protein 1	0.0013	0.0262	0.0262
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Trypanosoma cruzi	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	0.0076	0.3191	1
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0839	0.7759
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0262	0.2423
Plasmodium falciparum	GAF domain-related protein, putative	0.0018	0.0515	0.1614
Brugia malayi	nuclear receptor NHR-88	0.0008	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0432	0.0446
Echinococcus granulosus	phd:f box containing protein	0.0007	0.0005	0.0005
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0036	0.1317	0.3264
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0018	0.0488	0.0488
Giardia lamblia	DNA topoisomerase II	0.0029	0.1008	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0018	0.0488	0.1528
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0028	0.0029
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0008	0.0028	0.0087
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0007	0.0005	0.0017
Echinococcus granulosus	neuropeptide receptor A26	0.0203	0.9013	0.9013
Mycobacterium tuberculosis	Probable lipase LipD	0.0016	0.0432	0.04
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0013	0.0262	0.2423
Schistosoma mansoni	smdr2	0.0013	0.0262	0.0821
Brugia malayi	jmjC domain containing protein	0.0007	0.0005	0.0005
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0008	0.0028	0.0028
Chlamydia trachomatis	DNA gyrase subunit B	0.0018	0.0495	0.0797
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0262	0.2423
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0839	0.0867
Echinococcus multilocularis	FTZ F1 alpha	0.0008	0.0028	0.0028
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0008	0.0028	0.0028
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0016	0.0432	0.04
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0018	0.0495	0.0861
Loa Loa (eye worm)	hypothetical protein	0.0199	0.8838	0.9133
Schistosoma mansoni	thyroid hormone receptor	0.0008	0.0028	0.0087
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0025	0.0839	0.0839
Toxoplasma gondii	hypothetical protein	0.0018	0.0515	0.1614
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0036	0.1317	0.3264
Echinococcus granulosus	JmjC domain containing protein 4	0.0007	0.0005	0.0005
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0027	0.091	0.091
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0005	0.0006
Schistosoma mansoni	transcription factor	0.0073	0.3046	0.9547
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0008	0.0028	0.0028
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0016	0.0432	0.0432
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0018	0.0488	0.0488
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0025	0.0839	0.7759
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.0262	0.0262
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0085	0.3569	0.3569
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0262	0.2423
Toxoplasma gondii	acyltransferase domain-containing protein	0.0076	0.3191	1
Brugia malayi	steroid hormone receptor	0.0008	0.0028	0.0028
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0036	0.1317	0.4127
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0515	0.4765
Wolbachia endosymbiont of Brugia malayi	1-acyl-sn-glycerol-3-phosphate acyltransferase	0.0076	0.3191	1
Mycobacterium ulcerans	putative regulatory protein	0.0018	0.0515	0.0383
Treponema pallidum	lysophosphatidic acid acyltransferase	0.0076	0.3191	1
Echinococcus granulosus	peptidase Clp S14 family	0.0023	0.0752	0.0752
Trichomonas vaginalis	abcb9, putative	0.0013	0.0262	0.2423
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0007	0.0005	0.0005
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0008	0.0028	0.0028
Loa Loa (eye worm)	inositol-1	0.0016	0.0409	0.0422
Echinococcus granulosus	ecdysone induced protein 78C	0.0008	0.0028	0.0028
Echinococcus multilocularis	phd:f box containing protein	0.0007	0.0005	0.0005
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0008	0.0028	0.0087
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0018	0.0488	0.1528
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0008	0.0028	0.0029
Plasmodium falciparum	DNA gyrase subunit B	0.0018	0.0495	0.1553
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.0262	0.2423
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0031	0.1081	0.1081
Echinococcus granulosus	jun protein	0.0085	0.3569	0.3569
Plasmodium vivax	hypothetical protein, conserved	0.0018	0.0515	0.1614
Schistosoma mansoni	peptidase Clp (S14 family)	0.0036	0.1317	0.4127
Plasmodium vivax	multidrug resistance protein 1, putative	0.0013	0.0262	0.0821
Echinococcus multilocularis	DNA topoisomerase 1	0.0041	0.1555	0.1555
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0016	0.0409	0.128
Echinococcus multilocularis	multidrug resistance protein 1	0.0013	0.0262	0.0262
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0515	0.4765
Loa Loa (eye worm)	hypothetical protein	0.0217	0.9676	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0005	0.0006
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0008	0.0028	0.0028
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0018	0.0495	0.1553
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0029	0.1005	0.3151
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.0028	0.0962	0.2924
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0016	0.0432	0.04
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0432	0.0446
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.0262	0.2423
Echinococcus granulosus	1 acyl sn glycerol 3 phosphate acyltransferase	0.0076	0.3191	0.3191
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0021	0.0626	0.221
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0025	0.0839	0.7759
Brugia malayi	beta-lactamase family protein	0.0016	0.0432	0.0432
Mycobacterium ulcerans	bifunctional transmembrane phospholipid biosynthesis enzyme PlsC	0.0076	0.3191	1
Brugia malayi	multidrug resistance protein 3	0.0013	0.0262	0.0262
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0018	0.0495	0.0551
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0025	0.0839	0.2629
Schistosoma mansoni	phd/f-box containing protein	0.0007	0.0005	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0008	0.0028	0.0028
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0018	0.0488	0.0488
Mycobacterium tuberculosis	Probable lipase LipE	0.0016	0.0432	0.04
Schistosoma mansoni	hypothetical protein	0.0069	0.284	0.8901
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0008	0.0028	0.0087
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.0262	0.0262
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0013	0.0262	0.2423
Brugia malayi	jmjC domain containing protein	0.0007	0.0005	0.0005
Plasmodium vivax	DNA topoisomerase II, putative	0.0031	0.1081	0.3388
Toxoplasma gondii	DNA topoisomerase I, putative	0.0041	0.1555	0.4873
Plasmodium vivax	JmjC domain containing protein	0.0007	0.0005	0.0017
Schistosoma mansoni	jumonji domain containing protein	0.0027	0.091	0.2852
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0031	0.1081	0.3388
Echinococcus multilocularis	Phospholipid glycerol acyltransferase	0.0076	0.3191	0.3191
Brugia malayi	Nuclear hormone receptor-like 1	0.0008	0.0028	0.0028
Brugia malayi	Inositol-1	0.0016	0.0409	0.0409
Mycobacterium tuberculosis	Probable esterase LipL	0.0016	0.0432	0.04
Echinococcus granulosus	Msx-like	0.0073	0.3046	0.3046
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0008	0.0028	0.0029
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0023	0.0752	0.2255
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0021	0.0626	0.221
Schistosoma mansoni	DNA topoisomerase type I	0.0041	0.1555	0.4873
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0008	0.0028	0.0087
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0016	0.0432	0.1353
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0008	0.0028	0.0087
Echinococcus multilocularis	ecdysone induced protein 78C	0.0008	0.0028	0.0028
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0021	0.0626	0.221
Mycobacterium ulcerans	lipase LipD	0.0016	0.0432	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0627	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3463	0.3579
Leishmania major	hypothetical protein, conserved	0.0007	0.0005	0.0017
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.0262	0.0262
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0262	0.2423
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0036	0.1317	0.4127
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0007	0.0005	0.0017
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0008	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0432	0.0446
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0025	0.0839	0.2629
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0014	0.0332	0.0922
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0013	0.0262	0.2423
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0012	0.0241	0.0757
Leishmania major	DNA topoisomerase ii	0.0029	0.1005	0.3151
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0008	0.0028	0.0028
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0009	0.0085	0.0787
Brugia malayi	hypothetical protein	0.0066	0.2733	0.2733
Echinococcus multilocularis	lysine specific demethylase 5A	0.0027	0.091	0.091
Brugia malayi	ABC transporter family protein	0.0013	0.0262	0.0262
Echinococcus granulosus	1 acyl sn glycerol 3 phosphate acyltransferase	0.0076	0.3191	0.3191
Toxoplasma gondii	hypothetical protein	0.0018	0.0515	0.1614
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0013	0.0262	0.0262
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0007	0.0005	0.0017
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0013	0.0262	0.0262
Mycobacterium tuberculosis	Probable hydrolase	0.0016	0.0432	0.04
Chlamydia trachomatis	DNA gyrase subunit B	0.0014	0.0323	0.021
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0013	0.0262	0.0821
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0224	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.0262	0.2423
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0018	0.0488	0.0488
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0105	0.4501	1
Loa Loa (eye worm)	DNA topoisomerase I	0.0041	0.1555	0.1607
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0007	0.0005	0.0005
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0025	0.0839	0.2629
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Schistosoma mansoni	DNA topoisomerase type I	0.0041	0.1555	0.4873
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0008	0.0028	0.0029
Trypanosoma brucei	hypothetical protein, conserved	0.0016	0.0432	0.1353
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0262	0.0271
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0023	0.0752	0.0752
Echinococcus multilocularis	1 acyl sn glycerol 3 phosphate acyltransferase	0.0076	0.3191	0.3191
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0031	0.1081	0.1081
Echinococcus multilocularis	jumonji domain containing 1A	0.0007	0.0005	0.0005
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0023	0.0752	0.1155
Mycobacterium tuberculosis	1-acylglycerol-3-phosphate O-acyltransferase	0.0076	0.3191	0.6909
Loa Loa (eye worm)	transcription factor SMAD2	0.0042	0.1599	0.1652
Echinococcus multilocularis	lysine specific demethylase 6a	0.0007	0.0005	0.0005
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.0262	0.2423
Leishmania major	hypothetical protein, conserved	0.0016	0.0432	0.1353
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.002	0.0588	0.077
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0016	0.0409	0.128
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0013	0.0262	0.2423
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0515	0.4765
Brugia malayi	bZIP transcription factor family protein	0.0085	0.3569	0.3569
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0016	0.0432	0.04
Mycobacterium leprae	conserved hypothetical protein	0.0016	0.0432	0.1239
Schistosoma mansoni	protein phosphatase 2C	0.0007	0.0005	0.0017
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0085	0.3569	0.3569
Brugia malayi	ecdysteroid receptor	0.0008	0.0028	0.0028
Trichomonas vaginalis	D-aminoacylase, putative	0.0016	0.0432	0.3992
Onchocerca volvulus		0.0016	0.0432	0.1493
Brugia malayi	jmjC domain containing protein	0.0007	0.0005	0.0005
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0023	0.0752	0.1155
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0036	0.1317	0.3601
Plasmodium vivax	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	0.0076	0.3191	1
Echinococcus multilocularis	homeobox	0.0073	0.3046	0.3046
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0008	0.0028	0.0028
Echinococcus granulosus	FTZ F1 alpha	0.0008	0.0028	0.0028
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0013	0.0262	0.2423
Plasmodium falciparum	multidrug resistance protein 1	0.0013	0.0262	0.0821
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0016	0.0409	0.128
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0008	0.0028	0.0028
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0008	0.0028	0.0029
Brugia malayi	jmjC domain containing protein	0.0027	0.091	0.091
Toxoplasma gondii	acyltransferase domain-containing protein	0.0076	0.3191	1
Mycobacterium leprae	Probable lipase LipE	0.0016	0.0432	0.1239
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0008	0.0028	0.0029
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0036	0.1317	0.1317
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0007	0.0005	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0008	0.0028	0.0028
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0027	0.091	0.2852
Toxoplasma gondii	hypothetical protein	0.0012	0.0241	0.0757
Schistosoma mansoni	multidrug resistance protein	0.0013	0.0262	0.0821
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0036	0.1317	0.3264
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0016	0.0432	0.0083
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0018	0.0488	0.0488
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0016	0.0432	0.1353
Mycobacterium ulcerans	lipoprotein LpqF	0.0028	0.0962	0.199
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0031	0.1081	0.1081
Loa Loa (eye worm)	jmjC domain-containing protein	0.0027	0.091	0.094
Mycobacterium ulcerans	DNA gyrase subunit B	0.0018	0.0495	0.0312
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0224	1	1
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0025	0.0839	0.2629
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0025	0.0839	0.7759
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0007	0.0005	0.0017
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0025	0.0839	0.7759
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0016	0.0409	0.3779
Chlamydia trachomatis	glycerol-3-phosphate acyltransferase	0.0076	0.3191	1
Trichomonas vaginalis	ABC transporter, putative	0.0013	0.0262	0.2423
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0025	0.0839	0.7759
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0016	0.0409	0.1789
Schistosoma mansoni	DNA topoisomerase II	0.0031	0.1081	0.3388
Loa Loa (eye worm)	hypothetical protein	0.0073	0.3046	0.3148
Echinococcus granulosus	multidrug resistance protein 1	0.0009	0.0085	0.0085
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.002	0.0588	0.0646
Echinococcus granulosus	multidrug resistance protein 1	0.0009	0.0085	0.0085

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 5.2	SUPPLEMENTARY: Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay. Same assay as CHEMBL914418	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2449523

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1810692