Detailed information for compound 1821883

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 314.331 | Formula: C15H22O7
  • H donors: 5 H acceptors: 5 LogP: 0.05 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H](O[C@@H]1OC[C@H]([C@@H]([C@H]1O)O)O)CCc1ccc(cc1O)O
  • InChi: 1S/C15H22O7/c1-8(2-3-9-4-5-10(16)6-11(9)17)22-15-14(20)13(19)12(18)7-21-15/h4-6,8,12-20H,2-3,7H2,1H3/t8-,12+,13-,14+,15-/m0/s1
  • InChiKey: SSQDSAFOXKKNBY-BGXOLSLGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tyrosinase Starlite/ChEMBL References
Agaricus bisporus Tyrosinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00505 tyrosinase [EC1.14.18.1], putative Get druggable targets OG5_137498 All targets in OG5_137498
Schistosoma mansoni tyrosinase precursor Get druggable targets OG5_137498 All targets in OG5_137498
Schistosoma mansoni tyrosinase precursor Get druggable targets OG5_137498 All targets in OG5_137498
Schistosoma japonicum ko:K00505 tyrosinase [EC1.14.18.1], putative Get druggable targets OG5_137498 All targets in OG5_137498
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.004 0.0029 0.0284
Mycobacterium ulcerans beta-lactamase 0.0044 0.0034 0.0016
Brugia malayi hypothetical protein 0.0149 0.0195 0.301
Brugia malayi Bromodomain containing protein 0.0058 0.0056 0.0871
Giardia lamblia PHD finger protein 15 0.0058 0.0056 1
Trypanosoma brucei GDP-mannose pyrophosphorylase 0.0039 0.0027 0.7764
Echinococcus multilocularis caspase 2 0.0029 0.0012 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.0044 0.0034 0.0339
Brugia malayi Muscleblind-like protein 0.0158 0.0208 0.3221
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0056 0.0237
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0039 0.0027 0.0389
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0087 0.0099 0.1058
Trypanosoma cruzi metacaspase, putative 0.0029 0.0012 0.2903
Brugia malayi jmjC domain containing protein 0.0192 0.0259 0.4002
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0018 0.4832
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0086 0.089
Echinococcus multilocularis caspase 8 0.0029 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0158
Entamoeba histolytica acetyltransferase, putative 0.0033 0.0018 0.0171
Onchocerca volvulus 0.0023 0.0002 0.000000055258
Trypanosoma cruzi metacaspase, putative 0.0029 0.0012 0.2903
Trypanosoma cruzi serine acetyltransferase, putative 0.0033 0.0018 0.4832
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0044 0.0034 0.0016
Entamoeba histolytica serine acetyltransferase, putative 0.0033 0.0018 0.0171
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0131 0.0167 0.0717
Schistosoma mansoni caspase-7 (C14 family) 0.0029 0.0012 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0012 0.0108
Brugia malayi Protein cec-1. 0.0023 0.0002 0.003
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0002 0.002
Toxoplasma gondii GDP-D-mannose pyrophosphorylase 0.0039 0.0027 0.0202
Loa Loa (eye worm) hypothetical protein 0.0078 0.0085 0.1293
Trypanosoma brucei hypothetical protein, conserved 0.0044 0.0034 1
Entamoeba histolytica maltose O-acetyltransferase, putative 0.0033 0.0018 0.0171
Brugia malayi beta-lactamase family protein 0.0044 0.0034 0.0524
Echinococcus granulosus geminin 0.0495 0.072 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0022 0.031
Onchocerca volvulus 0.0508 0.074 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0012 0.0108
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0044 0.0034 0.0524
Loa Loa (eye worm) hypothetical protein 0.0222 0.0305 0.4707
Brugia malayi hypothetical protein 0.0033 0.0018 0.0278
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0029 0.0116
Schistosoma mansoni jumonji domain containing protein 0.0152 0.0199 0.2117
Giardia lamblia Translation initiation factor 0.0033 0.0018 0.2792
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0044 0.0034 0.0496
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0222 0.0305 0.4723
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0034 1
Brugia malayi hypothetical protein 0.0023 0.0002 0.003
Echinococcus granulosus caspase 8 0.0029 0.0012 0.0141
Onchocerca volvulus Alhambra homolog 0.0058 0.0056 0.0737
Brugia malayi Common central domain of tyrosinase family protein 0.0222 0.0305 0.4723
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0642 0.0944 1
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0002 0.003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0075 0.0799
Mycobacterium leprae Probable lipase LipE 0.0044 0.0034 0.0016
Brugia malayi CHD4 protein 0.0023 0.0002 0.003
Trypanosoma brucei nucleotidyl transferase, putative 0.0039 0.0027 0.7764
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0031 0.0015 0.0162
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0279 0.0392 0.0378
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0095 0.0985
Brugia malayi GDP-mannose pyrophosphorylase B 0.0039 0.0027 0.0418
Onchocerca volvulus 0.0149 0.0195 0.2609
Trypanosoma cruzi metacaspase 5, putative 0.0029 0.0012 0.2903
Schistosoma mansoni chromobox protein 0.0023 0.0002 0.002
Loa Loa (eye worm) hypothetical protein 0.0044 0.0034 0.0496
Trypanosoma brucei metacaspase MCA3 0.0029 0.0012 0.2903
Schistosoma mansoni glucosamine-1-phosphate N-acetyltransferase 0.0039 0.0027 0.0288
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0039 0.0027 0.0109
Trichomonas vaginalis set domain proteins, putative 0.0508 0.074 0.7834
Brugia malayi PHD-finger family protein 0.0058 0.0056 0.0871
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0024 0.0003 0.001
Plasmodium vivax mannose-1-phosphate guanyltransferase, putative 0.0039 0.0027 0.3992
Brugia malayi Nucleotidyl transferase family protein 0.0039 0.0027 0.0418
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0131 0.0167 0.1774
Entamoeba histolytica hypothetical protein 0.004 0.0029 0.0284
Mycobacterium ulcerans esterase/lipase LipP 0.0044 0.0034 0.0016
Entamoeba histolytica ankyrin, putative 0.0033 0.0018 0.0171
Plasmodium falciparum metacaspase-like protein 0.0029 0.0012 0.1867
Schistosoma mansoni chromobox protein 0.0139 0.0179 0.1902
Loa Loa (eye worm) ShTK domain-containing protein 0.0222 0.0305 0.4707
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0002 0.002
Echinococcus multilocularis caspase 0.0029 0.0012 0.0044
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0065 0.0874
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0012 0.1616
Echinococcus granulosus eukaryotic initiation factor 4A 0.0031 0.0015 0.0185
Onchocerca volvulus Cell death protein 3 homolog 0.0029 0.0012 0.0138
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0095 0.0985
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0272 0.0381 0.5884
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0056 0.0439
Echinococcus granulosus GPCR family 2 0.0036 0.0022 0.0278
Onchocerca volvulus 0.0222 0.0305 0.4109
Brugia malayi hypothetical protein 0.004 0.0029 0.0443
Trypanosoma cruzi serine acetyltransferase, putative 0.0033 0.0018 0.4832
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0029 0.0012 0.0141
Mycobacterium tuberculosis Conserved protein 0.0044 0.0034 0.0019
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0012 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0272 0.0381 0.1652
Mycobacterium tuberculosis Conserved hypothetical protein 0.0838 0.1241 0.1228
Trichomonas vaginalis esterase, putative 0.0044 0.0034 0.0339
Toxoplasma gondii eukaryotic initiation factor 2B epsilon subunit, putative 0.0033 0.0018 0.013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0065 0.0689
Loa Loa (eye worm) ShTK domain-containing protein 0.0222 0.0305 0.4707
Brugia malayi eukaryotic initiation factor 4A 0.0031 0.0015 0.0236
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0085 0.1319
Leishmania major eukaryotic initiation factor 4a, putative 0.0031 0.0015 0.3933
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0075 0.1017
Brugia malayi Heterochromatin protein 1 0.0139 0.0179 0.2763
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0113 0.014 0.214
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0034 1
Schistosoma mansoni caspase-7 (C14 family) 0.0029 0.0012 0.0129
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0065 0.0507
Trichomonas vaginalis penicillin-binding protein, putative 0.0044 0.0034 0.0339
Entamoeba histolytica acetyltransferase, putative 0.0033 0.0018 0.0171
Schistosoma mansoni hypothetical protein 0.0023 0.0002 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0065 0.0689
Trichomonas vaginalis chromobox protein, putative 0.0139 0.0179 0.1875
Trichomonas vaginalis penicillin-binding protein, putative 0.0044 0.0034 0.0339
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0002 0.003
Schistosoma mansoni hypothetical protein 0.0078 0.0085 0.0908
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0272 0.0381 0.4059
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.0259 0.1119
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0091 0.0389
Loa Loa (eye worm) hypothetical protein 0.0044 0.0034 0.0496
Echinococcus granulosus peregrin 0.0058 0.0056 0.0757
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0018 0.4832
Loa Loa (eye worm) hypothetical protein 0.0149 0.0195 0.2989
Leishmania major hypothetical protein, conserved 0.0033 0.0018 0.4832
Trypanosoma brucei Metacaspase-4 0.0029 0.0012 0.2903
Toxoplasma gondii hypothetical protein 0.0033 0.0018 0.013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0065 0.0274
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0033 0.0018 0.0192
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0031 0.0015 0.0185
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0131 0.0167 0.2292
Leishmania major hypothetical protein, conserved 0.0044 0.0034 1
Loa Loa (eye worm) heterochromatin protein 1 0.0139 0.0179 0.2742
Trypanosoma cruzi metacaspase, putative 0.0029 0.0012 0.2903
Echinococcus multilocularis peregrin 0.0058 0.0056 0.0237
Loa Loa (eye worm) hypothetical protein 0.0044 0.0034 0.0496
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0065 0.0274
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0029 0.0372
Echinococcus granulosus chromobox protein 1 0.0139 0.0179 0.2459
Echinococcus multilocularis geminin 0.0495 0.072 0.313
Schistosoma mansoni caspase-3 (C14 family) 0.0029 0.0012 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0051 0.0523
Loa Loa (eye worm) flap endonuclease-1 0.0024 0.0003 0.0019
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0039 0.0027 0.0349
Brugia malayi Pre-SET motif family protein 0.0447 0.0646 1
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0222 0.0305 0.4723
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Loa Loa (eye worm) hypothetical protein 0.0064 0.0065 0.0975
Mycobacterium tuberculosis Probable hydrolase 0.0044 0.0034 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0272 0.0381 0.5278
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0022 0.0087
Schistosoma mansoni hypothetical protein 0.0036 0.0022 0.0233
Brugia malayi beta-lactamase family protein 0.0044 0.0034 0.0524
Echinococcus granulosus dynactin 5 p25 0.0033 0.0018 0.0224
Brugia malayi zgc:92842 0.0033 0.0018 0.0278
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.6596 1 1
Trichomonas vaginalis chromobox protein, putative 0.0139 0.0179 0.1875
Onchocerca volvulus 0.0222 0.0305 0.4109
Schistosoma mansoni hypothetical protein 0.0036 0.0022 0.0233
Toxoplasma gondii ABC1 family protein 0.0044 0.0034 0.0258
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0031 0.0015 0.0058
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0031 0.0015 0.0141
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0029 0.0305
Plasmodium falciparum flap endonuclease 1 0.0024 0.0003 0.0227
Loa Loa (eye worm) hypothetical protein 0.0044 0.0034 0.0496
Schistosoma mansoni chromobox protein 0.0023 0.0002 0.002
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1532 0.2297 1
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0192
Plasmodium falciparum metacaspase 1 0.0029 0.0012 0.1867
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0033 0.0018 0.0224
Mycobacterium tuberculosis Possible transferase 0.0033 0.0018 0.0003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0031 0.0015 0.3933
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0056 0.0439
Chlamydia trachomatis acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase 0.0033 0.0018 0.5
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0031 0.0015 0.0141
Echinococcus granulosus caspase 0.0029 0.0012 0.0141
Echinococcus multilocularis flap endonuclease 1 0.0024 0.0003 0.0005
Echinococcus multilocularis GPCR, family 2 0.0036 0.0022 0.0087
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Plasmodium falciparum phd finger protein, putative 0.0058 0.0056 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.014 0.214
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0018 0.4832
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0131 0.0167 0.0717
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0033 0.0018 0.2956
Plasmodium falciparum eukaryotic initiation factor 4A 0.0031 0.0015 0.2448
Entamoeba histolytica acetyltransferase, putative 0.0033 0.0018 0.0171
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0022 0.0339
Loa Loa (eye worm) hypothetical protein 0.0078 0.0086 0.1301
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0249
Brugia malayi Calcitonin receptor-like protein seb-1 0.0113 0.014 0.2163
Onchocerca volvulus 0.0044 0.0034 0.0433
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0012 0.0108
Entamoeba histolytica serine acetyltransferase 1 0.0033 0.0018 0.0171
Entamoeba histolytica acetyltransferase, putative 0.0033 0.0018 0.0171
Echinococcus granulosus muscleblind protein 0.0158 0.0208 0.2871
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0044 0.0034 0.0019
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0018 0.0003
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0033 0.0018 0.0171
Chlamydia trachomatis UDP-3-O-acylglucosamine N-acyltransferase 0.0033 0.0018 0.5
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0838 0.1241 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0012 0.0108
Loa Loa (eye worm) hypothetical protein 0.0158 0.0208 0.3201
Loa Loa (eye worm) hypothetical protein 0.0158 0.0208 0.3201
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Entamoeba histolytica maltose O-acetyltransferase, putative 0.0033 0.0018 0.0171
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0222 0.0305 0.4723
Entamoeba histolytica acetyltransferase, putative 0.0033 0.0018 0.0171
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0838 0.1241 0.1226
Trichomonas vaginalis sugar-1-phosphate guanyl transferase, putative 0.0039 0.0027 0.0266
Echinococcus granulosus caspase 2 0.0029 0.0012 0.0141
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0022 0.0087
Treponema pallidum licC protein (licC) 0.0838 0.1241 1
Plasmodium falciparum mannose-1-phosphate guanyltransferase, putative 0.0039 0.0027 0.4612
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0031 0.0015 0.0141
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0033 0.0018 0.0249
Trypanosoma cruzi hypothetical protein 0.0033 0.0018 0.4832
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0272 0.0381 0.4059
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Leishmania major serine acetyltransferase 0.0033 0.0018 0.4832
Plasmodium vivax RNA helicase-1, putative 0.0031 0.0015 0.2119
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0447 0.0646 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0044 0.0034 0.0445
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0031 0.0015 0.2273
Echinococcus granulosus chromobox protein 1 0.0139 0.0179 0.2459
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0272 0.0381 0.1652
Mycobacterium ulcerans hypothetical protein 0.0838 0.1241 0.1226
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0075 0.1134
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0075 0.0799
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0031 0.0015 0.3933
Onchocerca volvulus 0.0222 0.0305 0.4109
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0031 0.0015 0.0107
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0033 0.0018 0.0171
Trichomonas vaginalis flap endonuclease-1, putative 0.0024 0.0003 0.0013
Schistosoma mansoni hypothetical protein 0.0495 0.072 0.7672
Brugia malayi ShTK domain containing protein 0.0222 0.0305 0.4723
Trichomonas vaginalis mannose-1-phosphate guanyltransferase, putative 0.0033 0.0018 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0086 0.089
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0012 0.0082
Plasmodium vivax dynactin subunit 5, putative 0.0033 0.0018 0.2559
Schistosoma mansoni tyrosinase precursor 0.0639 0.0939 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0012 0.0108
Onchocerca volvulus 0.0061 0.006 0.0789
Entamoeba histolytica serine acetyltransferase 1 0.0033 0.0018 0.0171
Echinococcus multilocularis beta LACTamase domain containing family member 0.0044 0.0034 0.0139
Mycobacterium tuberculosis Probable lipase LipD 0.0044 0.0034 0.0019
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0031 0.0015 0.0162
Mycobacterium tuberculosis Probable esterase LipL 0.0044 0.0034 0.0019
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0131 0.0167 0.2577
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.0151 0.2314
Schistosoma mansoni hypothetical protein 0.004 0.0029 0.0305
Entamoeba histolytica hypothetical protein 0.004 0.0029 0.0284
Trypanosoma cruzi Translation initiation factor eIF-2B subunit epsilon, putative 0.0039 0.0027 0.7764
Trypanosoma brucei metacaspase MCA2 0.0029 0.0012 0.2903
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0018 0.2559
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0022 0.0339
Brugia malayi SET domain containing protein 0.0025 0.0006 0.0085
Trypanosoma cruzi metacaspase, putative 0.0029 0.0012 0.2903
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0012 0.0108
Entamoeba histolytica translation initiation factor eIF-2B epsilon subunit, putative 0.0039 0.0027 0.0266
Echinococcus granulosus mannose 1 phosphate guanyltransferase 0.0039 0.0027 0.0349
Leishmania major GDP-mannose pyrophosphorylase 0.0039 0.0027 0.7764
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0018 0.4832
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0272 0.0381 0.5278
Leishmania major metacaspase, putative 0.0029 0.0012 0.2903
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0044 0.0034 0.0361
Trichomonas vaginalis glucose-1-phosphate thymidylyltransferase, putative 0.0039 0.0027 0.0266
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0033 0.0018 0.0003
Leishmania major hypothetical protein, conserved 0.0033 0.0018 0.4832
Entamoeba histolytica Flap nuclease, putative 0.0024 0.0003 0.0013
Brugia malayi Cell death protein 3 precursor 0.0029 0.0012 0.0187
Schistosoma mansoni hypothetical protein 0.0058 0.0056 0.06
Brugia malayi hypothetical protein 0.0033 0.0018 0.0278
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0022 0.0278
Loa Loa (eye worm) beta-lactamase 0.0044 0.0034 0.0496
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Leishmania major eukaryotic initiation factor 4a, putative 0.0031 0.0015 0.3933
Trypanosoma brucei metacaspase 5, putative 0.0029 0.0012 0.2903
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0131 0.0167 0.2555
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.6596 1 1
Echinococcus multilocularis mannose 1 phosphate guanyltransferase 0.0039 0.0027 0.0109
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0056 0.8656
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0018 0.4832
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0249
Loa Loa (eye worm) hypothetical protein 0.0044 0.0034 0.0496
Onchocerca volvulus 0.0087 0.0099 0.1319
Loa Loa (eye worm) dynactin 5 0.0033 0.0018 0.0249
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0018 0.4832
Loa Loa (eye worm) tyrosinase 1 0.0222 0.0305 0.4707
Echinococcus granulosus Chromobox protein 3 0.0023 0.0002 0.000000056786
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0029 0.0012 0.0129
Trichomonas vaginalis D-aminoacylase, putative 0.0044 0.0034 0.0339
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0031 0.0015 0.0058
Loa Loa (eye worm) hypothetical protein 0.01 0.012 0.183
Mycobacterium leprae conserved hypothetical protein 0.0044 0.0034 0.0016
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0002 0.003
Leishmania major hypothetical protein, conserved 0.0033 0.0018 0.4832
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0018 0.4832
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0131 0.0167 0.2292
Loa Loa (eye worm) nucleotidyl transferase 0.0039 0.0027 0.0389
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0033 0.0018 0.007
Onchocerca volvulus 0.0044 0.0034 0.0433
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.0259 0.3574
Echinococcus multilocularis muscleblind protein 1 0.0158 0.0208 0.0899
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0039 0.0027 0.7764
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0272 0.0381 0.4059
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0012 0.0082
Trypanosoma cruzi metacaspase 5, putative 0.0029 0.0012 0.2903
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0029 0.0012 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.0044 0.0034 0.0339
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0012 0.0108
Mycobacterium ulcerans d-alpha-D-mannose-1-phosphate guanylyltransferase ManB 0.0039 0.0027 0.0009
Loa Loa (eye worm) hypothetical protein 0.0058 0.0056 0.0844
Mycobacterium tuberculosis Conserved hypothetical protein 0.0838 0.1241 0.1228
Plasmodium falciparum liver specific protein 2, putative 0.0033 0.0018 0.2956
Echinococcus granulosus flap endonuclease 1 0.0024 0.0003 0.0017
Brugia malayi Flap endonuclease-1 0.0024 0.0003 0.0049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0044 0.0034 0.0361
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0022 0.0278
Brugia malayi Pre-SET motif family protein 0.0064 0.0065 0.1002
Loa Loa (eye worm) hypothetical protein 0.0044 0.0034 0.0496
Mycobacterium tuberculosis Conserved protein 0.0044 0.0034 0.0019
Plasmodium vivax flap endonuclease 1, putative 0.0024 0.0003 0.0197
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0078 0.0086 0.1136
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0002 0.000000017776
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0033 0.0018 0.0171
Loa Loa (eye worm) hypothetical protein 0.0061 0.006 0.0904
Loa Loa (eye worm) hypothetical protein 0.0031 0.0015 0.0207
Brugia malayi hypothetical protein 0.0033 0.0018 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0018 0.0171
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0044 0.0034 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0065 0.0689
Entamoeba histolytica acetyltransferase, putative 0.0033 0.0018 0.0171
Mycobacterium tuberculosis Conserved protein 0.0044 0.0034 0.0019
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0091 0.1242
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0056 0.0844
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0031 0.0015 0.3933
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0031 0.0015 0.0141
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0061 0.0825
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0033 0.0018 0.0171
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0002 0.002
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0002 0.002
Echinococcus multilocularis dynactin 5 p25 0.0033 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0222 0.0305 0.4707
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0222 0.0305 0.4723
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0002 0.003
Plasmodium falciparum dynactin subunit 5, putative 0.0033 0.0018 0.2956
Echinococcus multilocularis muscleblind protein 0.0158 0.0208 0.0899
Mycobacterium ulcerans hypothetical protein 0.0044 0.0034 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0051 0.0523
Echinococcus multilocularis chromobox protein 1 0.0139 0.0179 0.077
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0034 0.5085
Loa Loa (eye worm) hypothetical protein 0.0036 0.0022 0.031
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.6596 1 1
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0031 0.0015 0.018
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0084 0.0095 0.1258
Onchocerca volvulus 0.0222 0.0305 0.4109
Plasmodium vivax SET domain protein, putative 0.0064 0.0065 1
Toxoplasma gondii eukaryotic initiation factor-2B, epsilon subunit, putative 0.0033 0.0018 0.013
Schistosoma mansoni gdp-mannose pyrophosphorylase b isoform 2 0.0039 0.0027 0.0288
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0642 0.0944 1
Mycobacterium tuberculosis Possible siderophore-binding protein 0.0033 0.0018 0.0003
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0056 0.06
Schistosoma mansoni mannose-1-phosphate guanyltransferase 0.0039 0.0027 0.0288
Echinococcus multilocularis chromobox protein 1 0.0139 0.0179 0.077
Entamoeba histolytica hypothetical protein 0.004 0.0029 0.0284
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0075 0.0318
Mycobacterium ulcerans lipase LipD 0.0044 0.0034 0.0016
Schistosoma mansoni hypothetical protein 0.0036 0.0022 0.0233
Schistosoma mansoni chromobox protein 0.0139 0.0179 0.1902
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0044 0.0034 0.0019
Brugia malayi eIF4-gamma/eIF5/eIF2-epsilon family protein 0.0033 0.0018 0.0278
Mycobacterium ulcerans hypothetical protein 0.0838 0.1241 0.1226
Brugia malayi beta-lactamase 0.0044 0.0034 0.0524
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0039 0.0027 0.7764
Schistosoma mansoni tyrosinase precursor 0.0639 0.0939 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0056 0.0757
Schistosoma mansoni hypothetical protein 0.0036 0.0022 0.0233
Trypanosoma brucei metacaspase 0.0029 0.0012 0.2903
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0272 0.0381 0.5896
Brugia malayi jmjC domain containing protein 0.0071 0.0075 0.1161
Onchocerca volvulus 0.0044 0.0034 0.0433
Plasmodium vivax metacaspase 1, putative 0.0029 0.0012 0.1616
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0029 0.0012 0.0187
Schistosoma mansoni dynactin subunit P25 0.0033 0.0018 0.0192
Brugia malayi hypothetical protein 0.0033 0.0018 0.0278
Mycobacterium tuberculosis Probable lipase LipE 0.0044 0.0034 0.0019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0113 0.014 0.2163
Brugia malayi chromobox protein homolog 3 0.0078 0.0086 0.1327
Schistosoma mansoni hypothetical protein 0.0495 0.072 0.7672

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.56 uM Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as dopachrome formation after 5 mins by spectrophotometry ChEMBL. 24332496
IC50 (binding) = 4.56 uM Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis ChEMBL. 26386819

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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