Detailed information for compound 1865519

Basic information

Technical information
  • TDR Targets ID: 1865519
  • Name: N-[(4-methoxyphenyl)methyl]propan-2-amine
  • MW: 179.259 | Formula: C11H17NO
  • H donors: 1 H acceptors: 0 LogP: 2.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CNC(C)C
  • InChi: 1S/C11H17NO/c1-9(2)12-8-10-4-6-11(13-3)7-5-10/h4-7,9,12H,8H2,1-3H3
  • InChiKey: RVROZYOHWNUUNB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • isopropyl-(4-methoxybenzyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0236 0.0557
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0165 0.0165
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0027 0.0027
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0098 0.0855 0.0855
Plasmodium falciparum glutathione reductase 0.0051 0.0355 0.1369
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0279
Schistosoma mansoni hypothetical protein 0.0035 0.0183 0.0183
Toxoplasma gondii phosphoglycerate kinase PGKII 0.02 0.1954 1
Brugia malayi CXXC zinc finger family protein 0.0067 0.0521 0.0882
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0434 0.1797
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0165 0.0165
Onchocerca volvulus 0.0191 0.1858 0.4644
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0355 0.1369
Echinococcus multilocularis neuropeptide receptor A26 0.0544 0.5644 0.5644
Mycobacterium tuberculosis Probable reductase 0.0117 0.1058 0.5164
Trypanosoma brucei unspecified product 0.0045 0.0293 0.088
Plasmodium vivax ataxin-2 like protein, putative 0.0058 0.0434 0.1797
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0293 0.0496
Brugia malayi RNA binding protein 0.0313 0.3166 0.5357
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0293 0.088
Toxoplasma gondii NAC domain-containing protein 0.004 0.0236 0.0727
Echinococcus granulosus transcription factor Dp 1 0.0134 0.124 0.124
Brugia malayi hypothetical protein 0.0058 0.0434 0.0734
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0165 0.0279
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0165 0.0279
Schistosoma mansoni ap endonuclease 0.0044 0.028 0.028
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0434 0.147
Brugia malayi exodeoxyribonuclease III family protein 0.0044 0.028 0.0475
Trypanosoma brucei phosphoglycerate kinase 0.02 0.1954 0.8489
Schistosoma mansoni coup transcription factor 0.0033 0.0165 0.0165
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0165 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0165 0.0279
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0044 0.028 0.0969
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0183 0.0183
Trypanosoma brucei trypanothione reductase 0.0051 0.0355 0.1162
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0293 0.088
Brugia malayi isocitrate dehydrogenase 0.0035 0.0179 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0165 0.0279
Echinococcus multilocularis GPCR, family 2 0.0035 0.0183 0.0183
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.1058 0.5164
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0165 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0165 0.0279
Trypanosoma brucei phosphoglycerate kinase 0.0073 0.0594 0.226
Echinococcus granulosus microtubule associated protein 2 0.0811 0.8518 0.8518
Trichomonas vaginalis glucosylceramidase, putative 0.0393 0.4026 0.675
Echinococcus multilocularis transcription factor Dp 1 0.0134 0.124 0.124
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0179 0.0179
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0165 0.0165
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0165 0.0165
Treponema pallidum exodeoxyribonuclease (exoA) 0.0044 0.028 0.0969
Leishmania major phosphoglycerate kinase B, cytosolic 0.02 0.1954 0.8489
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0165 0.0279
Brugia malayi Phosphoglycerate kinase 0.0073 0.0594 0.1006
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0293 0.088
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0183 0.0309
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0165 0.0165
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0165 0.0165
Trichomonas vaginalis phosphoglycerate kinase, putative 0.02 0.1954 0.3175
Chlamydia trachomatis phosphoglycerate kinase 0.02 0.1954 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0141 0.1324 0.1324
Giardia lamblia DINP protein human, muc B family 0.0045 0.0293 0.0968
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0293 0.088
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0165 0.0165
Brugia malayi MH2 domain containing protein 0.0266 0.266 0.4502
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0024 0.0041
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0029 0.0115 0.0064
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0351 0.3572 0.6045
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0142 0.0187
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0279
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0029 0.0115 0.0076
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.0997 0.1688
Echinococcus multilocularis Eukaryotic translation initiation factor 4H 0.0313 0.3166 0.3166
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.1198 0.5918
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.0997 0.1688
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0293 0.088
Loa Loa (eye worm) hypothetical protein 0.0105 0.0936 0.1584
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.1058 0.5164
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0231 0.2284 0.2284
Echinococcus multilocularis neuropeptide s receptor 0.0544 0.5644 0.5644
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0279
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0179 0.0422
Trypanosoma cruzi phosphoglycerate kinase, putative 0.02 0.1954 0.8479
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.02 0.1954 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0231 0.2284 1
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0179 0.0303
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0236 0.0727
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0044 0.028 0.0969
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0165 0.0165
Trichomonas vaginalis glucosylceramidase, putative 0.0568 0.5909 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0165 0.0279
Echinococcus multilocularis dna polymerase eta 0.0105 0.0936 0.0936
Schistosoma mansoni microtubule-associated protein tau 0.0811 0.8518 0.8518
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.0997 0.1688
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0183 0.0183
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0029 0.0115 0.0076
Loa Loa (eye worm) hypothetical protein 0.0058 0.0434 0.0734
Brugia malayi beta-NAC-like protein 0.004 0.0236 0.0399
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0179 0.0422
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0293 0.0293
Echinococcus multilocularis dnaJ subfamily B 0.0949 1 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0073 0.0594 0.221
Brugia malayi glutathione reductase 0.0051 0.0355 0.06
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0073 0.0594 0.221
Toxoplasma gondii LsmAD domain-containing protein 0.0058 0.0434 0.1797
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0044 0.028 0.0823
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0165 0.0279
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0293 0.0307
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0179 0.0422
Mycobacterium ulcerans glutaminase 0.0313 0.3168 1
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0279
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0179 0.0358
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0179 0.0179
Trichomonas vaginalis glucosylceramidase, putative 0.0373 0.381 0.6378
Brugia malayi hypothetical protein 0.0351 0.3572 0.6045
Trichomonas vaginalis glucosylceramidase, putative 0.0568 0.5909 1
Schistosoma mansoni cpg binding protein 0.0067 0.0521 0.0521
Echinococcus multilocularis transcription factor btf3 0.004 0.0236 0.0236
Echinococcus granulosus neuropeptide receptor A26 0.0544 0.5644 0.5644
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.02 0.1954 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0142 0.0187
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0029 0.0115 0.0076
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0313 0.3166 0.3166
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0179 0.0179
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0183 0.0309
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0044 0.028 0.0969
Brugia malayi ImpB/MucB/SamB family protein 0.0105 0.0936 0.1584
Echinococcus multilocularis microtubule associated protein 2 0.0811 0.8518 0.8518
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0179 0.0296
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0165 0.0165
Schistosoma mansoni phosphoglycerate kinase 0.02 0.1954 0.1954
Schistosoma mansoni hypothetical protein 0.0949 1 1
Onchocerca volvulus Glucosylceramidase homolog 0.0373 0.381 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0293 0.0821
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0293 0.088
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0165 0.0165
Trypanosoma brucei DNA polymerase eta, putative 0.0105 0.0936 0.3826
Loa Loa (eye worm) transcription factor SMAD2 0.0266 0.266 0.4502
Echinococcus multilocularis phosphoglycerate kinase 1 0.02 0.1954 0.1954
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.1198 0.5918
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0179 0.0179
Echinococcus multilocularis L aminoadipate semialdehyde 0.0098 0.0855 0.0855
Leishmania major hypothetical protein, conserved 0.0058 0.0434 0.1525
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0293 0.088
Trichomonas vaginalis glucosylceramidase, putative 0.0568 0.5909 1
Trichomonas vaginalis phosphoglycerate kinase, putative 0.02 0.1954 0.3175
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0073 0.0594 0.221
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0098 0.0855 0.1447
Echinococcus granulosus Eukaryotic translation initiation factor 4H 0.0313 0.3166 0.3166
Schistosoma mansoni terminal deoxycytidyl transferase 0.0045 0.0293 0.0293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0165 0.0279
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0236 0.0617
Trichomonas vaginalis glucosylceramidase, putative 0.0373 0.381 0.6378
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0313 0.3166 0.3166
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0279
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0044 0.028 0.0475
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0165 0.0165
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0044 0.028 0.0969
Leishmania major basic transcription factor 3a, putative 0.004 0.0236 0.0617
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0029 0.0115 0.0194
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0045 0.0293 0.0293
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0165 0.0165
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0179 0.0179
Trypanosoma brucei unspecified product 0.0031 0.0142 0.0187
Trypanosoma cruzi DNA polymerase eta, putative 0.0105 0.0936 0.3786
Leishmania major DNA polymerase eta, putative 0.0105 0.0936 0.3826
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0231 0.2284 1
Plasmodium falciparum phosphoglycerate kinase 0.02 0.1954 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0183 0.0183
Echinococcus granulosus L aminoadipate semialdehyde 0.0098 0.0855 0.0855
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0044 0.028 0.0763
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0293 0.0626
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0236 0.0727
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0165 0.0165
Echinococcus granulosus GPCR family 2 0.0035 0.0183 0.0183
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0165 0.0165
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0293 0.0307
Plasmodium falciparum thioredoxin reductase 0.0051 0.0355 0.1369
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0165 0.0165
Trypanosoma brucei phosphoglycerate kinase 0.02 0.1954 0.8489
Trichomonas vaginalis glucosylceramidase, putative 0.0373 0.381 0.6378
Onchocerca volvulus 0.0067 0.0521 0.0977
Loa Loa (eye worm) glutathione reductase 0.0051 0.0355 0.06
Onchocerca volvulus 0.0098 0.0855 0.1894
Loa Loa (eye worm) hypothetical protein 0.0029 0.0115 0.0194
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0179 0.0358
Schistosoma mansoni hypothetical protein 0.0035 0.0183 0.0183
Trichomonas vaginalis ap endonuclease, putative 0.0044 0.028 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0165 0.0279
Trichomonas vaginalis glucosylceramidase, putative 0.0568 0.5909 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0165 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0293 0.088
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0165 0.0165
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0165 0.0279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0293 0.0821
Schistosoma mansoni phosphoglycerate kinase 0.02 0.1954 0.1954
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0191 0.1858 0.1858
Leishmania major phosphoglycerate kinase C, glycosomal 0.02 0.1954 0.8489
Echinococcus granulosus dna polymerase eta 0.0105 0.0936 0.0936
Treponema pallidum phosphoglycerate kinase 0.02 0.1954 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0165 0.0279
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0313 0.3166 0.3166
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0236 0.0557
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0236 0.0617
Brugia malayi nuclear receptor NHR-88 0.0033 0.0165 0.0279
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0231 0.2284 1
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0179 0.0422
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0355 0.1369
Schistosoma mansoni ap endonuclease 0.0044 0.028 0.028
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0191 0.1858 0.1858
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0279
Trypanosoma brucei phosphoglycerate kinase, putative 0.0073 0.0594 0.226
Leishmania major DNA polymerase kappa, putative 0.0045 0.0293 0.088
Toxoplasma gondii thioredoxin reductase 0.0051 0.0355 0.1369
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0165 0.0165
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0027 0.0046
Loa Loa (eye worm) glutaminase 0.0313 0.3168 0.5361
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0044 0.028 0.0586
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0165 0.0279
Loa Loa (eye worm) hypothetical protein 0.0035 0.0183 0.0309
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0044 0.028 0.0763
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0191 0.1858 0.1858
Schistosoma mansoni cpg binding protein 0.007 0.0562 0.0562
Trypanosoma brucei unspecified product 0.0031 0.0142 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0165 0.0279
Brugia malayi Thioredoxin reductase 0.0051 0.0355 0.06
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0044 0.028 0.0823
Echinococcus granulosus dna polymerase kappa 0.0045 0.0293 0.0293
Loa Loa (eye worm) ICD-1 protein 0.004 0.0236 0.0399
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0165 0.0165
Brugia malayi steroid hormone receptor 0.0033 0.0165 0.0279
Plasmodium vivax glutathione reductase, putative 0.0051 0.0355 0.1369
Schistosoma mansoni hypothetical protein 0.0026 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0076 0.062 0.105
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0434 0.147
Loa Loa (eye worm) hypothetical protein 0.02 0.1954 0.3307
Schistosoma mansoni cpg binding protein 0.007 0.0562 0.0562
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0165 0.0165
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0179 0.0179
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0044 0.028 0.0823
Toxoplasma gondii phosphoglycerate kinase PGKI 0.02 0.1954 1
Echinococcus multilocularis cpg binding protein 0.007 0.0562 0.0562
Brugia malayi hypothetical protein 0.0038 0.0211 0.0357
Loa Loa (eye worm) hypothetical protein 0.0313 0.3166 0.5357
Schistosoma mansoni hypothetical protein 0.0028 0.0111 0.0111
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0293 0.088
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0293 0.088
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.1058 0.5164
Loa Loa (eye worm) MH2 domain-containing protein 0.0266 0.266 0.4502
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0293 0.088
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0044 0.028 0.028
Plasmodium vivax phosphoglycerate kinase, putative 0.02 0.1954 1
Loa Loa (eye worm) hypothetical protein 0.0191 0.1858 0.3144
Loa Loa (eye worm) hypothetical protein 0.0111 0.0997 0.1688
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0087 0.0087
Loa Loa (eye worm) CXXC zinc finger family protein 0.0067 0.0521 0.0882
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0044 0.028 0.09
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0029 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0028 0.0111 0.0188
Echinococcus granulosus cpg binding protein 0.007 0.0562 0.0562
Schistosoma mansoni glutaminase 0.0313 0.3168 0.3168
Onchocerca volvulus 0.0351 0.3572 0.9346
Trichomonas vaginalis glucosylceramidase, putative 0.0373 0.381 0.6378
Trypanosoma cruzi DNA polymerase eta, putative 0.0074 0.06 0.2237
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0293 0.088
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0293 0.088
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0231 0.2284 0.3866
Trichomonas vaginalis glucosylceramidase, putative 0.0373 0.381 0.6378
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0142 0.0187
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0165 0.0165
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0231 0.2284 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0355 0.0355
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0293 0.088
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0355 0.0355
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0231 0.2284 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.02 0.1954 1
Brugia malayi Pip kinase protein 2 0.0191 0.1858 0.3144
Brugia malayi ecdysteroid receptor 0.0033 0.0165 0.0279
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0165 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0236 0.0208
Schistosoma mansoni hypothetical protein 0.0076 0.062 0.062
Trichomonas vaginalis glucosylceramidase, putative 0.0568 0.5909 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0165 0.0165
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.1198 0.5918
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0179 0.0296
Loa Loa (eye worm) pip kinase 2 0.0191 0.1858 0.3144
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0355 0.1105
Trichomonas vaginalis glucosylceramidase, putative 0.0393 0.4026 0.675
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0029 0.0115 0.0076
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0074 0.06 0.2693
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0568 0.5909 1
Trichomonas vaginalis ap endonuclease, putative 0.0044 0.028 0.0286
Trichomonas vaginalis glucosylceramidase, putative 0.0568 0.5909 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0231 0.2284 0.2284
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0045 0.0293 0.0293
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0073 0.0594 0.221
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0568 0.5909 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0165 0.0279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0165 0.0279
Trichomonas vaginalis glucosylceramidase, putative 0.0373 0.381 0.6378
Leishmania major hypothetical protein, conserved 0.0029 0.0115 0.0064
Schistosoma mansoni DNA polymerase eta 0.0105 0.0936 0.0936
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0029 0.0115 0.0064
Entamoeba histolytica deoxycytidyl transferase, putative 0.0045 0.0293 0.088
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0293 0.1036
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0231 0.2284 0.3866
Loa Loa (eye worm) hypothetical protein 0.0098 0.0855 0.1447
Trichomonas vaginalis glutaminase, putative 0.0313 0.3168 0.5269
Schistosoma mansoni transcription factor btf3 0.004 0.0236 0.0236
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0179 0.0179
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0027 0.0027
Brugia malayi Phosphoglycerate kinase 0.02 0.1954 0.3307
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0231 0.2284 0.2284
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0029 0.0115 0.0115
Giardia lamblia Phosphoglycerate kinase 0.02 0.1954 1
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.1198 0.5918
Trypanosoma cruzi phosphoglycerate kinase, putative 0.02 0.1954 0.8479
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0044 0.028 0.028
Schistosoma mansoni hypothetical protein 0.0035 0.0183 0.0183
Loa Loa (eye worm) glutaminase 2 0.0313 0.3168 0.5361
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0293 0.0626
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0434 0.1797
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0279
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0165 0.0279
Toxoplasma gondii exonuclease III APE 0.0044 0.028 0.0969
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0045 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.0279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0165 0.0279
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0165 0.0165
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0073 0.0594 0.226
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0293 0.1036
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0183 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0236 0.0208
Trichomonas vaginalis glucosylceramidase, putative 0.0373 0.381 0.6378
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0165 0.0279
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0179 0.0422
Echinococcus granulosus neuropeptide s receptor 0.0544 0.5644 0.5644
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0191 0.1858 0.1858
Trypanosoma brucei PAB1-binding protein , putative 0.0058 0.0434 0.1525
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.1058 0.5164
Echinococcus granulosus transcription factor btf3 0.004 0.0236 0.0236
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0293 0.0821
Echinococcus granulosus phosphoglycerate kinase 1 0.02 0.1954 0.1954
Mycobacterium ulcerans phosphoglycerate kinase 0.02 0.1954 0.6044
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0029 0.0115 0.0115
Entamoeba histolytica hypothetical protein 0.004 0.0236 0.0617
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0165 0.0165
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.1058 0.5164
Brugia malayi glutaminase DH11.1 0.0313 0.3168 0.5361
Entamoeba histolytica phosphoglycerate kinase, putative 0.02 0.1954 0.8489
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0165 0.0165
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0179 0.0303
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0183 0.0183
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.062 0.105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0165 0.0279
Brugia malayi nuclear hormone receptor 0.0033 0.0165 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0236 0.0208
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0179 0.0358
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0355 0.06
Toxoplasma gondii histone lysine methyltransferase SET1 0.0126 0.1162 0.5723
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0045 0.0293 0.0496
Schistosoma mansoni hypothetical protein 0.0035 0.0183 0.0183
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0165 0.0165
Echinococcus multilocularis 0.0029 0.0115 0.0115
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0029 0.0115 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0165 0.0279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0293 0.0821
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0165 0.0165
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0073 0.0594 0.221
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.1058 0.5164
Leishmania major DNA polymerase eta, putative 0.0074 0.06 0.2286
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0165 0.0279
Echinococcus granulosus CTD small phosphatase protein like 0.0029 0.0115 0.0115
Leishmania major trypanothione reductase 0.0051 0.0355 0.1162

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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