Detailed information for compound 19690

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 179.219 | Formula: C9H13N3O
  • H donors: 0 H acceptors: 1 LogP: 0.86 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO/N=C(\C1=CCCN(C1)C)/C#N
  • InChi: 1S/C9H13N3O/c1-12-5-3-4-8(7-12)9(6-10)11-13-2/h4H,3,5,7H2,1-2H3/b11-9-
  • InChiKey: CBOPDFIRBQHXIG-LUAWRHEFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Muscarinic acetylcholine receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) Muscarinic acetylcholine receptor   466 aa 461 aa 26.0 %
Schistosoma mansoni growth hormone secretagogue receptor Muscarinic acetylcholine receptor   466 aa 462 aa 19.9 %
Schistosoma japonicum Octopamine receptor, putative Muscarinic acetylcholine receptor   466 aa 462 aa 26.8 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Muscarinic acetylcholine receptor   466 aa 505 aa 26.9 %
Schistosoma japonicum Octopamine receptor 1, putative Muscarinic acetylcholine receptor   466 aa 412 aa 22.6 %
Echinococcus granulosus alpha 1A adrenergic receptor Muscarinic acetylcholine receptor   466 aa 459 aa 20.0 %
Onchocerca volvulus Muscarinic acetylcholine receptor   466 aa 472 aa 24.6 %
Echinococcus granulosus g protein coupled receptor Muscarinic acetylcholine receptor   466 aa 480 aa 18.5 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Muscarinic acetylcholine receptor   466 aa 510 aa 29.8 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Muscarinic acetylcholine receptor   466 aa 461 aa 23.9 %
Echinococcus multilocularis alpha 1A adrenergic receptor Muscarinic acetylcholine receptor   466 aa 459 aa 21.1 %
Loa Loa (eye worm) TYRA-2 protein Muscarinic acetylcholine receptor   466 aa 497 aa 24.7 %
Schistosoma mansoni biogenic amine receptor Muscarinic acetylcholine receptor   466 aa 484 aa 24.4 %
Schistosoma mansoni biogenic amine receptor Muscarinic acetylcholine receptor   466 aa 463 aa 24.2 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Muscarinic acetylcholine receptor   466 aa 493 aa 34.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0882 0.4438
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Onchocerca volvulus Peroxidase homolog 0.0077 0.2271 0.238
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0882 1
Brugia malayi Dopamine receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0035 0.0882 0.0882
Brugia malayi RE15519p 0.0046 0.1218 0.1295
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.1218 0.1295
Brugia malayi Animal haem peroxidase family protein 0.0077 0.2271 0.2414
Onchocerca volvulus Protein cereblon homolog 0.0294 0.9408 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Brugia malayi neuropeptide F receptor 0.0046 0.1218 0.1295
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0882 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0042 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0042 0.0045
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0021 0.0423 0.2404
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0046 0.1218 0.1295
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0423 0.1913
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0046 0.1218 0.1295
Loa Loa (eye worm) TYRA-2 protein 0.0046 0.1218 0.1218
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Mycobacterium ulcerans beta-lactamase 0.0035 0.0882 1
Echinococcus multilocularis g protein coupled receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.1218 0.1218
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0882 0.068
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) hypothetical protein 0.0035 0.0882 0.0882
Brugia malayi steroid hormone receptor 0.001 0.0042 0.0045
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0882 0.0937
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Schistosoma mansoni opsin-like receptor 0.0046 0.1218 0.1295
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0042 0.0042
Schistosoma mansoni nuclear hormone receptor 0.001 0.0042 0.0045
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.1855 0.1971
Echinococcus granulosus neuropeptide receptor A26 0.0046 0.1218 0.1295
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0042 0.0045
Echinococcus multilocularis g-protein coupled receptor 0.0046 0.1218 0.1295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Brugia malayi Animal haem peroxidase family protein 0.0077 0.2271 0.2414
Schistosoma mansoni opsin-like receptor 0.0046 0.1218 0.1295
Echinococcus granulosus bloom syndrome protein 0.0021 0.0406 0.0432
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.2271 0.2271
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0021 0.0423 0.0449
Echinococcus multilocularis geminin 0.0167 0.5208 0.5536
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0042 0.0045
Echinococcus multilocularis dro:myosuppressin receptor 0.0046 0.1218 0.1295
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0042 0.0045
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.1855 0.1971
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0021 0.0423 0.1913
Plasmodium falciparum thioredoxin reductase 0.0021 0.0423 0.2404
Echinococcus multilocularis allatostatin A receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus granulosus 7tm_1 domain containing protein 0.0046 0.1218 0.1295
Schistosoma mansoni hypothetical protein 0.0294 0.9408 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0882 1
Schistosoma mansoni hypothetical protein 0.0167 0.5208 0.5536
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0046 0.1218 0.1295
Brugia malayi G-protein coupled receptor 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0046 0.1218 0.1256
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0882 0.0882
Onchocerca volvulus 0.0046 0.1218 0.1256
Brugia malayi G protein-coupled receptor 0.0046 0.1218 0.1295
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0021 0.0423 0.2404
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.1855 0.1899
Brugia malayi putative neuropeptide receptor 0.0046 0.1218 0.1295
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0042 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0294 0.9408 0.9408
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.2271 0.2271
Mycobacterium tuberculosis Conserved protein 0.0035 0.0882 0.068
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Toxoplasma gondii NADPH-glutathione reductase 0.0021 0.0423 0.2404
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0042 0.0045
Onchocerca volvulus 0.0046 0.1218 0.1256
Trypanosoma brucei trypanothione reductase 0.0062 0.1758 0.9457
Echinococcus granulosus serotonin receptor 0.0046 0.1218 0.1295
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0021 0.0423 0.1913
Echinococcus granulosus dro:myosuppressin receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Onchocerca volvulus 0.0035 0.0882 0.0896
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.1218 0.1295
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0042 0.0045
Onchocerca volvulus 0.0077 0.2271 0.238
Echinococcus multilocularis g protein coupled receptor 0.0046 0.1218 0.1295
Echinococcus granulosus g protein coupled receptor 0.0046 0.1218 0.1295
Brugia malayi putative neuropeptide receptor NPR1 0.0046 0.1218 0.1295
Echinococcus multilocularis g protein coupled receptor 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0077 0.2271 0.238
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Brugia malayi Animal haem peroxidase family protein 0.0077 0.2271 0.2414
Schistosoma mansoni hypothetical protein 0.0046 0.1218 0.1295
Brugia malayi beta-lactamase family protein 0.0035 0.0882 0.0937
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0046 0.1218 0.1295
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.3796 0.4035
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0077 0.2271 0.238
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Schistosoma mansoni thyroid hormone receptor 0.0134 0.4124 0.4383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0042 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0042 0.0042
Echinococcus granulosus tachykinin peptides receptor 99D 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) blistered cuticle protein 3 0.0077 0.2271 0.2271
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1855 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.1218 0.1295
Plasmodium falciparum glutathione reductase 0.0062 0.1758 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Echinococcus multilocularis sex peptide receptor 0.0046 0.1218 0.1295
Schistosoma mansoni growth hormone secretagogue receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0046 0.1218 0.1218
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.1218 0.1295
Schistosoma mansoni amine GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0017 0.0266 0.0266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0046 0.1218 0.1256
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Brugia malayi hypothetical protein 0.012 0.3661 0.3891
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0882 0.068
Onchocerca volvulus 0.0046 0.1218 0.1256
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.1855 0.1855
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0042 0.0045
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0046 0.1218 0.1295
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.1218 0.1295
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0042 0.0045
Onchocerca volvulus 0.0046 0.1218 0.1256
Onchocerca volvulus 0.0035 0.0882 0.0896
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0046 0.1218 0.1256
Echinococcus granulosus allatostatin A receptor 0.0046 0.1218 0.1295
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0042 0.0045
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0042 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0042 0.0045
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0423 0.1913
Onchocerca volvulus 0.0046 0.1218 0.1256
Echinococcus multilocularis neuropeptide receptor A26 0.0046 0.1218 0.1295
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0042 0.0045
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0046 0.1218 0.1256
Echinococcus granulosus sex peptide receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Schistosoma mansoni hypothetical protein 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Brugia malayi Melatonin receptor type 1A 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) beta-lactamase 0.0035 0.0882 0.0882
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0882 0.4505
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0882 0.068
Schistosoma mansoni hypothetical protein 0.0124 0.3796 0.4035
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0042 0.0045
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0042 0.0045
Brugia malayi Peroxidasin 0.0077 0.2271 0.2414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Trichomonas vaginalis glutathione reductase, putative 0.0021 0.0423 0.4246
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Onchocerca volvulus 0.0046 0.1218 0.1256
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0042 0.0042
Brugia malayi follicle stimulating hormone receptor 0.0272 0.8676 0.9222
Echinococcus multilocularis thyroid hormone receptor alpha 0.0134 0.4124 0.4383
Loa Loa (eye worm) thioredoxin reductase 0.0062 0.1758 0.1758
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0882 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0062 0.1758 0.1869
Echinococcus multilocularis neuropeptide FF receptor 2 0.0046 0.1218 0.1295
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Schistosoma mansoni alpha-1 adrenergic receptor 0.0046 0.1218 0.1295
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Schistosoma mansoni neuropeptide receptor 0.0046 0.1218 0.1295
Schistosoma mansoni peroxidasin 0.0077 0.2271 0.2414
Echinococcus granulosus somatostatin receptor 0.0046 0.1218 0.1295
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0042 0.0045
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.1218 0.1295
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0882 0.0937
Schistosoma mansoni myosin xvIII 0.0046 0.1218 0.1295
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.1218 0.1295
Trichomonas vaginalis esterase, putative 0.0035 0.0882 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.1218 0.1295
Echinococcus multilocularis G protein coupled receptor 139 0.0046 0.1218 0.1295
Echinococcus multilocularis neuropeptide receptor 0.0046 0.1218 0.1295
Echinococcus granulosus protein cereblon 0.0294 0.9408 1
Onchocerca volvulus Peroxidasin homolog 0.0077 0.2271 0.238
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus granulosus hypothetical protein 0.0046 0.1218 0.1295
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Onchocerca volvulus 0.0046 0.1218 0.1256
Trichomonas vaginalis mercuric reductase, putative 0.0021 0.0423 0.4246
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0062 0.1758 0.1979
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Mycobacterium tuberculosis Conserved protein 0.0035 0.0882 0.068
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.1218 0.1218
Schistosoma mansoni amine GPCR 0.0046 0.1218 0.1295
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0272 0.8676 0.8676
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Schistosoma mansoni biogenic amine receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.1218 0.1295
Echinococcus granulosus fmrfamide receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Brugia malayi GnHR receptor homolog 0.0046 0.1218 0.1295
Echinococcus granulosus peroxidasin 0.0077 0.2271 0.2414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0042 0.0042
Loa Loa (eye worm) melatonin receptor type 1A 0.0046 0.1218 0.1218
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0042 0.0045
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.1218 0.1295
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0042 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0882 0.4505
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0046 0.1218 0.1295
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.1218 0.1295
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus granulosus neuropeptide receptor 0.0046 0.1218 0.1295
Brugia malayi G-protein coupled receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0042 0.0042
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0021 0.0423 0.1526
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Schistosoma mansoni hypothetical protein 0.0046 0.1218 0.1295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Echinococcus granulosus geminin 0.0167 0.5208 0.5536
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.00000000013006 0.00000000073963
Brugia malayi Blistered cuticle protein 3 0.0077 0.2271 0.2414
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0235 0.0249
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0021 0.0423 0.5
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0882 0.068
Echinococcus multilocularis G-protein coupled receptor, putative 0.0046 0.1218 0.1295
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0046 0.1218 0.1295
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0042 0.0045
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0021 0.0423 0.1913
Echinococcus multilocularis serotonin receptor 0.0046 0.1218 0.1295
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0046 0.1218 0.1295
Schistosoma mansoni biogenic amine receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) RecQ helicase 0.0021 0.0406 0.0406
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0046 0.1218 0.1256
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.1218 0.1295
Brugia malayi Thioredoxin reductase 0.0062 0.1758 0.1869
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0322 0.1832
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Brugia malayi hypothetical protein 0.0294 0.9408 1
Schistosoma mansoni hypothetical protein 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Schistosoma mansoni histamine h1 receptor 0.0046 0.1218 0.1295
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0021 0.0423 0.0449
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0406 0.0432
Brugia malayi sulfakinin receptor protein 0.0046 0.1218 0.1295
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0177 0.1005
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0046 0.1218 0.1295
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0882 1
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0021 0.0423 0.2404
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0882 0.068
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0882 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0042 0.0045
Echinococcus multilocularis serotonin receptor 0.0046 0.1218 0.1295
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0882 0.4505
Loa Loa (eye worm) hypothetical protein 0.0035 0.0882 0.0882
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Toxoplasma gondii ABC1 family protein 0.0035 0.0882 0.5014
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Treponema pallidum NADH oxidase 0.0021 0.0423 0.5
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.1855 1
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.1218 0.1218
Leishmania major hypothetical protein, conserved 0.0035 0.0882 0.4505
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.1218 0.1218
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0406 0.4039
Echinococcus granulosus 7TM GPCR rhodopsin 0.0046 0.1218 0.1295
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0882 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.1218 0.1295
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Brugia malayi AKH receptor 0.0046 0.1218 0.1295
Schistosoma mansoni amine GPCR 0.0046 0.1218 0.1295
Brugia malayi Dopamine receptor protein 2 0.0046 0.1218 0.1295
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0042 0.0045
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.1758 0.9457
Brugia malayi Animal haem peroxidase family protein 0.0077 0.2271 0.2414
Loa Loa (eye worm) glutathione reductase 0.0062 0.1758 0.1758
Giardia lamblia NADH oxidase lateral transfer candidate 0.0021 0.0423 1
Onchocerca volvulus 0.0046 0.1218 0.1256
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0046 0.1218 0.1295
Leishmania major trypanothione reductase 0.0062 0.1758 0.9457
Brugia malayi neuropeptide F receptor 0.0046 0.1218 0.1295
Onchocerca volvulus Dual oxidase homolog 0.0077 0.2271 0.238
Echinococcus granulosus orexin receptor type 2 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Schistosoma mansoni neuropeptide f receptor 76f 0.0046 0.1218 0.1295
Echinococcus granulosus neuropeptide s receptor 0.0046 0.1218 0.1295
Toxoplasma gondii thioredoxin reductase 0.0062 0.1758 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0882 1
Brugia malayi glutathione reductase 0.0062 0.1758 0.1869
Brugia malayi hypothetical protein 0.0077 0.2271 0.2414
Schistosoma mansoni peroxidasin 0.0077 0.2271 0.2414
Schistosoma mansoni hypothetical protein 0.0167 0.5208 0.5536
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0953 0.1013
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0046 0.1218 0.1295
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Brugia malayi Serotonin receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0042 0.0042
Brugia malayi G protein-coupled receptor F59B2.13 0.0046 0.1218 0.1295
Plasmodium vivax thioredoxin reductase, putative 0.0062 0.1758 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Brugia malayi larval opioid receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis fmrfamide receptor 0.0046 0.1218 0.1295
Echinococcus granulosus peptide allatostatin:somatostatin 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Plasmodium vivax glutathione reductase, putative 0.0062 0.1758 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0046 0.1218 0.1295
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0406 0.0432
Echinococcus granulosus neuropeptide receptor 0.0046 0.1218 0.1295
Schistosoma mansoni neuropeptide receptor 0.0046 0.1218 0.1295
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0046 0.1218 0.1256
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0042 0.0045
Echinococcus granulosus neuropeptide FF receptor 2 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0423 0.1913
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis neuropeptide s receptor 0.0046 0.1218 0.1295
Schistosoma mansoni neuropeptide receptor 0.0046 0.1218 0.1295
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.1218 0.1295
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0042 0.0045
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0021 0.0423 0.0449
Schistosoma mansoni opsin-like receptor 0.0046 0.1218 0.1295
Brugia malayi nuclear hormone receptor 0.001 0.0042 0.0045
Mycobacterium leprae Probable lipase LipE 0.0035 0.0882 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0021 0.0423 0.1913
Echinococcus multilocularis thioredoxin glutathione reductase 0.0062 0.1758 0.1869
Onchocerca volvulus 0.0046 0.1218 0.1256
Brugia malayi Tachykinin-like peptides receptor 99D 0.0046 0.1218 0.1295
Echinococcus multilocularis neuropeptide receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0042 0.0045
Onchocerca volvulus 0.0046 0.1218 0.1256
Onchocerca volvulus Neuropeptide F receptor homolog 0.0046 0.1218 0.1256
Echinococcus multilocularis fmrfamide receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0882 0.0937
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.1218 0.1295
Brugia malayi Dopamine receptor protein 1 0.0046 0.1218 0.1295
Brugia malayi Serotonin receptor 0.0046 0.1218 0.1295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.1855 0.1971
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.2271 0.2271
Brugia malayi ORL1-like opioid receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0042 0.0045
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1855 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0042 0.0045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0042 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0423 0.1913
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Echinococcus granulosus alpha 1A adrenergic receptor 0.0046 0.1218 0.1295
Plasmodium falciparum thioredoxin reductase 0.0062 0.1758 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0042 0.0045
Schistosoma mansoni amine GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.1218 0.1295
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0042 0.0045
Schistosoma mansoni thyroid hormone receptor 0.0134 0.4124 0.4383
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus multilocularis somatostatin receptor 0.0046 0.1218 0.1295
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0882 0.068
Schistosoma mansoni amine GPCR 0.0046 0.1218 0.1295
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1855 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0042 0.0045
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0021 0.0423 0.1526
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0882 0.068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0046 0.1218 0.1218
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis peroxidasin 0.0077 0.2271 0.2414
Schistosoma mansoni biogenic amine receptor 0.0046 0.1218 0.1295
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0042 0.0045
Brugia malayi beta-lactamase 0.0035 0.0882 0.0937
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.2271 0.2271
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.1218 0.1295
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.1218 0.1295
Onchocerca volvulus Chorion peroxidase homolog 0.0077 0.2271 0.238
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0406 0.4039
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0042 0.0042
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0423 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0042 0.0045
Brugia malayi nuclear receptor NHR-88 0.001 0.0042 0.0045
Plasmodium falciparum glutathione reductase 0.0021 0.0423 0.2404
Brugia malayi Animal haem peroxidase family protein 0.0077 0.2271 0.2414
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0423 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0046 0.1218 0.1295
Schistosoma mansoni neuropeptide receptor 0.0046 0.1218 0.1295
Mycobacterium tuberculosis Conserved protein 0.0035 0.0882 0.068
Onchocerca volvulus Peroxidasin homolog 0.0077 0.2271 0.238
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0042 0.0045
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0046 0.1218 0.1295
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0021 0.0423 0.0449
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.0423 0.1913
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.7172 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0046 0.1218 0.1218
Echinococcus granulosus g-protein coupled receptor 0.0046 0.1218 0.1295
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0882 0.0937
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0235 0.0249
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0035 0.0882 0.0882
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.1218 0.1295
Entamoeba histolytica hypothetical protein, conserved 0.0294 0.9408 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0882 1
Schistosoma mansoni coup transcription factor 0.001 0.0042 0.0045
Echinococcus multilocularis protein cereblon 0.0294 0.9408 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0046 0.1218 0.1295
Brugia malayi ecdysteroid receptor 0.001 0.0042 0.0045
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0423 0.1913
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0882 0.0937
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.1218 0.1295
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0953 0.1013
Echinococcus multilocularis orexin receptor type 2 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0046 0.1218 0.1256
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0882 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0882 0.0882
Echinococcus granulosus g protein coupled receptor 0.0046 0.1218 0.1295
Schistosoma mansoni adenoreceptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Brugia malayi beta-lactamase family protein 0.0035 0.0882 0.0937
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0261 0.0277
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0035 0.0882 0.0896
Onchocerca volvulus Peroxidase homolog 0.0077 0.2271 0.238
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0042 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0035 0.0882 0.0882
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0046 0.1218 0.1218
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.3796 0.4035
Brugia malayi hypothetical protein 0.0046 0.1218 0.1295
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0046 0.1218 0.1295
Echinococcus granulosus g protein coupled receptor 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.1218 0.1295
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0042 0.0045
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.1855 0.1971
Echinococcus granulosus G protein coupled receptor 139 0.0046 0.1218 0.1295
Onchocerca volvulus 0.0046 0.1218 0.1256
Loa Loa (eye worm) hypothetical protein 0.0077 0.2271 0.2271
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0046 0.1218 0.1218

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 150 nM Compound was tested for its ability to inhibit muscarinic receptor in rat cerebral cortex using [3H]-oxotremorine-M (OXO-M); Range is 120-220 ChEMBL. No reference
IC50 (binding) = 150 nM Compound was tested for its ability to inhibit muscarinic receptor in rat cerebral cortex using [3H]-oxotremorine-M (OXO-M); Range is 120-220 ChEMBL. No reference
IC50 (binding) = 4500 nM Compound was tested for its ability to inhibit muscarinic receptor in rat cerebral cortex using [3H]-quinuclidinyl benzilate (QNB); Range is 4300-9500 ChEMBL. No reference
IC50 (binding) = 4500 nM Compound was tested for its ability to inhibit muscarinic receptor in rat cerebral cortex using [3H]-quinuclidinyl benzilate (QNB); Range is 4300-9500 ChEMBL. No reference
Ratio (binding) 30 Efficacy ratio was determined against Muscarinic receptor using QNB/ OXO- M ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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