Detailed information for compound 1834825

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 375.464 | Formula: C23H25N3O2
  • H donors: 1 H acceptors: 2 LogP: 4.27 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1[C@@H]2CCC[C@H]1C[C@@H](C2)NC(=O)c1cccc2c1oc(n2)c1ccccc1
  • InChi: 1S/C23H25N3O2/c1-26-17-9-5-10-18(26)14-16(13-17)24-22(27)19-11-6-12-20-21(19)28-23(25-20)15-7-3-2-4-8-15/h2-4,6-8,11-12,16-18H,5,9-10,13-14H2,1H3,(H,24,27)/t16-,17-,18+
  • InChiKey: ZXDOWRQWHIUDFJ-NNZMDNLPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cation transporter family protein 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 484 aa 469 aa 28.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0079 0.1938 0.2061
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0037 0.0674 0.0717
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0353 0.7217
Echinococcus granulosus single minded 2 0.0076 0.1852 0.1969
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0042 0.0809 0.0861
Entamoeba histolytica Ran family GTPase 0.0023 0.0225 0.0811
Schistosoma mansoni intermediate filament proteins 0.0029 0.0409 0.0435
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0238 0.0253
Echinococcus granulosus snurportin 1 0.0327 0.9405 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.1938 0.1938
Brugia malayi hypothetical protein 0.0027 0.0353 0.0353
Echinococcus multilocularis ecdysone induced protein 78C 0.0079 0.1938 0.2061
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0674
Schistosoma mansoni lamin 0.0029 0.0409 0.0435
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0079 0.1938 0.1938
Trichomonas vaginalis ran, putative 0.0023 0.0225 0.0331
Loa Loa (eye worm) hypothetical protein 0.0027 0.0353 0.0353
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0052 0.0052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0079 0.1938 0.2061
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0052 0.0055
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0809 0.0809
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0082 0.0726
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1589 1
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0023 0.0238 0.0427
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.149 0.1585
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1589 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0809 0.0809
Loa Loa (eye worm) nuclear hormone receptor 0.0037 0.0674 0.0674
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1589 1
Echinococcus granulosus geminin 0.018 0.4973 0.5287
Leishmania major hypothetical protein, conserved 0.0027 0.0353 0.196
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0353 0.2094
Echinococcus multilocularis lamin 0.0029 0.0409 0.0435
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0225 0.113
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0469 0.0499
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0674
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0294 0.0491
Echinococcus multilocularis musashi 0.0029 0.0409 0.0435
Echinococcus multilocularis transfer RNA-Lys 0.0076 0.1852 0.1969
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0355 0.1976
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0079 0.1938 0.1938
Brugia malayi photoreceptor-specific nuclear receptor 0.0079 0.1938 0.1938
Echinococcus multilocularis aryl hydrocarbon receptor 0.0027 0.0355 0.0378
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0353 0.196
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0674 0.0717
Onchocerca volvulus 0.0018 0.0082 0.0422
Schistosoma mansoni nuclear receptor 0.0037 0.0674 0.0717
Echinococcus multilocularis nuclear receptor nhr 48 0.0037 0.0674 0.0717
Brugia malayi nuclear receptor NHR-67 0.0037 0.0674 0.0674
Brugia malayi Cathepsin L-like precursor 0.0018 0.0082 0.0082
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0225 0.416
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0355 0.0631
Onchocerca volvulus 0.0051 0.109 0.5626
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0674
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0037 0.0674 0.0717
Echinococcus granulosus Aminotransferase class III 0.0023 0.0238 0.0253
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0037 0.0674 0.0674
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0042 0.0809 0.0861
Entamoeba histolytica hypothetical protein 0.0076 0.185 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0674 0.0717
Leishmania major cathepsin L-like protease 0.0018 0.0082 0.0197
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0082 0.0087
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0052 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0079 0.1938 0.1938
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0469 0.2716
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0674 0.0717
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.149 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.1938 0.1938
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0079 0.1938 0.1938
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0082
Schistosoma mansoni hypothetical protein 0.0327 0.9405 1
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0082 0.0422
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0082 0.0197
Leishmania major protein kinase, putative 0.0027 0.0355 0.1976
Brugia malayi Cytochrome P450 family protein 0.003 0.0447 0.0447
Echinococcus granulosus ecdysone induced protein 78C 0.0079 0.1938 0.2061
Mycobacterium ulcerans putative regulatory protein 0.0076 0.1852 0.3864
Echinococcus multilocularis snurportin 1 0.0327 0.9405 1
Loa Loa (eye worm) fibroinase 0.0018 0.0082 0.0082
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0674 0.0717
Schistosoma mansoni retinoic acid receptor RXR 0.0079 0.1938 0.2061
Loa Loa (eye worm) hypothetical protein 0.0042 0.0809 0.0809
Schistosoma mansoni importin beta-1 0.0031 0.0469 0.0499
Loa Loa (eye worm) hypothetical protein 0.0079 0.1938 0.1938
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0079 0.1938 0.1938
Plasmodium falciparum importin beta, putative 0.0031 0.0469 1
Leishmania major cytochrome p450-like protein 0.003 0.0447 0.2571
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0225 0.416
Mycobacterium ulcerans hypothetical protein 0.0161 0.4415 1
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0023 0.0238 0.0427
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0079 0.1938 0.1938
Schistosoma mansoni lamin 0.0029 0.0409 0.0435
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0027 0.0355 0.0378
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0355 0.1976
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.149 0.3298
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0355 0.0631
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0225 0.113
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0079 0.1938 0.2061
Schistosoma mansoni RAR-like nuclear receptor 0.0079 0.1938 0.2061
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0082 0.0422
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0225 0.0225
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0079 0.1938 0.2061
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.1589 1
Schistosoma mansoni hypothetical protein 0.0051 0.109 0.1159
Brugia malayi bHLH-PAS transcription factor 0.0076 0.1852 0.1852
Onchocerca volvulus Bile acid receptor homolog 0.0079 0.1938 1
Plasmodium vivax ornithine aminotransferase, putative 0.0023 0.0238 0.446
Leishmania major importin beta-1 subunit, putative 0.0025 0.0294 0.158
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0079 0.1938 0.2061
Brugia malayi nuclear hormone receptor family member odr-7 0.0037 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0674
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0355 0.1976
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0294 0.158
Echinococcus granulosus lamin 0.0029 0.0409 0.0435
Entamoeba histolytica hypothetical protein 0.0076 0.185 1
Echinococcus multilocularis Aminotransferase class III 0.0023 0.0238 0.0253
Echinococcus granulosus lamin dm0 0.0029 0.0409 0.0435
Onchocerca volvulus 0.0029 0.0409 0.2112
Schistosoma mansoni hypothetical protein 0.0047 0.0966 0.1027
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0008 0.0008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.149 0.2999
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.0238 0.0253
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0079 0.1938 0.2061
Brugia malayi hypothetical protein 0.0042 0.0809 0.0809
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0079 0.1938 0.1938
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0294 0.0491
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.0447 0.0501
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0079 0.1938 0.2061
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0079 0.1938 0.2061
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0674 0.0674
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0674 0.0717
Entamoeba histolytica hypothetical protein 0.0076 0.185 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.1152 0.7155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1589 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0674
Brugia malayi hypothetical protein 0.0042 0.0809 0.0809
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0355 0.0631
Loa Loa (eye worm) hypothetical protein 0.0029 0.0409 0.0409
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.0355 0.0355
Echinococcus granulosus nuclear receptor nhr 48 0.0037 0.0674 0.0717
Loa Loa (eye worm) hypothetical protein 0.0079 0.1938 0.1938
Schistosoma mansoni coup transcription factor 0.0079 0.1938 0.2061
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0037 0.0674 0.0717
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0674 0.0717
Leishmania major cathepsin L-like protease 0.0018 0.0082 0.0197
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0674
Entamoeba histolytica hypothetical protein 0.0076 0.185 1
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0023 0.0238 0.0427
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0052 0.0055
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.149 0.2999
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0353 0.7217
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0353 0.7217
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0042 0.0809 0.0809
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0355 0.0631
Brugia malayi Nuclear hormone receptor-like 1 0.0079 0.1938 0.1938
Brugia malayi Cathepsin L-like precursor 0.0018 0.0082 0.0082
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.149 0.1585
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0161 0.4415 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1589 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.1938 0.1938
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0082 0.0082
Loa Loa (eye worm) nuclear receptor NHR-67 0.0037 0.0674 0.0674
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1589 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0079 0.1938 0.2061
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0082 0.0082
Brugia malayi Importin beta-1 subunit 0.0031 0.0469 0.0469
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0079 0.1938 0.2061
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0082 0.0087
Brugia malayi nuclear receptor RXR 0.0042 0.0809 0.0809
Brugia malayi intermediate filament protein 0.0029 0.0409 0.0409
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0082 0.0087
Brugia malayi orphan nuclear receptor NR2E1 0.0037 0.0674 0.0674
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0082 0.0087
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0674
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0225 0.024
Leishmania major cathepsin L-like protease 0.0068 0.1589 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0079 0.1938 0.1938
Loa Loa (eye worm) hypothetical protein 0.0042 0.0809 0.0809
Onchocerca volvulus 0.0018 0.0082 0.0422
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0052 0.0052
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.149 0.1585
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0355 0.0631
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.712 0.757
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.149 0.2999
Schistosoma mansoni nuclear receptor nhr-48 0.0037 0.0674 0.0717
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0447 0.2571
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0355 0.1976
Brugia malayi nuclear receptor NHR-88 0.0037 0.0674 0.0674
Brugia malayi Cathepsin L-like precursor 0.0018 0.0082 0.0082
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0079 0.1938 0.2061
Schistosoma mansoni thyroid hormone receptor 0.0079 0.1938 0.2061
Leishmania major cathepsin L-like protease 0.0068 0.1589 1
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0674 0.0717
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0079 0.1938 0.2061
Loa Loa (eye worm) hypothetical protein 0.0042 0.0809 0.0809
Brugia malayi nuclear hormone receptor 0.0037 0.0674 0.0674
Echinococcus granulosus cathepsin l1 0.0018 0.0082 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0079 0.1938 0.1938
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0079 0.1938 0.1938
Onchocerca volvulus 0.0018 0.0082 0.0422
Leishmania major protein kinase, putative 0.0027 0.0355 0.1976
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0353 0.196
Onchocerca volvulus 0.0018 0.0082 0.0422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1589 1
Brugia malayi hypothetical protein 0.0037 0.0674 0.0674
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0355 0.0631
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0079 0.1938 0.1938
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0079 0.1938 0.1938
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0409 0.0409
Brugia malayi ecdysteroid receptor 0.0079 0.1938 0.1938
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0082 0.0087
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0052 0.0055
Echinococcus multilocularis FTZ F1 alpha 0.0079 0.1938 0.2061
Trypanosoma brucei cytochrome P450, putative 0.003 0.0447 0.2571
Echinococcus granulosus thyroid hormone receptor alpha 0.0037 0.0674 0.0717
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0355 0.0631
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0809 0.0809
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0355 0.1976
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.185 0.1967
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0079 0.1938 0.1938
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0079 0.1938 0.2061
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0079 0.1938 0.2061
Leishmania major cathepsin L-like protease 0.0018 0.0082 0.0197
Loa Loa (eye worm) ctsf protein 0.0018 0.0082 0.0082
Onchocerca volvulus 0.0018 0.0082 0.0422
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0161 0.4415 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0052 0.0055
Onchocerca volvulus 0.0037 0.0674 0.3478
Brugia malayi nuclear hormone receptor family member nhr-6 0.0037 0.0674 0.0674
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.185 0.1967
Loa Loa (eye worm) hypothetical protein 0.0251 0.712 0.712
Loa Loa (eye worm) steroid hormone receptor 0.0079 0.1938 0.1938
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0238 0.0253
Loa Loa (eye worm) CYP4Cod1 0.003 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.0107
Entamoeba histolytica hypothetical protein 0.0025 0.0294 0.1202
Brugia malayi nuclear receptor NHR-88 0.0079 0.1938 0.1938
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0082 0.0082
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0225 0.024
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0225 0.5
Echinococcus multilocularis lamin dm0 0.0029 0.0409 0.0435
Brugia malayi Cathepsin L-like precursor 0.0018 0.0082 0.0082
Onchocerca volvulus 0.0018 0.0082 0.0422
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0079 0.1938 0.2061
Brugia malayi ecdysone receptor 0.0037 0.0674 0.0674
Echinococcus multilocularis geminin 0.018 0.4973 0.5287
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0079 0.1938 0.1938
Echinococcus granulosus FTZ F1 alpha 0.0079 0.1938 0.2061
Leishmania major GTP-binding protein, putative 0.0023 0.0225 0.113
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0079 0.1938 0.2061
Brugia malayi PAS domain containing protein 0.0103 0.2662 0.2662
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0447 0.0447
Echinococcus granulosus intermediate filament protein 0.0029 0.0409 0.0435
Plasmodium vivax importin-beta 2, putative 0.0031 0.0469 1
Plasmodium vivax vivapain-2 0.0018 0.0082 0.0726
Trichomonas vaginalis adenylate cyclase, putative 0.0027 0.0355 0.0631
Brugia malayi steroid hormone receptor 0.0079 0.1938 0.1938
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0082 0.0726
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0809 0.0861
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0674 0.0674
Loa Loa (eye worm) hypoxia-induced factor 1 0.0319 0.919 0.919
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0355 0.1976
Schistosoma mansoni ran 0.0023 0.0225 0.024
Echinococcus multilocularis cysteine protease 0.0018 0.0082 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0353 0.196
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0042 0.0809 0.0861
Onchocerca volvulus 0.0037 0.0674 0.3478
Onchocerca volvulus 0.0076 0.1852 0.9555
Onchocerca volvulus 0.0079 0.1938 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0079 0.1938 0.2061
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0082 0.0422
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0008 0.0008
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0327 0.9405 0.9405
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0082 0.0087
Schistosoma mansoni steroid hormone receptor ad4bp 0.0079 0.1938 0.2061
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0079 0.1938 0.2061
Loa Loa (eye worm) hypothetical protein 0.0079 0.1938 0.1938
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.712 0.757
Echinococcus granulosus aryl hydrocarbon receptor 0.0027 0.0355 0.0378
Schistosoma mansoni survival motor neuron protein 0.0051 0.109 0.1159
Plasmodium falciparum ornithine aminotransferase 0.0023 0.0238 0.446
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0082 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1589 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0674
Schistosoma mansoni hypothetical protein 0.018 0.4973 0.5287
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.149 0.1585
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0023 0.0238 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0079 0.1938 0.1938
Loa Loa (eye worm) hypothetical protein 0.0028 0.0393 0.0393
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.185 0.1967
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0674 0.3478
Brugia malayi tailless protein 0.0037 0.0674 0.0674
Brugia malayi Cathepsin L-like precursor 0.0018 0.0082 0.0082
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0052 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0079 0.1938 0.1938
Leishmania major cathepsin L-like protease 0.0018 0.0082 0.0197
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0225 0.0225
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0037 0.0674 0.0717
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0409 0.0409
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.109 0.109
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.149 0.9359
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0023 0.0238 0.0427
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0161 0.4415 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0355 0.0355
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0355 0.1976
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0225 0.1207
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0294 0.0491
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0079 0.1938 0.1938
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0079 0.1938 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0079 0.1938 0.1938
Schistosoma mansoni single-minded 0.0103 0.2662 0.283
Brugia malayi hypothetical protein 0.0076 0.185 0.185
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0037 0.0674 0.0674
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0161 0.4415 1
Brugia malayi hypothetical protein 0.0037 0.0674 0.0674
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0225 0.113
Schistosoma mansoni hypothetical protein 0.0076 0.185 0.1967
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0027 0.0355 0.0631
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1589 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0809 0.0809
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1589 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0079 0.1938 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1589 1
Schistosoma mansoni hypothetical protein 0.018 0.4973 0.5287
Brugia malayi conserved hypotetical protein 0.0037 0.0674 0.0674
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0674 0.3478
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0082 0.0087
Schistosoma mansoni zinc finger protein 0.0037 0.0674 0.0717
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0052 0.0055
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0674
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0023 0.0238 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0082 0.0197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0079 0.1938 0.1938
Schistosoma mansoni ran 0.0023 0.0225 0.024
Brugia malayi hypothetical protein 0.0017 0.0067 0.0067
Schistosoma mansoni nuclear receptor 0.0037 0.0674 0.0717
Loa Loa (eye worm) DR-78 0.0037 0.0674 0.0674
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0355 0.0631
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1589 1
Echinococcus granulosus importin subunit beta 1 0.0031 0.0469 0.0499
Leishmania major cathepsin L-like protease 0.0068 0.1589 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1589 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0082 0.0082
Schistosoma mansoni aryl hydrocarbon receptor 0.0103 0.2662 0.283
Onchocerca volvulus 0.0027 0.0355 0.1834
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0674
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1589 1
Brugia malayi isocitrate dehydrogenase 0.0017 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0079 0.1938 0.1938
Brugia malayi Steroid receptor seven-up type 2 0.0079 0.1938 0.1938
Schistosoma mansoni nuclear hormone receptor 0.0079 0.1938 0.2061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0079 0.1938 0.2061
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0027 0.0355 0.0631
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.1412 0.8847
Brugia malayi hypothetical protein 0.0251 0.712 0.712
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0409 0.0409
Plasmodium vivax vivapain-2 0.0018 0.0082 0.0726
Mycobacterium leprae Possible regulatory protein 0.0027 0.0355 0.0282
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0469 0.2716
Brugia malayi hypoxia-induced factor 1 0.0319 0.919 0.919
Mycobacterium tuberculosis Probable aminotransferase 0.0161 0.4415 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0079 0.1938 0.2061
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0674
Schistosoma mansoni thyroid hormone receptor 0.0079 0.1938 0.2061
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0037 0.0674 0.0717
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0674
Leishmania major cathepsin L-like protease 0.0018 0.0082 0.0197
Brugia malayi Cytochrome P450 family protein 0.003 0.0447 0.0447
Brugia malayi nuclear hormone receptor 0.0079 0.1938 0.1938
Loa Loa (eye worm) hypothetical protein 0.0031 0.0469 0.0469
Toxoplasma gondii cathepsin CPL 0.0018 0.0082 0.0211
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0674 0.0717
Loa Loa (eye worm) hypothetical protein 0.0079 0.1938 0.1938
Loa Loa (eye worm) cysteine protease 0.0018 0.0082 0.0082
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0447 0.0447
Echinococcus granulosus ornithine aminotransferase 0.0023 0.0238 0.0253
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0674
Brugia malayi nuclear receptor RXR 0.0037 0.0674 0.0674
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0082 0.0726
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0027 0.0355 0.0378
Brugia malayi RNA, U transporter 1 0.0087 0.2172 0.2172
Loa Loa (eye worm) hypothetical protein 0.0079 0.1938 0.1938
Onchocerca volvulus 0.0018 0.0082 0.0422
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0447 0.2571
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0469 0.2902
Echinococcus multilocularis cysteine protease 0.0018 0.0082 0.0087
Onchocerca volvulus 0.0029 0.0409 0.2112
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0023 0.0238 0.1294

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 40.4 nM Binding affinity to human HT3A receptor ChEMBL. 20889341

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.