Detailed information for compound 206866

Basic information

Technical information
  • TDR Targets ID: 206866
  • Name: 2-iodo-7,12-dihydro-5H-indolo[3,2-d][1]benzaz epin-6-one
  • MW: 374.176 | Formula: C16H11IN2O
  • H donors: 2 H acceptors: 1 LogP: 3.21 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Ic1ccc2c(c1)c1[nH]c3c(c1CC(=O)N2)cccc3
  • InChi: 1S/C16H11IN2O/c17-9-5-6-14-12(7-9)16-11(8-15(20)18-14)10-3-1-2-4-13(10)19-16/h1-7,19H,8H2,(H,18,20)
  • InChiKey: ISVUJGXTZKJOGX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Paullone Analog 20

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin B1 References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References
Homo sapiens cyclin B2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0114 0.0959 0.0959
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0114 0.0959 0.0959
Echinococcus multilocularis g-protein coupled receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Schistosoma mansoni neuropeptide receptor 0.0114 0.0959 0.0959
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0114 0.0959 0.0959
Echinococcus granulosus cyclin B 0.0124 0.1168 0.1168
Entamoeba histolytica cell division protein kinase 2, putative 0.0105 0.0789 0.6748
Trichomonas vaginalis cyclins, putative 0.0124 0.1168 1
Schistosoma mansoni amine GPCR 0.0114 0.0959 0.0959
Echinococcus granulosus orexin receptor type 2 0.0114 0.0959 0.0959
Schistosoma mansoni amine GPCR 0.0114 0.0959 0.0959
Brugia malayi hypothetical protein 0.0114 0.0959 0.0323
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0114 0.0959 0.0959
Echinococcus granulosus rhodopsin orphan GPCR 0.0114 0.0959 0.0959
Echinococcus granulosus allatostatin A receptor 0.0114 0.0959 0.0959
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0114 0.0959 0.0959
Brugia malayi Protein kinase domain containing protein 0.0105 0.0789 0.014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0114 0.0959 0.0959
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0114 0.0959 0.0959
Brugia malayi Dopamine receptor protein 2 0.0114 0.0959 0.0323
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0105 0.0789 0.014
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0124 0.1168 1
Brugia malayi neuropeptide F receptor 0.0114 0.0959 0.0323
Schistosoma mansoni sodium/chloride dependent transporter 0.0577 1 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0098 0.0657 0.0657
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0098 0.0657 0.0657
Echinococcus multilocularis cyclin dependent kinase 5 0.0105 0.0789 0.0789
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus multilocularis neuropeptide receptor A26 0.0114 0.0959 0.0959
Echinococcus multilocularis sodium and chloride dependent glycine 0.0098 0.0657 0.0657
Brugia malayi GnHR receptor homolog 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0124 0.1168 0.0547
Onchocerca volvulus 0.0114 0.0959 0.0323
Echinococcus granulosus tachykinin peptides receptor 99D 0.0114 0.0959 0.0959
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0577 1 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0114 0.0959 0.0959
Trypanosoma cruzi cyclin 6, putative 0.0124 0.1168 1
Schistosoma mansoni hypothetical protein 0.0114 0.0959 0.0959
Echinococcus multilocularis sodium and chloride dependent glycine 0.0098 0.0657 0.0657
Echinococcus granulosus cyclin dependent kinase 5 0.0105 0.0789 0.0789
Loa Loa (eye worm) hypothetical protein 0.0148 0.163 0.1041
Schistosoma mansoni amine GPCR 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0098 0.0657 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus multilocularis serotonin receptor 0.0114 0.0959 0.0959
Echinococcus granulosus sodium and chloride dependent glycine 0.0098 0.0657 0.0657
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Schistosoma mansoni biogenic amine (5HT) receptor 0.0114 0.0959 0.0959
Echinococcus multilocularis cyclin dependent kinase 1 0.0105 0.0789 0.0789
Echinococcus granulosus neuropeptide receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0114 0.0959 0.0323
Echinococcus multilocularis neuropeptide Y receptor 0.0114 0.0959 0.0959
Echinococcus multilocularis rhodopsin orphan GPCR 0.0114 0.0959 0.0959
Echinococcus multilocularis neuropeptide receptor 0.0114 0.0959 0.0959
Schistosoma mansoni hypothetical protein 0.0114 0.0959 0.0959
Schistosoma mansoni biogenic amine receptor 0.0114 0.0959 0.0959
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0114 0.0959 0.0959
Echinococcus granulosus sex peptide receptor 0.0114 0.0959 0.0959
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0105 0.0789 1
Echinococcus granulosus neuropeptide receptor A26 0.0114 0.0959 0.0959
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0098 0.0657 0.0657
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.4769 0.4769
Echinococcus multilocularis G-protein coupled receptor, putative 0.0114 0.0959 0.0959
Onchocerca volvulus 0.0114 0.0959 0.0323
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus multilocularis serotonin receptor 0.0114 0.0959 0.0959
Trichomonas vaginalis cyclin B, putative 0.0124 0.1168 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) melatonin receptor type 1A 0.0114 0.0959 0.0323
Plasmodium falciparum protein kinase 5 0.0105 0.0789 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) G-protein coupled receptor 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Entamoeba histolytica cell division protein kinase 2, putative 0.0105 0.0789 0.6748
Echinococcus granulosus cyclin dependent kinase 0.0105 0.0789 0.0789
Onchocerca volvulus 0.0114 0.0959 0.0323
Echinococcus multilocularis rhodopsin orphan GPCR 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus granulosus tm gpcr rhodopsin 0.0114 0.0959 0.0959
Echinococcus granulosus hypothetical protein 0.0114 0.0959 0.0959
Echinococcus multilocularis g protein coupled receptor 0.0114 0.0959 0.0959
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0114 0.0959 0.0959
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0789 0.6748
Echinococcus multilocularis g protein coupled receptor 0.0114 0.0959 0.0959
Echinococcus granulosus serotonin receptor 0.0114 0.0959 0.0959
Entamoeba histolytica cyclin, putative 0.0124 0.1168 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0098 0.0657 0.0657
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.4769 0.4769
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0114 0.0959 0.0959
Onchocerca volvulus 0.0114 0.0959 0.0323
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0098 0.0657 0.0657
Echinococcus granulosus neuropeptide receptor 0.0114 0.0959 0.0959
Schistosoma mansoni growth hormone secretagogue receptor 0.0114 0.0959 0.0959
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0114 0.0959 0.0959
Brugia malayi hypothetical protein 0.0114 0.0959 0.0323
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0114 0.0959 0.0323
Brugia malayi hypothetical protein 0.0148 0.163 0.1041
Echinococcus granulosus 7TM GPCR rhodopsin 0.0114 0.0959 0.0959
Onchocerca volvulus 0.0114 0.0959 0.0323
Loa Loa (eye worm) norepinephrine transporter 0.0577 1 1
Loa Loa (eye worm) hypothetical protein 0.0577 1 1
Brugia malayi cell division control protein 2 homolog 0.0105 0.0789 0.014
Echinococcus granulosus g protein coupled receptor 0.0114 0.0959 0.0959
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0114 0.0959 0.0959
Schistosoma mansoni amine GPCR 0.0114 0.0959 0.0959
Trypanosoma cruzi cyclin, putative 0.0124 0.1168 1
Trichomonas vaginalis cyclin B, putative 0.0124 0.1168 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0124 0.1168 0.0547
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0105 0.0789 0.0789
Echinococcus multilocularis orexin receptor type 2 0.0114 0.0959 0.0959
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0199 0.2618 0.2618
Schistosoma mansoni neuropeptide F-like receptor 0.0114 0.0959 0.0959
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0199 0.2618 0.2618
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Brugia malayi follicle stimulating hormone receptor 0.0114 0.0959 0.0323
Onchocerca volvulus 0.0114 0.0959 0.0323
Giardia lamblia Kinase, CMGC CDK 0.0105 0.0789 0.6748
Echinococcus multilocularis rhodopsin orphan GPCR 0.0114 0.0959 0.0959
Brugia malayi hypothetical protein 0.0114 0.0959 0.0323
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0098 0.0657 0.0657
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0114 0.0959 0.0959
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0114 0.0959 0.0959
Echinococcus granulosus somatostatin receptor 0.0114 0.0959 0.0959
Echinococcus granulosus alpha 1A adrenergic receptor 0.0114 0.0959 0.0959
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0789 0.0789
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Trichomonas vaginalis cyclins, putative 0.0124 0.1168 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0114 0.0959 0.0959
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0114 0.0959 0.0959
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0114 0.0959 0.0323
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0098 0.0657 0.0657
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0114 0.0959 0.0959
Echinococcus multilocularis cyclin dependent kinase 1 0.0105 0.0789 0.0789
Trichomonas vaginalis cyclin B, putative 0.0124 0.1168 1
Onchocerca volvulus 0.0114 0.0959 0.0323
Brugia malayi hypothetical protein 0.0114 0.0959 0.0323
Schistosoma mansoni sodium/chloride dependent transporter 0.01 0.069 0.069
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.1168 0.0547
Brugia malayi Serotonin receptor 0.0114 0.0959 0.0323
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0098 0.0657 0.0657
Echinococcus granulosus g protein coupled receptor 0.0114 0.0959 0.0959
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0114 0.0959 0.0323
Schistosoma mansoni amine GPCR 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus multilocularis fmrfamide receptor 0.0114 0.0959 0.0959
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0789 0.6748
Plasmodium falciparum amino acid transporter, putative 0.0098 0.0657 0.8336
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus granulosus neuropeptides capa receptor 0.0114 0.0959 0.0959
Brugia malayi hypothetical protein 0.0114 0.0959 0.0323
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0114 0.0959 0.0959
Echinococcus granulosus neuropeptide Y receptor 0.0114 0.0959 0.0959
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0114 0.0959 0.0323
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0114 0.0959 0.0959
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.2618 0.2098
Schistosoma mansoni biogenic amine receptor 0.0114 0.0959 0.0959
Brugia malayi G protein-coupled receptor 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0114 0.0959 0.0959
Trichomonas vaginalis cyclin B, putative 0.0124 0.1168 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0114 0.0959 0.0323
Schistosoma mansoni cyclin B 0.0124 0.1168 0.1168
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0105 0.0789 0.014
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0098 0.0657 0.0657
Schistosoma mansoni neuropeptide F-like receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0105 0.0789 0.014
Loa Loa (eye worm) G-protein coupled receptor 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus multilocularis neuropeptide Y receptor 0.0114 0.0959 0.0959
Echinococcus granulosus cyclin dependent kinase 1 0.0105 0.0789 0.0789
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0114 0.0959 0.0959
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0098 0.0657 0.0657
Loa Loa (eye worm) hypothetical protein 0.0577 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0114 0.0959 0.0959
Echinococcus multilocularis g protein coupled receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0103 0.0756 0.0106
Brugia malayi ORL1-like opioid receptor 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0148 0.163 0.1041
Echinococcus multilocularis allatostatin A receptor 0.0114 0.0959 0.0959
Brugia malayi Dopamine receptor 0.0114 0.0959 0.0323
Echinococcus granulosus G protein coupled receptor 139 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Onchocerca volvulus 0.0114 0.0959 0.0323
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0114 0.0959 0.0959
Brugia malayi G-protein coupled receptor 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0577 1 1
Echinococcus granulosus serotonin transporter 0.0577 1 1
Onchocerca volvulus 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0789 0.6748
Plasmodium vivax protein kinase Crk2 0.0105 0.0789 1
Schistosoma mansoni opsin-like receptor 0.0114 0.0959 0.0959
Echinococcus granulosus g-protein coupled receptor 0.0114 0.0959 0.0959
Echinococcus multilocularis neuropeptide s receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0114 0.0959 0.0323
Brugia malayi Serotonin receptor 0.0114 0.0959 0.0323
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0098 0.0657 0.0657
Schistosoma mansoni neuropeptide receptor 0.0114 0.0959 0.0959
Brugia malayi AKH receptor 0.0114 0.0959 0.0323
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0789 0.0789
Echinococcus multilocularis neuropeptide receptor 0.0114 0.0959 0.0959
Schistosoma mansoni opsin-like receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) solute carrier family 6 member 4 0.0577 1 1
Brugia malayi hypothetical protein 0.0114 0.0959 0.0323
Echinococcus multilocularis rhodopsin orphan GPCR 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Brugia malayi larval opioid receptor 0.0114 0.0959 0.0323
Echinococcus granulosus tm gpcr rhodopsin 0.0114 0.0959 0.0959
Loa Loa (eye worm) neuropeptide F receptor 0.0114 0.0959 0.0323
Onchocerca volvulus 0.0114 0.0959 0.0323
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.4769 0.4769
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0114 0.0959 0.0959
Schistosoma mansoni biogenic amine (5HT) receptor 0.0114 0.0959 0.0959
Leishmania major cyclin 0.0124 0.1168 1
Trypanosoma brucei mitotic cyclin 6 0.0124 0.1168 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0114 0.0959 0.0959
Echinococcus multilocularis serotonin transporter 0.0577 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus multilocularis dro:myosuppressin receptor 0.0114 0.0959 0.0959
Plasmodium falciparum transporter, putative 0.0098 0.0657 0.8336
Brugia malayi hypothetical protein 0.0114 0.0959 0.0323
Trichomonas vaginalis cyclin A, putative 0.0124 0.1168 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0114 0.0959 0.0323
Echinococcus multilocularis rhodopsin orphan GPCR 0.0114 0.0959 0.0959
Schistosoma mansoni neuropeptide receptor 0.0114 0.0959 0.0959
Echinococcus granulosus neuropeptide s receptor 0.0114 0.0959 0.0959
Trichomonas vaginalis cyclins, putative 0.0124 0.1168 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus granulosus rhodopsin orphan GPCR 0.0114 0.0959 0.0959
Loa Loa (eye worm) serotonin transporter b 0.0577 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0114 0.0959 0.0959
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.2618 0.2098
Schistosoma mansoni biogenic amine receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0114 0.0959 0.0959
Echinococcus multilocularis rhodopsin orphan GPCR 0.0114 0.0959 0.0959
Echinococcus multilocularis cyclin dependent kinase 0.0105 0.0789 0.0789
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Brugia malayi sulfakinin receptor protein 0.0114 0.0959 0.0323
Brugia malayi hypothetical protein 0.0114 0.0959 0.0323
Brugia malayi putative neuropeptide receptor NPR1 0.0114 0.0959 0.0323
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0114 0.0959 0.0959
Echinococcus granulosus rhodopsin orphan GPCR 0.0114 0.0959 0.0959
Onchocerca volvulus 0.0114 0.0959 0.0323
Echinococcus multilocularis sex peptide receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Schistosoma mansoni hypothetical protein 0.0114 0.0959 0.0959
Echinococcus granulosus rhodopsin orphan GPCR 0.0114 0.0959 0.0959
Onchocerca volvulus 0.0114 0.0959 0.0323
Schistosoma mansoni opsin-like receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) neuropeptide F receptor 0.0114 0.0959 0.0323
Echinococcus multilocularis rhodopsin orphan GPCR 0.0114 0.0959 0.0959
Schistosoma mansoni cyclin B3 0.0199 0.2618 0.2618
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus granulosus neuropeptide Y receptor 0.0114 0.0959 0.0959
Brugia malayi putative neuropeptide receptor 0.0114 0.0959 0.0323
Giardia lamblia Kinase, CMGC CDK 0.0105 0.0789 0.6748
Trichomonas vaginalis cyclins, putative 0.0124 0.1168 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0098 0.0657 0.0657
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0114 0.0959 0.0959
Brugia malayi hypothetical protein 0.0114 0.0959 0.0323
Schistosoma mansoni myosin xvIII 0.0114 0.0959 0.0959
Echinococcus multilocularis somatostatin receptor 0.0114 0.0959 0.0959
Treponema pallidum sodium- and chloride- dependent transporter 0.0577 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Brugia malayi hypothetical protein 0.0114 0.0959 0.0323
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0098 0.0657 0.0657
Onchocerca volvulus 0.0577 1 1
Echinococcus granulosus g protein coupled receptor 0.0114 0.0959 0.0959
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0098 0.0657 0.0657
Echinococcus granulosus biogenic amine 5HT receptor 0.0114 0.0959 0.0959
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0114 0.0959 0.0959
Echinococcus granulosus neuropeptides capa receptor 0.0114 0.0959 0.0959
Onchocerca volvulus 0.0114 0.0959 0.0323
Echinococcus multilocularis fmrfamide receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus multilocularis rhodopsin orphan GPCR 0.0114 0.0959 0.0959
Brugia malayi Dopamine receptor protein 1 0.0114 0.0959 0.0323
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0114 0.0959 0.0959
Brugia malayi RE15519p 0.0114 0.0959 0.0323
Brugia malayi neuropeptide F receptor 0.0114 0.0959 0.0323
Echinococcus granulosus biogenic amine 5HT receptor 0.0114 0.0959 0.0959
Trichomonas vaginalis cyclins, putative 0.0075 0.0218 0.1865
Echinococcus multilocularis neuropeptides capa receptor 0.0114 0.0959 0.0959
Echinococcus multilocularis G protein coupled receptor 139 0.0114 0.0959 0.0959
Schistosoma mansoni sodium-dependent amino acid transporter 0.0098 0.0657 0.0657
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0309 0.4769 0.4401
Giardia lamblia G2/mitotic-specific cyclin B 0.0124 0.1168 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0114 0.0959 0.0959
Echinococcus granulosus rhodopsin orphan GPCR 0.0114 0.0959 0.0959
Trypanosoma cruzi CYC2-like cyclin, putative 0.0124 0.1168 1
Echinococcus multilocularis neuropeptides capa receptor 0.0114 0.0959 0.0959
Echinococcus granulosus neuropeptide FF receptor 2 0.0114 0.0959 0.0959
Schistosoma mansoni hypothetical protein 0.0114 0.0959 0.0959
Onchocerca volvulus 0.0114 0.0959 0.0323
Onchocerca volvulus 0.0114 0.0959 0.0323
Schistosoma mansoni adenoreceptor 0.0114 0.0959 0.0959
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0114 0.0959 0.0323
Schistosoma mansoni alpha-1 adrenergic receptor 0.0114 0.0959 0.0959
Schistosoma mansoni neuropeptide f receptor 76f 0.0114 0.0959 0.0959
Echinococcus multilocularis cyclin B 0.0124 0.1168 0.1168
Schistosoma mansoni histamine h1 receptor 0.0114 0.0959 0.0959
Echinococcus granulosus fmrfamide receptor 0.0114 0.0959 0.0959
Echinococcus granulosus dro:myosuppressin receptor 0.0114 0.0959 0.0959
Schistosoma mansoni neuropeptide receptor 0.0114 0.0959 0.0959
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0098 0.0657 0.0657
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0114 0.0959 0.0959
Brugia malayi Tachykinin-like peptides receptor 99D 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0098 0.0657 0.0657
Brugia malayi G-protein coupled receptor 0.0114 0.0959 0.0323
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0114 0.0959 0.0323
Brugia malayi Melatonin receptor type 1A 0.0114 0.0959 0.0323
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0098 0.0657 0.0657
Onchocerca volvulus Neuropeptide F receptor homolog 0.0114 0.0959 0.0323
Brugia malayi G protein-coupled receptor F59B2.13 0.0114 0.0959 0.0323
Onchocerca volvulus 0.0114 0.0959 0.0323
Onchocerca volvulus 0.0114 0.0959 0.0323
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus multilocularis neuropeptide FF receptor 2 0.0114 0.0959 0.0959
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Echinococcus granulosus tm gpcr rhodopsin 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.1168 0.0547
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0114 0.0959 0.0959
Onchocerca volvulus 0.0124 0.1168 0.0547
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0114 0.0959 0.0959
Loa Loa (eye worm) TYRA-2 protein 0.0114 0.0959 0.0323
Trypanosoma cruzi cyclin, putative 0.0124 0.1168 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0114 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0114 0.0959 0.0323

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.131 Inhibitory activity against cyclin-dependent kinase 5/p25 ChEMBL. 14695817
IC50 (binding) = 5.432 Inhibitory activity against cyclin dependent kinase 1-cyclinB extracted from M phase starfish (Marthasterias glacialis) oocytes ChEMBL. 14695817
IC50 (binding) = 6.602 Inhibitory activity against glycogen synthase kinase-3 beta purified from insect sf9 cells ChEMBL. 14695817
Log IC50 (binding) = 5.131 Inhibitory activity against cyclin-dependent kinase 5/p25 ChEMBL. 14695817
Log IC50 (binding) = 5.432 Inhibitory activity against cyclin dependent kinase 1-cyclinB extracted from M phase starfish (Marthasterias glacialis) oocytes ChEMBL. 14695817
Log IC50 (binding) = 6.602 Inhibitory activity against glycogen synthase kinase-3 beta purified from insect sf9 cells ChEMBL. 14695817

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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