Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0242 | 0.0724 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1949 | 0.8005 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 0.0939 | 0.0939 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.1949 | 0.8005 | 0.8005 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0242 | 0.0724 | 0.0344 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0258 | 0.0796 | 0.0418 |
Giardia lamblia | Kinase, CMGC CDK | 0.0242 | 0.0724 | 0.0434 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.2417 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0242 | 0.0724 | 0.0344 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0242 | 0.0724 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0242 | 0.0724 | 0.0704 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.1949 | 0.8005 | 0.7924 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0258 | 0.0796 | 0.0701 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 0.0939 | 0.0939 |
Trichomonas vaginalis | cyclin B, putative | 0.0164 | 0.0394 | 0.0283 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0242 | 0.0724 | 0.0724 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2417 | 1 | 1 |
Loa Loa (eye worm) | TTK protein kinase | 0.1949 | 0.8005 | 0.7985 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 0.0939 | 0.0846 |
Brugia malayi | Protein kinase domain containing protein | 0.1949 | 0.8005 | 0.7924 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0242 | 0.0724 | 0.0344 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0242 | 0.0724 | 0.0628 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 0.0939 | 0.0846 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.0939 | 0.0846 |
Trichomonas vaginalis | cyclin A, putative | 0.0164 | 0.0394 | 0.0283 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0242 | 0.0724 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0242 | 0.0724 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 0.0939 | 0.0568 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.0939 | 0.0846 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0242 | 0.0724 | 0.0344 |
Brugia malayi | Stress-activated protein kinase jnk-1 | 0.0258 | 0.0796 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.063 | 0.0533 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0242 | 0.0724 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0242 | 0.0724 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1949 | 0.8005 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0242 | 0.0724 | 0.0628 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0242 | 0.0724 | 0.0724 |
Trichomonas vaginalis | cyclins, putative | 0.0164 | 0.0394 | 0.0283 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.2417 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0242 | 0.0724 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 0.0939 | 0.5 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0258 | 0.0796 | 0.0418 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.2417 | 1 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0242 | 0.0724 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0394 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.0939 | 0.0846 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.2417 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0164 | 0.0394 | 0.0283 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0242 | 0.0724 | 0.0344 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0258 | 0.0796 | 0.0796 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.2417 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase | 0.0242 | 0.0724 | 0.0344 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.1949 | 0.8005 | 0.7924 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 0.0939 | 0.0846 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0242 | 0.0724 | 0.0628 |
Brugia malayi | cell division control protein 2 homolog | 0.0242 | 0.0724 | 0.0344 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0242 | 0.0724 | 1 |
Schistosoma mansoni | cyclin B | 0.0164 | 0.0394 | 0.0394 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0242 | 0.0724 | 0.0704 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 0.0939 | 0.0568 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0292 | 0.0939 | 0.0568 |
Trichomonas vaginalis | cyclin B, putative | 0.0164 | 0.0394 | 0.0283 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0242 | 0.0724 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0394 | 0.0295 |
Giardia lamblia | Kinase, TTK | 0.1949 | 0.8005 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0242 | 0.0724 | 0.5 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.2417 | 1 | 1 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.1949 | 0.8005 | 0.7924 |
Trichomonas vaginalis | cyclin B, putative | 0.0164 | 0.0394 | 0.0283 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0242 | 0.0724 | 0.0704 |
Giardia lamblia | Kinase, CMGC CDK | 0.0242 | 0.0724 | 0.0434 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0242 | 0.0724 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0164 | 0.0394 | 0.0283 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0242 | 0.0724 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0242 | 0.0724 | 0.0344 |
Trichomonas vaginalis | cyclins, putative | 0.0164 | 0.0394 | 0.0283 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0242 | 0.0724 | 0.0344 |
Brugia malayi | Protein kinase domain containing protein | 0.0242 | 0.0724 | 0.0344 |
Trichomonas vaginalis | cyclin B, putative | 0.0164 | 0.0394 | 0.0283 |
Onchocerca volvulus | 0.0292 | 0.0939 | 0.0568 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 454 nM | Displacement of [3H]-dopamine from rat striatum DAT after 5 mins | ChEMBL. | 24315194 |
Ki (binding) | = 739 nM | Displacement of [3H]-dopamine from rat cerebral cortex NET after 7 mins | ChEMBL. | 24315194 |
Ki (binding) | = 844 nM | Displacement of [3H]5-HT from rat cerebral cortex SERT after 10 mins | ChEMBL. | 24315194 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.