Detailed information for compound 205574

Basic information

Technical information
  • TDR Targets ID: 205574
  • Name: 1-[10-(4-oxoquinolin-1-yl)decyl]quinolin-4-on e
  • MW: 428.566 | Formula: C28H32N2O2
  • H donors: 0 H acceptors: 2 LogP: 8.46 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]c1cc[n+](c2c1cccc2)CCCCCCCCCC[n+]1ccc(c2c1cccc2)[O-]
  • InChi: 1S/C28H32N2O2/c31-27-17-21-29(25-15-9-7-13-23(25)27)19-11-5-3-1-2-4-6-12-20-30-22-18-28(32)24-14-8-10-16-26(24)30/h7-10,13-18,21-22H,1-6,11-12,19-20H2
  • InChiKey: FREREHUYTIRPOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[10-(4-oxo-1-quinolyl)decyl]quinolin-4-one
  • 1-[10-(4-oxo-1-quinolyl)decyl]-4-quinolinone
  • 1-[10-(4-keto-1-quinolyl)decyl]-4-quinolone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Small conductance calcium-activated potassium channel Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus small conductance calcium activated potassium Small conductance calcium-activated potassium channel   580 aa 475 aa 48.0 %
Echinococcus multilocularis small conductance calcium activated potassium Small conductance calcium-activated potassium channel   580 aa 475 aa 48.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0011 0.0082 0.2232
Schistosoma mansoni hypothetical protein 0.001 0.0067 0.0067
Echinococcus multilocularis twik family of potassium channels 0.0009 0.0051 0.0024
Echinococcus multilocularis cathepsin L cysteine protease 0.0011 0.0082 0.0055
Entamoeba histolytica cysteine protease, putative 0.0011 0.0082 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Brugia malayi Calcitonin receptor-like protein seb-1 0.0031 0.0569 0.0817
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0082 0.2232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0082 0.2232
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0365 0.4344
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0011 0.0082 0.2232
Loa Loa (eye worm) hypothetical protein 0.0008 0.0019 0.0028
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0732 0.0732
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0011 0.0082 0.2232
Schistosoma mansoni twik family of potassium channels-related 0.0009 0.0051 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0775 1
Echinococcus granulosus integrin alpha ps 0.0067 0.1397 0.1397
Echinococcus multilocularis lamin 0.0017 0.0232 0.0206
Echinococcus granulosus adam 0.001 0.0065 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0775 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Brugia malayi cytoplasmic intermediate filament protein 0.0009 0.0048 0.0068
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0009 0.0051 0.0073
Loa Loa (eye worm) hypothetical protein 0.0095 0.2055 0.2949
Schistosoma mansoni twik family of potassium channels-related 0.0009 0.0051 0.0051
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.001 0.0067 0.0096
Loa Loa (eye worm) hypothetical protein 0.0085 0.1828 0.2622
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0023 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0011 0.0082 0.0117
Schistosoma mansoni intermediate filament proteins 0.0017 0.0232 0.0232
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0031 0.0569 0.0817
Trichomonas vaginalis penicillin-binding protein, putative 0.0023 0.0365 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0082 0.2232
Schistosoma mansoni calcium-activated potassium channel 0.0181 0.4048 0.4048
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.001 0.0067 0.0067
Onchocerca volvulus 0.0011 0.0082 0.2232
Echinococcus granulosus twik family of potassium channels 0.0009 0.0051 0.0051
Brugia malayi hypothetical protein 0.0009 0.0051 0.0073
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0051 0.1392
Brugia malayi EGF-like domain containing protein 0.001 0.0065 0.0093
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0011 0.0082 0.0117
Onchocerca volvulus Cathepsin L homolog 0.0011 0.0082 0.2232
Onchocerca volvulus 0.0009 0.0051 0.1392
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0009 0.0051 0.0073
Echinococcus granulosus potassium channel subfamily K 8 0.0009 0.0051 0.0051
Trypanosoma cruzi cruzipain precursor, putative 0.004 0.0775 1
Brugia malayi beta-lactamase 0.0023 0.0365 0.0524
Schistosoma mansoni integrin alpha 0.0149 0.3319 0.3319
Brugia malayi hypothetical protein 0.0009 0.0051 0.0073
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0051 0.1392
Toxoplasma gondii histone lysine methyltransferase SET1 0.0034 0.0636 1
Brugia malayi Latrophilin receptor protein 2 0.001 0.0067 0.0096
Onchocerca volvulus Cathepsin F homolog 0.0011 0.0082 0.2232
Echinococcus multilocularis lamin dm0 0.0017 0.0232 0.0206
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0113 0.247 0.3544
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0011 0.0082 0.2232
Loa Loa (eye worm) hypothetical protein 0.0023 0.0365 0.0524
Echinococcus multilocularis integrin alpha 3 0.0115 0.2506 0.2486
Onchocerca volvulus 0.0009 0.0051 0.1392
Mycobacterium tuberculosis Probable hydrolase 0.0023 0.0365 0.0991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0082 0.2232
Loa Loa (eye worm) hypothetical protein 0.0031 0.0569 0.0817
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0047 0.0919 0.1319
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0011 0.0082 0.2232
Echinococcus granulosus calcium activated potassium channel variant 0.0009 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0365 1
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0009 0.0051 0.0073
Loa Loa (eye worm) hypothetical protein 0.0035 0.0648 0.093
Echinococcus granulosus integrin beta 2 0.0227 0.5121 0.5121
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0017 0.0232 0.0333
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0009 0.0051 0.0024
Brugia malayi intermediate filament protein 0.0017 0.0232 0.0333
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0093
Brugia malayi Integrin beta pat-3 precursor 0.0306 0.6971 1
Echinococcus multilocularis twik family of potassium channels 0.0009 0.0051 0.0024
Echinococcus multilocularis GPCR, family 2 0.001 0.0067 0.0041
Echinococcus granulosus dnaJ subfamily B 0.0258 0.586 0.586
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0009 0.0051 0.0073
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0082 0.2232
Brugia malayi CXXC zinc finger family protein 0.0018 0.0258 0.037
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Echinococcus granulosus cathepsin l1 0.0011 0.0082 0.0082
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0023 0.0365 0.0991
Echinococcus multilocularis integrin alpha ps 0.0067 0.1397 0.1374
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Onchocerca volvulus 0.0011 0.0082 0.2232
Onchocerca volvulus 0.0009 0.0051 0.1392
Leishmania major cathepsin L-like protease 0.0011 0.0082 0.0424
Trypanosoma cruzi cysteine peptidase, putative 0.0011 0.0082 0.0424
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0051 0.1392
Onchocerca volvulus 0.0011 0.0082 0.2232
Mycobacterium tuberculosis Probable lipase LipE 0.0023 0.0365 0.0991
Echinococcus granulosus integrin alpha ps 0.0032 0.0584 0.0584
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0037 0.0693 0.8873
Schistosoma mansoni lamin 0.0017 0.0232 0.0232
Brugia malayi EGF-like domain containing protein 0.001 0.0065 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0082 0.2232
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0009 0.0051 0.0073
Schistosoma mansoni calcium-activated potassium channel 0.019 0.4264 0.4264
Onchocerca volvulus 0.0017 0.0232 0.6356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0011 0.0082 0.2232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0011 0.0082 0.2232
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0093
Echinococcus multilocularis integrin alpha ps 0.0067 0.1397 0.1374
Giardia lamblia High cysteine protein 0.001 0.0065 1
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0009 0.0051 0.0051
Brugia malayi latrophilin 2 splice variant baaae 0.0022 0.0337 0.0483
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0082 0.2232
Mycobacterium ulcerans hypothetical protein 0.0023 0.0365 1
Loa Loa (eye worm) TWK-28 protein 0.0009 0.0051 0.0073
Echinococcus multilocularis dnaJ subfamily B 0.0258 0.586 0.5849
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0011 0.0082 1
Echinococcus multilocularis musashi 0.0017 0.0232 0.0206
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Brugia malayi beta-lactamase family protein 0.0023 0.0365 0.0524
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0093
Giardia lamblia hypothetical protein 0.001 0.0065 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0023 0.0365 0.0365
Leishmania major cysteine peptidase A (CPA) 0.0011 0.0082 0.0424
Toxoplasma gondii cathepsin CPL 0.0011 0.0082 0.0524
Onchocerca volvulus 0.0023 0.0365 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0082 0.2232
Schistosoma mansoni hypothetical protein 0.001 0.0067 0.0067
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0011 0.0082 0.0055
Echinococcus granulosus fibrillin 2 0.001 0.0065 0.0065
Echinococcus multilocularis calcium activated potassium channel variant 0.0009 0.0051 0.0024
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0011 0.0082 0.0117
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0011 0.0082 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0082 0.2232
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0009 0.0051 0.0073
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0008 0.0027 0.0027
Loa Loa (eye worm) latrophilin receptor protein 2 0.001 0.0067 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0096
Giardia lamblia Tenascin-like 0.001 0.0065 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0009 0.0051 0.0073
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0009 0.0051 0.0073
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0009 0.0051 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0365 0.0524
Trichomonas vaginalis penicillin-binding protein, putative 0.0023 0.0365 1
Leishmania major cathepsin L-like protease 0.004 0.0775 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Plasmodium vivax vivapain-2 0.0011 0.0082 0.0977
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0051 0.1392
Schistosoma mansoni cpg binding protein 0.0019 0.0282 0.0282
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0009 0.0051 0.0073
Trypanosoma cruzi cysteine peptidase, putative 0.004 0.0775 1
Schistosoma mansoni hypothetical protein 0.0022 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Giardia lamblia High cysteine protein 0.001 0.0065 1
Brugia malayi Cathepsin L-like precursor 0.0011 0.0082 0.0117
Giardia lamblia Tenascin-37 0.001 0.0065 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0011 0.0082 0.2232
Trichomonas vaginalis esterase, putative 0.0023 0.0365 1
Loa Loa (eye worm) uncoordinated protein 58 0.0009 0.0051 0.0073
Brugia malayi Kelch motif family protein 0.0047 0.0919 0.1319
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0775 1
Echinococcus granulosus small conductance calcium activated potassium 0.019 0.4264 0.4264
Schistosoma mansoni twik family of potassium channels-related 0.0009 0.0051 0.0051
Loa Loa (eye worm) CXXC zinc finger family protein 0.0018 0.0258 0.037
Echinococcus multilocularis potassium channel subfamily K 0.0009 0.0051 0.0024
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0365 0.5
Echinococcus multilocularis potassium channel subfamily K 8 0.0009 0.0051 0.0024
Echinococcus granulosus beta LACTamase domain containing family member 0.0023 0.0365 0.0365
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0009 0.0051 0.0073
Echinococcus multilocularis fibrillin 2 0.001 0.0065 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0337 0.0483
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0775 1
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0365 1
Toxoplasma gondii ABC1 family protein 0.0023 0.0365 0.537
Loa Loa (eye worm) hypothetical protein 0.0023 0.0365 0.0524
Echinococcus granulosus integrin alpha 3 0.0115 0.2506 0.2506
Onchocerca volvulus 0.0018 0.0258 0.7062
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0009 0.0051 0.0073
Brugia malayi Cathepsin L-like precursor 0.0011 0.0082 0.0117
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0009 0.0051 0.0073
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0009 0.0051 0.0073
Trichomonas vaginalis hypothetical protein 0.001 0.0065 0.1776
Leishmania major cathepsin L-like protease 0.004 0.0775 1
Echinococcus multilocularis cysteine protease 0.0011 0.0082 0.0055
Brugia malayi Cathepsin L-like precursor 0.0011 0.0082 0.0117
Loa Loa (eye worm) cysteine protease 0.0011 0.0082 0.0117
Schistosoma mansoni cpg binding protein 0.0019 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Loa Loa (eye worm) intermediate filament protein 0.0017 0.0232 0.0333
Mycobacterium tuberculosis Probable lipase LipD 0.0023 0.0365 0.0991
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0145 0.3223 1
Trypanosoma cruzi cysteine peptidase, putative 0.004 0.0775 1
Echinococcus multilocularis integrin beta 2 0.0227 0.5121 0.5108
Schistosoma mansoni integrin beta subunit 0.018 0.4037 0.4037
Loa Loa (eye worm) hypothetical protein 0.0023 0.0365 0.0524
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0365 0.4344
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0011 0.0082 0.0055
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0023 0.0365 0.0991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0082 0.2232
Leishmania major cathepsin L-like protease 0.0011 0.0082 0.0424
Mycobacterium ulcerans beta-lactamase 0.0023 0.0365 1
Giardia lamblia Neurogenic locus Notch protein precursor 0.001 0.0065 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0023 0.0365 0.0524
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0365 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0775 1
Schistosoma mansoni lamin 0.0017 0.0232 0.0232
Giardia lamblia Tenascin precursor 0.001 0.0065 1
Loa Loa (eye worm) ctsf protein 0.0011 0.0082 0.0117
Onchocerca volvulus 0.0011 0.0082 0.2232
Loa Loa (eye worm) hypothetical protein 0.0117 0.257 0.3687
Schistosoma mansoni hypothetical protein 0.0032 0.0584 0.0584
Leishmania major cathepsin L-like protease 0.0011 0.0082 0.0424
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Mycobacterium tuberculosis Conserved protein 0.0023 0.0365 0.0991
Onchocerca volvulus 0.0009 0.0051 0.1392
Onchocerca volvulus Cathepsin L homolog 0.0011 0.0082 0.2232
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Onchocerca volvulus 0.0011 0.0082 0.2232
Giardia lamblia Tenascin-X 0.001 0.0065 1
Giardia lamblia Neurogenic locus notch-like protein 0.001 0.0065 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0082 0.2232
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0009 0.0051 0.0073
Schistosoma mansoni hypothetical protein 0.001 0.0067 0.0067
Plasmodium falciparum cysteine proteinase falcipain 3 0.0011 0.0082 1
Toxoplasma gondii hypothetical protein 0.001 0.0065 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0082 0.2232
Onchocerca volvulus 0.0023 0.0365 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Schistosoma mansoni twik family of potassium channels-related 0.0009 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Brugia malayi Cathepsin L-like precursor 0.0011 0.0082 0.0117
Loa Loa (eye worm) hypothetical protein 0.0023 0.0365 0.0524
Leishmania major cathepsin L-like protease 0.004 0.0775 1
Loa Loa (eye worm) integrin alpha pat-2 0.023 0.5205 0.7467
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0009 0.0048 0.0068
Loa Loa (eye worm) hypothetical protein 0.0082 0.1757 0.252
Echinococcus multilocularis potassium channel subfamily K 8 0.0009 0.0051 0.0024
Echinococcus granulosus lamin dm0 0.0017 0.0232 0.0232
Echinococcus granulosus potassium channel subfamily K 8 0.0009 0.0051 0.0051
Loa Loa (eye worm) fibroinase 0.0011 0.0082 0.0117
Loa Loa (eye worm) hypothetical protein 0.0017 0.0225 0.0323
Echinococcus multilocularis cathepsin L cysteine protease 0.0011 0.0082 0.0055
Echinococcus multilocularis beta LACTamase domain containing family member 0.0023 0.0365 0.034
Onchocerca volvulus 0.0009 0.0051 0.1392
Plasmodium vivax vivapain-2 0.0011 0.0082 0.0977
Schistosoma mansoni hypothetical protein 0.001 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Schistosoma mansoni calcium-activated potassium channel 0.0009 0.0051 0.0051
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.001 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0113 0.247 0.3544
Echinococcus granulosus lamin 0.0017 0.0232 0.0232
Mycobacterium ulcerans esterase/lipase LipP 0.0023 0.0365 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0365 0.0524
Onchocerca volvulus 0.0009 0.0051 0.1392
Brugia malayi EGF-like domain containing protein 0.001 0.0065 0.0093
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Loa Loa (eye worm) hypothetical protein 0.0017 0.0232 0.0333
Echinococcus granulosus GPCR family 2 0.001 0.0067 0.0067
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.001 0.0067 0.0041
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.001 0.0065 0.1776
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0082 0.2232
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0082 0.0082
Echinococcus multilocularis cpg binding protein 0.0019 0.0282 0.0256
Brugia malayi Cathepsin L-like precursor 0.0011 0.0082 0.0117
Brugia malayi Intermediate filament tail domain containing protein 0.0017 0.0232 0.0333
Mycobacterium leprae Probable lipase LipE 0.0023 0.0365 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0011 0.0082 0.2232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0011 0.0082 0.2232
Schistosoma mansoni microtubule-associated protein tau 0.0436 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0775 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0082 0.2232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0775 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0082 1
Mycobacterium tuberculosis Conserved protein 0.0023 0.0365 0.0991
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Loa Loa (eye worm) hypothetical protein 0.0032 0.0584 0.0837
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0023 0.0365 0.0524
Loa Loa (eye worm) beta-lactamase 0.0023 0.0365 0.0524
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0011 0.0082 0.2232
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0365 0.4344
Schistosoma mansoni cpg binding protein 0.0018 0.0258 0.0258
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0082 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0031 0.0569 0.0817
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0775 1
Loa Loa (eye worm) TWK-7 protein 0.0009 0.0051 0.0073
Schistosoma mansoni integrin alpha-ps 0.0067 0.1397 0.1397
Echinococcus multilocularis small conductance calcium activated potassium 0.019 0.4264 0.4249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0775 1
Brugia malayi hypothetical protein 0.0047 0.0919 0.1319
Schistosoma mansoni twik family of potassium channels-related 0.0009 0.0051 0.0051
Schistosoma mansoni twik family of potassium channels-related 0.0009 0.0051 0.0051
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0009 0.0051 0.0073
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.001 0.0067 0.0041
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Loa Loa (eye worm) hypothetical protein 0.0047 0.0919 0.1319
Loa Loa (eye worm) integrin beta-2 0.0306 0.6971 1
Leishmania major cathepsin L-like protease 0.0011 0.0082 0.0424
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0009 0.0051 0.6235
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0009 0.0051 0.0024
Schistosoma mansoni twik family of potassium channels-related 0.0009 0.0051 0.0051
Schistosoma mansoni calcium-activated potassium channel 0.0009 0.0051 0.0051
Echinococcus multilocularis integrin alpha ps 0.0032 0.0584 0.0558
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0023 0.0365 0.0991
Echinococcus granulosus cathepsin L cysteine proteinase 0.0011 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0009 0.0051 0.0051
Onchocerca volvulus 0.0011 0.0082 0.2232
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0365 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0009 0.0051 0.0073
Echinococcus multilocularis fibrillin 1 0.001 0.0065 0.0038
Echinococcus granulosus cpg binding protein 0.0019 0.0282 0.0282
Echinococcus granulosus intermediate filament protein 0.0017 0.0232 0.0232
Mycobacterium ulcerans lipase LipD 0.0023 0.0365 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0032 0.0573 0.7221
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0051 0.1392
Brugia malayi Cathepsin L-like precursor 0.0011 0.0082 0.0117
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0009 0.0051 0.0073
Echinococcus granulosus twik family of potassium channels 0.0009 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Mycobacterium tuberculosis Conserved protein 0.0023 0.0365 0.0991
Brugia malayi Integrin alpha pat-2 precursor 0.0149 0.3319 0.4761
Onchocerca volvulus 0.0023 0.0365 1
Brugia malayi Papain family cysteine protease containing protein 0.0011 0.0082 0.0117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0775 1
Schistosoma mansoni integrin alpha-ps 0.0035 0.0648 0.0648
Schistosoma mansoni hypothetical protein 0.0009 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0008 0.0019 0.0028
Onchocerca volvulus 0.0017 0.0232 0.6356
Loa Loa (eye worm) hypothetical protein 0.019 0.4264 0.6117
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0009 0.0051 0.0073
Mycobacterium tuberculosis Probable esterase LipL 0.0023 0.0365 0.0991
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0775 1
Echinococcus granulosus fibrillin 1 0.001 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Schistosoma mansoni hypothetical protein 0.0258 0.586 0.586
Echinococcus granulosus potassium channel subfamily K 0.0009 0.0051 0.0051
Echinococcus multilocularis adam 0.001 0.0065 0.0038
Leishmania major hypothetical protein, conserved 0.0023 0.0365 0.4344
Onchocerca volvulus 0.0009 0.0051 0.1392
Schistosoma mansoni hypothetical protein 0.019 0.4264 0.4264
Onchocerca volvulus 0.001 0.0065 0.1776
Onchocerca volvulus 0.0009 0.0051 0.1392
Leishmania major cathepsin L-like protease 0.0011 0.0082 0.0424
Echinococcus multilocularis protein jagged 2 0.001 0.0065 0.0038
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0073
Onchocerca volvulus 0.0011 0.0082 0.2232
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0009 0.0051 0.0073
Brugia malayi EGF-like domain containing protein 0.001 0.0065 0.0093
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0023 0.0365 1
Schistosoma mansoni twik family of potassium channels-related 0.0009 0.0051 0.0051
Echinococcus multilocularis cysteine protease 0.0011 0.0082 0.0055
Echinococcus granulosus cathepsin l cysteine peptidase 0.0011 0.0082 0.0082
Brugia malayi beta-lactamase family protein 0.0023 0.0365 0.0524
Echinococcus multilocularis microtubule associated protein 2 0.0436 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0038
Trypanosoma cruzi cysteine peptidase, putative 0.004 0.0775 1

Activities

Activity type Activity value Assay description Source Reference
EMR (functional) > 10 Equieffective molar ratio(EMR) of the compound to that of the dequalinium, causing 50% inhibition of AHP(action potential). ChEMBL. 7658440
IC50 (functional) > 10 uM The SKCa-blocking action was assessed by its ability to inhibit the after hyperpolarization (AHP) in cultured rat sympathetic neurones ChEMBL. 7658440
IC50 (functional) > 10 uM The SKCa-blocking action was assessed by its ability to inhibit the after hyperpolarization (AHP) in cultured rat sympathetic neurones ChEMBL. 7658440

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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