TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 546.659 | Formula: C34H34N4O3
H donors: 4 H acceptors: 3 LogP: 6.01 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: CC(CNC(=O)c1ccc(c(c1)C(=O)O)c1ccccc1[C@H]1Nc2ccc(cc2[C@H](C1)c1ccccc1)C(=N)N)C
InChi: 1S/C34H34N4O3/c1-20(2)19-37-33(39)23-12-14-25(29(17-23)34(40)41)24-10-6-7-11-26(24)31-18-27(21-8-4-3-5-9-21)28-16-22(32(35)36)13-15-30(28)38-31/h3-17,20,27,31,38H,18-19H2,1-2H3,(H3,35,36)(H,37,39)(H,40,41)/t27-,31+/m1/s1
InChiKey: VLLIPYLLTCVTAW-JOMNFKBKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	coagulation factor XI	Starlite/ChEMBL	References
Homo sapiens	coagulation factor X	Starlite/ChEMBL	References
Homo sapiens	coagulation factor VII (serum prothrombin conversion accelerator)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	PAN domain-containing protein	Get druggable targets OG5_134971	All targets in OG5_134971
Neospora caninum	hypothetical protein	Get druggable targets OG5_134971	All targets in OG5_134971
Neospora caninum	hypothetical protein	Get druggable targets OG5_134971	All targets in OG5_134971
Toxoplasma gondii	PAN domain-containing protein	Get druggable targets OG5_134971	All targets in OG5_134971
Neospora caninum	hypothetical protein	Get druggable targets OG5_134971	All targets in OG5_134971

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	glycoprotein Antigen 5	coagulation factor VII (serum prothrombin conversion accelerator)	466 aa	384 aa	23.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0017	0.0089	0.0104
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0014	0.0053	0.0049
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0249	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0012	0.0025	0.003
Echinococcus granulosus	protein jagged 1	0.0014	0.0053	0.0057
Onchocerca volvulus		0.0012	0.0025	0.0841
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0347	0.0409
Onchocerca volvulus	Arrow homolog	0.0016	0.0082	0.3171
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Schistosoma mansoni	hypothetical protein	0.0014	0.0053	0.0063
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0016	0.0082	0.1213
Echinococcus granulosus	delta-like protein 1	0.0014	0.0053	0.0057
Toxoplasma gondii	PAN domain-containing protein	0.0356	0.4375	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0249	0.3825
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0126	0.5
Schistosoma mansoni	hypothetical protein	0.0014	0.0053	0.0063
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0001
Echinococcus multilocularis	microtubule associated protein 2	0.0682	0.8492	0.8491
Schistosoma mansoni	notch	0.0014	0.0053	0.0063
Brugia malayi	Cadherin domain containing protein	0.0014	0.0053	0.0447
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0005	0.0006
Schistosoma mansoni	cell polarity protein	0.0014	0.0053	0.0063
Brugia malayi	PAN domain containing protein	0.0023	0.0168	0.1502
Schistosoma mansoni	notch	0.0014	0.0053	0.0063
Brugia malayi	Bloom's syndrome protein homolog	0.002	0.0126	0.1116
Schistosoma mansoni	hypothetical protein	0.0034	0.0312	0.0367
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0449	0.0528
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0001
Echinococcus granulosus	dnaJ subfamily B	0.0404	0.4974	0.5855
Schistosoma mansoni	DNA helicase recq5	0.002	0.0126	0.0148
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0079	0.0087
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0126	0.0288
Schistosoma mansoni	hypothetical protein	0.0016	0.0079	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0168	0.2558
Schistosoma mansoni	egf-like domain protein	0.0016	0.0082	0.0097
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.002	0.0126	0.19
Schistosoma mansoni	hypothetical protein	0.0036	0.0336	0.0395
Echinococcus granulosus	peregrin	0.0029	0.0249	0.0288
Echinococcus granulosus	neural cadherin	0.0014	0.0053	0.0057
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0014	0.0053	0.1991
Brugia malayi	Trypsin family protein	0.0012	0.0025	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0168	0.2558
Onchocerca volvulus		0.0023	0.0168	0.6687
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0079	0.0074
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0449	0.695
Loa Loa (eye worm)	PAN domain-containing protein	0.0023	0.0168	0.2558
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0016	0.0082	0.0712
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.002	0.0126	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Toxoplasma gondii	PAN domain-containing protein	0.0023	0.0168	0.0384
Brugia malayi	EGF-like domain containing protein	0.0014	0.0053	0.0447
Onchocerca volvulus		0.0014	0.0053	0.1991
Schistosoma mansoni	hypothetical protein	0.0012	0.0025	0.003
Echinococcus granulosus	neurogenic locus notch protein 4	0.0014	0.0053	0.0057
Onchocerca volvulus		0.0014	0.0053	0.1991
Echinococcus multilocularis	neurogenic locus protein delta	0.0014	0.0053	0.0049
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0005	0.0006
Loa Loa (eye worm)	hypothetical protein	0.005	0.0512	0.7942
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0025	0.0323
Echinococcus multilocularis	bloom syndrome protein	0.002	0.0126	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Echinococcus granulosus	microtubule associated protein 2	0.0682	0.8492	1
Echinococcus multilocularis	Mastin	0.0012	0.0025	0.0021
Loa Loa (eye worm)	notch protein	0.0014	0.0053	0.0762
Brugia malayi	EGF-like domain containing protein	0.0014	0.0053	0.0447
Toxoplasma gondii	PAN domain-containing protein	0.0023	0.0168	0.0384
Schistosoma mansoni	cercarial elastase (S01 family)	0.0012	0.0025	0.003
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0001
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0126	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0512	0.4666
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0126	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0005	0.0006
Echinococcus multilocularis	slit 2 protein	0.0014	0.0053	0.0049
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0249	0.0288
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0001
Entamoeba histolytica	hypothetical protein	0.0036	0.0336	1
Brugia malayi	Bromodomain containing protein	0.0029	0.0249	0.2247
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0449	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0082	0.1213
Schistosoma mansoni	cpg binding protein	0.003	0.0257	0.0302
Echinococcus granulosus	neurogenic locus notch protein	0.0014	0.0053	0.0057
Echinococcus multilocularis	cpg binding protein	0.003	0.0257	0.0252
Brugia malayi	Cadherin domain containing protein	0.0014	0.0053	0.0447
Trichomonas vaginalis	DNA helicase recq1, putative	0.002	0.0126	0.5
Echinococcus granulosus	notch	0.0014	0.0053	0.0057
Giardia lamblia	Sgs1 DNA helicase, putative	0.002	0.0126	0.3714
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0082	0.1213
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0394	0.0389
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0347	0.0409
Brugia malayi	Delta serrate ligand family protein	0.0014	0.0053	0.0447
Loa Loa (eye worm)	Notch2	0.0014	0.0053	0.0762
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0016	0.0082	0.0097
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0449	0.4083
Echinococcus multilocularis	neurogenic locus notch protein	0.0014	0.0053	0.0049
Onchocerca volvulus		0.0012	0.0025	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0082	0.1213
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.001	0.0005	0.0193
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0126	0.1116
Onchocerca volvulus		0.0023	0.0168	0.6687
Echinococcus granulosus	protein jagged 1	0.0014	0.0053	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Toxoplasma gondii	microneme protein, putative	0.0023	0.0168	0.0384
Brugia malayi	notch-like transmembrane receptor	0.0014	0.0053	0.0447
Onchocerca volvulus		0.0014	0.0053	0.1991
Schistosoma mansoni	hypothetical protein	0.0012	0.0025	0.003
Schistosoma mansoni	hypothetical protein	0.0014	0.0053	0.0063
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0005	0.0011
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0096	0.1091	0.1087
Echinococcus multilocularis	peregrin	0.0029	0.0249	0.0244
Brugia malayi	Calcium binding EGF domain containing protein	0.0014	0.0053	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0079	0.1163
Toxoplasma gondii	microneme protein MIC17A	0.0023	0.0168	0.0384
Echinococcus multilocularis	fibrillin 1	0.0016	0.0082	0.0077
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0236	0.3629
Giardia lamblia	PHD finger protein 15	0.0029	0.0249	1
Loa Loa (eye worm)	trypsin family protein	0.0012	0.0025	0.0323
Brugia malayi	hypothetical protein	0.0012	0.0025	0.0189
Brugia malayi	PAN domain containing protein	0.0023	0.0168	0.1502
Onchocerca volvulus		0.0014	0.0053	0.1991
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0096	0.1091	0.128
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0005	0.0006
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0005	0.0001
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0005	0.0006
Echinococcus multilocularis	notch	0.0014	0.0053	0.0049
Onchocerca volvulus		0.0014	0.0053	0.1991
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0347	0.5364
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0347	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0001
Echinococcus multilocularis	neurogenic locus notch protein	0.0014	0.0053	0.0049
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0023	0.0168	0.0384
Echinococcus multilocularis	fibropellin Ia	0.0014	0.0053	0.0049
Brugia malayi	PAN domain containing protein	0.0023	0.0168	0.1502
Schistosoma mansoni	notch	0.0014	0.0053	0.0063
Loa Loa (eye worm)	hypothetical protein	0.002	0.0126	0.19
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0168	0.2558
Loa Loa (eye worm)	hypothetical protein	0.0011	0.002	0.024
Onchocerca volvulus		0.0023	0.0168	0.6687
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0025	0.0323
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.002	0.0126	0.0121
Brugia malayi	PAN domain containing protein	0.0023	0.0168	0.1502
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0394	0.0459
Echinococcus granulosus	glycoprotein Antigen 5	0.0012	0.0025	0.0024
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0249	0.0569
Loa Loa (eye worm)	PAN domain-containing protein	0.0023	0.0168	0.2558
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0012	0.0025	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0449	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Entamoeba histolytica	hypothetical protein	0.0036	0.0336	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0012	0.0025	0.003
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0336	0.039
Schistosoma mansoni	hypothetical protein	0.0016	0.0079	0.0093
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0012	0.0025	0.003
Onchocerca volvulus		0.0023	0.0168	0.6687
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0001
Schistosoma mansoni	cpg binding protein	0.0028	0.0236	0.0278
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0012	0.0025	0.003
Toxoplasma gondii	EGF family domain-containing protein	0.0014	0.0053	0.0122
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0000000015977
Toxoplasma gondii	PAN domain-containing protein	0.0023	0.0168	0.0384
Schistosoma mansoni	notch	0.0014	0.0053	0.0063
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0079	0.0074
Schistosoma mansoni	cercarial elastase (S01 family)	0.0012	0.0025	0.003
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0014	0.0053	0.0063
Brugia malayi	Fibulin-1 precursor	0.0016	0.0082	0.0712
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0011	0.0019	0.0016
Brugia malayi	EGF-like domain containing protein	0.0014	0.0053	0.0447
Schistosoma mansoni	hypothetical protein	0.0014	0.0053	0.0063
Onchocerca volvulus		0.0012	0.0025	0.0841
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0012	0.0025	0.003
Echinococcus multilocularis	protein jagged 1	0.0014	0.0053	0.0049
Echinococcus granulosus	fibropellin Ia	0.0014	0.0053	0.0057
Onchocerca volvulus	Alhambra homolog	0.0029	0.0249	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0005	0.0001
Schistosoma mansoni	cercarial elastase (S01 family)	0.0012	0.0025	0.003
Entamoeba histolytica	hypothetical protein	0.0036	0.0336	1
Brugia malayi	Trypsin family protein	0.0012	0.0025	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Toxoplasma gondii	microneme protein MIC17C	0.0023	0.0168	0.0384
Toxoplasma gondii	hypothetical protein	0.0023	0.0168	0.0384
Onchocerca volvulus		0.0028	0.0236	0.9488
Schistosoma mansoni	notch	0.0014	0.0053	0.0063
Onchocerca volvulus		0.0023	0.0168	0.6687
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0168	0.2558
Onchocerca volvulus		0.0012	0.0025	0.0841
Schistosoma mansoni	cercarial elastase (S01 family)	0.0012	0.0025	0.003
Mycobacterium ulcerans	hypothetical protein	0.0012	0.0025	0.5
Treponema pallidum	ATP-dependent DNA helicase	0.001	0.0005	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0005	0.0001
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0012	0.0025	0.0021
Loa Loa (eye worm)	RecQ helicase	0.002	0.0126	0.19
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0512	0.4666
Echinococcus granulosus	laminin	0.0016	0.0082	0.0091
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0126	0.1116
Echinococcus granulosus	neurogenic locus protein delta	0.0014	0.0053	0.0057
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0005	0.0006
Schistosoma mansoni	notch	0.0014	0.0053	0.0063
Echinococcus multilocularis	dnaJ subfamily B	0.0404	0.4974	0.4972
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.002	0.0126	0.0143
Entamoeba histolytica	recQ family helicase, putative	0.002	0.0126	0.3757
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0249	1
Toxoplasma gondii	microneme protein MIC17B	0.0023	0.0168	0.0384
Echinococcus granulosus	transmembrane protease serine 3	0.0012	0.0025	0.0024
Schistosoma mansoni	hypothetical protein	0.0016	0.0079	0.0093
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0079	0.0087
Entamoeba histolytica	hypothetical protein	0.0036	0.0336	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0449	0.0528
Onchocerca volvulus		0.0023	0.0168	0.6687
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0012	0.0025	0.003
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0236	0.2132
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0079	0.1163
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0449	0.0523
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0005	0.0001
Brugia malayi	PAN domain containing protein	0.0023	0.0168	0.1502
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0005	0.0001
Schistosoma mansoni	septate junction protein	0.0014	0.0053	0.0063
Toxoplasma gondii	PAN domain-containing protein	0.0023	0.0168	0.0384
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.002	0.0126	0.4596
Echinococcus granulosus	slit 2 protein	0.0014	0.0053	0.0057
Echinococcus multilocularis	protein jagged 2	0.0014	0.0053	0.0049
Brugia malayi	GCC2 and GCC3 family protein	0.0014	0.0053	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0082	0.1213
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0011	0.0019	0.0014
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0557	0.1272
Brugia malayi	Trypsin family protein	0.0012	0.0025	0.0189
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0449	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Brugia malayi	Calcium binding EGF domain containing protein	0.0014	0.0053	0.0447
Onchocerca volvulus		0.0023	0.0168	0.6687
Brugia malayi	hypothetical protein	0.0036	0.0336	0.3044
Loa Loa (eye worm)	PAN domain-containing protein	0.0023	0.0168	0.2558
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0336	0.0395
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0014	0.0053	0.0447
Onchocerca volvulus		0.0023	0.0168	0.6687
Toxoplasma gondii	microneme protein MIC4	0.0023	0.0168	0.0384
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.0126	0.5
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0079	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0327	0.0322
Echinococcus multilocularis	glycoprotein Antigen 5	0.0012	0.0025	0.0021
Entamoeba histolytica	recQ family DNA helicase	0.001	0.0005	0.0143
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.0005	0.0006
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0023	0.0168	0.0384
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0336	0.0331
Toxoplasma gondii	hypothetical protein	0.0023	0.0168	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0082	0.1213
Brugia malayi	PAN domain containing protein	0.0023	0.0168	0.1502
Echinococcus granulosus	Mastin	0.0012	0.0025	0.0024
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0005	0.0006
Brugia malayi	Muscle positioning protein 4	0.0014	0.0053	0.0447
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0249	0.0244
Echinococcus granulosus	protein jagged 2	0.0014	0.0053	0.0057
Echinococcus granulosus	neurogenic locus notch protein	0.0014	0.0053	0.0057
Schistosoma mansoni	laminin gamma-3 chain	0.0014	0.0053	0.0063
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0079	0.0074
Schistosoma mansoni	DNA helicase recq1	0.002	0.0126	0.0148
Echinococcus multilocularis	protein jagged 1	0.0014	0.0053	0.0049
Loa Loa (eye worm)	PAN domain-containing protein	0.0023	0.0168	0.2558
Schistosoma mansoni	slit	0.0014	0.0053	0.0063
Schistosoma mansoni	cpg binding protein	0.003	0.0257	0.0302
Echinococcus granulosus	protein jagged 2	0.0014	0.0053	0.0057
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0249	0.3825
Onchocerca volvulus	Neurogenic locus notch homolog	0.0014	0.0053	0.1991
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0249	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0168	0.2558
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0025	0.0323
Schistosoma mansoni	hypothetical protein	0.0404	0.4974	0.5857
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0005	0.0006
Loa Loa (eye worm)	PAN domain-containing protein	0.0023	0.0168	0.2558
Brugia malayi	EGF-like domain containing protein	0.0014	0.0053	0.0447
Onchocerca volvulus		0.0023	0.0168	0.6687
Echinococcus multilocularis	enteropeptidase	0.0012	0.0025	0.0021
Brugia malayi	Calcium binding EGF domain containing protein	0.0016	0.0082	0.0712
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0012	0.0025	0.003
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0025	0.0323
Brugia malayi	jmjC domain containing protein	0.0037	0.0347	0.3151
Schistosoma mansoni	hypothetical protein	0.0016	0.0079	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0312	0.4804
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0005	0.0001
Echinococcus granulosus	enteropeptidase	0.0012	0.0025	0.0024
Echinococcus granulosus	bloom syndrome protein	0.002	0.0126	0.0143
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0016	0.0082	0.0188
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0638	0.0751
Echinococcus granulosus	cpg binding protein	0.003	0.0257	0.0297
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.002	0.0126	0.0121
Brugia malayi	PAN domain containing protein	0.0023	0.0168	0.1502
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0012	0.0025	0.003
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0168	0.2558
Onchocerca volvulus		0.0023	0.0168	0.6687
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0079	0.0683
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0005	0.0001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0005	0.0001
Loa Loa (eye worm)	hypothetical protein	0.005	0.0514	0.7968
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Schistosoma mansoni	hypothetical protein	0.0014	0.0053	0.0063
Schistosoma mansoni	cercarial elastase (S01 family)	0.0012	0.0025	0.003
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0025	0.0323
Brugia malayi	jmjC domain containing protein	0.0096	0.1091	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0005	0.0006
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0014	0.0053	0.0049
Schistosoma mansoni	coup transcription factor	0.001	0.0005	0.0006
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0012	0.0025	0.0024
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0012	0.0025	0.0189
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0643	1
Schistosoma mansoni	hypothetical protein	0.0014	0.0053	0.0063
Echinococcus multilocularis	Tolloid protein 1	0.0016	0.0082	0.0077
Toxoplasma gondii	subtilisin SUB12	0.0023	0.0168	0.0384
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0005	0.0006
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0016	0.0082	0.1213
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.0126	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0449	0.0528
Onchocerca volvulus		0.0023	0.0168	0.6687
Brugia malayi	PHD-finger family protein	0.0011	0.002	0.0141
Brugia malayi	Calcium binding EGF domain containing protein	0.0014	0.0053	0.0447
Brugia malayi	EGF-like domain containing protein	0.0014	0.0053	0.0447
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0512	0.7942
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Echinococcus multilocularis	neural cadherin	0.0014	0.0053	0.0049
Brugia malayi	PAN domain containing protein	0.0023	0.0168	0.1502
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0005	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Onchocerca volvulus	Slit protein homolog	0.0014	0.0053	0.1991
Onchocerca volvulus		0.0012	0.0025	0.0841
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0012	0.0025	0.003
Schistosoma mansoni	cercarial elastase (S01 family)	0.0012	0.0025	0.003
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Echinococcus granulosus	GPCR family 2	0.0016	0.0079	0.0087
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0012	0.0025	0.003
Onchocerca volvulus	Putative cubilin	0.0014	0.0053	0.1991
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0168	0.2558
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Schistosoma mansoni	cercarial elastase (S01 family)	0.0012	0.0025	0.003
Schistosoma mansoni	hypothetical protein	0.0029	0.0249	0.0293
Echinococcus multilocularis	neurogenic locus protein delta	0.0014	0.0053	0.0049
Echinococcus multilocularis	transmembrane protease serine 3	0.0012	0.0025	0.0021
Brugia malayi	PAN domain containing protein	0.0023	0.0168	0.1502
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0005	0.0006
Plasmodium vivax	hypothetical protein, conserved	0.0011	0.0022	0.0865
Toxoplasma gondii	PAN domain-containing protein	0.0356	0.4375	1
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0016	0.0082	0.1213
Brugia malayi	Trypsin family protein	0.0012	0.0025	0.0189
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.0109	0.0959
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0249	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0762
Echinococcus multilocularis	laminin	0.0016	0.0082	0.0077
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0312	0.2822
Schistosoma mansoni	cercarial elastase (S01 family)	0.0012	0.0025	0.003
Schistosoma mansoni	microtubule-associated protein tau	0.0682	0.8492	1
Brugia malayi	EGF-like domain containing protein	0.0014	0.0053	0.0447
Echinococcus granulosus	Tolloid protein 1	0.0016	0.0082	0.0091
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0126	0.4596
Schistosoma mansoni	jumonji domain containing protein	0.0076	0.0842	0.0992
Onchocerca volvulus		0.0012	0.0025	0.0841
Brugia malayi	PHD-finger family protein	0.0029	0.0249	0.2247
Schistosoma mansoni	hypothetical protein	0.0014	0.0053	0.0063
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0126	0.0288
Brugia malayi	PAN domain containing protein	0.0023	0.0168	0.1502
Schistosoma mansoni	cercarial elastase (S01 family)	0.0012	0.0025	0.003
Brugia malayi	EGF-like domain containing protein	0.0014	0.0053	0.0447
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0016	0.0082	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0025	0.0323
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0012	0.0025	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0025	0.0323
Brugia malayi	Trypsin-like protease protein 5	0.0012	0.0025	0.0189

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 25 nM	Binding affinity to human factor 11a assessed as release of p-nitroaniline after 10 to 120 mins by spectrophotometric analysis	ChEMBL.	24405333
Ki (binding)	= 95 nM	Binding affinity to human factor 7a assessed as release of p-nitroaniline after 10 to 120 mins by spectrophotometric analysis	ChEMBL.	24405333
Ki (binding)	= 1100 nM	Binding affinity to human factor 10a assessed as release of p-nitroaniline after 10 to 120 mins by spectrophotometric analysis	ChEMBL.	24405333

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3127464

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1823074