Detailed information for compound 1965274

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 527.484 | Formula: C32H28Cl2N2O
  • H donors: 1 H acceptors: 1 LogP: 8.41 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(c1ccc2c(c1)c(C)c(n2Cc1ccc(cc1)c1ccccc1)C)N[C@H](c1c(Cl)cccc1Cl)C
  • InChi: 1S/C32H28Cl2N2O/c1-20-22(3)36(19-23-12-14-25(15-13-23)24-8-5-4-6-9-24)30-17-16-26(18-27(20)30)32(37)35-21(2)31-28(33)10-7-11-29(31)34/h4-18,21H,19H2,1-3H3,(H,35,37)/t21-/m0/s1
  • InChiKey: LXZZPDSSVYIFFL-NRFANRHFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peroxisome proliferator-activated receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus ecdysone induced protein 78C peroxisome proliferator-activated receptor gamma 477 aa 447 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cyclin B3, putative 0.0031 0.0108 0.044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.0885 0.0808
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.012 0.0488
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0224 0.0908
Trichomonas vaginalis cyclin B, putative 0.0248 0.2465 1
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0115 0.0011
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.012 0.1078 0.1544
Brugia malayi PHD-finger family protein 0.0032 0.0115 0.0031
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.024 0.0973
Echinococcus multilocularis cyclin dependent kinase 5 0.0105 0.0913 0.0892
Echinococcus granulosus cyclin dependent kinase 0.0105 0.0913 0.1286
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0196 0.0166
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.1042 0.4226
Brugia malayi hypothetical protein 0.0113 0.0999 0.1092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.012 0.0488
Schistosoma mansoni hypothetical protein 0.0031 0.0108 0.0029
Trypanosoma cruzi cdc2-related kinase 1 0.0105 0.0913 0.3416
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0031 0.0108 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0098 0.0396
Echinococcus granulosus peregrin 0.0032 0.0115 0.004
Echinococcus multilocularis lactate dehydrogenase a 0.0043 0.024 0.0163
Onchocerca volvulus Alhambra homolog 0.0032 0.0115 0.0108
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0224 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0108 0.044
Echinococcus multilocularis nAChR subunit 0.0233 0.2305 0.2399
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0043 0.024 0.0558
Schistosoma mansoni malate dehydrogenase 0.0043 0.024 0.0235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.012 0.0488
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0108 0.0025
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0113 0.0998 0.1419
Loa Loa (eye worm) GABA receptor subunit 0.012 0.1078 0.1003
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0233 0.2305 0.266
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0113 0.0999 0.0985
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0031 0.0108 0.0025
Plasmodium vivax malate dehydrogenase, putative 0.0043 0.024 0.0204
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0885 0.1241
Toxoplasma gondii ABC1 family protein 0.0042 0.0224 0.1336
Schistosoma mansoni hypothetical protein 0.0113 0.0998 0.1419
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0105 0.0913 0.1286
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0396 0.4077 0.432
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.004 0.021 0.0188
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0105 0.0913 0.0837
Loa Loa (eye worm) hypothetical protein 0.0795 0.8416 0.8402
Echinococcus multilocularis cyclin dependent kinase 0.0105 0.0913 0.0892
Brugia malayi cell division control protein 2 homolog 0.0105 0.0913 0.0989
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0224 0.0908
Brugia malayi hypothetical protein 0.0039 0.0196 0.0127
Loa Loa (eye worm) hypothetical protein 0.012 0.1078 0.1003
Brugia malayi Bromodomain containing protein 0.0032 0.0115 0.0031
Onchocerca volvulus 0.0233 0.2305 0.9324
Onchocerca volvulus Cyclin L homolog 0.0031 0.0108 0.0079
Loa Loa (eye worm) hypothetical protein 0.0113 0.0999 0.0922
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0043 0.024 0.5
Echinococcus granulosus cyclins 0.0128 0.1166 0.168
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0031 0.0108 0.0114
Brugia malayi beta-lactamase family protein 0.0042 0.0224 0.0161
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0188 0.0106
Plasmodium falciparum lactate dehydrogenase, putative 0.0043 0.024 0.1244
Echinococcus multilocularis cyclins 0.0128 0.1166 0.1166
Echinococcus multilocularis microtubule associated protein 2 0.0618 0.6493 0.6937
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0224 0.0209
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0233 0.2305 0.2399
Echinococcus multilocularis cyclin B 0.0248 0.2465 0.2573
Echinococcus granulosus glycine receptor subunit beta 0.0233 0.2305 0.3459
Entamoeba histolytica cyclin family protein 0.0128 0.1166 0.4486
Entamoeba histolytica protein kinase, putative 0.0117 0.1042 0.3961
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.012 0.1078 0.1187
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0233 0.2305 0.266
Schistosoma mansoni hypothetical protein 0.0032 0.0115 0.004
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.024 0.0973
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0233 0.2305 0.2239
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0108 0.0022
Entamoeba histolytica protein kinase domain containing protein 0.0117 0.1042 0.3961
Schistosoma mansoni cyclin G2 0.0031 0.0108 0.0029
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0108 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0008 0.0033
Schistosoma mansoni nAChR subunit 0.0233 0.2305 0.3459
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0624 0.6554 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0518 0.0669
Echinococcus granulosus cyclin y 0.0031 0.0108 0.0029
Brugia malayi Cation transporter family protein 0.0233 0.2305 0.266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0034 0.0136
Trypanosoma brucei cdc2-related kinase 1 0.0105 0.0913 0.3416
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0233 0.2305 0.3459
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0224 0.0908
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0105 0.0913 0.3416
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0224 0.049
Onchocerca volvulus 0.0233 0.2305 0.9324
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0224 0.0161
Plasmodium falciparum protein kinase 5 0.0105 0.0913 0.7615
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0233 0.2305 0.266
Trypanosoma cruzi cyclin 6, putative 0.0248 0.2465 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0795 0.8416 1
Echinococcus multilocularis cyclin G2 0.0031 0.0108 0.002
Onchocerca volvulus Putative nachr subunit 0.0233 0.2305 0.9324
Entamoeba histolytica hypothetical protein 0.0039 0.0196 0.0371
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0113 0.0999 0.0985
Loa Loa (eye worm) hypothetical protein 0.0032 0.0115 0.0032
Loa Loa (eye worm) hypothetical protein 0.012 0.1078 0.1003
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0233 0.2305 0.3459
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0113 0.0999 0.0985
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0034 0.0136
Echinococcus granulosus nAChR subunit 0.012 0.1078 0.1544
Onchocerca volvulus 0.0031 0.0108 0.0079
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0224 0.0209
Echinococcus granulosus cyclin dependent kinase 5 0.0105 0.0913 0.1286
Entamoeba histolytica hypothetical protein 0.0039 0.0196 0.0371
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.012 0.1078 0.1187
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0086 0.0709 0.2547
Trichomonas vaginalis cyclin B, putative 0.0248 0.2465 1
Brugia malayi beta-lactamase 0.0042 0.0224 0.0161
Echinococcus multilocularis cyclins 0.0128 0.1166 0.1166
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.024 0.0973
Schistosoma mansoni acetylcholine receptor-related 0.0113 0.0999 0.1419
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0086 0.0709 0.2547
Trichomonas vaginalis cyclin D, putative 0.0031 0.0108 0.044
Echinococcus granulosus cyclin A3 4 0.0031 0.0108 0.0029
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0043 0.024 1
Toxoplasma gondii cyclin 4, putative 0.0031 0.0108 0.0114
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0031 0.0108 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0108 0.044
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0233 0.2305 0.2239
Trypanosoma cruzi malate dehydrogenase, putative 0.0043 0.024 0.0558
Brugia malayi cyclin fold protein 1 variant b 0.0031 0.0108 0.0022
Schistosoma mansoni cyclin k 0.0031 0.0108 0.0029
Leishmania major cyclin 0.0248 0.2465 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0359 0.0278
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0031 0.0108 0.0029
Schistosoma mansoni jumonji domain containing protein 0.0082 0.0665 0.0899
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.024 0.0973
Toxoplasma gondii lactate dehydrogenase LDH1 0.0043 0.024 0.1506
Loa Loa (eye worm) hypothetical protein 0.0031 0.0108 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0098 0.0396
Trypanosoma cruzi CYC2-like cyclin, putative 0.0248 0.2465 1
Trichomonas vaginalis cyclins, putative 0.0128 0.1166 0.4728
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0188 0.0153
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.024 0.0973
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0481 0.04
Echinococcus granulosus cyclin B3 1 0.0128 0.1166 0.168
Schistosoma mansoni L-lactate dehydrogenase 0.0043 0.024 0.0235
Entamoeba histolytica hypothetical protein 0.0039 0.0196 0.0371
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0108 0.0025
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0031 0.0108 0.0114
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0265 0.2658 1
Brugia malayi lactate dehydrogenase. 0.0043 0.024 0.018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0196 0.0166
Trichomonas vaginalis cyclin B3, putative 0.0031 0.0108 0.044
Giardia lamblia Kinase, CMGC CDK 0.0105 0.0913 0.3416
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0173 0.0101
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0233 0.2305 0.3459
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.024 0.0973
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.021 0.0851
Schistosoma mansoni nAChR subunit 0.0233 0.2305 0.3459
Trypanosoma cruzi cdc2-related kinase 1 0.0105 0.0913 0.3416
Brugia malayi hypothetical protein 0.0031 0.0108 0.0022
Schistosoma mansoni malate dehydrogenase 0.0086 0.0709 0.0966
Leishmania major cytosolic malate dehydrogenase 0.0043 0.024 0.0558
Loa Loa (eye worm) hypothetical protein 0.0113 0.0999 0.0922
Trypanosoma brucei cytosolic malate dehydrogenase 0.0043 0.024 0.0558
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0117 0.1042 0.3961
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.024 0.0973
Echinococcus multilocularis cyclin t1 0.0031 0.0108 0.002
Schistosoma mansoni nAChR subunit 0.0233 0.2305 0.3459
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0913 0.3705
Onchocerca volvulus 0.012 0.1078 0.4161
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0113 0.0999 0.1419
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.024 0.0973
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0233 0.2305 0.3459
Schistosoma mansoni nAChR subunit 0.0113 0.0999 0.1419
Trypanosoma brucei cdc2-related kinase 3 0.0105 0.0913 0.3416
Brugia malayi Cyclin, N-terminal domain containing protein 0.0248 0.2465 0.2853
Echinococcus granulosus nAChR subunit 0.0233 0.2305 0.3459
Loa Loa (eye worm) hypothetical protein 0.0113 0.0999 0.0922
Toxoplasma gondii malate dehydrogenase MDH 0.0043 0.024 0.1506
Loa Loa (eye worm) acetylcholine receptor protein 0.0113 0.0999 0.0922
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0233 0.2305 0.2399
Brugia malayi Cyclin, N-terminal domain containing protein 0.0248 0.2465 0.2853
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0233 0.2305 0.3459
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0105 0.0913 0.0837
Giardia lamblia GTOR 0.004 0.021 0.043
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0233 0.2305 0.2399
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Echinococcus multilocularis cyclin B3 1 0.0128 0.1166 0.1166
Echinococcus granulosus jumonji domain containing protein 0.0044 0.025 0.025
Echinococcus granulosus cyclin k 0.0031 0.0108 0.0029
Loa Loa (eye worm) hypothetical protein 0.0119 0.1072 0.0996
Brugia malayi beta-lactamase family protein 0.0042 0.0224 0.0161
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0518 0.0669
Trypanosoma cruzi cdc2-related kinase 3 0.0105 0.0913 0.3416
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0885 0.1241
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0233 0.2305 0.3459
Trypanosoma brucei glycosomal malate dehydrogenase 0.0086 0.0709 0.2547
Trypanosoma cruzi cyclin, putative 0.0248 0.2465 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0999 0.0922
Schistosoma mansoni neurotransmitter gated ion channel 0.0113 0.0999 0.1419
Schistosoma mansoni hypothetical protein 0.0037 0.0173 0.0131
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.024 0.0973
Toxoplasma gondii hypothetical protein 0.0097 0.0829 0.7749
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0115 0.0188
Echinococcus multilocularis cyclin A3 4 0.0031 0.0108 0.002
Entamoeba histolytica malate dehydrogenase, putative 0.0043 0.024 0.0558
Trichomonas vaginalis cyclins, putative 0.0248 0.2465 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.024 0.0973
Schistosoma mansoni nAChR subunit 0.0233 0.2305 0.3459
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0518 0.0669
Schistosoma mansoni acetylcholine receptor subunit beta 0.0113 0.0999 0.1419
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0043 0.024 0.0163
Echinococcus multilocularis cyclins 0.0128 0.1166 0.1166
Toxoplasma gondii hypothetical protein 0.0031 0.0108 0.0114
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0885 0.0861
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0224 0.0908
Schistosoma mansoni nAChR subunit 0.0233 0.2305 0.3459
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0233 0.2305 0.266
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0233 0.2305 0.2399
Echinococcus granulosus malate dehydrogenase 0.0086 0.0709 0.0966
Loa Loa (eye worm) hypothetical protein 0.012 0.1078 0.1003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0008 0.0034
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0113 0.0999 0.1092
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0913 0.1286
Loa Loa (eye worm) phosphatidylinositol 3 0.004 0.021 0.0127
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.004 0.021 0.043
Loa Loa (eye worm) hypothetical protein 0.0031 0.0108 0.0025
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Trichomonas vaginalis cyclin B, putative 0.0031 0.0108 0.044
Loa Loa (eye worm) hypothetical protein 0.0113 0.0999 0.0922
Echinococcus multilocularis cyclin y 0.0031 0.0108 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.024 0.0157
Schistosoma mansoni cyclins 0.0128 0.1166 0.168
Loa Loa (eye worm) hypothetical protein 0.0113 0.0999 0.0922
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0098 0.0396
Loa Loa (eye worm) hypothetical protein 0.0113 0.0999 0.0922
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.004 0.021 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.021 0.0851
Onchocerca volvulus 0.0248 0.2465 1
Trichomonas vaginalis cyclin A, putative 0.0248 0.2465 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0131 0.1196 0.1199
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0115 0.0032
Entamoeba histolytica hypothetical protein 0.0039 0.0196 0.0371
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0086 0.0709 0.2547
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0008 0.0034
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0117 0.1042 1
Trichomonas vaginalis cyclin D, putative 0.0128 0.1166 0.4728
Brugia malayi Cyclin C 0.0031 0.0108 0.0022
Schistosoma mansoni nAChR subunit 0.0113 0.0999 0.1419
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0233 0.2305 0.3459
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0885 0.0861
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0913 0.3705
Echinococcus granulosus glycine receptor subunit alpha 1 0.0233 0.2305 0.3459
Schistosoma mansoni cyclin B 0.0248 0.2465 0.371
Brugia malayi hypothetical protein 0.0113 0.0999 0.1092
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0117 0.1042 0.3961
Trichomonas vaginalis cyclin A, putative 0.0031 0.0108 0.044
Echinococcus multilocularis cyclin k 0.0031 0.0108 0.002
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0086 0.0709 0.2547
Echinococcus multilocularis cyclin b3 0.0128 0.1166 0.1166
Plasmodium falciparum glycogen synthase kinase 3 0.0117 0.1042 0.8829
Echinococcus multilocularis lactate dehydrogenase a 0.0043 0.024 0.0163
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Schistosoma mansoni nAChR subunit 0.0233 0.2305 0.3459
Loa Loa (eye worm) hypothetical protein 0.0113 0.0999 0.0922
Onchocerca volvulus 0.0113 0.0999 0.3826
Schistosoma mansoni cyclin d 0.0031 0.0108 0.0029
Brugia malayi RNA binding protein 0.0069 0.0518 0.0514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0066 0.0267
Echinococcus granulosus L lactate dehydrogenase B chain 0.0043 0.024 0.0235
Loa Loa (eye worm) ACC-1 protein 0.0233 0.2305 0.2239
Schistosoma mansoni malate dehydrogenase 0.0043 0.024 0.0235
Giardia lamblia Malate dehydrogenase 0.0043 0.024 0.0558
Plasmodium vivax lactate dehydrogenase 0.0043 0.024 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.021 0.0851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0008 0.0033
Onchocerca volvulus 0.0042 0.0224 0.0565
Trichomonas vaginalis cyclins, putative 0.0248 0.2465 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.009 0.0006
Trichomonas vaginalis cyclin B, putative 0.0128 0.1166 0.4728
Onchocerca volvulus 0.012 0.1078 0.4161
Brugia malayi hypothetical protein 0.0113 0.0999 0.1092
Trypanosoma brucei mitotic cyclin 6 0.0248 0.2465 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0105 0.0913 0.0837
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0878 0.9321 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.009 0.0006
Toxoplasma gondii cyclin dependent kinase binding protein 0.0031 0.0108 0.0114
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0233 0.2305 0.3459
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0233 0.2305 0.2239
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0233 0.2305 0.266
Loa Loa (eye worm) hypothetical protein 0.0113 0.0999 0.0922
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.004 0.021 0.0188
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0188 0.0153
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0043 0.024 0.0558
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0113 0.0999 0.1092
Trichomonas vaginalis cyclin B, putative 0.0248 0.2465 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0224 0.0141
Onchocerca volvulus 0.0233 0.2305 0.9324
Brugia malayi intracellular kinase 0.0117 0.1042 0.1144
Echinococcus granulosus cytosolic malate dehydrogenase 0.0043 0.024 0.0235
Loa Loa (eye worm) hypothetical protein 0.0042 0.0224 0.0141
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0196 0.0115
Trichomonas vaginalis cyclins, putative 0.0031 0.0108 0.044
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0359 0.0324
Echinococcus granulosus cyclin B 0.0248 0.2465 0.371
Schistosoma mansoni hypothetical protein 0.0039 0.0196 0.0166
Schistosoma mansoni neurotransmitter gated ion channel 0.012 0.1078 0.1544
Echinococcus multilocularis cyclins 0.0128 0.1166 0.1166
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0043 0.024 0.0558
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.1166 0.4728
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0233 0.2305 0.2399
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.025 0.0174
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0233 0.2305 0.2239
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0113 0.0999 0.0922
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.004 0.021 0.013
Loa Loa (eye worm) hypothetical protein 0.012 0.1078 0.1003
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.012 0.1078 0.1187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.012 0.0488
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.024 0.0973
Entamoeba histolytica protein kinase domain containing protein 0.0117 0.1042 0.3961
Onchocerca volvulus 0.0117 0.1042 0.4008
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0105 0.0913 0.3416
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0188 0.0153
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0115 0.0188
Echinococcus granulosus protein kinase shaggy 0.0117 0.1042 0.1487
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.0896 0.126
Entamoeba histolytica cyclin, putative 0.0248 0.2465 1
Leishmania major glycosomal malate dehydrogenase 0.0086 0.0709 0.2547
Giardia lamblia PHD finger protein 15 0.0032 0.0115 0.003
Echinococcus granulosus cyclin G2 0.0031 0.0108 0.0029
Onchocerca volvulus Cyclin L homolog 0.0031 0.0108 0.0079
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.024 0.0973
Brugia malayi jmjC domain containing protein 0.0038 0.0188 0.0118
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0359 0.0324
Entamoeba histolytica hypothetical protein 0.012 0.1078 0.4115
Loa Loa (eye worm) hypothetical protein 0.0113 0.0999 0.0922
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0885 0.1241
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.004 0.021 0.043
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.0896 0.0874
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0224 0.0179
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Onchocerca volvulus 0.0113 0.0999 0.3826
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0098 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0008 0.0034
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0115 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0098 0.0396
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0108 0.0022
Trichomonas vaginalis cyclins, putative 0.0248 0.2465 1
Loa Loa (eye worm) hypothetical protein 0.012 0.1078 0.1003
Echinococcus granulosus G1:S specific cyclin D1 0.0031 0.0108 0.0029
Schistosoma mansoni cyclin B3 0.0396 0.4077 0.6227
Loa Loa (eye worm) hypothetical protein 0.012 0.1078 0.1003
Echinococcus multilocularis cyclin dependent kinase 1 0.0105 0.0913 0.0892
Loa Loa (eye worm) hypothetical protein 0.0037 0.0173 0.009
Schistosoma mansoni hypothetical protein 0.0031 0.0108 0.0029
Schistosoma mansoni thyroid hormone receptor 0.0131 0.1196 0.1728
Onchocerca volvulus 0.0233 0.2305 0.9324
Echinococcus granulosus cyclin b3 0.0128 0.1166 0.168
Echinococcus multilocularis cyclins 0.0128 0.1166 0.1166
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0108 0.044
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0233 0.2305 0.2239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0034 0.0136
Echinococcus multilocularis cyclin y 0.0031 0.0108 0.002
Entamoeba histolytica malate dehydrogenase, putative 0.0043 0.024 0.0558
Echinococcus multilocularis protein kinase shaggy 0.0117 0.1042 0.1031
Echinococcus granulosus lactate dehydrogenase a 0.0043 0.024 0.0235
Echinococcus multilocularis lactate dehydrogenase a 0.0043 0.024 0.0163
Loa Loa (eye worm) hypothetical protein 0.0103 0.0889 0.0812
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.0885 0.0955
Echinococcus multilocularis cyclin 0.0031 0.0108 0.002
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0233 0.2305 0.2399
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0233 0.2305 0.266
Echinococcus granulosus cyclins 0.0128 0.1166 0.168
Leishmania major hypothetical protein, conserved 0.0042 0.0224 0.049
Echinococcus multilocularis lactate dehydrogenase protein 0.0043 0.024 0.0163
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.004 0.021 0.043
Plasmodium falciparum cyclin 0.0128 0.1166 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0031 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0108 0.044
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0233 0.2305 0.2399
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0108 0.0025
Echinococcus multilocularis glycine receptor subunit beta 0.0233 0.2305 0.2399
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0031 0.0108 0.0029
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Brugia malayi hypothetical protein 0.0113 0.0999 0.1092
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0233 0.2305 0.266
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0224 0.0908
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0113 0.0998 0.0984
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0117 0.1042 0.0966
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0518 0.0514
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.024 0.0973
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0233 0.2305 0.3459
Echinococcus granulosus cyclins 0.0128 0.1166 0.168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0008 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0008 0.0034
Schistosoma mansoni thyroid hormone receptor 0.0131 0.1196 0.1728
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0233 0.2305 0.266
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0115 0.004
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0108 0.0022
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0043 0.024 0.0066
Brugia malayi hypothetical protein 0.0031 0.0108 0.0022
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0108 0.0025
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0359 0.0278
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0224 0.049
Trichomonas vaginalis cyclins, putative 0.0248 0.2465 1
Echinococcus granulosus cyclins 0.0128 0.1166 0.168
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Trichomonas vaginalis cyclin B3, putative 0.0128 0.1166 0.4728
Mycobacterium ulcerans malate dehydrogenase 0.0043 0.024 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0233 0.2305 0.266
Leishmania major malate dehydrogenase, putative 0.0043 0.024 0.0558
Echinococcus multilocularis cyclin dependent kinase 1 0.0105 0.0913 0.0892
Schistosoma mansoni g1/s-specific cyclin C 0.0031 0.0108 0.0029
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0233 0.2305 0.3459
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0032 0.0121 0.0052
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0233 0.2305 0.2239
Brugia malayi excitatory GABA receptor EXP-1A 0.0233 0.2305 0.266
Loa Loa (eye worm) hypothetical protein 0.0042 0.0224 0.0141
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0518 0.0438
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0117 0.1042 0.1031
Echinococcus granulosus tar DNA binding protein 0.0069 0.0518 0.0669
Loa Loa (eye worm) hypothetical protein 0.0113 0.0999 0.0922
Echinococcus granulosus malate dehydrogenase 0.0086 0.0709 0.0966
Loa Loa (eye worm) hypothetical protein 0.0248 0.2465 0.2401
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.021 0.0144
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0115 0.004
Loa Loa (eye worm) CYL-1 protein 0.0031 0.0108 0.0025
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.024 0.0973
Echinococcus granulosus cyclin t1 0.0031 0.0108 0.0029
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0043 0.024 0.018
Onchocerca volvulus 0.0113 0.0999 0.3826
Schistosoma mansoni cyclin l 0.0031 0.0108 0.0029
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0396 0.4077 0.6227
Trichomonas vaginalis cyclins, putative 0.015 0.1408 0.5711
Giardia lamblia Kinase, CMGC GSK 0.0117 0.1042 0.3961
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0233 0.2305 0.266
Trypanosoma cruzi cyclin, putative 0.0248 0.2465 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0233 0.2305 0.3459
Giardia lamblia G2/mitotic-specific cyclin B 0.0248 0.2465 1
Onchocerca volvulus 0.0042 0.0224 0.0565
Onchocerca volvulus Protein CNPPD1 homolog 0.0031 0.0108 0.0079
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0233 0.2305 0.266
Echinococcus granulosus glycine receptor subunit beta 0.0233 0.2305 0.3459
Plasmodium vivax protein kinase Crk2 0.0105 0.0913 0.1249
Loa Loa (eye worm) hypothetical protein 0.0113 0.0999 0.0922
Echinococcus multilocularis glycine receptor subunit beta 0.0233 0.2305 0.2399
Schistosoma mansoni malate dehydrogenase 0.0043 0.024 0.0235
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0113 0.0999 0.1092
Leishmania major mitochondrial malate dehydrogenase 0.0086 0.0709 0.2547
Plasmodium vivax glycogen synthase kinase 3, putative 0.0117 0.1042 0.1448
Giardia lamblia Hypothetical protein 0.0128 0.1166 0.4486
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.004 0.021 0.043
Chlamydia trachomatis malate dehydrogenase 0.0043 0.024 0.5
Echinococcus granulosus microtubule associated protein 2 0.0618 0.6493 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0224 0.0141
Trypanosoma brucei malate dehydrogenase-related 0.0043 0.024 0.0558
Schistosoma mansoni Cyclin fold protein 0.0031 0.0108 0.0029
Loa Loa (eye worm) hypothetical protein 0.012 0.1078 0.1003
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0108 0.0025
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0233 0.2305 0.2399
Loa Loa (eye worm) ACC-1 protein 0.0233 0.2305 0.2239
Loa Loa (eye worm) hypothetical protein 0.012 0.1078 0.1003
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0043 0.024 0.0163
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0233 0.2305 0.3459
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0518 0.0669
Echinococcus multilocularis cyclins 0.0128 0.1166 0.1166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0885 0.1241
Leishmania major malate dehydrogenase, putative 0.0043 0.024 0.0558
Echinococcus granulosus cyclin dependent kinase 1 0.0105 0.0913 0.1286
Echinococcus multilocularis nAChR subunit 0.012 0.1078 0.1071
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0108 0.0025
Loa Loa (eye worm) hypothetical protein 0.0113 0.0999 0.0922
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0248 0.2465 1
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0518 0.0438
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0043 0.024 0.0163
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0117 0.1042 0.0966
Loa Loa (eye worm) hypothetical protein 0.0248 0.2465 0.2401
Schistosoma mansoni cyclin G 0.0031 0.0108 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0056 0.0228
Giardia lamblia Cyclin A 0.0128 0.1166 0.4486
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.1042 0.4226
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0108 0.0022
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0108 0.0022
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Schistosoma mansoni L-lactate dehydrogenase 0.0043 0.024 0.0235
Loa Loa (eye worm) intermediate filament protein 0.0029 0.009 0.0006
Echinococcus granulosus cyclin G2 0.0031 0.0108 0.0029
Schistosoma mansoni microtubule-associated protein tau 0.0618 0.6493 1
Plasmodium falciparum L-lactate dehydrogenase 0.0043 0.024 0.1244
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0108 0.0022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0113 0.0999 0.1092
Echinococcus multilocularis cyclins 0.0128 0.1166 0.1166
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0086 0.0709 0.0743
Brugia malayi Cation transporter family protein 0.0233 0.2305 0.266
Trichomonas vaginalis esterase, putative 0.0042 0.0224 0.0908
Onchocerca volvulus 0.0233 0.2305 0.9324
Echinococcus granulosus cyclin y 0.0031 0.0108 0.0029
Schistosoma mansoni nAChR subunit 0.0233 0.2305 0.3459
Loa Loa (eye worm) hypothetical protein 0.0113 0.0999 0.0922
Loa Loa (eye worm) hypothetical protein 0.0682 0.7189 0.7165
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0113 0.0999 0.1419
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Echinococcus granulosus cytosolic malate dehydrogenase 0.0043 0.024 0.0235
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0518 0.0464
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.004 0.021 0.043
Toxoplasma gondii lactate dehydrogenase LDH2 0.0043 0.024 0.1506
Schistosoma mansoni neurotransmitter gated ion channel 0.0113 0.0999 0.1419
Echinococcus granulosus lactate dehydrogenase a 0.0043 0.024 0.0235
Loa Loa (eye worm) RNA binding protein 0.0069 0.0518 0.0438
Echinococcus granulosus lactate dehydrogenase protein 0.0043 0.024 0.0235
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.024 0.0973
Brugia malayi hypothetical protein 0.0113 0.0999 0.1092
Echinococcus granulosus glycine receptor subunit alpha 1 0.0233 0.2305 0.3459
Loa Loa (eye worm) malate dehydrogenase 0.0086 0.0709 0.063
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0113 0.0999 0.1092
Trichomonas vaginalis cyclins, putative 0.0031 0.0108 0.044
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0032 0.0121 0.0052
Loa Loa (eye worm) cyclin domain-containing protein 0.0396 0.4077 0.4027
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0224 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0098 0.0396
Echinococcus multilocularis malate dehydrogenase 0.0086 0.0709 0.067
Echinococcus granulosus glycine receptor subunit alpha 1 0.0233 0.2305 0.3459
Brugia malayi Cation transporter family protein 0.0233 0.2305 0.266
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0913 0.1286
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0233 0.2305 0.2399
Loa Loa (eye worm) LGC-31 protein 0.0233 0.2305 0.2239
Brugia malayi TAR-binding protein 0.0069 0.0518 0.0514
Echinococcus multilocularis Cyclin L1 0.0031 0.0108 0.002
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0105 0.0913 0.864
Echinococcus multilocularis malate dehydrogenase 0.0086 0.0709 0.067
Trichomonas vaginalis cyclin B, putative 0.0031 0.0108 0.044
Onchocerca volvulus 0.0042 0.0224 0.0565
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0233 0.2305 0.266
Loa Loa (eye worm) cyclin C 0.0031 0.0108 0.0025
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0233 0.2305 0.3459
Loa Loa (eye worm) malate dehydrogenase 0.0043 0.024 0.0157
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.012 0.1078 0.1544
Trypanosoma cruzi malate dehydrogenase, putative 0.0086 0.0709 0.2547
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0117 0.1042 0.1487
Entamoeba histolytica cell division protein kinase 2, putative 0.0105 0.0913 0.3416
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.012 0.1078 0.1187
Brugia malayi Cyclin, N-terminal domain containing protein 0.0396 0.4077 0.4789
Entamoeba histolytica cyclin family protein 0.0128 0.1166 0.4486
Onchocerca volvulus 0.0233 0.2305 0.9324
Trichomonas vaginalis cyclin B, putative 0.0248 0.2465 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.004 0.021 0.043
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0233 0.2305 0.3459
Loa Loa (eye worm) hypothetical protein 0.0042 0.0224 0.0141
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0224 0.0209
Loa Loa (eye worm) hypothetical protein 0.0233 0.2305 0.2239
Echinococcus granulosus cyclins 0.0031 0.0108 0.0029
Brugia malayi Protein kinase domain containing protein 0.0105 0.0913 0.0989
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.012 0.0488
Trichomonas vaginalis cyclin D, putative 0.0128 0.1166 0.4728
Loa Loa (eye worm) beta-lactamase 0.0042 0.0224 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0098 0.0396
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0233 0.2305 0.266
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0188 0.0105
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0233 0.2305 0.266
Echinococcus granulosus cyclin 0.0031 0.0108 0.0029
Echinococcus multilocularis G1:S specific cyclin D1 0.0031 0.0108 0.002
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0233 0.2305 0.2399
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0031 0.0108 0.002
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0113 0.0999 0.0922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0031 0.0126
Echinococcus granulosus cyclins 0.0128 0.1166 0.168
Leishmania major malate dehydrogenase 0.0086 0.0709 0.2547
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.004 0.021 0.043
Entamoeba histolytica cyclin, putative 0.0128 0.1166 0.4486
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0885 0.1241
Plasmodium falciparum phd finger protein, putative 0.0032 0.0115 0.0067
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.024 0.0973
Echinococcus granulosus Cyclin L1 0.0031 0.0108 0.0029
Entamoeba histolytica cell division protein kinase 2, putative 0.0105 0.0913 0.3416
Echinococcus multilocularis peregrin 0.0032 0.0115 0.0028
Loa Loa (eye worm) hypothetical protein 0.0042 0.0224 0.0141
Echinococcus multilocularis cyclin G2 0.0031 0.0108 0.002
Plasmodium falciparum malate dehydrogenase 0.0043 0.024 0.1244
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0043 0.024 0.0204
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0113 0.0999 0.1092
Loa Loa (eye worm) hypothetical protein 0.0113 0.0999 0.0922
Giardia lamblia Kinase, CMGC CDK 0.0105 0.0913 0.3416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0146 0.0591
Loa Loa (eye worm) hypothetical protein 0.0054 0.0361 0.0279
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0233 0.2305 0.266
Loa Loa (eye worm) hypothetical protein 0.0042 0.0224 0.0141
Trypanosoma cruzi target of rapamycin kinase 3 0.0032 0.0121 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0518 0.0669
Giardia lamblia Kinase, CMGC GSK 0.0117 0.1042 0.3961
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0117 0.1042 0.1487
Brugia malayi jmjC domain containing protein 0.0103 0.0896 0.0969
Trypanosoma cruzi cdc2-related kinase 3 0.0105 0.0913 0.3416
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0913 0.3705
Trypanosoma brucei protein kinase, putative 0.0117 0.1042 0.3961

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 51 nM BindingDB_Patents: Lanthascreen Competitive Binding Assay. The assay was performed according to manufacturer protocol. A mixture of nM GST-PPARG-LBD, 5 nM Tb-GST-antibody, 5 nM Fluormone Pan-PPAR Green, and serial dilutions of the experimental compound, beginning at 10 µM downwards, was added to wells of black 384-well low-volume plates (Greiner) to a total volume of 18 µL. All dilutions were made in TR-FRET assay buffer C. DMSO at 2% final concentration was used as a no-ligand control. Experiment was performed in triplicate, and incubated for 2 hours in the dark prior to assay read in Perkin Elmer ViewLux ultra HTS microplate reader. FRET signal was measured by excitation at 340 nm and emission at 520 nm for fluorescein and 490 nm for terbium. Fold change over DMSO was calculated using GraphPad Prism Software (La Jolla, Calif.) by calculating 520 nm/490 nm ratio. Graphs were plotted as fold change of FRET signal for compound treatment over DMSO-only control. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.