Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0008 | 0.0037 | 0.0037 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0005 | 0.0016 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Plasmodium vivax | aspartyl protease, putative | 0.0008 | 0.0037 | 0.0879 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0008 | 0.0037 | 0.0037 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.003 | 0.0231 | 0.0231 |
Brugia malayi | Cathepsin L-like precursor | 0.0005 | 0.0016 | 0.0016 |
Plasmodium falciparum | plasmepsin IX | 0.0008 | 0.0037 | 0.0879 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0231 | 0.0231 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0005 | 0.0016 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0005 | 0.0016 | 0.0673 |
Loa Loa (eye worm) | RING finger protein nhl-1 | 0.003 | 0.0231 | 0.0231 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0008 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | B-box zinc finger family protein | 0.003 | 0.0231 | 0.0231 |
Leishmania major | cathepsin L-like protease | 0.0005 | 0.0016 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0033 | 0.0257 | 0.0257 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0096 | 0.0818 | 0.0818 |
Leishmania major | cathepsin L-like protease | 0.0005 | 0.0016 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0005 | 0.0016 | 0.0016 |
Brugia malayi | Hypothetical RING finger protein F54G8.4 in chromosome III | 0.003 | 0.0231 | 0.0231 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0047 | 0.0388 | 0.0373 |
Leishmania major | cathepsin L-like protease | 0.0005 | 0.0016 | 0.5 |
Onchocerca volvulus | Cathepsin F homolog | 0.0005 | 0.0016 | 0.4227 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0231 | 0.0231 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0005 | 0.0016 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0033 | 0.0257 | 0.0242 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Brugia malayi | B-box zinc finger family protein | 0.003 | 0.0231 | 0.0231 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0008 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0037 | 0.0037 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Entamoeba histolytica | cysteine protease, putative | 0.0005 | 0.0016 | 0.0673 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0005 | 0.0016 | 0.0016 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0005 | 0.0016 | 0.0016 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0008 | 0.0037 | 0.0037 |
Plasmodium falciparum | plasmepsin III | 0.0008 | 0.0037 | 0.0879 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Mycobacterium tuberculosis | PE-PGRS family protein PE_PGRS17 | 0.003 | 0.0231 | 0.5 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0008 | 0.0037 | 0.0037 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Giardia lamblia | Haloacid dehalogenase-like hydrolase family | 0.003 | 0.0231 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0005 | 0.0016 | 0.0016 |
Leishmania major | cathepsin L-like protease | 0.0005 | 0.0016 | 0.5 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0008 | 0.0037 | 0.0879 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0047 | 0.0388 | 0.0388 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0008 | 0.0037 | 0.0879 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0008 | 0.0037 | 0.0037 |
Giardia lamblia | Hypothetical protein | 0.003 | 0.0231 | 0.5 |
Echinococcus granulosus | tripartite motif containing protein 3 | 0.003 | 0.0231 | 0.0231 |
Leishmania major | cysteine peptidase A (CPA) | 0.0005 | 0.0016 | 0.5 |
Plasmodium falciparum | plasmepsin II | 0.0033 | 0.0257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0016 | 0.0016 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0047 | 0.0388 | 0.0373 |
Loa Loa (eye worm) | fibroinase | 0.0005 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0005 | 0.0016 | 0.0016 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0047 | 0.0388 | 0.0388 |
Brugia malayi | Cathepsin L-like precursor | 0.0005 | 0.0016 | 0.0016 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0008 | 0.0037 | 0.0879 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0231 | 0.0231 |
Onchocerca volvulus | 0.0005 | 0.0016 | 0.4227 | |
Toxoplasma gondii | aspartyl protease | 0.0008 | 0.0037 | 0.0879 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Loa Loa (eye worm) | cysteine protease | 0.0005 | 0.0016 | 0.0016 |
Echinococcus multilocularis | tripartite motif containing protein 3 | 0.003 | 0.0231 | 0.0216 |
Echinococcus granulosus | cathepsin l1 | 0.0005 | 0.0016 | 0.0016 |
Leishmania major | cathepsin L-like protease | 0.0005 | 0.0016 | 0.5 |
Brugia malayi | B-box zinc finger family protein | 0.003 | 0.0231 | 0.0231 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.0008 | 0.0037 | 0.0879 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Plasmodium falciparum | plasmepsin VII | 0.0008 | 0.0037 | 0.0879 |
Plasmodium falciparum | plasmepsin I | 0.0033 | 0.0257 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Onchocerca volvulus | 0.0005 | 0.0016 | 0.4227 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0005 | 0.0016 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0047 | 0.0388 | 0.0388 |
Onchocerca volvulus | 0.0005 | 0.0016 | 0.4227 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0005 | 0.0016 | 0.0673 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0047 | 0.0388 | 0.0388 |
Plasmodium falciparum | plasmepsin IV | 0.0033 | 0.0257 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0033 | 0.0257 | 0.0257 |
Plasmodium falciparum | plasmepsin VI | 0.0033 | 0.0257 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Plasmodium vivax | plasmepsin V, putative | 0.0008 | 0.0037 | 0.0879 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Plasmodium falciparum | plasmepsin V | 0.0008 | 0.0037 | 0.0879 |
Loa Loa (eye worm) | B-box zinc finger family protein | 0.003 | 0.0231 | 0.0231 |
Loa Loa (eye worm) | ctsf protein | 0.0005 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0005 | 0.0016 | 0.4227 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Loa Loa (eye worm) | NCL-1 protein | 0.003 | 0.0231 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0257 | 0.0257 |
Plasmodium falciparum | plasmepsin X | 0.0008 | 0.0037 | 0.0879 |
Onchocerca volvulus | 0.0005 | 0.0016 | 0.4227 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Brugia malayi | Cathepsin L-like precursor | 0.0005 | 0.0016 | 0.0016 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0047 | 0.0388 | 0.0388 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0005 | 0.0016 | 0.0016 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0033 | 0.0257 | 1 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0601 | 0.5296 | 0.5296 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0096 | 0.0818 | 0.0818 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0601 | 0.5296 | 0.5296 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0008 | 0.0037 | 0.0037 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Onchocerca volvulus | 0.0005 | 0.0016 | 0.4227 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.0231 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0008 | 0.0037 | 0.0037 |
Echinococcus granulosus | brain tumor protein | 0.003 | 0.0231 | 0.0231 |
Plasmodium vivax | aspartyl protease, putative | 0.0008 | 0.0037 | 0.0879 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0033 | 0.0257 | 1 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.003 | 0.0231 | 0.5 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0601 | 0.5296 | 0.5296 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0231 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0231 | 0.0231 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0305 | 0.2672 | 0.2672 |
Mycobacterium tuberculosis | PE-PGRS family protein PE_PGRS18 | 0.003 | 0.0231 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0008 | 0.0037 | 0.0037 |
Onchocerca volvulus | 0.0008 | 0.0037 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0005 | 0.0016 | 1 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0231 | 0.0231 |
Leishmania major | cathepsin L-like protease | 0.0005 | 0.0016 | 0.5 |
Brugia malayi | Pepsin A precursor | 0.0008 | 0.0037 | 0.0037 |
Onchocerca volvulus | 0.0005 | 0.0016 | 0.4227 | |
Trypanosoma brucei | flagellum-adhesion glycoprotein, putative | 0.003 | 0.0231 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0005 | 0.0016 | 0.4227 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0008 | 0.0037 | 0.0037 |
Brugia malayi | Cathepsin L-like precursor | 0.0005 | 0.0016 | 0.0016 |
Onchocerca volvulus | Cathepsin L homolog | 0.0005 | 0.0016 | 0.4227 |
Trypanosoma brucei | flagellum-adhesion glycoprotein, putative | 0.003 | 0.0231 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0008 | 0.0037 | 0.0037 |
Brugia malayi | hypothetical protein | 0.0008 | 0.0037 | 0.0037 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Leishmania major | cathepsin L-like protease | 0.0005 | 0.0016 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Leishmania major | cathepsin L-like protease | 0.0005 | 0.0016 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0008 | 0.0037 | 0.0037 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0008 | 0.0037 | 0.0037 |
Onchocerca volvulus | 0.0008 | 0.0037 | 1 | |
Brugia malayi | B-box type zinc-finger protein ncl-1 | 0.003 | 0.0231 | 0.0231 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Brugia malayi | Cathepsin L-like precursor | 0.0005 | 0.0016 | 0.0016 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0296 | 0.2593 | 0.2593 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0005 | 0.0016 | 0.0016 |
Echinococcus multilocularis | brain tumor protein | 0.003 | 0.0231 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0601 | 0.5296 | 0.5296 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0037 | 0.0037 |
Schistosoma mansoni | brat protein | 0.003 | 0.0231 | 0.0231 |
Plasmodium vivax | plasmepsin IV, putative | 0.0033 | 0.0257 | 1 |
Echinococcus multilocularis | brain tumor protein | 0.003 | 0.0231 | 0.0216 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0033 | 0.0257 | 0.0257 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0005 | 0.0016 | 0.0016 |
Plasmodium vivax | aspartyl protease, putative | 0.0008 | 0.0037 | 0.0879 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0033 | 0.0257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0231 | 0.0231 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0008 | 0.0037 | 0.0037 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0033 | 0.0257 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0005 | 0.0016 | 0.0604 |
Brugia malayi | B-box type zinc-finger protein ncl-1 | 0.003 | 0.0231 | 0.0231 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 150 mg/L | Cytotoxicity against human HEK293 cells after 36 hrs by MTT assay | ChEMBL. | 26459210 |
MIC=>90 (functional) | = 16 mg/L | Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis FJ05120 after 3 to 4 weeks by microplate alamar blue assay | ChEMBL. | 26459210 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.