TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 348.4 | Formula: C14H12N4O3S2
H donors: 2 H acceptors: 5 LogP: 1.72 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1nnc(s1)c1ccc(cc1)C)CC1SC(=O)NC1=O
InChi: 1S/C14H12N4O3S2/c1-7-2-4-8(5-3-7)12-17-18-13(23-12)15-10(19)6-9-11(20)16-14(21)22-9/h2-5,9H,6H2,1H3,(H,15,18,19)(H,16,20,21)
InChiKey: VZBDMMVHQYNDOB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0085	0.0993	0.0993
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0085	0.0993	0.0993
Onchocerca volvulus		0.0085	0.0993	0.3592
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0016	0.006	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0016	0.006	0.0095
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0085	0.0993	0.1569
Schistosoma mansoni	hypothetical protein	0.0012	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0085	0.0993	0.1156
Brugia malayi	hypothetical protein	0.0085	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0085	0.0993	0.1569
Onchocerca volvulus		0.0085	0.0993	0.3592
Echinococcus multilocularis	transfer RNA-Phe	0.0012	0.0002	0.0002
Schistosoma mansoni	serine/threonine protein kinase	0.0012	0.0002	0.0003
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0344	0.45	0.7113
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0114	0.1387	0.1615
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0213	0.2732	0.3181
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0012	0.0002	0.0003
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0085	0.0993	0.1569
Loa Loa (eye worm)	CAMK protein kinase	0.0012	0.0002	0.0003
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0086	0.1011	0.1177
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0085	0.0993	0.1111
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0016	0.006	0.0095
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0213	0.2732	0.4318
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0086	0.1011	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0215	0.2764	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0085	0.0993	0.1156
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0012	0.0002	0.0003
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0016	0.006	0.0095
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0085	0.0993	0.1569
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0085	0.0993	0.1569
Giardia lamblia	Dual specificity phosphatase, catalytic	0.0192	0.2444	0.8194
Onchocerca volvulus		0.0085	0.0993	0.3592
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0085	0.0993	0.1569
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0117	0.1433	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0085	0.0993	0.1569
Schistosoma mansoni	hemicentin	0.0012	0.0002	0.0003
Onchocerca volvulus		0.0085	0.0993	0.3592
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0085	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0106	0.1275	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0085	0.0993	0.1569
Onchocerca volvulus		0.0085	0.0993	0.3592
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0114	0.1387	0.2192
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Onchocerca volvulus		0.0085	0.0993	0.3592
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0215	0.2764	0.4369
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0012	0.0002	0.0002
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase	0.0085	0.0993	0.1569
Onchocerca volvulus		0.0085	0.0993	0.3592
Brugia malayi	hypothetical protein	0.0085	0.0993	0.1569
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0016	0.006	0.0095
Onchocerca volvulus		0.0215	0.2764	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0085	0.0993	0.1111
Brugia malayi	protein unc-22	0.0012	0.0002	0.0003
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0012	0.0002	0.0003
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0085	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0645	0.8588	0.8588
Onchocerca volvulus		0.0085	0.0993	0.3592
Schistosoma mansoni	cell adhesion molecule	0.0012	0.0002	0.0003
Echinococcus multilocularis	sortilin receptor	0.0021	0.0125	0.0146
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0344	0.45	0.45
Onchocerca volvulus		0.0085	0.0993	0.3592
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0223	0.2872	0.454
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0085	0.0993	0.1569
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0106	0.1275	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0085	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0215	0.2764	0.3092
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0172	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Echinococcus multilocularis	roundabout 2	0.0012	0.0002	0.0002
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0215	0.2764	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0237	0.0375
Brugia malayi	Protein-tyrosine phosphatase	0.0093	0.1105	0.1747
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Onchocerca volvulus		0.0085	0.0993	0.3592
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0085	0.0993	0.0993
Onchocerca volvulus		0.0192	0.2444	0.8843
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0478	0.6326	0.6326
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0085	0.0995	0.1573
Echinococcus granulosus	carbonic anhydrase	0.0016	0.006	0.006
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0645	0.8588	1
Schistosoma mansoni	hypothetical protein	0.0016	0.006	0.0095
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0478	0.6326	0.7367
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0215	0.2764	0.2465
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Echinococcus multilocularis	roundabout 2	0.0012	0.0002	0.0002
Trichomonas vaginalis	pten, drome, putative	0.0085	0.0993	0.0304
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0106	0.1275	0.2015
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0114	0.1387	0.2192
Echinococcus multilocularis	roundabout 2	0.0012	0.0002	0.0002
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0085	0.0993	0.7679
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0117	0.1433	0.2266
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0215	0.2764	0.2465
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Onchocerca volvulus		0.0012	0.0002	0.0007
Echinococcus multilocularis	dual specificity protein phosphatase	0.0192	0.2444	0.2846
Echinococcus granulosus	neuroglian	0.0012	0.0002	0.0002
Onchocerca volvulus		0.0085	0.0993	0.3592
Plasmodium falciparum	carbonic anhydrase	0.0016	0.006	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0012	0.0002	0.0003
Schistosoma mansoni	carbonic anhydrase-related	0.0016	0.006	0.0095
Onchocerca volvulus		0.0085	0.0993	0.3592
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0093	0.1105	0.1747
Echinococcus multilocularis	carbonic anhydrase	0.0016	0.006	0.007
Onchocerca volvulus		0.0085	0.0993	0.3592
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0085	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0344	0.45	0.524
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Echinococcus multilocularis	carbonic anhydrase II	0.0016	0.006	0.007
Schistosoma mansoni	nephrin	0.0012	0.0002	0.0003
Schistosoma mansoni	myosin-binding protein-related	0.0012	0.0002	0.0003
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0215	0.2764	0.3092
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0003
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0215	0.2764	0.2465
Brugia malayi	Ferm domain	0.0091	0.1077	0.1703
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0085	0.0993	1
Onchocerca volvulus		0.0085	0.0993	0.3592
Schistosoma mansoni	protein tyrosine phosphatase	0.0093	0.1105	0.1747
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0223	0.2872	0.2872
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0085	0.0993	0.1156
Onchocerca volvulus		0.0085	0.0993	0.3592
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0114	0.1387	0.1615
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0114	0.1387	0.2192
Echinococcus multilocularis	titin	0.0012	0.0002	0.0002
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0344	0.45	0.45
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0085	0.0993	0.1569
Onchocerca volvulus		0.0012	0.0002	0.0007
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0149	0.1864	0.5
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Onchocerca volvulus		0.0106	0.1275	0.4612
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Echinococcus granulosus	nephrin	0.0012	0.0002	0.0002
Echinococcus multilocularis	neuroglian	0.0012	0.0002	0.0002
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1077	0.1703
Echinococcus granulosus	roundabout 2	0.0012	0.0002	0.0002
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0085	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase 1	0.0086	0.1011	0.1598
Entamoeba histolytica	dual specificity protein phosphatase, putative	0.0671	0.8939	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0117	0.1433	0.1433
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0478	0.6326	1
Schistosoma mansoni	carbonic anhydrase-related	0.0016	0.006	0.0095
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0085	0.0993	0.1569
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0344	0.45	0.7113
Toxoplasma gondii	hypothetical protein	0.0016	0.006	0.5
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0085	0.0993	0.1569
Echinococcus granulosus	titin	0.0012	0.0002	0.0002
Echinococcus granulosus	carbonic anhydrase	0.0016	0.006	0.006
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0085	0.0993	0.0993
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0085	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Echinococcus multilocularis	hypothetical protein	0.0085	0.0993	0.1156
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0016	0.006	0.0095
Leishmania major	tyrosine specific protein phosphatase, putative	0.0106	0.1275	1
Loa Loa (eye worm)	dual specificity phosphatase	0.0192	0.2444	0.3863
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0215	0.2764	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0344	0.45	0.7113
Leishmania major	hypothetical protein, conserved	0.0066	0.0744	0.5627
Onchocerca volvulus		0.0085	0.0993	0.3592
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0106	0.1275	0.1484
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0085	0.0993	0.1569
Trypanosoma cruzi	hypothetical protein, conserved	0.0066	0.0744	0.5627
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0016	0.006	0.0095
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0085	0.0993	0.1569
Echinococcus granulosus	titin	0.0012	0.0002	0.0002
Schistosoma mansoni	carbonic anhydrase-related	0.0016	0.006	0.0095
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0117	0.1433	0.1433
Schistosoma mansoni	cell adhesion molecule	0.0012	0.0002	0.0003
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0213	0.2732	0.2732
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0012	0.0002	0.0003
Schistosoma mansoni	carbonic anhydrase	0.0016	0.006	0.0095
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0215	0.2764	0.2465
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0653	0.87	0.87
Trypanosoma cruzi	hypothetical protein, conserved	0.0066	0.0744	0.5627
Echinococcus granulosus	roundabout 2	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0003
Echinococcus granulosus	roundabout 2	0.0012	0.0002	0.0002
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0106	0.1275	0.1484
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0016	0.006	0.0095
Brugia malayi	hypothetical protein	0.0085	0.0993	0.1569
Onchocerca volvulus		0.0085	0.0993	0.3592
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Schistosoma mansoni	neuroglian	0.0012	0.0002	0.0003
Schistosoma mansoni	titin	0.0012	0.0002	0.0003
Onchocerca volvulus		0.0085	0.0993	0.3592
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0003
Loa Loa (eye worm)	projectin	0.0012	0.0002	0.0003
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0012	0.0002	0.0003
Echinococcus granulosus	carbonic anhydrase	0.0016	0.006	0.006
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0085	0.0993	0.1156
Brugia malayi	Dual specificity phosphatase, catalytic domain containing protein	0.0192	0.2444	0.3863
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0478	0.6326	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0215	0.2764	0.2465
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Onchocerca volvulus		0.0085	0.0993	0.3592
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0085	0.0993	0.1156
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0086	0.1011	0.1598
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Echinococcus granulosus	carbonic anhydrase II	0.0016	0.006	0.006
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.0671	0.8939	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0117	0.1433	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0016	0.006	0.0095
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0117	0.1433	0.1669
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0215	0.276	0.3087
Schistosoma mansoni	titin	0.0012	0.0002	0.0003
Brugia malayi	hypothetical protein	0.0085	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Schistosoma mansoni	cell adhesion molecule	0.0012	0.0002	0.0003
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0085	0.0993	0.1156
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0066	0.0744	0.7328
Onchocerca volvulus		0.0085	0.0993	0.3592
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0016	0.006	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0016	0.006	0.0095
Onchocerca volvulus		0.0085	0.0993	0.3592
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0478	0.6326	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0344	0.45	0.524
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Schistosoma mansoni	protein tyrosine phosphatase	0.0085	0.0993	0.1569
Schistosoma mansoni	pcd6 interacting protein-related	0.0085	0.0993	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Echinococcus granulosus	contactin	0.0012	0.0002	0.0002
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0085	0.0993	0.0993
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0016	0.006	0.0095
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0016	0.006	0.0095
Echinococcus granulosus	dual specificity protein phosphatase	0.0192	0.2444	0.2444
Schistosoma mansoni	protein tyrosine phosphatase	0.0085	0.0993	0.1569
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0085	0.0993	0.0993
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0085	0.0993	0.1569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0223	0.2872	0.3344
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0085	0.0993	0.1569
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0213	0.273	0.3179
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0085	0.0993	0.1569
Onchocerca volvulus		0.0012	0.0002	0.0007
Brugia malayi	hypothetical protein	0.0085	0.0993	0.1569
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0016	0.006	0.0095
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0085	0.0993	0.0993
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0993	0.1569
Schistosoma mansoni	nephrin	0.0012	0.0002	0.0003
Onchocerca volvulus	4.1 G protein, putative homolog	0.0089	0.1056	0.3819
Schistosoma mansoni	dual specificity protein phosphatase	0.0192	0.2444	0.3863
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0085	0.0993	0.1569
Onchocerca volvulus		0.0091	0.1077	0.3898
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0002	0.0003
Onchocerca volvulus		0.0085	0.0993	0.3592
Echinococcus multilocularis	carbonic anhydrase	0.0016	0.006	0.007
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0106	0.1275	0.1484
Echinococcus multilocularis		0.0085	0.0993	0.1156
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0215	0.2764	0.2465
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0085	0.0993	0.0993
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0085	0.0993	0.7679
Loa Loa (eye worm)	carbonic anhydrase 3	0.0016	0.006	0.0095
Echinococcus multilocularis	carbonic anhydrase	0.0016	0.006	0.007
Schistosoma mansoni	cell adhesion molecule	0.0012	0.0002	0.0003

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 52 uM	Cytotoxicity against Homo sapiens (human) MCF7 cells after 24 hr by MTT assay	ChEMBL.	No reference
MIC (functional)	= 16 ug ml-1	Antifungal activity against Candida albicans ATCC 2091 after 48 hr by NCCLS two-fold serial dilution method	ChEMBL.	No reference
MIC (functional)	= 16 ug ml-1	Antibacterial activity against Escherichia coli ATCC 35218 after 24 hr by NCCLS two-fold serial dilution method	ChEMBL.	No reference
MIC (functional)	= 32 ug ml-1	Antifungal activity against Cryptococcus neoformans clinical isolate after 48 hr by NCCLS two-fold serial dilution method	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2260543

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1841225