Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hypothetical WD-repeat protein F21H12.1 in chromosome II | 0.0071 | 0.0572 | 0.0518 |
Schistosoma mansoni | hypothetical protein | 0.0622 | 1 | 1 |
Loa Loa (eye worm) | SPRY domain-containing protein | 0.0041 | 0.0056 | 0.0056 |
Schistosoma mansoni | retinoblastoma binding protein | 0.0071 | 0.0572 | 0.0518 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0071 | 0.0572 | 0.0572 |
Echinococcus granulosus | serotonin transporter | 0.0182 | 0.2475 | 0.2432 |
Onchocerca volvulus | 0.0622 | 1 | 1 | |
Toxoplasma gondii | SPRY domain-containing protein | 0.0038 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0056 | 0.5 |
Trichomonas vaginalis | retinoblastoma binding protein, putative | 0.0071 | 0.0572 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2475 | 0.2475 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0182 | 0.2475 | 0.2475 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0572 | 0.0572 |
Echinococcus multilocularis | protein will die slowly | 0.0622 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0182 | 0.2475 | 0.2432 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2475 | 0.2475 |
Echinococcus granulosus | wd40 repeat | 0.0071 | 0.0572 | 0.0518 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0182 | 0.2475 | 0.2475 |
Echinococcus multilocularis | serotonin transporter | 0.0182 | 0.2475 | 0.2432 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | serotonin transporter b | 0.0182 | 0.2475 | 0.2475 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0182 | 0.2475 | 0.2432 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0056 | 0.0056 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0182 | 0.2475 | 0.2432 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0182 | 0.2475 | 0.5 |
Plasmodium falciparum | SPRY domain, putative | 0.0041 | 0.0056 | 0.5 |
Echinococcus multilocularis | wd40 repeat | 0.0071 | 0.0572 | 0.0518 |
Echinococcus granulosus | protein will die slowly | 0.0622 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2475 | 0.2475 |
Trichomonas vaginalis | WD repeat domain, putative | 0.0622 | 1 | 1 |
Loa Loa (eye worm) | WD40 repeat protein | 0.0622 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 557 nM | Displacement of [3H]citalopram from Sprague-Dawley rat brain SERT after 60 mins by liquid scintillation counting analysis | ChEMBL. | 24494745 |
Ki (binding) | = 1270 nM | Displacement of [3H]WIN35,428 from Sprague-Dawley rat brain DAT after 120 mins by liquid scintillation counting analysis | ChEMBL. | 24494745 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.