TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 378.805 | Formula: C22H15ClO4
H donors: 0 H acceptors: 2 LogP: 3.95 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CCCC2=C1C(c1ccccc1Cl)c1c(O2)c2ccccc2oc1=O
InChi: 1S/C22H15ClO4/c23-14-8-3-1-6-12(14)18-19-15(24)9-5-11-17(19)26-21-13-7-2-4-10-16(13)27-22(25)20(18)21/h1-4,6-8,10,18H,5,9,11H2
InChiKey: NXPFBZIQWOQICZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan MH, family M28, aminopeptidase S-like metallopeptidase	0.0055	0.1037	0.1832
Echinococcus multilocularis	caspase 3	0.0074	0.1498	0.1448
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0018	0.0103	0.0045
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0165	0.3778	0.3742
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0058	0.007
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0018	0.0103	0.0124
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0058	0.007
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus multilocularis	allatostatin A receptor	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Onchocerca volvulus		0.0018	0.0103	0.0124
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0165	0.3778	0.3742
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0103	0.0045
Onchocerca volvulus		0.0018	0.0103	0.0124
Echinococcus granulosus	ubiquitin specific protease 41	0.0037	0.0594	0.0539
Echinococcus multilocularis	dnaJ subfamily B	0.0414	1	1
Brugia malayi	Dopamine receptor protein 2	0.0018	0.0103	0.0124
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0594	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0543	0.096
Loa Loa (eye worm)	neuropeptide F receptor	0.0018	0.0103	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0701	0.0843
Trypanosoma brucei	metacaspase	0.0045	0.0778	0.7499
Brugia malayi	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0386	0.033
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0018	0.0103	0.0045
Mycobacterium ulcerans	hypothetical protein	0.0055	0.1037	0.5
Schistosoma mansoni	histamine h1 receptor	0.0018	0.0103	0.0045
Schistosoma mansoni	amine GPCR	0.0018	0.0103	0.0045
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.043	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Brugia malayi	AKH receptor	0.0018	0.0103	0.0124
Brugia malayi	RE15519p	0.0018	0.0103	0.0124
Onchocerca volvulus		0.0042	0.0701	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Brugia malayi	FXNA	0.0055	0.1037	0.1247
Trypanosoma cruzi	glutaminyl cyclase, putative	0.0055	0.1037	1
Echinococcus multilocularis	neuropeptide receptor	0.0018	0.0103	0.0045
Trypanosoma brucei	metacaspase 5, putative	0.0045	0.0778	0.7499
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0594	0.0539
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0103	0.0045
Trypanosoma brucei	metacaspase MCA2	0.0045	0.0778	0.7499
Trypanosoma cruzi	metacaspase, putative	0.0045	0.0778	0.7499
Mycobacterium tuberculosis	Conserved protein	0.0055	0.1037	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0103	0.0045
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0045	0.0778	0.5496
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Schistosoma mansoni	opsin-like receptor	0.0018	0.0103	0.0045
Brugia malayi	Melatonin receptor type 1A	0.0018	0.0103	0.0124
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0018	0.0103	0.0124
Loa Loa (eye worm)	leucyl aminopeptidase	0.0055	0.1037	0.1247
Echinococcus multilocularis	G protein coupled receptor 139	0.0018	0.0103	0.0045
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0543	0.5239
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0103	0.0045
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0018	0.0103	0.0045
Schistosoma mansoni	caspase-7 (C14 family)	0.0087	0.1819	0.1771
Schistosoma mansoni	transcription factor btf3	0.0035	0.0543	0.0488
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0018	0.0103	0.0124
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0778	0.1373
Mycobacterium ulcerans	lipoprotein aminopeptidase LpqL	0.0055	0.1037	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0018	0.0103	0.0124
Brugia malayi	hypothetical protein	0.0018	0.0103	0.0124
Loa Loa (eye worm)	melatonin receptor type 1A	0.0018	0.0103	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.092	0.1106
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0103	0.0045
Onchocerca volvulus		0.0018	0.0103	0.0124
Onchocerca volvulus		0.0055	0.1037	0.1247
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0574	0.5529
Schistosoma mansoni	NAALADASE L peptidase (M28 family)	0.0055	0.1037	0.0985
Brugia malayi	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0018	0.0103	0.0045
Echinococcus granulosus	fmrfamide receptor	0.0018	0.0103	0.0045
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0594	0.5731
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0045	0.0778	0.5496
Brugia malayi	G protein-coupled receptor F59B2.13	0.0018	0.0103	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0386	0.0464
Echinococcus multilocularis	ubiquitin specific protease 41	0.0037	0.0594	0.0539
Echinococcus multilocularis	neuropeptide receptor	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0103	0.0045
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0018	0.0103	0.0045
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0018	0.0103	0.0045
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0018	0.0103	0.0045
Brugia malayi	G-protein coupled receptor	0.0018	0.0103	0.0124
Loa Loa (eye worm)	G-protein coupled receptor	0.0018	0.0103	0.0124
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0045	0.0778	0.5496
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0018	0.0103	0.0045
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0045	0.0778	0.1373
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0103	0.0045
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0055	0.1037	0.0985
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0574	0.1013
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0037	0.0574	0.2267
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0543	0.096
Echinococcus granulosus	lysosomal alpha glucosidase	0.0165	0.3778	0.3742
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0103	0.0045
Echinococcus multilocularis	transcription factor btf3	0.0035	0.0543	0.0488
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0386	0.0464
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0103	0.0045
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0031	0.043	0.0517
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.1227	0.1176
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0103	0.0045
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0042	0.0701	0.0647
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0018	0.0103	0.0045
Onchocerca volvulus		0.0018	0.0103	0.0124
Echinococcus granulosus	geminin	0.0172	0.3943	0.3908
Schistosoma mansoni	growth hormone secretagogue receptor	0.0018	0.0103	0.0045
Echinococcus multilocularis	geminin	0.0172	0.3943	0.3908
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0018	0.0103	0.0045
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0594	0.5731
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.043	0.0374
Loa Loa (eye worm)	TYRA-2 protein	0.0018	0.0103	0.0124
Brugia malayi	hypothetical protein	0.0306	0.73	0.8776
Onchocerca volvulus		0.0306	0.73	0.8776
Brugia malayi	hypothetical protein	0.0042	0.0701	0.0843
Onchocerca volvulus		0.0018	0.0103	0.0124
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0103	0.0045
Echinococcus multilocularis	orexin receptor type 2	0.0018	0.0103	0.0045
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0037	0.0594	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Trypanosoma cruzi	metacaspase, putative	0.0045	0.0778	0.7499
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0521	0.0627
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0574	0.1013
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0037	0.0594	0.5731
Echinococcus multilocularis	fmrfamide receptor	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0778	0.0935
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0778	0.1373
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0118	0.2616	0.2573
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0103	0.0045
Trypanosoma cruzi	metacaspase, putative	0.0045	0.0778	0.7499
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0103	0.0045
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0018	0.0103	0.0124
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0103	0.0045
Echinococcus multilocularis	serotonin receptor	0.0018	0.0103	0.0045
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0037	0.0574	0.1013
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0103	0.0045
Brugia malayi	Cell death protein 3 precursor	0.0087	0.1819	0.2187
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0103	0.0045
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0103	0.0045
Brugia malayi	beta-NAC-like protein	0.0035	0.0543	0.0653
Plasmodium vivax	hypothetical protein, conserved	0.0045	0.0778	1
Brugia malayi	follicle stimulating hormone receptor	0.0251	0.5918	0.7115
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0018	0.0103	0.0045
Entamoeba histolytica	hypothetical protein	0.0035	0.0543	0.9142
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0778	0.1373
Trichomonas vaginalis	set domain proteins, putative	0.0241	0.5664	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0103	0.0045
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0165	0.3778	0.4543
Brugia malayi	Dopamine receptor protein 1	0.0018	0.0103	0.0124
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0778	0.1373
Echinococcus multilocularis	somatostatin receptor	0.0018	0.0103	0.0045
Leishmania major	metacaspase, putative	0.0045	0.0778	0.7499
Onchocerca volvulus	Huntingtin homolog	0.0124	0.2757	0.3314
Schistosoma mansoni	Fxna peptidase (M28 family)	0.0055	0.1037	0.0985
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0018	0.0103	0.0045
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0018	0.0103	0.0045
Onchocerca volvulus		0.0018	0.0103	0.0124
Toxoplasma gondii	NAC domain-containing protein	0.0035	0.0543	0.1792
Echinococcus multilocularis	cpg binding protein	0.0031	0.0427	0.0371
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0251	0.5918	0.7115
Echinococcus granulosus	G protein coupled receptor 139	0.0018	0.0103	0.0045
Echinococcus multilocularis	neuropeptide s receptor	0.0018	0.0103	0.0045
Schistosoma mansoni	neuropeptide F-like receptor	0.0018	0.0103	0.0045
Plasmodium falciparum	metacaspase-like protein	0.0045	0.0778	1
Schistosoma mansoni	amine GPCR	0.0018	0.0103	0.0045
Plasmodium vivax	basic transcription factor 3b, putative	0.0035	0.0543	0.3259
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0058	0.007
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0543	0.5239
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.043	0.0374
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0543	0.096
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0103	0.0045
Echinococcus multilocularis	n acetylated alpha linked acidic dipeptidase 2	0.0055	0.1037	0.0985
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0018	0.0103	0.0045
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0574	0.1013
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0037	0.0594	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0018	0.0103	0.0124
Schistosoma mansoni	amine GPCR	0.0018	0.0103	0.0045
Schistosoma mansoni	adenoreceptor	0.0018	0.0103	0.0045
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.1037	0.1832
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0103	0.0045
Brugia malayi	G-protein coupled receptor	0.0018	0.0103	0.0124
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0045	0.0778	0.0724
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0103	0.0045
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0574	0.1013
Echinococcus multilocularis	serotonin receptor	0.0018	0.0103	0.0045
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0594	0.105
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0018	0.0103	0.0045
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0055	0.1037	0.0985
Toxoplasma gondii	peptidase, M28 family protein	0.0055	0.1037	0.9596
Echinococcus granulosus	caspase 8	0.0045	0.0778	0.0724
Echinococcus granulosus	neuropeptide Y receptor	0.0018	0.0103	0.0045
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0037	0.0574	0.069
Brugia malayi	Pre-SET motif family protein	0.0031	0.043	0.0517
Brugia malayi	hypothetical protein	0.0124	0.2757	0.3314
Echinococcus multilocularis	dro:myosuppressin receptor	0.0018	0.0103	0.0045
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.1063	1
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0045	0.0778	0.0935
Schistosoma mansoni	hypothetical protein	0.0018	0.0103	0.0045
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0037	0.0594	0.0539
Echinococcus granulosus	neuropeptides capa receptor	0.0018	0.0103	0.0045
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0778	0.1373
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Schistosoma mansoni	opsin-like receptor	0.0018	0.0103	0.0045
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0045	0.0778	0.1373
Onchocerca volvulus		0.0018	0.0103	0.0124
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.043	0.0374
Echinococcus granulosus	caspase 3	0.0074	0.1498	0.1448
Schistosoma mansoni	cpg binding protein	0.0031	0.0427	0.0371
Echinococcus granulosus	neutral alpha glucosidase AB	0.0037	0.0574	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0018	0.0103	0.0124
Mycobacterium tuberculosis	Probable lipoprotein aminopeptidase LpqL	0.0055	0.1037	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0018	0.0103	0.0045
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0574	0.9648
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0018	0.0103	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus granulosus	biogenic amine 5HT receptor	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1037	0.1247
Brugia malayi	hypothetical protein	0.0018	0.0103	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0521	0.0627
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0594	0.105
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0018	0.0103	0.0045
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0103	0.0045
Echinococcus granulosus	neuropeptide FF receptor 2	0.0018	0.0103	0.0045
Onchocerca volvulus		0.0018	0.0103	0.0124
Echinococcus granulosus	caspase 2	0.0087	0.1819	0.1771
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0574	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Schistosoma mansoni	hypothetical protein	0.0172	0.3943	0.3908
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0594	0.0539
Echinococcus granulosus	biogenic amine 5HT receptor	0.0018	0.0103	0.0045
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0058	0.007
Onchocerca volvulus	Fxna peptidase homolog	0.0055	0.1037	0.1247
Schistosoma mansoni	caspase-3 (C14 family)	0.0118	0.2616	0.2573
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0018	0.0103	0.0045
Schistosoma mansoni	nicalin (M28 family)	0.0055	0.1037	0.0985
Loa Loa (eye worm)	G-protein coupled receptor	0.0018	0.0103	0.0124
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0037	0.0574	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1819	0.2187
Schistosoma mansoni	hypothetical protein	0.0172	0.3943	0.3908
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0018	0.0103	0.0045
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.1037	0.1832
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0018	0.0103	0.0045
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0018	0.0103	0.0045
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0574	0.1013
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Schistosoma mansoni	glutaminyl cyclase (M28 family)	0.0347	0.8318	0.8308
Onchocerca volvulus	Fxna peptidase homolog	0.0055	0.1037	0.1247
Leishmania major	glutaminyl cyclase, putative	0.0055	0.1037	1
Onchocerca volvulus	Fxna peptidase homolog	0.0055	0.1037	0.1247
Trypanosoma cruzi	metacaspase 5, putative	0.0045	0.0778	0.7499
Echinococcus granulosus	allatostatin A receptor	0.0018	0.0103	0.0045
Echinococcus granulosus	sex peptide receptor	0.0018	0.0103	0.0045
Echinococcus multilocularis	neuropeptides capa receptor	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0103	0.0045
Schistosoma mansoni	caspase-7 (C14 family)	0.0118	0.2616	0.2573
Brugia malayi	hypothetical protein	0.0018	0.0103	0.0124
Onchocerca volvulus		0.0018	0.0103	0.0124
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0778	0.1373
Brugia malayi	GnHR receptor homolog	0.0018	0.0103	0.0124
Echinococcus granulosus	hypothetical protein	0.0018	0.0103	0.0045
Echinococcus multilocularis	fmrfamide receptor	0.0018	0.0103	0.0045
Echinococcus granulosus	somatostatin receptor	0.0018	0.0103	0.0045
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0574	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0124	0.2757	0.3314
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0103	0.0045
Loa Loa (eye worm)	neuropeptide F receptor	0.0018	0.0103	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0103	0.0045
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0018	0.0103	0.0045
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0045	0.0778	0.1373
Schistosoma mansoni	amine GPCR	0.0018	0.0103	0.0045
Trypanosoma brucei	transcription factor BTF3, putative	0.0035	0.0543	0.5239
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0018	0.0103	0.0045
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0018	0.0103	0.0124
Schistosoma mansoni	amine GPCR	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus granulosus	7tm_1 domain containing protein	0.0018	0.0103	0.0045
Echinococcus multilocularis	caspase 2	0.0087	0.1819	0.1771
Loa Loa (eye worm)	hypothetical protein	0.0347	0.8318	1
Echinococcus granulosus	caspase	0.0118	0.2616	0.2573
Loa Loa (eye worm)	hypothetical protein	0.005	0.092	0.1106
Brugia malayi	larval opioid receptor	0.0018	0.0103	0.0124
Echinococcus granulosus	glutaminyl peptide cyclotransferase	0.0347	0.8318	0.8308
Echinococcus multilocularis	caspase	0.0118	0.2616	0.2573
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0165	0.3778	0.4543
Onchocerca volvulus	Cell death protein 3 homolog	0.0087	0.1819	0.2187
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0103	0.0045
Leishmania major	alpha glucosidase II subunit, putative	0.0037	0.0574	0.5529
Brugia malayi	hypothetical protein	0.0018	0.0103	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0124	0.2757	0.3314
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.043	0.0374
Brugia malayi	Serotonin receptor	0.0018	0.0103	0.0124
Echinococcus granulosus	dro:myosuppressin receptor	0.0018	0.0103	0.0045
Schistosoma mansoni	myosin xvIII	0.0018	0.0103	0.0045
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0018	0.0103	0.0045
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0103	0.0045
Onchocerca volvulus	Glutaminyl cyclase homolog	0.0347	0.8318	1
Schistosoma mansoni	hypothetical protein	0.0414	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus multilocularis	glutaminyl peptide cyclotransferase	0.0347	0.8318	0.8308
Schistosoma mansoni	glutaminyl-peptide cyclotransferase-related	0.0055	0.1037	0.0985
Onchocerca volvulus		0.0018	0.0103	0.0124
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0594	0.0539
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0211	0.4937	0.5935
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Schistosoma mansoni	hypothetical protein	0.0042	0.0701	0.0647
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0018	0.0103	0.0045
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0103	0.0045
Echinococcus multilocularis	caspase 8	0.0045	0.0778	0.0724
Echinococcus multilocularis	g-protein coupled receptor	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0306	0.73	0.8776
Echinococcus multilocularis	sex peptide receptor	0.0018	0.0103	0.0045
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0018	0.0103	0.0124
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0103	0.0045
Entamoeba histolytica	transcription factor BTF3, putative	0.0035	0.0543	0.9142
Echinococcus granulosus	cpg binding protein	0.0031	0.0427	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Schistosoma mansoni	hypothetical protein	0.0018	0.0103	0.0045
Trypanosoma brucei	metacaspase MCA3	0.0045	0.0778	0.7499
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0037	0.0594	0.0539
Trypanosoma cruzi	metacaspase 5, putative	0.0045	0.0778	0.7499
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Schistosoma mansoni	neuropeptide F-like receptor	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0103	0.0045
Onchocerca volvulus		0.0018	0.0103	0.0124
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0103	0.0045
Onchocerca volvulus		0.0018	0.0103	0.0124
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0018	0.0103	0.0124
Schistosoma mansoni	hypothetical protein	0.0018	0.0103	0.0045
Echinococcus granulosus	neuropeptide receptor	0.0018	0.0103	0.0045
Onchocerca volvulus		0.0018	0.0103	0.0124
Brugia malayi	nicalin	0.0055	0.1037	0.1247
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0574	0.9648
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.092	0.1106
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0103	0.0045
Schistosoma mansoni	alpha glucosidase	0.0037	0.0574	0.0518
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0018	0.0103	0.0045
Onchocerca volvulus		0.0018	0.0103	0.0124
Brugia malayi	hypothetical protein	0.0018	0.0103	0.0124
Schistosoma mansoni	alpha-glucosidase	0.0142	0.3205	0.3165
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0103	0.0045
Brugia malayi	G protein-coupled receptor	0.0018	0.0103	0.0124
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0045	0.0778	0.1373
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0018	0.0103	0.0045
Schistosoma mansoni	opsin-like receptor	0.0018	0.0103	0.0045
Trypanosoma cruzi	metacaspase, putative	0.0045	0.0778	0.7499
Echinococcus granulosus	g-protein coupled receptor	0.0018	0.0103	0.0045
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0018	0.0103	0.0124
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.043	0.0374
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0018	0.0103	0.0045
Brugia malayi	leucyl aminopeptidase	0.0055	0.1037	0.1247
Schistosoma mansoni	cpg binding protein	0.0029	0.0386	0.0329
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.1037	0.1832
Trypanosoma brucei	glutaminyl cyclase, putative	0.0055	0.1037	1
Schistosoma mansoni	alpha-glucosidase	0.0142	0.3205	0.3165
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0574	0.5529
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0037	0.0594	0.0715
Toxoplasma gondii	hypothetical protein	0.0055	0.1037	0.9596
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0103	0.0045
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0045	0.0778	0.1373
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0103	0.0045
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0018	0.0103	0.0045
Trypanosoma brucei	Metacaspase-4	0.0045	0.0778	0.7499
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.043	0.0374
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0103	0.0045
Echinococcus granulosus	neuropeptide s receptor	0.0018	0.0103	0.0045
Echinococcus granulosus	neuropeptide receptor A26	0.0018	0.0103	0.0045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0103	0.0045
Brugia malayi	putative neuropeptide receptor NPR1	0.0018	0.0103	0.0124
Echinococcus multilocularis	neuropeptide Y receptor	0.0018	0.0103	0.0045
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0018	0.0103	0.0045
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0055	0.1037	0.0985
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.092	0.1106
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0103	0.0045
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0045	0.0778	0.1373
Brugia malayi	neuropeptide F receptor	0.0018	0.0103	0.0124
Echinococcus granulosus	orexin receptor type 2	0.0018	0.0103	0.0045
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0018	0.0103	0.0045
Onchocerca volvulus		0.0018	0.0103	0.0124
Loa Loa (eye worm)	ICD-1 protein	0.0035	0.0543	0.0653
Echinococcus granulosus	neuropeptides capa receptor	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0594	0.0715
Onchocerca volvulus		0.0031	0.043	0.0517
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0594	0.105
Brugia malayi	putative neuropeptide receptor	0.0018	0.0103	0.0124
Trypanosoma cruzi	glutaminyl cyclase, putative	0.0055	0.1037	1
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0103	0.0045
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0103	0.0045
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0118	0.2616	0.2573
Plasmodium falciparum	metacaspase 1	0.0045	0.0778	1
Brugia malayi	Dopamine receptor	0.0018	0.0103	0.0124
Brugia malayi	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0103	0.0045
Brugia malayi	Serotonin receptor	0.0018	0.0103	0.0124
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0037	0.0574	0.1013
Schistosoma mansoni	hypothetical protein	0.0035	0.0521	0.0465
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0055	0.1037	0.0985
Plasmodium vivax	metacaspase 1, putative	0.0045	0.0778	1
Echinococcus granulosus	neuropeptide Y receptor	0.0018	0.0103	0.0045
Schistosoma mansoni	neuropeptide f receptor 76f	0.0018	0.0103	0.0045
Trypanosoma brucei	glucosidase, putative	0.0037	0.0574	0.5529
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Leishmania major	basic transcription factor 3a, putative	0.0035	0.0543	0.5239
Brugia malayi	sulfakinin receptor protein	0.0018	0.0103	0.0124
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0103	0.0045
Brugia malayi	neuropeptide F receptor	0.0018	0.0103	0.0124
Echinococcus granulosus	apoptotic protease activating factor 1	0.0042	0.0701	0.0647
Onchocerca volvulus		0.0241	0.5664	0.6809
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1037	0.1247
Echinococcus granulosus	transcription factor btf3	0.0035	0.0543	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus granulosus	neuropeptide receptor	0.0018	0.0103	0.0045
Brugia malayi	Pre-SET motif family protein	0.0211	0.4937	0.5935
Schistosoma mansoni	cpg binding protein	0.0031	0.0427	0.0371
Brugia malayi	ORL1-like opioid receptor	0.0018	0.0103	0.0124
Onchocerca volvulus		0.0029	0.0386	0.0464
Brugia malayi	Peptidase family M28 containing protein	0.0347	0.8318	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1037	0.1247
Leishmania major	hypothetical protein, conserved	0.0055	0.1037	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0018	0.0103	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus multilocularis	neuropeptide receptor A26	0.0018	0.0103	0.0045
Onchocerca volvulus	Huntingtin homolog	0.0124	0.2757	0.3314
Echinococcus multilocularis	neuropeptide Y receptor	0.0018	0.0103	0.0045
Onchocerca volvulus		0.0018	0.0103	0.0124
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0037	0.0574	0.069
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0045	0.0778	0.1373
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0103	0.0124
Echinococcus granulosus	serotonin receptor	0.0018	0.0103	0.0045
Brugia malayi	hypothetical protein	0.0018	0.0103	0.0124
Onchocerca volvulus		0.0018	0.0103	0.0124
Onchocerca volvulus		0.0095	0.2042	0.2455
Schistosoma mansoni	hypothetical protein	0.0018	0.0103	0.0045
Echinococcus multilocularis	neuropeptides capa receptor	0.0018	0.0103	0.0045
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0045	0.0778	0.1373
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1037	0.1247
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0045	0.0778	0.1373
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0103	0.0045
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0594	0.5731
Brugia malayi	hypothetical protein	0.0018	0.0103	0.0124

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 25 uM	Cytotoxicity against Homo sapiens (human) Raji cells after 96 hr by MTT assay	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2234091

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1813743