Detailed information for compound 2069271

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 343.443 | Formula: C18H21N3O2S
  • H donors: 0 H acceptors: 3 LogP: 1.69 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)C(=O)c1cc(sc1C)C)Cc1ccccn1
  • InChi: 1S/C18H21N3O2S/c1-13-11-16(14(2)24-13)18(23)21-9-7-20(8-10-21)17(22)12-15-5-3-4-6-19-15/h3-6,11H,7-10,12H2,1-2H3
  • InChiKey: IRRABMFKMMOFDT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus protein kinase C gamma type 0.0028 0.0582 0.0582
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0027 0.0554 0.0595
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0011 0.0153 0.0301
Loa Loa (eye worm) hypothetical protein 0.0231 0.5887 1
Echinococcus granulosus Protein kinase C brain isozyme 0.0031 0.067 0.067
Echinococcus granulosus Polycystic kidney disease protein 0.0011 0.0152 0.0152
Schistosoma mansoni disulfide oxidoreductase 0.0011 0.0153 0.0153
Schistosoma mansoni lipoxygenase 0.0011 0.0152 0.0152
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.067 0.067
Brugia malayi MIR domain containing protein 0.0037 0.0832 0.0893
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0037 0.0832 0.0832
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0309 0.0744
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0081 0.196 1
Trichomonas vaginalis glutamate synthase, putative 0.0011 0.0153 0.0367
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0153 0.0301
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0016 0.0272 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0188 0.0453
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0027 0.0554 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0153 0.0367
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.02 0.5079 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0081 0.196 0.7339
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0027 0.0554 0.0554
Brugia malayi phosphoinositide-dependent protein kinase I 0.0017 0.0309 0.0332
Trypanosoma cruzi trypanothione reductase, putative 0.0027 0.0554 0.1091
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0272 0.0462
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0272 0.0292
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1091
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0011 0.0153 0.0002
Schistosoma mansoni glutamate synthase 0.0011 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0259
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0017 0.0309 0.0309
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0013 0.0189 0.0554
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0017 0.0309 0.0525
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0027 0.0554 0.163
Giardia lamblia NADH oxidase lateral transfer candidate 0.0027 0.0554 0.1003
Trypanosoma cruzi target of rapamycin kinase 3 0.0013 0.0189 0.0372
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0027 0.0554 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0016 0.0272 0.0299
Echinococcus granulosus ryanodine receptor 44f 0.0132 0.3295 0.3295
Giardia lamblia Fructose-bisphosphate aldolase 0.0165 0.4156 1
Brugia malayi protein kinase C II. 0.0009 0.0097 0.0104
Echinococcus multilocularis ryanodine receptor 44f 0.0132 0.3295 0.3295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0083 0.0201
Trypanosoma cruzi trypanothione reductase, putative 0.0106 0.2615 0.5149
Schistosoma mansoni rab6-interacting 0.0011 0.0152 0.0152
Leishmania major trypanothione reductase 0.0106 0.2615 0.7672
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0011 0.0153 0.0367
Toxoplasma gondii target of rapamycin (TOR), putative 0.0012 0.0167 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0097 0.0097
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0264 0.0283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0167 0.0402
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0016 0.0272 0.0536
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0554 0.1091
Leishmania major hypothetical protein, conserved 0.0011 0.0153 0.0448
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0011 0.0153 0.0301
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0153 0.0367
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0153 0.0301
Schistosoma mansoni hypothetical protein 0.0011 0.0153 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0107 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0272 0.0655
Schistosoma mansoni sulfide quinone reductase 0.0011 0.0153 0.0153
Onchocerca volvulus 0.0011 0.0153 0.0007
Trichomonas vaginalis mercuric reductase, putative 0.0027 0.0554 0.1333
Echinococcus multilocularis stromal cell derived factor 2 0.0037 0.0832 0.0832
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0011 0.0153 0.0153
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0153 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0188 0.0453
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Brugia malayi glutamate synthase 0.0011 0.0153 0.0164
Trypanosoma cruzi NADH dehydrogenase, putative 0.0011 0.0153 0.0301
Toxoplasma gondii thioredoxin reductase 0.0106 0.2615 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0011 0.0153 0.0153
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0011 0.0153 0.0002
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0011 0.0153 0.0367
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0027 0.0554 0.1626
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0295 0.7557 0.7557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0272 0.0655
Schistosoma mansoni atypical protein kinase C 0.0008 0.0079 0.0079
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1626
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0264 0.0283
Loa Loa (eye worm) glutathione reductase 0.0106 0.2615 0.4443
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0272 0.0655
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0017 0.0309 0.0525
Echinococcus multilocularis glutamate synthase 0.0011 0.0153 0.0153
Loa Loa (eye worm) thioredoxin reductase 0.0106 0.2615 0.4443
Schistosoma mansoni lipoxygenase 0.0031 0.0674 0.0674
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0027 0.0554 0.1632
Plasmodium falciparum thioredoxin reductase 0.0027 0.0554 0.1632
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0167 0.0402
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0016 0.0272 0.0536
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1091
Plasmodium falciparum glutathione reductase 0.0027 0.0554 0.1632
Treponema pallidum fructose-bisphosphate aldolase 0.0165 0.4156 1
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0011 0.0153 0.0301
Brugia malayi hypothetical protein 0.0011 0.0152 0.0163
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0027 0.0554 0.2221
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0011 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0022 0.0435 0.0739
Schistosoma mansoni glutamate synthase 0.0011 0.0153 0.0153
Treponema pallidum NADH oxidase 0.0027 0.0554 0.1003
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0011 0.0153 0.0153
Echinococcus multilocularis RUN 0.0011 0.0152 0.0152
Echinococcus granulosus thioredoxin glutathione reductase 0.0106 0.2636 0.2636
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0016 0.0272 0.0272
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0193 0.4896 0.4896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0167 0.0402
Schistosoma mansoni glutamate synthase 0.0011 0.0153 0.0153
Echinococcus multilocularis lipoxygenase domain containing protein 0.0011 0.0152 0.0152
Leishmania major hypothetical protein, conserved 0.0011 0.0153 0.0448
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0167 0.0402
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0007 0.0056 0.0111
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0031 0.0674 0.0674
Echinococcus granulosus protein kinase c epsilon type 0.0009 0.0097 0.0097
Trichomonas vaginalis apoptosis inducing factor, putative 0.0011 0.0153 0.0367
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0259
Echinococcus granulosus lipoxygenase domain containing protein 0.0011 0.0152 0.0152
Mycobacterium tuberculosis Probable oxidoreductase 0.0027 0.0554 0.163
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0011 0.0153 0.0153
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.02 0.5079 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0084 0.0202
Plasmodium falciparum ferrodoxin reductase-like protein 0.0011 0.0153 0.0002
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0011 0.0153 0.0448
Echinococcus multilocularis serine threonine protein kinase 0.0028 0.0582 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0107 0.0258
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1091
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0153 0.0301
Plasmodium falciparum glutathione reductase 0.0106 0.2615 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0153 0.0301
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0027 0.0554 0.1632
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0022 0.0435 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0167 0.0402
Echinococcus multilocularis protein kinase c epsilon type 0.0009 0.0097 0.0097
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0064 0.1533 0.1533
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0031 0.0674 0.0674
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0237 0.6048 0.649
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0027 0.0554 0.1091
Entamoeba histolytica protein kinase, putative 0.0017 0.0309 0.0391
Brugia malayi Protein kinase c protein 2 0.0026 0.0548 0.0588
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0009 0.0097 0.0165
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0011 0.0153 0.0153
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0011 0.0153 0.0259
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.067 0.067
Loa Loa (eye worm) MIR domain-containing protein 0.0037 0.0832 0.1413
Loa Loa (eye worm) hypothetical protein 0.0227 0.5773 0.9807
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0153 0.0301
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0165 0.4156 1
Loa Loa (eye worm) doublecortin family protein 0.0011 0.0152 0.0259
Brugia malayi Thioredoxin reductase 0.0106 0.2615 0.2806
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0027 0.0554 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0105 0.0253
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0011 0.0153 0.0301
Trypanosoma brucei NADH dehydrogenase 0.0011 0.0153 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0105 0.0253
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0309 0.0744
Schistosoma mansoni hypothetical protein 0.0011 0.0152 0.0152
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0027 0.0554 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0027 0.0554 0.1091
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0016 0.0272 0.0536
Brugia malayi Protein kinase domain containing protein 0.0017 0.0309 0.0332
Plasmodium vivax thioredoxin reductase, putative 0.0106 0.2615 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0153 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0084 0.0202
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1091
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0007 0.0033 0.0065
Leishmania major hypothetical protein, conserved 0.0011 0.0153 0.0448
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0137 0.0331
Echinococcus granulosus ryanodine receptor 44f 0.017 0.4286 0.4286
Trichomonas vaginalis mannosyltransferase 1, putative 0.0037 0.0832 0.2001
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0016 0.0272 0.0799
Onchocerca volvulus 0.0037 0.0832 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0011 0.0153 0.0153
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0011 0.0153 0.0153
Brugia malayi hypothetical protein 0.0011 0.0152 0.0163
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0165 0.4156 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0027 0.0554 0.2221
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0011 0.0153 0.0164
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0011 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0011 0.0153 0.0259
Brugia malayi cation channel family protein 0.0363 0.9319 1
Loa Loa (eye worm) hypothetical protein 0.0193 0.4896 0.8317
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0554 0.1091
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1626
Schistosoma mansoni rab6-interacting 0.0011 0.0152 0.0152
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0081 0.196 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0016 0.0272 0.0799
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0011 0.0153 0.0153
Toxoplasma gondii NADPH-glutathione reductase 0.0027 0.0554 0.163
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0011 0.0153 0.0367
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0027 0.0554 0.163
Leishmania major NADH dehydrogenase, putative 0.0011 0.0153 0.0448
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1091
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0011 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.017 0.4286 0.7281
Brugia malayi Doublecortin family protein 0.0011 0.0152 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0309 0.0744
Echinococcus granulosus RNA directed DNA polymerase 0.0022 0.0435 0.0435
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0554 0.1091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0107 0.0258
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Leishmania major hypothetical protein, conserved 0.0136 0.3409 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1091
Echinococcus multilocularis microtubule associated protein 2 0.0389 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0016 0.0272 0.0272
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0027 0.0554 0.0554
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0153 0.0301
Loa Loa (eye worm) programmed cell death 8 0.0011 0.0153 0.0259
Loa Loa (eye worm) hypothetical protein 0.0025 0.0523 0.0888
Schistosoma mansoni loxhd1 0.0011 0.0152 0.0152
Echinococcus multilocularis thioredoxin glutathione reductase 0.0106 0.2636 0.2636
Brugia malayi glutathione reductase 0.0106 0.2615 0.2806
Giardia lamblia GTOR 0.0016 0.0272 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0167 0.0402
Schistosoma mansoni ryanodine receptor related 0.0237 0.6048 0.6048
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0027 0.0554 0.163
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0309 0.0309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0167 0.0402
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0027 0.0554 0.1626
Echinococcus multilocularis ryanodine receptor 44f 0.017 0.4286 0.4286
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0011 0.0153 0.0164
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0188 0.0453
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0017 0.0309 0.0309
Entamoeba histolytica MIR domain protein 0.0037 0.0832 0.1696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0084 0.0202
Echinococcus granulosus glutamate synthase 0.0011 0.0153 0.0153
Echinococcus granulosus stromal cell derived factor 2 0.0037 0.0832 0.0832
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0027 0.0554 0.1632
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0027 0.0554 0.163
Echinococcus multilocularis protein kinase c iota type 0.0008 0.0079 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0083 0.0201
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0016 0.0272 0.0272
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0188 0.0453
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0023 0.046 0.0782
Schistosoma mansoni polycystin 1-related 0.0011 0.0152 0.0152
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0027 0.0554 0.2221
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0011 0.0153 0.0002
Trichomonas vaginalis glutamate synthase, putative 0.0011 0.0153 0.0367
Trypanosoma cruzi NADH dehydrogenase, putative 0.0011 0.0153 0.0301
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0106 0.2615 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Trichomonas vaginalis glutathione reductase, putative 0.0027 0.0554 0.1333
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0011 0.0153 0.0448
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0554 0.1091
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0129 0.0309
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0153 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0084 0.0202
Schistosoma mansoni sulfide quinone reductase 0.0011 0.0153 0.0153
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0153 0.0367
Echinococcus granulosus RUN 0.0011 0.0152 0.0152
Plasmodium vivax glutathione reductase, putative 0.0106 0.2615 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0011 0.0152 0.0152
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0013 0.0189 0.0372
Echinococcus multilocularis RNA directed DNA polymerase 0.0022 0.0435 0.0435
Plasmodium vivax ferrodoxin reductase, putative 0.0011 0.0153 0.0002
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0011 0.0153 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0083 0.0201
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0027 0.0554 0.2221
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0027 0.0554 0.1632
Echinococcus multilocularis Polycystic kidney disease protein 0.0011 0.0152 0.0152
Trypanosoma brucei trypanothione reductase 0.0106 0.2615 0.5149
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0031 0.067 0.067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0212 0.0511
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0016 0.0272 0.0299
Plasmodium falciparum thioredoxin reductase 0.0106 0.2615 1
Loa Loa (eye worm) ryanodine receptor 0.0064 0.1533 0.2604
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0011 0.0153 0.0002
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0011 0.0153 0.0153
Schistosoma mansoni microtubule-associated protein tau 0.0389 1 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0011 0.0153 0.0367
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0153 0.0367
Echinococcus granulosus protein kinase c iota type 0.0008 0.0079 0.0079
Echinococcus multilocularis lipoxygenase domain containing protein 0.0011 0.0152 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0188 0.0453
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0011 0.0153 0.0301

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.