Detailed information for compound 182331

Basic information

Technical information
  • TDR Targets ID: 182331
  • Name: 6-(2,6-dichlorophenyl)-2-(3-hydroxyanilino)-8 -methylpyrido[2,3-d]pyrimidin-7-one
  • MW: 413.257 | Formula: C20H14Cl2N4O2
  • H donors: 2 H acceptors: 4 LogP: 4.54 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cccc(c1)Nc1ncc2c(n1)n(C)c(=O)c(c2)c1c(Cl)cccc1Cl
  • InChi: 1S/C20H14Cl2N4O2/c1-26-18-11(8-14(19(26)28)17-15(21)6-3-7-16(17)22)10-23-20(25-18)24-12-4-2-5-13(27)9-12/h2-10,27H,1H3,(H,23,24,25)
  • InChiKey: YLOVBNCIDYKIDW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(2,6-dichlorophenyl)-2-(3-hydroxyanilino)-8-methyl-pyrido[2,3-d]pyrimidin-7-one
  • 6-(2,6-dichlorophenyl)-2-(3-hydroxyanilino)-8-methyl-7-pyrido[2,3-d]pyrimidinone
  • 6-(2,6-dichlorophenyl)-2-[(3-hydroxyphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7-one
  • 6-(2,6-dichlorophenyl)-2-[(3-hydroxyphenyl)amino]-8-methylpyrido[6,5-d]pyrimidin-7-one
  • 6-(2,6-dichlorophenyl)-2-[(3-hydroxyphenyl)amino]-8-methyl-pyrido[6,5-d]pyrimidin-7-one
  • 6-(2,6-dichlorophenyl)-2-[(3-hydroxyphenyl)amino]-8-methyl-7-pyrido[6,5-d]pyrimidinone
  • 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 50

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Starlite/ChEMBL References
Homo sapiens platelet-derived growth factor receptor, beta polypeptide References
Mus musculus platelet derived growth factor receptor, beta polypeptide Starlite/ChEMBL References
Homo sapiens platelet-derived growth factor receptor, alpha polypeptide Starlite/ChEMBL References
Gallus gallus Tyrosine-protein kinase SRC Starlite/ChEMBL References
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL References
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens fibroblast growth factor receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_128769 All targets in OG5_128769
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Abl Get druggable targets OG5_131234 All targets in OG5_131234
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK/ABL protein kinase Get druggable targets OG5_131234 All targets in OG5_131234
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Fibroblast growth factor receptor precursor, putative Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus granulosus basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_128769 All targets in OG5_128769
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus macrophage colony stimulating factor 1 receptor Get druggable targets OG5_132967 All targets in OG5_132967
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Tyrosine-protein kinase abl-1 Get druggable targets OG5_131234 All targets in OG5_131234
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase ABL1, putative Get druggable targets OG5_131234 All targets in OG5_131234
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Tyrosine-protein kinase abl-1 Tyrosine-protein kinase SRC   533 aa 455 aa 44.4 %
Onchocerca volvulus Cyclin-H homolog Tyrosine-protein kinase SRC   533 aa 453 aa 44.8 %
Schistosoma mansoni serine/threonine protein kinase Tyrosine-protein kinase SRC   533 aa 473 aa 24.5 %
Echinococcus multilocularis tyrosine protein kinase Btk29A Tyrosine-protein kinase SRC   533 aa 500 aa 35.0 %
Schistosoma mansoni tyrosine kinase Tyrosine-protein kinase SRC   533 aa 501 aa 35.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %
Echinococcus multilocularis tyrosine protein kinase Abl Tyrosine-protein kinase SRC   533 aa 506 aa 36.6 %
Echinococcus granulosus c src tyrosine kinase Tyrosine-protein kinase SRC   533 aa 513 aa 33.7 %
Onchocerca volvulus Tyrosine-protein kinase SRC   533 aa 435 aa 27.4 %
Echinococcus multilocularis c src tyrosine kinase Tyrosine-protein kinase SRC   533 aa 513 aa 33.9 %
Echinococcus multilocularis tyrosine protein kinase ABL1 Tyrosine-protein kinase SRC   533 aa 473 aa 39.1 %
Echinococcus granulosus tyrosine protein kinase ABL1 Tyrosine-protein kinase SRC   533 aa 473 aa 39.5 %
Echinococcus granulosus tyrosine protein kinase Btk29A Tyrosine-protein kinase SRC   533 aa 500 aa 35.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AUR protein kinase 0.0068 0.0123 0.0081
Trypanosoma brucei aurora B kinase 0.0068 0.0123 0.0872
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.017 0.1651 0.3973
Loa Loa (eye worm) TK protein kinase 0.0157 0.1464 0.3379
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0241 0.2718 0.6544
Echinococcus granulosus tyrosine protein kinase shark 0.0087 0.0403 0.0403
Echinococcus multilocularis tyrosine protein kinase shark 0.0087 0.0403 0.0971
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0068 0.0123 0.0297
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0153 0.1402 0.1402
Echinococcus granulosus c src tyrosine kinase 0.0099 0.059 0.059
Echinococcus multilocularis tyrosine kinase 0.0087 0.0403 0.0971
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0123 0.0332
Schistosoma mansoni nephrin 0.0069 0.0135 0.0365
Schistosoma mansoni tyrosine kinase 0.0096 0.0534 0.1438
Echinococcus multilocularis epidermal growth factor receptor 0.0153 0.1402 0.3375
Loa Loa (eye worm) SRC-1 0.017 0.1651 0.3839
Echinococcus granulosus aurora kinase A 0.0068 0.0123 0.0123
Brugia malayi Tyrosine-protein kinase abl-1 0.0195 0.2024 0.7325
Echinococcus multilocularis tyrosine protein kinase HCK 0.0128 0.1021 0.2457
Echinococcus multilocularis tyrosine protein kinase Src42A 0.01 0.0595 0.1433
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.1409 0.4954
Loa Loa (eye worm) TK/EGFR protein kinase 0.0237 0.2657 0.6316
Brugia malayi SRC-1 0.017 0.1651 0.5885
Echinococcus granulosus tyrosine protein kinase Srms 0.0087 0.0403 0.0403
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0157 0.1464 0.1464
Echinococcus granulosus tyrosine protein kinase HCK 0.0128 0.1021 0.1021
Echinococcus granulosus mitogen activated protein kinase 14 0.0154 0.1413 0.1413
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0154 0.1413 1
Schistosoma mansoni tyrosine kinase 0.0237 0.2657 0.7159
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0099 0.059 0.159
Loa Loa (eye worm) hypothetical protein 0.0153 0.1395 0.3209
Echinococcus granulosus tyrosine kinase 0.0087 0.0403 0.0403
Schistosoma mansoni tyrosine kinase 0.017 0.1651 0.4447
Echinococcus granulosus epidermal growth factor receptor 0.0153 0.1402 0.1402
Loa Loa (eye worm) TK/INSR protein kinase 0.0114 0.0812 0.1775
Echinococcus multilocularis tyrosine protein kinase Blk 0.0157 0.1464 0.3523
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0087 0.0403 0.0971
Schistosoma mansoni tyrosine kinase 0.0096 0.0534 0.1438
Loa Loa (eye worm) TK protein kinase 0.0128 0.1021 0.229
Echinococcus granulosus tyrosine protein kinase Src42A 0.017 0.1651 0.1651
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.017 0.1651 0.1651
Echinococcus multilocularis tyrosine protein kinase Fgr 0.017 0.1651 0.3973
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.0123 0.1207
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0069 0.013 0.013
Entamoeba histolytica protein kinase , putative 0.0068 0.0123 0.1207
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0241 0.2718 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0069 0.013 0.0097
Brugia malayi Protein kinase domain containing protein 0.0241 0.2718 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0154 0.1413 0.3402
Onchocerca volvulus 0.0087 0.0403 0.1057
Echinococcus multilocularis mitogen activated protein kinase 11 0.0154 0.1413 0.3402
Echinococcus multilocularis tyrosine protein kinase Fyn 0.017 0.1651 0.3973
Loa Loa (eye worm) TK/ABL protein kinase 0.0336 0.4154 1
Echinococcus multilocularis neuroglian 0.0069 0.0135 0.0326
Echinococcus granulosus tyrosine protein kinase Lyn 0.0173 0.169 0.169
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0099 0.059 0.142
Echinococcus granulosus tyrosine protein kinase Fyn 0.017 0.1651 0.1651
Echinococcus multilocularis insulin receptor 0.0114 0.0812 0.1954
Loa Loa (eye worm) hypothetical protein 0.0078 0.026 0.0416
Loa Loa (eye worm) hypothetical protein 0.0078 0.026 0.0416
Schistosoma mansoni tyrosine kinase 0.017 0.1651 0.4447
Schistosoma mansoni tyrosine kinase 0.0096 0.0534 0.1438
Trypanosoma cruzi aurora B kinase, putative 0.0068 0.0123 0.0872
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0154 0.1413 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0177 0.1753 0.1753
Echinococcus multilocularis tyrosine protein kinase Abl 0.0195 0.2024 0.4873
Schistosoma mansoni tyrosine kinase 0.0114 0.0812 0.2187
Brugia malayi Immunoglobulin I-set domain containing protein 0.0124 0.0959 0.3219
Brugia malayi P38 map kinase family protein 2 0.0154 0.1413 0.4971
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0068 0.0123 0.1207
Onchocerca volvulus 0.0087 0.0403 0.1057
Brugia malayi Protein kinase domain containing protein 0.0114 0.0812 0.2653
Echinococcus multilocularis roundabout 2 0.0078 0.026 0.0625
Echinococcus multilocularis tyrosine protein kinase Src42A 0.017 0.1651 0.3973
Entamoeba histolytica protein kinase, putative 0.0068 0.0123 0.1207
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0068 0.0123 0.1207
Brugia malayi Furin-like cysteine rich region family protein 0.0237 0.2657 0.9764
Trichomonas vaginalis CAMK family protein kinase 0.0241 0.2718 1
Echinococcus multilocularis aurora kinase A 0.0068 0.0123 0.0297
Echinococcus granulosus tyrosine protein kinase ABL1 0.0336 0.4154 0.4154
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0069 0.013 0.0312
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0157 0.1464 0.3523
Echinococcus granulosus neuroglian 0.0069 0.0135 0.0135
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0087 0.0403 0.3949
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.017 0.1651 0.3973
Schistosoma mansoni cell adhesion molecule 0.0066 0.009 0.0243
Echinococcus multilocularis c src tyrosine kinase 0.0099 0.059 0.142
Toxoplasma gondii aurora kinase 0.0068 0.0123 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.017 0.1651 0.1651
Brugia malayi Protein kinase domain containing protein 0.0087 0.0403 0.1079
Schistosoma mansoni tyrosine kinase 0.0177 0.1753 0.4724
Schistosoma mansoni tyrosine kinase 0.0114 0.0812 0.2187
Leishmania major protein kinase, putative 0.0068 0.0123 0.0872
Schistosoma mansoni tyrosine kinase 0.0077 0.0254 0.0684
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0336 0.4154 1
Echinococcus granulosus mitogen activated protein kinase 11 0.0154 0.1413 0.1413
Loa Loa (eye worm) AUR protein kinase 0.0068 0.0123 0.0081
Schistosoma mansoni tyrosine kinase 0.0099 0.059 0.159
Schistosoma mansoni tyrosine kinase 0.0307 0.3711 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.017 0.1651 0.3973
Onchocerca volvulus 0.0087 0.0403 0.1057
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0241 0.2718 0.7325
Echinococcus granulosus tyrosine protein kinase Blk 0.0157 0.1464 0.1464
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0403 0.077
Echinococcus granulosus insulin receptor 0.0114 0.0812 0.0812
Schistosoma mansoni tyrosine kinase 0.0087 0.0403 0.1086
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0403 0.077
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0154 0.1413 1
Schistosoma mansoni protein kinase 0.0068 0.0123 0.0332
Onchocerca volvulus 0.0087 0.0403 0.1057
Onchocerca volvulus 0.0087 0.0403 0.1057
Echinococcus multilocularis mitogen activated protein kinase 14 0.0154 0.1413 0.3402
Onchocerca volvulus 0.0087 0.0403 0.1057
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0403 0.077
Echinococcus granulosus roundabout 2 0.0078 0.026 0.026
Plasmodium falciparum serine/threonine protein kinase, putative 0.0068 0.0123 1
Echinococcus granulosus tyrosine kinase 0.0157 0.1464 0.1464
Schistosoma mansoni tyrosine kinase 0.0087 0.0403 0.1086
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0403 0.077
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0087 0.0403 0.0403
Echinococcus multilocularis tyrosine protein kinase Srms 0.0157 0.1464 0.3523
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0147 0.0397
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0403 0.077
Brugia malayi protein-tyrosine kinase 0.0157 0.1464 0.5165
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0099 0.059 0.059
Echinococcus granulosus tyrosine protein kinase Fyn 0.017 0.1651 0.1651
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0114 0.0812 0.0812
Loa Loa (eye worm) TK protein kinase 0.0188 0.1922 0.4508
Echinococcus granulosus twitchin 0.0072 0.0175 0.0175
Echinococcus multilocularis epidermal growth factor receptor 0.0237 0.2657 0.6396
Entamoeba histolytica protein kinase, putative 0.0128 0.1021 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.017 0.1651 0.3973
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0124 0.0959 0.2137
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0403 0.077
Brugia malayi SH2 domain containing protein 0.0087 0.0403 0.1079
Echinococcus multilocularis tyrosine protein kinase Fyn 0.017 0.1651 0.3973
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0177 0.1753 0.422
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0177 0.1753 0.422
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0154 0.1413 0.3255
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0154 0.1413 1
Entamoeba histolytica protein kinase, putative 0.0068 0.0123 0.1207
Echinococcus granulosus tyrosine protein kinase Fyn 0.017 0.1651 0.1651
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0403 0.077
Giardia lamblia Kinase, TTK 0.0241 0.2718 1
Brugia malayi SH2 domain containing protein 0.0087 0.0403 0.1079
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0068 0.0123 0.1207
Schistosoma mansoni tyrosine kinase 0.0099 0.059 0.159
Loa Loa (eye worm) TTK protein kinase 0.0241 0.2718 0.6467
Brugia malayi Immunoglobulin I-set domain containing protein 0.0188 0.1922 0.6933
Echinococcus multilocularis mitogen activated protein kinase 14 0.0154 0.1413 0.3402
Echinococcus granulosus tyrosine protein kinase Src64B 0.017 0.1651 0.1651
Brugia malayi Protein kinase domain containing protein 0.0087 0.0403 0.1079
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0241 0.2718 0.2718
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0068 0.0123 0.5
Schistosoma mansoni tyrosine kinase 0.0153 0.1402 0.3778
Brugia malayi Protein kinase domain containing protein 0.0087 0.0403 0.1079
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0066 0.009 0.009
Echinococcus granulosus epidermal growth factor receptor 0.0237 0.2657 0.2657
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0177 0.1753 0.1753
Brugia malayi Protein kinase domain containing protein 0.0087 0.0403 0.1079
Echinococcus multilocularis tyrosine protein kinase Src64B 0.017 0.1651 0.3973
Loa Loa (eye worm) hypothetical protein 0.0087 0.0403 0.077
Trichomonas vaginalis CAMK family protein kinase 0.0241 0.2718 1
Brugia malayi Protein kinase domain containing protein 0.0087 0.0403 0.1079
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0114 0.0812 0.1954
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0068 0.0123 0.0123
Loa Loa (eye worm) AUR protein kinase 0.0068 0.0123 0.0081
Schistosoma mansoni tyrosine kinase 0.0153 0.1402 0.3778
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0403 0.077
Echinococcus granulosus tyrosine protein kinase Src42A 0.01 0.0595 0.0595
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0403 0.077
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.0403 0.077
Brugia malayi hypothetical protein 0.0087 0.0403 0.1079

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.6 nM Inhibition of human recombinant Abl ChEMBL. 19889540
IC50 (functional) < 10 nM Cytotoxicity against Philadelphia chromosome positive human MEG01 cells by Alamar Blue fluorescent assay ChEMBL. 19889540
IC50 (functional) < 10 nM Cytotoxicity against Philadelphia chromosome positive human K562 cells by Alamar Blue fluorescent assay ChEMBL. 19889540
IC50 (binding) = 43 nM Inhibition of human recombinant Src ChEMBL. 19889540
IC50 (binding) = 76 nM Inhibition of human recombinant PDGFR ChEMBL. 19889540
IC50 (binding) = 187 nM Inhibition of human recombinant P38alpha ChEMBL. 19889540
IC50 (binding) > 1000 nM Inhibition of human recombinant C-Kit ChEMBL. 19889540
IC50 (functional) = 5000 nM Cytotoxicity against Philadelphia chromosome negative human Jurkat cells by Alamar Blue fluorescent assay ChEMBL. 19889540
IC50 (binding) = 0.02 uM Inhibition of avian c-Src tyrosine kinase ChEMBL. 9703473
IC50 (binding) = 0.02 uM Inhibition of avian c-Src tyrosine kinase ChEMBL. 9703473
IC50 (binding) = 0.15 uM Inhibitory concentration was evaluated against epidermal growth factor receptor (EGFr) tyrosine kinase ChEMBL. 9703473
IC50 (binding) = 0.15 uM Inhibitory concentration was evaluated against epidermal growth factor receptor (EGFr) tyrosine kinase ChEMBL. 9703473
IC50 (binding) = 0.18 uM Inhibitory concentration evaluated against fibroblast growth factor receptor 1. ChEMBL. 9703473
IC50 (binding) = 0.18 uM Inhibitory concentration evaluated against fibroblast growth factor receptor 1. ChEMBL. 9703473
IC50 (binding) = 0.41 uM Inhibitory concentration of the compound was evaluated against Platelet-derived growth factor receptor beta (PDGFr) tyrosine kinase ChEMBL. 9703473
IC50 (binding) = 0.41 uM Inhibitory concentration of the compound was evaluated against Platelet-derived growth factor receptor beta (PDGFr) tyrosine kinase ChEMBL. 9703473

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19889540

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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