Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Gonadotropin-releasing hormone receptor | Starlite/ChEMBL | References |
Homo sapiens | gonadotropin-releasing hormone receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | GnHR receptor homolog | Get druggable targets OG5_131719 | All targets in OG5_131719 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0553 | 0.0314 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0553 | 0.0314 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0666 | 0.2252 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0666 | 0.2252 | 0.4785 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0666 | 0.2252 | 0.4785 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0553 | 0.0314 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0666 | 0.2252 | 0.4785 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0809 | 0.4706 | 1 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0553 | 0.0314 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0666 | 0.2252 | 0.4785 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0666 | 0.2252 | 0.4785 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0809 | 0.4706 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0535 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0535 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0666 | 0.2252 | 0.4785 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0809 | 0.4706 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0666 | 0.2252 | 0.4785 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0666 | 0.2252 | 0.4785 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0553 | 0.0314 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0553 | 0.0314 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0666 | 0.2252 | 0.4785 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0666 | 0.2252 | 0.4785 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 180 nM | In vitro binding affinity to human gonadotropin-releasing hormone receptor | ChEMBL. | 12419385 |
Ki (binding) | = 180 nM | In vitro binding affinity to human gonadotropin-releasing hormone receptor | ChEMBL. | 12419385 |
Ki (binding) | = 1200 nM | Binding affinity to rat gonadotropin-releasing hormone receptor | ChEMBL. | 12419385 |
Ki (binding) | = 1200 nM | Binding affinity to rat gonadotropin-releasing hormone receptor | ChEMBL. | 12419385 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.