Detailed information for compound 206856

Basic information

Technical information
  • TDR Targets ID: 206856
  • Name: Paullone Analogue 73
  • MW: 288.752 | Formula: C14H9ClN2OS
  • H donors: 2 H acceptors: 1 LogP: 2.9 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2ccsc2c2c(C1)c1cc(Cl)ccc1[nH]2
  • InChi: 1S/C14H9ClN2OS/c15-7-1-2-10-8(5-7)9-6-12(18)16-11-3-4-19-14(11)13(9)17-10/h1-5,17H,6H2,(H,16,18)
  • InChiKey: IUCQPIROBHBEID-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens cyclin B1 References
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens cyclin B2 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0199 0.1068 0.1068
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0067 0.0023 0.0087
Trichomonas vaginalis cyclins, putative 0.0124 0.0477 1
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0322 0.6748
Trypanosoma cruzi cyclin 6, putative 0.0124 0.0477 0.026
Plasmodium vivax protein kinase Crk2 0.0105 0.0322 1
Loa Loa (eye worm) hypothetical protein 0.0396 0.2634 0.4177
Loa Loa (eye worm) hypothetical protein 0.0436 0.2957 0.4694
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0067 0.0023 0.0087
Echinococcus multilocularis cyclin B 0.0124 0.0477 0.0477
Echinococcus multilocularis cyclin dependent kinase 1 0.0105 0.0322 0.0322
Chlamydia trachomatis glutamine binding protein 0.0102 0.0298 1
Trichomonas vaginalis cyclin B, putative 0.0124 0.0477 1
Leishmania major cyclin 0.0124 0.0477 0.026
Loa Loa (eye worm) norepinephrine transporter 0.0396 0.2634 0.4177
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.1068 0.1671
Entamoeba histolytica cell division protein kinase 2, putative 0.0105 0.0322 0.6748
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0067 0.0023 0.0023
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0124 0.0477 0.026
Echinococcus granulosus cyclin B 0.0124 0.0477 0.0477
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0067 0.0023 0.0087
Plasmodium falciparum protein kinase 5 0.0105 0.0322 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0069 0.0036 0.0137
Echinococcus granulosus nmda type glutamate receptor 0.0141 0.0613 0.0613
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0322 0.1221
Echinococcus multilocularis nmda type glutamate receptor 0.0141 0.0613 0.0613
Schistosoma mansoni cyclin B 0.0124 0.0477 0.1809
Echinococcus multilocularis sodium and chloride dependent glycine 0.0067 0.0023 0.0023
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0396 0.2634 0.4177
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.1945 0.1945
Schistosoma mansoni cyclin B3 0.0199 0.1068 0.4053
Echinococcus multilocularis cyclin dependent kinase 1 0.0105 0.0322 0.0322
Trichomonas vaginalis cyclins, putative 0.0075 0.0089 0.1865
Echinococcus granulosus cyclin dependent kinase 5 0.0105 0.0322 0.0322
Schistosoma mansoni sodium-dependent amino acid transporter 0.0067 0.0023 0.0087
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0067 0.0023 0.0023
Loa Loa (eye worm) serotonin transporter b 0.0396 0.2634 0.4177
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0854 0.6273 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0105 0.0322 0.6748
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.1945 0.7384
Entamoeba histolytica cyclin, putative 0.0124 0.0477 1
Echinococcus multilocularis cyclin dependent kinase 0.0105 0.0322 0.0322
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0105 0.0322 0.0478
Loa Loa (eye worm) hypothetical protein 0.0148 0.0665 0.1027
Brugia malayi Protein kinase domain containing protein 0.0105 0.0322 0.0478
Trichomonas vaginalis cyclins, putative 0.0124 0.0477 1
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.1945 0.1945
Echinococcus granulosus serotonin transporter 0.0396 0.2634 0.2634
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0102 0.0298 1
Trypanosoma cruzi cyclin, putative 0.0124 0.0477 0.026
Trypanosoma cruzi CYC2-like cyclin, putative 0.0124 0.0477 0.026
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1323 1 1
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0199 0.1068 0.1068
Trypanosoma brucei mitotic cyclin 6 0.0124 0.0477 0.026
Onchocerca volvulus 0.0396 0.2634 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.0477 0.0726
Trichomonas vaginalis cyclin B, putative 0.0124 0.0477 1
Trichomonas vaginalis cyclins, putative 0.0124 0.0477 1
Loa Loa (eye worm) hypothetical protein 0.0396 0.2634 0.4177
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0067 0.0023 0.0087
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0067 0.0023 0.0087
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0067 0.0023 0.0023
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0396 0.2634 1
Trichomonas vaginalis cyclin A, putative 0.0124 0.0477 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0067 0.0023 0.0023
Echinococcus multilocularis serotonin transporter 0.0396 0.2634 0.2634
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0067 0.0023 0.0087
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0067 0.0023 0.0023
Brugia malayi cell division control protein 2 homolog 0.0105 0.0322 0.0478
Plasmodium falciparum amino acid transporter, putative 0.0067 0.0023 0.0712
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0373 0.2456 0.5
Loa Loa (eye worm) solute carrier family 6 member 4 0.0396 0.2634 0.4177
Echinococcus granulosus cyclin dependent kinase 1 0.0105 0.0322 0.0322
Echinococcus granulosus sodium and chloride dependent glycine 0.0067 0.0023 0.0023
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0067 0.0023 0.0087
Onchocerca volvulus 0.0124 0.0477 0.1737
Trypanosoma brucei C-8 sterol isomerase, putative 0.0854 0.6273 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0141 0.0613 0.0613
Plasmodium falciparum transporter, putative 0.0067 0.0023 0.0712
Loa Loa (eye worm) hypothetical protein 0.0309 0.1945 0.3075
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.0477 0.0726
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0105 0.0322 0.0322
Echinococcus multilocularis thymidine phosphorylase 0.1323 1 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0105 0.0322 0.0478
Trichomonas vaginalis cyclin B, putative 0.0124 0.0477 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0105 0.0322 0.0322
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0322 0.1221
Loa Loa (eye worm) hypothetical protein 0.0124 0.0477 0.0726
Treponema pallidum sodium- and chloride- dependent transporter 0.0396 0.2634 1
Loa Loa (eye worm) hypothetical protein 0.0396 0.2634 0.4177
Brugia malayi hypothetical protein 0.0148 0.0665 0.1027
Giardia lamblia Kinase, CMGC CDK 0.0105 0.0322 0.6748
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0373 0.2456 0.2224
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0854 0.6273 1
Giardia lamblia Kinase, CMGC CDK 0.0105 0.0322 0.6748
Mycobacterium ulcerans thymidine phosphorylase 0.1323 1 1
Trichomonas vaginalis cyclin B, putative 0.0124 0.0477 1
Trichomonas vaginalis cyclins, putative 0.0124 0.0477 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0067 0.0023 0.0023
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0105 0.0322 0.0478
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0067 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0854 0.6273 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0665 0.1027
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0105 0.0322 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0067 0.0023 0.0087
Loa Loa (eye worm) hypothetical protein 0.0103 0.0308 0.0457
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.1068 0.1671
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0373 0.2456 0.2224
Giardia lamblia G2/mitotic-specific cyclin B 0.0124 0.0477 1
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0322 0.6748
Echinococcus granulosus sodium and chloride dependent glycine 0.0067 0.0023 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0322 0.6748
Leishmania major C-8 sterol isomerase-like protein 0.0854 0.6273 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0396 0.2634 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0067 0.0023 0.0087
Echinococcus granulosus cyclin dependent kinase 0.0105 0.0322 0.0322
Trypanosoma cruzi cyclin, putative 0.0124 0.0477 0.026
Loa Loa (eye worm) hypothetical protein 0.0124 0.0477 0.0726
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0067 0.0023 0.0023

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.301 Inhibitory activity against cyclin-dependent kinase 5/p25 ChEMBL. 14695817
IC50 (binding) = 6.301 Inhibitory activity against cyclin dependent kinase 1-cyclinB extracted from M phase starfish (Marthasterias glacialis) oocytes ChEMBL. 14695817
IC50 (binding) = 6.398 Inhibitory activity against glycogen synthase kinase-3 beta purified from insect sf9 cells ChEMBL. 14695817
Log IC50 (binding) = 5.301 Inhibitory activity against cyclin-dependent kinase 5/p25 ChEMBL. 14695817
Log IC50 (binding) = 6.301 Inhibitory activity against cyclin dependent kinase 1-cyclinB extracted from M phase starfish (Marthasterias glacialis) oocytes ChEMBL. 14695817
Log IC50 (binding) = 6.398 Inhibitory activity against glycogen synthase kinase-3 beta purified from insect sf9 cells ChEMBL. 14695817

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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