Detailed information for compound 1821883

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 314.331 | Formula: C15H22O7
  • H donors: 5 H acceptors: 5 LogP: 0.05 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H](O[C@@H]1OC[C@H]([C@@H]([C@H]1O)O)O)CCc1ccc(cc1O)O
  • InChi: 1S/C15H22O7/c1-8(2-3-9-4-5-10(16)6-11(9)17)22-15-14(20)13(19)12(18)7-21-15/h4-6,8,12-20H,2-3,7H2,1H3/t8-,12+,13-,14+,15-/m0/s1
  • InChiKey: SSQDSAFOXKKNBY-BGXOLSLGSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tyrosinase Starlite/ChEMBL References
Agaricus bisporus Tyrosinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00505 tyrosinase [EC1.14.18.1], putative Get druggable targets OG5_137498 All targets in OG5_137498
Schistosoma mansoni tyrosinase precursor Get druggable targets OG5_137498 All targets in OG5_137498
Schistosoma japonicum ko:K00505 tyrosinase [EC1.14.18.1], putative Get druggable targets OG5_137498 All targets in OG5_137498
Schistosoma mansoni tyrosinase precursor Get druggable targets OG5_137498 All targets in OG5_137498
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans beta-lactamase 0.0044 0.0034 0.0016
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0078 0.0086 0.1136
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0029 0.0012 0.0187
Plasmodium vivax mannose-1-phosphate guanyltransferase, putative 0.0039 0.0027 0.3992
Giardia lamblia PHD finger protein 15 0.0058 0.0056 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0002 0.002
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0031 0.0015 0.3933
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0272 0.0381 0.1652
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0056 0.06
Trypanosoma cruzi metacaspase, putative 0.0029 0.0012 0.2903
Trypanosoma brucei nucleotidyl transferase, putative 0.0039 0.0027 0.7764
Leishmania major eukaryotic initiation factor 4a, putative 0.0031 0.0015 0.3933
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0012 0.0108
Entamoeba histolytica serine acetyltransferase 1 0.0033 0.0018 0.0171
Chlamydia trachomatis acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase 0.0033 0.0018 0.5
Echinococcus multilocularis caspase 2 0.0029 0.0012 0.0044
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0272 0.0381 0.5278
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0018 0.0171
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0002 0.003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0272 0.0381 0.5884
Loa Loa (eye worm) heterochromatin protein 1 0.0139 0.0179 0.2742
Trypanosoma brucei metacaspase MCA2 0.0029 0.0012 0.2903
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0095 0.0985
Loa Loa (eye worm) dynactin 5 0.0033 0.0018 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0012 0.0108
Entamoeba histolytica maltose O-acetyltransferase, putative 0.0033 0.0018 0.0171
Loa Loa (eye worm) beta-lactamase 0.0044 0.0034 0.0496
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0022 0.0339
Loa Loa (eye worm) hypothetical protein 0.0158 0.0208 0.3201
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0207
Loa Loa (eye worm) hypothetical protein 0.0036 0.0022 0.031
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0056 0.8656
Brugia malayi hypothetical protein 0.004 0.0029 0.0443
Echinococcus granulosus geminin 0.0495 0.072 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.0208 0.3201
Plasmodium vivax metacaspase 1, putative 0.0029 0.0012 0.1616
Schistosoma mansoni hypothetical protein 0.004 0.0029 0.0305
Toxoplasma gondii GDP-D-mannose pyrophosphorylase 0.0039 0.0027 0.0202
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0249
Schistosoma mansoni caspase-3 (C14 family) 0.0029 0.0012 0.0129
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0024 0.0003 0.001
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0044 0.0034 0.0019
Echinococcus granulosus eukaryotic initiation factor 4A 0.0031 0.0015 0.0185
Mycobacterium tuberculosis Conserved hypothetical protein 0.0838 0.1241 0.1228
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0051 0.0523
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.6596 1 1
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0033 0.0018 0.007
Brugia malayi jmjC domain containing protein 0.0071 0.0075 0.1161
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0002 0.002
Schistosoma mansoni hypothetical protein 0.0495 0.072 0.7672
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0031 0.0015 0.3933
Brugia malayi ShTK domain containing protein 0.0222 0.0305 0.4723
Loa Loa (eye worm) ShTK domain-containing protein 0.0222 0.0305 0.4707
Entamoeba histolytica acetyltransferase, putative 0.0033 0.0018 0.0171
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0085 0.1319
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0272 0.0381 0.1652
Plasmodium vivax RNA helicase-1, putative 0.0031 0.0015 0.2119
Mycobacterium tuberculosis Probable hydrolase 0.0044 0.0034 0.0019
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0061 0.0825
Trichomonas vaginalis glucose-1-phosphate thymidylyltransferase, putative 0.0039 0.0027 0.0266
Loa Loa (eye worm) hypothetical protein 0.0058 0.0056 0.0844
Echinococcus granulosus caspase 2 0.0029 0.0012 0.0141
Schistosoma mansoni tyrosinase precursor 0.0639 0.0939 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0279 0.0392 0.0378
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0039 0.0027 0.0389
Schistosoma mansoni hypothetical protein 0.0036 0.0022 0.0233
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0029 0.0305
Echinococcus granulosus beta LACTamase domain containing family member 0.0044 0.0034 0.0445
Trypanosoma cruzi serine acetyltransferase, putative 0.0033 0.0018 0.4832
Entamoeba histolytica acetyltransferase, putative 0.0033 0.0018 0.0171
Onchocerca volvulus 0.0087 0.0099 0.1319
Brugia malayi zgc:92842 0.0033 0.0018 0.0278
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0065 0.0507
Brugia malayi eIF4-gamma/eIF5/eIF2-epsilon family protein 0.0033 0.0018 0.0278
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Loa Loa (eye worm) ShTK domain-containing protein 0.0222 0.0305 0.4707
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0031 0.0015 0.0141
Mycobacterium ulcerans hypothetical protein 0.0044 0.0034 0.0016
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0044 0.0034 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0034 0.5085
Loa Loa (eye worm) hypothetical protein 0.0044 0.0034 0.0496
Loa Loa (eye worm) hypothetical protein 0.0149 0.0195 0.2989
Entamoeba histolytica hypothetical protein 0.004 0.0029 0.0284
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0018 0.4832
Loa Loa (eye worm) hypothetical protein 0.0078 0.0085 0.1293
Trypanosoma brucei metacaspase 0.0029 0.0012 0.2903
Loa Loa (eye worm) hypothetical protein 0.0222 0.0305 0.4707
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0056 0.0757
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0031 0.0015 0.0162
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0031 0.0015 0.0058
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0084 0.0095 0.1258
Mycobacterium ulcerans esterase/lipase LipP 0.0044 0.0034 0.0016
Mycobacterium leprae conserved hypothetical protein 0.0044 0.0034 0.0016
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0031 0.0015 0.0162
Brugia malayi CHD4 protein 0.0023 0.0002 0.003
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0065 0.0874
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.0151 0.2314
Echinococcus multilocularis peregrin 0.0058 0.0056 0.0237
Echinococcus granulosus GPCR family 2 0.0036 0.0022 0.0278
Mycobacterium tuberculosis Conserved protein 0.0044 0.0034 0.0019
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0642 0.0944 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0044 0.0034 0.0019
Onchocerca volvulus 0.0061 0.006 0.0789
Entamoeba histolytica serine acetyltransferase, putative 0.0033 0.0018 0.0171
Loa Loa (eye worm) hypothetical protein 0.0044 0.0034 0.0496
Onchocerca volvulus 0.0044 0.0034 0.0433
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0158
Entamoeba histolytica hypothetical protein 0.004 0.0029 0.0284
Trichomonas vaginalis sugar-1-phosphate guanyl transferase, putative 0.0039 0.0027 0.0266
Leishmania major hypothetical protein, conserved 0.0033 0.0018 0.4832
Trichomonas vaginalis flap endonuclease-1, putative 0.0024 0.0003 0.0013
Brugia malayi beta-lactamase family protein 0.0044 0.0034 0.0524
Brugia malayi Protein cec-1. 0.0023 0.0002 0.003
Brugia malayi beta-lactamase 0.0044 0.0034 0.0524
Entamoeba histolytica Flap nuclease, putative 0.0024 0.0003 0.0013
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0044 0.0034 0.0019
Schistosoma mansoni chromobox protein 0.0023 0.0002 0.002
Plasmodium falciparum mannose-1-phosphate guanyltransferase, putative 0.0039 0.0027 0.4612
Trichomonas vaginalis chromobox protein, putative 0.0139 0.0179 0.1875
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0087 0.0099 0.1058
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Trypanosoma brucei Metacaspase-4 0.0029 0.0012 0.2903
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0012 0.0082
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0222 0.0305 0.4723
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0065 0.0274
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.0259 0.3574
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0838 0.1241 1
Brugia malayi SET domain containing protein 0.0025 0.0006 0.0085
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0095 0.0985
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0033 0.0018 0.0224
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0272 0.0381 0.5278
Onchocerca volvulus Alhambra homolog 0.0058 0.0056 0.0737
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0033 0.0018 0.0171
Onchocerca volvulus 0.0044 0.0034 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0012 0.0108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0249
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0039 0.0027 0.0349
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0012 0.0082
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0158
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0029 0.0012 0.0044
Brugia malayi Pre-SET motif family protein 0.0447 0.0646 1
Schistosoma mansoni chromobox protein 0.0023 0.0002 0.002
Brugia malayi eukaryotic initiation factor 4A 0.0031 0.0015 0.0236
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0029 0.0012 0.0129
Trypanosoma brucei metacaspase 5, putative 0.0029 0.0012 0.2903
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1532 0.2297 1
Schistosoma mansoni caspase-7 (C14 family) 0.0029 0.0012 0.0129
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0075 0.0799
Trichomonas vaginalis D-aminoacylase, putative 0.0044 0.0034 0.0339
Trypanosoma cruzi metacaspase, putative 0.0029 0.0012 0.2903
Trypanosoma cruzi serine acetyltransferase, putative 0.0033 0.0018 0.4832
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0222 0.0305 0.4723
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0031 0.0015 0.0141
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0002 0.000000017776
Plasmodium vivax dynactin subunit 5, putative 0.0033 0.0018 0.2559
Leishmania major eukaryotic initiation factor 4a, putative 0.0031 0.0015 0.3933
Trypanosoma brucei GDP-mannose pyrophosphorylase 0.0039 0.0027 0.7764
Trypanosoma cruzi hypothetical protein 0.0033 0.0018 0.4832
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0012 0.0108
Toxoplasma gondii eukaryotic initiation factor 2B epsilon subunit, putative 0.0033 0.0018 0.013
Brugia malayi GDP-mannose pyrophosphorylase B 0.0039 0.0027 0.0418
Leishmania major metacaspase, putative 0.0029 0.0012 0.2903
Onchocerca volvulus 0.0222 0.0305 0.4109
Brugia malayi beta-lactamase family protein 0.0044 0.0034 0.0524
Schistosoma mansoni chromobox protein 0.0139 0.0179 0.1902
Brugia malayi Pre-SET motif family protein 0.0064 0.0065 0.1002
Schistosoma mansoni mannose-1-phosphate guanyltransferase 0.0039 0.0027 0.0288
Loa Loa (eye worm) flap endonuclease-1 0.0024 0.0003 0.0019
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0031 0.0015 0.0141
Loa Loa (eye worm) hypothetical protein 0.0064 0.0065 0.0975
Plasmodium falciparum liver specific protein 2, putative 0.0033 0.0018 0.2956
Schistosoma mansoni glucosamine-1-phosphate N-acetyltransferase 0.0039 0.0027 0.0288
Brugia malayi hypothetical protein 0.0033 0.0018 0.0278
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0033 0.0018 0.0003
Plasmodium falciparum eukaryotic initiation factor 4A 0.0031 0.0015 0.2448
Onchocerca volvulus 0.0222 0.0305 0.4109
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0018 0.0003
Brugia malayi chromobox protein homolog 3 0.0078 0.0086 0.1327
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0131 0.0167 0.0717
Onchocerca volvulus 0.0222 0.0305 0.4109
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0039 0.0027 0.0109
Mycobacterium tuberculosis Possible siderophore-binding protein 0.0033 0.0018 0.0003
Echinococcus multilocularis chromobox protein 1 0.0139 0.0179 0.077
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0131 0.0167 0.1774
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0075 0.0318
Brugia malayi Nucleotidyl transferase family protein 0.0039 0.0027 0.0418
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0091 0.1242
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0222 0.0305 0.4723
Brugia malayi Common central domain of tyrosinase family protein 0.0222 0.0305 0.4723
Entamoeba histolytica hypothetical protein 0.004 0.0029 0.0284
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0033 0.0018 0.0249
Brugia malayi Muscleblind-like protein 0.0158 0.0208 0.3221
Echinococcus granulosus caspase 8 0.0029 0.0012 0.0141
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0031 0.0015 0.0107
Schistosoma mansoni dynactin subunit P25 0.0033 0.0018 0.0192
Brugia malayi Heterochromatin protein 1 0.0139 0.0179 0.2763
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0018 0.4832
Echinococcus granulosus mannose 1 phosphate guanyltransferase 0.0039 0.0027 0.0349
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0272 0.0381 0.4059
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0044 0.0034 0.0361
Entamoeba histolytica serine acetyltransferase 1 0.0033 0.0018 0.0171
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0031 0.0015 0.0141
Echinococcus granulosus peregrin 0.0058 0.0056 0.0757
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0002 0.003
Plasmodium falciparum phd finger protein, putative 0.0058 0.0056 1
Entamoeba histolytica ankyrin, putative 0.0033 0.0018 0.0171
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0022 0.0087
Schistosoma mansoni caspase-7 (C14 family) 0.0029 0.0012 0.0129
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0075 0.0799
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0012 0.0108
Mycobacterium tuberculosis Possible transferase 0.0033 0.0018 0.0003
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0131 0.0167 0.0717
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0033 0.0018 0.0192
Plasmodium vivax SET domain protein, putative 0.0064 0.0065 1
Schistosoma mansoni chromobox protein 0.0139 0.0179 0.1902
Echinococcus multilocularis muscleblind protein 1 0.0158 0.0208 0.0899
Schistosoma mansoni tyrosinase precursor 0.0639 0.0939 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0272 0.0381 0.5896
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0044 0.0034 0.0361
Leishmania major GDP-mannose pyrophosphorylase 0.0039 0.0027 0.7764
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0056 0.0237
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0056 0.0439
Entamoeba histolytica acetyltransferase, putative 0.0033 0.0018 0.0171
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0039 0.0027 0.7764
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0018 0.4832
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0002 0.003
Loa Loa (eye worm) hypothetical protein 0.0222 0.0305 0.4707
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0065 0.0274
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0012 0.1616
Toxoplasma gondii eukaryotic initiation factor-2B, epsilon subunit, putative 0.0033 0.0018 0.013
Echinococcus multilocularis GPCR, family 2 0.0036 0.0022 0.0087
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0022 0.0278
Trypanosoma cruzi metacaspase 5, putative 0.0029 0.0012 0.2903
Loa Loa (eye worm) hypothetical protein 0.0078 0.0086 0.1301
Toxoplasma gondii ABC1 family protein 0.0044 0.0034 0.0258
Trichomonas vaginalis penicillin-binding protein, putative 0.0044 0.0034 0.0339
Echinococcus granulosus caspase 0.0029 0.0012 0.0141
Mycobacterium tuberculosis Probable lipase LipD 0.0044 0.0034 0.0019
Toxoplasma gondii hypothetical protein 0.0033 0.0018 0.013
Trypanosoma cruzi metacaspase 5, putative 0.0029 0.0012 0.2903
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0018 0.4832
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0033 0.0018 0.2956
Schistosoma mansoni hypothetical protein 0.0023 0.0002 0.002
Mycobacterium tuberculosis Probable esterase LipL 0.0044 0.0034 0.0019
Mycobacterium tuberculosis Conserved protein 0.0044 0.0034 0.0019
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0056 0.0439
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0044 0.0034 0.0524
Plasmodium falciparum dynactin subunit 5, putative 0.0033 0.0018 0.2956
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0002 0.002
Loa Loa (eye worm) hypothetical protein 0.0044 0.0034 0.0496
Trypanosoma brucei hypothetical protein, conserved 0.0044 0.0034 1
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0192
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.6596 1 1
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0002 0.003
Onchocerca volvulus Cell death protein 3 homolog 0.0029 0.0012 0.0138
Entamoeba histolytica acetyltransferase, putative 0.0033 0.0018 0.0171
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0022 0.0087
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.6596 1 1
Loa Loa (eye worm) hypothetical protein 0.01 0.012 0.183
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0131 0.0167 0.2292
Brugia malayi hypothetical protein 0.0023 0.0002 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0022 0.031
Brugia malayi Calcitonin receptor-like protein seb-1 0.0113 0.014 0.2163
Echinococcus multilocularis muscleblind protein 0.0158 0.0208 0.0899
Entamoeba histolytica translation initiation factor eIF-2B epsilon subunit, putative 0.0039 0.0027 0.0266
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0031 0.0015 0.0185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0272 0.0381 0.4059
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0056 0.0844
Echinococcus multilocularis geminin 0.0495 0.072 0.313
Trichomonas vaginalis esterase, putative 0.0044 0.0034 0.0339
Onchocerca volvulus 0.0044 0.0034 0.0433
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0029 0.0372
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0031 0.0015 0.2273
Trichomonas vaginalis mannose-1-phosphate guanyltransferase, putative 0.0033 0.0018 0.0171
Echinococcus multilocularis dynactin 5 p25 0.0033 0.0018 0.007
Echinococcus granulosus chromobox protein 1 0.0139 0.0179 0.2459
Schistosoma mansoni hypothetical protein 0.0036 0.0022 0.0233
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0034 1
Brugia malayi Flap endonuclease-1 0.0024 0.0003 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0065 0.0689
Trypanosoma cruzi metacaspase, putative 0.0029 0.0012 0.2903
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0012 0.0082
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0167 0.2577
Echinococcus multilocularis mannose 1 phosphate guanyltransferase 0.0039 0.0027 0.0109
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0033 0.0018 0.0171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0065 0.0689
Echinococcus granulosus Chromobox protein 3 0.0023 0.0002 0.000000056786
Giardia lamblia Translation initiation factor 0.0033 0.0018 0.2792
Brugia malayi PHD-finger family protein 0.0058 0.0056 0.0871
Loa Loa (eye worm) hypothetical protein 0.0044 0.0034 0.0496
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.0259 0.1119
Brugia malayi hypothetical protein 0.0033 0.0018 0.0278
Schistosoma mansoni hypothetical protein 0.0495 0.072 0.7672
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0113 0.014 0.214
Schistosoma mansoni gdp-mannose pyrophosphorylase b isoform 2 0.0039 0.0027 0.0288
Entamoeba histolytica maltose O-acetyltransferase, putative 0.0033 0.0018 0.0171
Mycobacterium leprae Probable lipase LipE 0.0044 0.0034 0.0016
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0642 0.0944 1
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0091 0.0389
Treponema pallidum licC protein (licC) 0.0838 0.1241 1
Echinococcus granulosus dynactin 5 p25 0.0033 0.0018 0.0224
Loa Loa (eye worm) tyrosinase 1 0.0222 0.0305 0.4707
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0018 0.4832
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0222 0.0305 0.4723
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0039 0.0027 0.7764
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0075 0.1017
Loa Loa (eye worm) hypothetical protein 0.0113 0.014 0.214
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0018 0.2559
Schistosoma mansoni hypothetical protein 0.0078 0.0085 0.0908
Onchocerca volvulus 0.0149 0.0195 0.2609
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0034 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Leishmania major serine acetyltransferase 0.0033 0.0018 0.4832
Onchocerca volvulus 0.0222 0.0305 0.4109
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0033 0.0018 0.0171
Trichomonas vaginalis D-aminoacylase, putative 0.0044 0.0034 0.0339
Brugia malayi hypothetical protein 0.0033 0.0018 0.0278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0065 0.0689
Mycobacterium ulcerans d-alpha-D-mannose-1-phosphate guanylyltransferase ManB 0.0039 0.0027 0.0009
Trichomonas vaginalis set domain proteins, putative 0.0508 0.074 0.7834
Trichomonas vaginalis penicillin-binding protein, putative 0.0044 0.0034 0.0339
Echinococcus multilocularis flap endonuclease 1 0.0024 0.0003 0.0005
Schistosoma mansoni hypothetical protein 0.0058 0.0056 0.06
Echinococcus granulosus chromobox protein 1 0.0139 0.0179 0.2459
Entamoeba histolytica acetyltransferase, putative 0.0033 0.0018 0.0171
Mycobacterium tuberculosis Probable lipase LipE 0.0044 0.0034 0.0019
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0031 0.0015 0.3933
Plasmodium falciparum metacaspase-like protein 0.0029 0.0012 0.1867
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0031 0.0015 0.018
Mycobacterium ulcerans hypothetical protein 0.0838 0.1241 0.1226
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0051 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0086 0.089
Mycobacterium tuberculosis Conserved hypothetical protein 0.0838 0.1241 0.1228
Echinococcus multilocularis beta LACTamase domain containing family member 0.0044 0.0034 0.0139
Schistosoma mansoni hypothetical protein 0.0036 0.0022 0.0233
Plasmodium falciparum flap endonuclease 1 0.0024 0.0003 0.0227
Leishmania major hypothetical protein, conserved 0.0033 0.0018 0.4832
Loa Loa (eye worm) hypothetical protein 0.0044 0.0034 0.0496
Echinococcus multilocularis caspase 8 0.0029 0.0012 0.0044
Entamoeba histolytica hypothetical protein 0.004 0.0029 0.0284
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0029 0.0012 0.0141
Chlamydia trachomatis UDP-3-O-acylglucosamine N-acyltransferase 0.0033 0.0018 0.5
Schistosoma mansoni jumonji domain containing protein 0.0152 0.0199 0.2117
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0018 0.4832
Mycobacterium tuberculosis Conserved protein 0.0044 0.0034 0.0019
Trichomonas vaginalis chromobox protein, putative 0.0139 0.0179 0.1875
Plasmodium vivax flap endonuclease 1, putative 0.0024 0.0003 0.0197
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0447 0.0646 1
Schistosoma mansoni hypothetical protein 0.0036 0.0022 0.0233
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0033 0.0018 0.0171
Loa Loa (eye worm) hypothetical protein 0.0061 0.006 0.0904
Echinococcus multilocularis caspase 0.0029 0.0012 0.0044
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0022 0.0278
Loa Loa (eye worm) hypothetical protein 0.0044 0.0034 0.0496
Mycobacterium ulcerans hypothetical protein 0.0838 0.1241 0.1226
Brugia malayi hypothetical protein 0.0149 0.0195 0.301
Brugia malayi Bromodomain containing protein 0.0058 0.0056 0.0871
Trichomonas vaginalis D-aminoacylase, putative 0.0044 0.0034 0.0339
Loa Loa (eye worm) nucleotidyl transferase 0.0039 0.0027 0.0389
Plasmodium falciparum metacaspase 1 0.0029 0.0012 0.1867
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0086 0.089
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Mycobacterium ulcerans lipase LipD 0.0044 0.0034 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0272 0.0381 0.4059
Entamoeba histolytica acetyltransferase, putative 0.0033 0.0018 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0012 0.0108
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0838 0.1241 0.1226
Onchocerca volvulus 0.0023 0.0002 0.000000055258
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0167 0.2555
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0075 0.1134
Trypanosoma cruzi metacaspase, putative 0.0029 0.0012 0.2903
Trypanosoma brucei metacaspase MCA3 0.0029 0.0012 0.2903
Echinococcus granulosus muscleblind protein 0.0158 0.0208 0.2871
Onchocerca volvulus 0.0508 0.074 1
Trypanosoma cruzi Translation initiation factor eIF-2B subunit epsilon, putative 0.0039 0.0027 0.7764
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0022 0.0339
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0029 0.0116
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0044 0.0034 0.0496
Brugia malayi hypothetical protein 0.0033 0.0018 0.0278
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0018 0.4832
Brugia malayi Cell death protein 3 precursor 0.0029 0.0012 0.0187
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0031 0.0015 0.0058
Echinococcus multilocularis chromobox protein 1 0.0139 0.0179 0.077
Echinococcus granulosus flap endonuclease 1 0.0024 0.0003 0.0017
Leishmania major hypothetical protein, conserved 0.0044 0.0034 1
Brugia malayi jmjC domain containing protein 0.0192 0.0259 0.4002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0113 0.014 0.2163
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0002 0.002
Leishmania major hypothetical protein, conserved 0.0033 0.0018 0.4832
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0131 0.0167 0.2292

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.56 uM Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as dopachrome formation after 5 mins by spectrophotometry ChEMBL. 24332496
IC50 (binding) = 4.56 uM Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis ChEMBL. 26386819

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.