Detailed information for compound 1877634

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 251.371 | Formula: C11H13N3S2
  • H donors: 0 H acceptors: 0 LogP: 2.61 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC/N=c/1\scc(n1/N=C/c1cscc1)C
  • InChi: 1S/C11H13N3S2/c1-3-12-11-14(9(2)7-16-11)13-6-10-4-5-15-8-10/h4-8H,3H2,1-2H3/b12-11-,13-6+
  • InChiKey: HAVRRKKHDQKNIX-CNZPJCCLSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii calcium binding egf domain-containing protein 0.0125 0.0722 0.1863
Echinococcus multilocularis expressed conserved protein 0.0112 0.058 0.058
Brugia malayi PAN domain containing protein 0.0063 0.0055 0.0131
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0169 0.1208 0.1435
Schistosoma mansoni cercarial elastase (S01 family) 0.0125 0.072 0.0856
Brugia malayi Trypsin family protein 0.0125 0.072 0.1708
Echinococcus granulosus tumor protein p63 0.0408 0.3798 0.4409
Onchocerca volvulus 0.0073 0.0157 0.0371
Schistosoma mansoni egf-like domain protein 0.0125 0.0722 0.0858
Onchocerca volvulus 0.0063 0.0055 0.0131
Brugia malayi PAN domain containing protein 0.0063 0.0055 0.0131
Onchocerca volvulus 0.0063 0.0055 0.0131
Schistosoma mansoni hypothetical protein 0.0399 0.37 0.4396
Loa Loa (eye worm) hypothetical protein 0.0117 0.0642 0.149
Echinococcus granulosus enteropeptidase 0.0125 0.072 0.0682
Echinococcus multilocularis fibrillin 1 0.0125 0.0722 0.0722
Echinococcus multilocularis transmembrane protease serine 3 0.0125 0.072 0.072
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0125 0.0722 0.1681
Loa Loa (eye worm) hypothetical protein 0.0092 0.037 0.0842
Onchocerca volvulus 0.0125 0.072 0.1708
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0242 0.1995 0.237
Onchocerca volvulus 0.0399 0.37 0.8774
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0125 0.072 0.072
Brugia malayi Protein kinase domain containing protein 0.0393 0.3636 0.8623
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0073 0.0157 0.0371
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0125 0.072 0.0856
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8416 1
Echinococcus granulosus transmembrane protease serine 3 0.0125 0.072 0.0682
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0125 0.072 0.0856
Onchocerca volvulus Arrow homolog 0.0197 0.1511 0.3584
Loa Loa (eye worm) hypothetical protein 0.0125 0.072 0.1676
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0659 0.1562
Brugia malayi PAN domain containing protein 0.0063 0.0055 0.0131
Loa Loa (eye worm) hypothetical protein 0.0063 0.0055 0.0093
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0659 0.5
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0125 0.072 0.0856
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0073 0.0157 0.0157
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0073 0.0157 0.0371
Echinococcus granulosus expressed conserved protein 0.0112 0.058 0.0513
Onchocerca volvulus 0.0063 0.0055 0.0131
Loa Loa (eye worm) hypothetical protein 0.0073 0.0157 0.0334
Schistosoma mansoni hypothetical protein 0.0125 0.072 0.0856
Brugia malayi PAN domain containing protein 0.0063 0.0055 0.0131
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0073 0.0157 0.0186
Toxoplasma gondii calcium binding egf domain-containing protein 0.0125 0.0722 0.1863
Brugia malayi Calcium binding EGF domain containing protein 0.0073 0.0157 0.0371
Onchocerca volvulus 0.0125 0.072 0.1708
Onchocerca volvulus 0.0125 0.072 0.1708
Echinococcus granulosus glycoprotein Antigen 5 0.0125 0.072 0.0682
Loa Loa (eye worm) hypothetical protein 0.0063 0.0055 0.0093
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0073 0.0157 0.0186
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0659 0.0608
Onchocerca volvulus 0.0063 0.0055 0.0131
Onchocerca volvulus 0.0063 0.0055 0.0131
Toxoplasma gondii kringle domain-containing protein 0.0393 0.3636 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0125 0.072 0.0856
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0169 0.1208 0.2837
Brugia malayi Trypsin family protein 0.0125 0.072 0.1708
Loa Loa (eye worm) hypothetical protein 0.0399 0.37 0.877
Onchocerca volvulus 0.0073 0.0157 0.0371
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0016 0.0019
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0197 0.1511 0.3559
Echinococcus multilocularis enteropeptidase 0.0125 0.072 0.072
Onchocerca volvulus 0.0125 0.072 0.1708
Onchocerca volvulus 0.0073 0.0157 0.0371
Onchocerca volvulus 0.0399 0.37 0.8774
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8416 1
Loa Loa (eye worm) PAN domain-containing protein 0.0063 0.0055 0.0093
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2468 0.2799
Brugia malayi hypothetical protein 0.0286 0.2468 0.5853
Brugia malayi Trypsin family protein 0.0125 0.072 0.1708
Loa Loa (eye worm) hypothetical protein 0.0073 0.0157 0.0334
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0073 0.0157 0.0186
Brugia malayi PAN domain containing protein 0.0063 0.0055 0.0131
Brugia malayi Fibulin-1 precursor 0.0125 0.0722 0.1713
Loa Loa (eye worm) hypothetical protein 0.0447 0.4217 1
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0125 0.072 0.0682
Brugia malayi PAN domain containing protein 0.0063 0.0055 0.0131
Brugia malayi CUB domain containing protein 0.0117 0.0642 0.1523
Loa Loa (eye worm) hypothetical protein 0.0063 0.0055 0.0093
Schistosoma mansoni cercarial elastase (S01 family) 0.0125 0.072 0.0856
Brugia malayi hypothetical protein 0.0125 0.072 0.1708
Brugia malayi PAN domain containing protein 0.0063 0.0055 0.0131
Loa Loa (eye worm) PAN domain-containing protein 0.0063 0.0055 0.0093
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0073 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0073 0.0157 0.0334
Echinococcus multilocularis Mastin 0.0125 0.072 0.072
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0073 0.0157 0.0334
Schistosoma mansoni hypothetical protein 0.0073 0.0157 0.0186
Loa Loa (eye worm) hypothetical protein 0.0073 0.0157 0.0334
Echinococcus granulosus tissue type plasminogen activator 0.0393 0.3636 0.4213
Schistosoma mansoni hypothetical protein 0.0073 0.0157 0.0186
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0073 0.0157 0.0157
Schistosoma mansoni cercarial elastase (S01 family) 0.0125 0.072 0.0856
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0073 0.0157 0.0371
Schistosoma mansoni cercarial elastase (S01 family) 0.0125 0.072 0.0856
Schistosoma mansoni cercarial elastase (S01 family) 0.0125 0.072 0.0856
Onchocerca volvulus 0.0399 0.37 0.8774
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2468 0.2468
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0169 0.1206 0.1433
Echinococcus granulosus laminin 0.0125 0.0722 0.0685
Onchocerca volvulus 0.0073 0.0157 0.0371
Loa Loa (eye worm) hypothetical protein 0.0125 0.072 0.1676
Brugia malayi Calcium binding EGF domain containing protein 0.0125 0.0722 0.1713
Echinococcus granulosus Mastin 0.0125 0.072 0.0682
Loa Loa (eye worm) hypothetical protein 0.0242 0.1997 0.4715
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0679 0.0806
Schistosoma mansoni cercarial elastase (S01 family) 0.0125 0.072 0.0856
Echinococcus multilocularis low density lipoprotein receptor protein 0.0073 0.0157 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.0393 0.3636 0.5
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0073 0.0157 0.0157
Onchocerca volvulus 0.0125 0.072 0.1708
Loa Loa (eye worm) hypothetical protein 0.0119 0.0659 0.1529
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0073 0.0157 0.0371
Loa Loa (eye worm) hypothetical protein 0.0073 0.0157 0.0334
Loa Loa (eye worm) hypothetical protein 0.0063 0.0055 0.0093
Loa Loa (eye worm) hypothetical protein 0.0125 0.0722 0.1681
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8416 0.8416
Loa Loa (eye worm) hypothetical protein 0.0073 0.0157 0.0334
Loa Loa (eye worm) hypothetical protein 0.0125 0.072 0.1676
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0073 0.0157 0.0157
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0073 0.0157 0.0371
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0073 0.0157 0.0371
Onchocerca volvulus 0.0399 0.37 0.8774
Brugia malayi Calcium binding EGF domain containing protein 0.0092 0.037 0.0877
Loa Loa (eye worm) hypothetical protein 0.0063 0.0055 0.0093
Loa Loa (eye worm) PAN domain-containing protein 0.0063 0.0055 0.0093
Echinococcus multilocularis Tolloid protein 1 0.0169 0.1208 0.1208
Onchocerca volvulus 0.0447 0.4217 1
Brugia malayi Muscle positioning protein 4 0.0447 0.4217 1
Brugia malayi PAN domain containing protein 0.0063 0.0055 0.0131
Loa Loa (eye worm) hypothetical protein 0.0169 0.1208 0.2837
Echinococcus multilocularis tumor protein p63 0.0408 0.3798 0.3798
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0073 0.0157 0.0334
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0125 0.072 0.0856
Loa Loa (eye worm) hypothetical protein 0.0197 0.1511 0.3559
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0073 0.0157 0.0371
Leishmania major hypothetical protein, conserved 0.0393 0.3636 0.5
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0125 0.072 0.0682
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0073 0.0157 0.0157
Schistosoma mansoni cercarial elastase (S01 family) 0.0125 0.072 0.0856
Brugia malayi Kringle domain containing protein 0.0393 0.3636 0.8623
Loa Loa (eye worm) hypothetical protein 0.0125 0.0722 0.1681
Loa Loa (eye worm) hypothetical protein 0.0062 0.0046 0.0072
Loa Loa (eye worm) hypothetical protein 0.0063 0.0055 0.0093
Loa Loa (eye worm) hypothetical protein 0.0393 0.3636 0.8617
Schistosoma mansoni cercarial elastase (S01 family) 0.0125 0.072 0.0856
Brugia malayi Trypsin family protein 0.0125 0.072 0.1708
Onchocerca volvulus 0.006 0.0016 0.0038
Plasmodium falciparum cysteine repeat modular protein 1 0.0393 0.3636 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0125 0.072 0.0856
Onchocerca volvulus 0.0063 0.0055 0.0131
Onchocerca volvulus 0.0073 0.0157 0.0371
Brugia malayi PAN domain containing protein 0.0063 0.0055 0.0131
Loa Loa (eye worm) hypothetical protein 0.0125 0.072 0.1676
Schistosoma mansoni hypothetical protein 0.0393 0.3636 0.432
Mycobacterium ulcerans hypothetical protein 0.0125 0.072 0.5
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0073 0.0157 0.0371
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1213 0.1278
Onchocerca volvulus 0.0393 0.3636 0.8623
Loa Loa (eye worm) hypothetical protein 0.0125 0.072 0.1676
Loa Loa (eye worm) trypsin family protein 0.0125 0.072 0.1676
Loa Loa (eye worm) hypothetical protein 0.0073 0.0157 0.0334
Schistosoma mansoni hypothetical protein 0.0125 0.072 0.0856
Onchocerca volvulus 0.0073 0.0157 0.0371
Echinococcus multilocularis laminin 0.0125 0.0722 0.0722
Loa Loa (eye worm) TK/ROR protein kinase 0.0393 0.3636 0.8617
Loa Loa (eye worm) hypothetical protein 0.0073 0.0157 0.0334
Loa Loa (eye worm) hypothetical protein 0.0073 0.0157 0.0334
Brugia malayi PAN domain containing protein 0.0063 0.0055 0.0131
Brugia malayi basement membrane proteoglycan precursor 0.0073 0.0157 0.0371
Loa Loa (eye worm) hypothetical protein 0.0125 0.072 0.1676
Onchocerca volvulus 0.0063 0.0055 0.0131
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0659 0.0659
Onchocerca volvulus 0.0063 0.0055 0.0131
Loa Loa (eye worm) DOMON domain-containing protein 0.0399 0.37 0.877
Loa Loa (eye worm) hypothetical protein 0.0073 0.0157 0.0334
Loa Loa (eye worm) hypothetical protein 0.0125 0.072 0.1676
Onchocerca volvulus Putative cubilin 0.0092 0.037 0.0877
Loa Loa (eye worm) PAN domain-containing protein 0.0063 0.0055 0.0093
Onchocerca volvulus 0.0063 0.0055 0.0131
Loa Loa (eye worm) hypothetical protein 0.0063 0.0055 0.0093
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1213 0.1213
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0073 0.0157 0.0371
Onchocerca volvulus 0.0063 0.0055 0.0131
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0197 0.1511 0.3584
Echinococcus multilocularis tissue type plasminogen activator 0.0393 0.3636 0.3636
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0125 0.072 0.0856
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0073 0.0157 0.0157
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0125 0.072 0.0856
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0073 0.0157 0.0371
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0073 0.0157 0.0334
Onchocerca volvulus 0.0063 0.0055 0.0131
Schistosoma mansoni cercarial elastase (S01 family) 0.0125 0.072 0.0856
Loa Loa (eye worm) PAN domain-containing protein 0.0063 0.0055 0.0093
Echinococcus granulosus Tolloid protein 1 0.0169 0.1208 0.1273
Loa Loa (eye worm) hypothetical protein 0.0286 0.2468 0.5837
Brugia malayi enteropeptidase precursor 0.0073 0.0157 0.0371
Echinococcus multilocularis glycoprotein Antigen 5 0.0125 0.072 0.072
Brugia malayi Trypsin-like protease protein 5 0.0125 0.072 0.1708
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0073 0.0157 0.0334
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0125 0.072 0.1708
Onchocerca volvulus 0.0125 0.072 0.1708
Brugia malayi SEA domain containing protein 0.0399 0.37 0.8774
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0393 0.3636 0.5
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0125 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0073 0.0157 0.0334

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 11.088 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
Potency (functional) 0.3981 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1095 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 6.7456 uM PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Secondary FLuc Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 7.0795 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Firefly Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 2309 (Probe Summary for Inhibitors and Stabilizers of Firefly Luciferase)] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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