Detailed information for compound 2069271

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 343.443 | Formula: C18H21N3O2S
  • H donors: 0 H acceptors: 3 LogP: 1.69 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)C(=O)c1cc(sc1C)C)Cc1ccccn1
  • InChi: 1S/C18H21N3O2S/c1-13-11-16(14(2)24-13)18(23)21-9-7-20(8-10-21)17(22)12-15-5-3-4-6-19-15/h3-6,11H,7-10,12H2,1-2H3
  • InChiKey: IRRABMFKMMOFDT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0027 0.0554 0.163
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0027 0.0554 0.163
Schistosoma mansoni hypothetical protein 0.0011 0.0152 0.0152
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0011 0.0153 0.0153
Trichomonas vaginalis apoptosis inducing factor, putative 0.0011 0.0153 0.0367
Schistosoma mansoni loxhd1 0.0011 0.0152 0.0152
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0007 0.0056 0.0111
Brugia malayi Thioredoxin reductase 0.0106 0.2615 0.2806
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0064 0.1533 0.1533
Schistosoma mansoni atypical protein kinase C 0.0008 0.0079 0.0079
Schistosoma mansoni lipoxygenase 0.0031 0.0674 0.0674
Echinococcus multilocularis protein kinase c iota type 0.0008 0.0079 0.0079
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0011 0.0153 0.0301
Brugia malayi cation channel family protein 0.0363 0.9319 1
Plasmodium falciparum thioredoxin reductase 0.0106 0.2615 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0084 0.0202
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0017 0.0309 0.0309
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0027 0.0554 0.1632
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1091
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0027 0.0554 0.2221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0212 0.0511
Leishmania major trypanothione reductase 0.0106 0.2615 0.7672
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0193 0.4896 0.4896
Trypanosoma brucei trypanothione reductase 0.0106 0.2615 0.5149
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0031 0.067 0.067
Onchocerca volvulus 0.0011 0.0153 0.0007
Trypanosoma cruzi trypanothione reductase, putative 0.0027 0.0554 0.1091
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0011 0.0153 0.0153
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0031 0.0674 0.0674
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0083 0.0201
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1626
Schistosoma mansoni sulfide quinone reductase 0.0011 0.0153 0.0153
Schistosoma mansoni microtubule-associated protein tau 0.0389 1 1
Loa Loa (eye worm) ryanodine receptor 0.0064 0.1533 0.2604
Trypanosoma cruzi NADH dehydrogenase, putative 0.0011 0.0153 0.0301
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0011 0.0153 0.0002
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0027 0.0554 0.1632
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1091
Echinococcus granulosus Polycystic kidney disease protein 0.0011 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0231 0.5887 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0153 0.0367
Echinococcus multilocularis ryanodine receptor 44f 0.017 0.4286 0.4286
Brugia malayi hypothetical protein 0.0011 0.0152 0.0163
Schistosoma mansoni disulfide oxidoreductase 0.0011 0.0153 0.0153
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0011 0.0153 0.0301
Echinococcus granulosus stromal cell derived factor 2 0.0037 0.0832 0.0832
Trichomonas vaginalis mannosyltransferase 1, putative 0.0037 0.0832 0.2001
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0153 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0107 0.0258
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0165 0.4156 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0027 0.0554 0.2221
Echinococcus granulosus RNA directed DNA polymerase 0.0022 0.0435 0.0435
Schistosoma mansoni glutamate synthase 0.0011 0.0153 0.0153
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0081 0.196 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0554 0.1091
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0016 0.0272 0.0536
Loa Loa (eye worm) hypothetical protein 0.017 0.4286 0.7281
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0027 0.0554 0.0595
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0017 0.0309 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0272 0.0655
Echinococcus granulosus Protein kinase C brain isozyme 0.0031 0.067 0.067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0167 0.0402
Trichomonas vaginalis glutamate synthase, putative 0.0011 0.0153 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0167 0.0402
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0259
Brugia malayi hypothetical protein 0.0011 0.0152 0.0163
Loa Loa (eye worm) hypothetical protein 0.0025 0.0523 0.0888
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0011 0.0153 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0272 0.0655
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0027 0.0554 0.0554
Brugia malayi glutathione reductase 0.0106 0.2615 0.2806
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0554 0.1091
Schistosoma mansoni glutamate synthase 0.0011 0.0153 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0188 0.0453
Treponema pallidum NADH oxidase 0.0027 0.0554 0.1003
Echinococcus granulosus RUN 0.0011 0.0152 0.0152
Schistosoma mansoni hypothetical protein 0.0011 0.0153 0.0153
Leishmania major NADH dehydrogenase, putative 0.0011 0.0153 0.0448
Leishmania major hypothetical protein, conserved 0.0011 0.0153 0.0448
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0153 0.0367
Loa Loa (eye worm) hypothetical protein 0.0011 0.0152 0.0259
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.067 0.067
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0153 0.0301
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0153 0.0301
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1091
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0011 0.0153 0.0002
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0027 0.0554 0.1626
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.02 0.5079 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0027 0.0554 0.0554
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0027 0.0554 0.1091
Loa Loa (eye worm) programmed cell death 8 0.0011 0.0153 0.0259
Brugia malayi glutamate synthase 0.0011 0.0153 0.0164
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0017 0.0309 0.0525
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0011 0.0153 0.0259
Brugia malayi Doublecortin family protein 0.0011 0.0152 0.0163
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0106 0.2615 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0011 0.0153 0.0153
Echinococcus multilocularis Polycystic kidney disease protein 0.0011 0.0152 0.0152
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0272 0.0462
Plasmodium vivax glutathione reductase, putative 0.0106 0.2615 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0027 0.0554 0.1003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Echinococcus multilocularis microtubule associated protein 2 0.0389 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0167 0.0402
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0011 0.0153 0.0153
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0081 0.196 0.7339
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0016 0.0272 0.0299
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0011 0.0153 0.0164
Echinococcus multilocularis lipoxygenase domain containing protein 0.0011 0.0152 0.0152
Entamoeba histolytica protein kinase, putative 0.0017 0.0309 0.0391
Toxoplasma gondii NADPH-glutathione reductase 0.0027 0.0554 0.163
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0081 0.196 1
Trypanosoma brucei NADH dehydrogenase 0.0011 0.0153 0.0301
Schistosoma mansoni polycystin 1-related 0.0011 0.0152 0.0152
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0007 0.0033 0.0065
Brugia malayi Protein kinase c protein 2 0.0026 0.0548 0.0588
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0105 0.0253
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0016 0.0272 0.0799
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0027 0.0554 0.2221
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0011 0.0153 0.0367
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0153 0.0367
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0016 0.0272 0.0299
Giardia lamblia GTOR 0.0016 0.0272 0.0299
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0153 0.0367
Plasmodium falciparum ferrodoxin reductase-like protein 0.0011 0.0153 0.0002
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0016 0.0272 0.0272
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0153 0.0301
Echinococcus multilocularis lipoxygenase domain containing protein 0.0011 0.0152 0.0152
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0011 0.0153 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0083 0.0201
Mycobacterium tuberculosis Probable oxidoreductase 0.0027 0.0554 0.163
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0011 0.0153 0.0153
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0027 0.0554 0.2221
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0153 0.0367
Loa Loa (eye worm) hypothetical protein 0.0227 0.5773 0.9807
Echinococcus multilocularis thioredoxin glutathione reductase 0.0106 0.2636 0.2636
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0009 0.0097 0.0165
Echinococcus multilocularis protein kinase c epsilon type 0.0009 0.0097 0.0097
Leishmania major hypothetical protein, conserved 0.0136 0.3409 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0016 0.0272 0.0536
Loa Loa (eye worm) glutathione reductase 0.0106 0.2615 0.4443
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0167 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0167 0.0402
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0011 0.0153 0.0153
Echinococcus multilocularis glutamate synthase 0.0011 0.0153 0.0153
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0011 0.0153 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0129 0.0309
Loa Loa (eye worm) hypothetical protein 0.0022 0.0435 0.0739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0105 0.0253
Schistosoma mansoni ryanodine receptor related 0.0237 0.6048 0.6048
Trichomonas vaginalis mercuric reductase, putative 0.0027 0.0554 0.1333
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0011 0.0153 0.0153
Echinococcus granulosus lipoxygenase domain containing protein 0.0011 0.0152 0.0152
Echinococcus granulosus ryanodine receptor 44f 0.017 0.4286 0.4286
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0016 0.0272 0.0799
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0011 0.0153 0.0301
Echinococcus multilocularis stromal cell derived factor 2 0.0037 0.0832 0.0832
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0016 0.0272 0.0536
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0027 0.0554 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0031 0.0674 0.0674
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0011 0.0153 0.0301
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1091
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0013 0.0189 0.0554
Brugia malayi phosphoinositide-dependent protein kinase I 0.0017 0.0309 0.0332
Trypanosoma cruzi NADH dehydrogenase, putative 0.0011 0.0153 0.0301
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0011 0.0153 0.0301
Trypanosoma cruzi target of rapamycin kinase 3 0.0013 0.0189 0.0372
Echinococcus multilocularis ryanodine receptor 44f 0.0132 0.3295 0.3295
Plasmodium falciparum glutathione reductase 0.0027 0.0554 0.1632
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0027 0.0554 0.163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0083 0.0201
Brugia malayi Protein kinase domain containing protein 0.0017 0.0309 0.0332
Loa Loa (eye worm) hypothetical protein 0.0193 0.4896 0.8317
Loa Loa (eye worm) MIR domain-containing protein 0.0037 0.0832 0.1413
Trypanosoma cruzi trypanothione reductase, putative 0.0106 0.2615 0.5149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0084 0.0202
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0309 0.0744
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0027 0.0554 0.1626
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0011 0.0153 0.0367
Echinococcus multilocularis RNA directed DNA polymerase 0.0022 0.0435 0.0435
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1091
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0027 0.0554 0.1632
Echinococcus granulosus thioredoxin glutathione reductase 0.0106 0.2636 0.2636
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0011 0.0153 0.0153
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0017 0.0309 0.0309
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0011 0.0153 0.0153
Trichomonas vaginalis glutathione reductase, putative 0.0027 0.0554 0.1333
Plasmodium falciparum glutathione reductase 0.0106 0.2615 1
Plasmodium falciparum thioredoxin reductase 0.0027 0.0554 0.1632
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0153 0.0301
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0264 0.0283
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0027 0.0554 0.1091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0137 0.0331
Entamoeba histolytica MIR domain protein 0.0037 0.0832 0.1696
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0011 0.0153 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0309 0.0744
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0011 0.0153 0.0164
Toxoplasma gondii target of rapamycin (TOR), putative 0.0012 0.0167 0.0059
Loa Loa (eye worm) doublecortin family protein 0.0011 0.0152 0.0259
Echinococcus granulosus glutamate synthase 0.0011 0.0153 0.0153
Echinococcus granulosus lipoxygenase domain containing protein 0.0011 0.0152 0.0152
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0309 0.0309
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0023 0.046 0.0782
Brugia malayi protein kinase C II. 0.0009 0.0097 0.0104
Trichomonas vaginalis glutamate synthase, putative 0.0011 0.0153 0.0367
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0097 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0167 0.0402
Echinococcus multilocularis RUN 0.0011 0.0152 0.0152
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0153 0.0367
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1091
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0554 0.1091
Loa Loa (eye worm) hypothetical protein 0.0011 0.0153 0.0259
Schistosoma mansoni glutamate synthase 0.0011 0.0153 0.0153
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0027 0.0554 0.0554
Leishmania major hypothetical protein, conserved 0.0011 0.0153 0.0448
Plasmodium vivax ferrodoxin reductase, putative 0.0011 0.0153 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0188 0.0453
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Echinococcus granulosus protein kinase c iota type 0.0008 0.0079 0.0079
Schistosoma mansoni rab6-interacting 0.0011 0.0152 0.0152
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0027 0.0554 0.1632
Giardia lamblia Fructose-bisphosphate aldolase 0.0165 0.4156 1
Echinococcus multilocularis serine threonine protein kinase 0.0028 0.0582 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0272 0.0655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0188 0.0453
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0016 0.0272 0.0272
Echinococcus granulosus ryanodine receptor 44f 0.0132 0.3295 0.3295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0107 0.0258
Plasmodium vivax thioredoxin reductase, putative 0.0106 0.2615 1
Onchocerca volvulus 0.0037 0.0832 1
Brugia malayi MIR domain containing protein 0.0037 0.0832 0.0893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0188 0.0453
Echinococcus granulosus protein kinase c epsilon type 0.0009 0.0097 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0084 0.0202
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0554 0.1091
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0153 0.0301
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0153 0.0301
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0016 0.0272 0.0272
Schistosoma mansoni rab6-interacting 0.0011 0.0152 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0107 0.0258
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0554 0.1626
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0264 0.0283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0167 0.0402
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0011 0.0153 0.0153
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0272 0.0292
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.02 0.5079 1
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0309 0.0744
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0011 0.0153 0.0367
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0237 0.6048 0.649
Schistosoma mansoni lipoxygenase 0.0011 0.0152 0.0152
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0295 0.7557 0.7557
Toxoplasma gondii thioredoxin reductase 0.0106 0.2615 1
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0022 0.0435 0.0435
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0037 0.0832 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0188 0.0453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0084 0.0202
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.067 0.067
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0011 0.0153 0.0002
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0027 0.0554 1
Treponema pallidum fructose-bisphosphate aldolase 0.0165 0.4156 1
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0011 0.0153 0.0448
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0027 0.0554 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.4156 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0027 0.0554 0.163
Echinococcus granulosus protein kinase C gamma type 0.0028 0.0582 0.0582
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0165 0.4156 1
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0011 0.0153 0.0448
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0016 0.0272 0.0536
Leishmania major hypothetical protein, conserved 0.0011 0.0153 0.0448
Schistosoma mansoni sulfide quinone reductase 0.0011 0.0153 0.0153
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0011 0.0153 0.0164
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0013 0.0189 0.0372
Loa Loa (eye worm) thioredoxin reductase 0.0106 0.2615 0.4443

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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