Detailed information for compound 2070071

Basic information

Technical information
  • TDR Targets ID: 2070071
  • Name: 2-[5-(4-fluorophenyl)-2-oxo-1,3,4-oxadiazol-3 -yl]-N-[(2-methoxyphenyl)methyl]acetamide
  • MW: 357.336 | Formula: C18H16FN3O4
  • H donors: 1 H acceptors: 2 LogP: 2.52 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CNC(=O)Cn1nc(oc1=O)c1ccc(cc1)F
  • InChi: 1S/C18H16FN3O4/c1-25-15-5-3-2-4-13(15)10-20-16(23)11-22-18(24)26-17(21-22)12-6-8-14(19)9-7-12/h2-9H,10-11H2,1H3,(H,20,23)
  • InChiKey: HAAADSJXTOSIOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[5-(4-fluorophenyl)-2-keto-1,3,4-oxadiazol-3-yl]-N-(2-methoxybenzyl)acetamide
  • 2-[5-(4-fluorophenyl)-2-oxo-1,3,4-oxadiazol-3-yl]-N-[(2-methoxyphenyl)methyl]ethanamide
  • T5944235
  • ZINC08136285

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.009 0.087 0.127
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0683 0.066
Loa Loa (eye worm) hypothetical protein 0.0191 0.2547 0.3724
Loa Loa (eye worm) hypothetical protein 0.0101 0.105 0.1454
Brugia malayi nuclear receptor RXR 0.0101 0.105 0.1539
Brugia malayi nuclear receptor NHR-88 0.0191 0.2547 0.3787
Brugia malayi hypothetical protein 0.009 0.087 0.127
Loa Loa (eye worm) hypothetical protein 0.0075 0.0615 0.0794
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0045 0.012 1
Brugia malayi intermediate filament protein 0.0054 0.0276 0.0378
Brugia malayi nuclear receptor RXR 0.009 0.087 0.127
Loa Loa (eye worm) steroid hormone receptor 0.0191 0.2547 0.3724
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0519 0.0742
Echinococcus multilocularis thyroid hormone receptor alpha 0.0191 0.2547 0.2528
Loa Loa (eye worm) hypothetical protein 0.0075 0.0615 0.0794
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0191 0.2547 0.2506
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.009 0.087 0.082
Treponema pallidum sodium- and chloride- dependent transporter 0.0441 0.6685 0.5
Loa Loa (eye worm) hypothetical protein 0.009 0.087 0.1182
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0101 0.105 0.1028
Echinococcus multilocularis jun protein 0.0188 0.2482 0.2464
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0101 0.105 0.1454
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0276 0.0378
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0519 0.0467
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0519 0.0467
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0075 0.0615 0.0563
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0256
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0093 0.0921 0.5951
Brugia malayi nuclear hormone receptor 0.009 0.087 0.127
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0075 0.0615 0.0563
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0055 0.003
Echinococcus granulosus sodium and chloride dependent glycine 0.0075 0.0615 0.0592
Brugia malayi hypothetical protein 0.0147 0.1815 0.2688
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0201 0.0147
Schistosoma mansoni retinoic acid receptor RXR 0.0191 0.2547 0.2506
Onchocerca volvulus 0.0075 0.0615 0.0886
Brugia malayi orphan nuclear receptor NR2E1 0.009 0.087 0.127
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0201 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0191 0.2547 0.3787
Onchocerca volvulus Bile acid receptor homolog 0.0191 0.2547 0.3787
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0191 0.2547 0.2528
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0191 0.2547 0.3724
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0067 0.0481 0.5229
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0075 0.0615 0.0592
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0191 0.2547 0.2528
Trypanosoma brucei cytochrome P450, putative 0.0043 0.0091 0.5
Brugia malayi Cytochrome P450 family protein 0.0088 0.0834 0.1216
Loa Loa (eye worm) hypothetical protein 0.0441 0.6685 1
Loa Loa (eye worm) hypothetical protein 0.0191 0.2547 0.3724
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0075 0.0615 0.0563
Brugia malayi nuclear hormone receptor family member odr-7 0.009 0.087 0.127
Brugia malayi Ets-domain containing protein 0.0079 0.0683 0.0989
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0191 0.2547 0.2528
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0075 0.0615 0.0592
Onchocerca volvulus 0.0075 0.0615 0.0886
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0191 0.2547 0.3787
Schistosoma mansoni intermediate filament proteins 0.0054 0.0276 0.0223
Schistosoma mansoni nuclear receptor 0.009 0.087 0.082
Loa Loa (eye worm) hypothetical protein 0.0441 0.6685 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.009 0.087 0.0848
Schistosoma mansoni gabp alpha 0.0079 0.0683 0.0632
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0075 0.0615 0.5
Echinococcus granulosus tar DNA binding protein 0.0069 0.0519 0.0496
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.009 0.087 0.0848
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0191 0.2547 0.2528
Schistosoma mansoni lamin 0.0054 0.0276 0.0223
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0063 0.0419 0.0395
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0059 0.0346 0.2238
Schistosoma mansoni nuclear hormone receptor 0.0191 0.2547 0.2506
Echinococcus multilocularis microtubule associated protein 2 0.0641 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.009 0.087 0.082
Brugia malayi Fli-1 protein 0.024 0.3349 0.4991
Brugia malayi photoreceptor-specific nuclear receptor 0.0191 0.2547 0.3787
Loa Loa (eye worm) DR-78 0.009 0.087 0.1182
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0191 0.2547 0.3787
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.009 0.087 0.127
Brugia malayi Nuclear hormone receptor-like 1 0.0101 0.105 0.1539
Echinococcus multilocularis sodium and chloride dependent glycine 0.0075 0.0615 0.0592
Echinococcus granulosus lamin dm0 0.0054 0.0276 0.0252
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0191 0.2547 0.2528
Echinococcus granulosus ecdysone induced protein 78C 0.0191 0.2547 0.2528
Loa Loa (eye worm) nuclear receptor nhr-7B 0.009 0.087 0.1182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0191 0.2547 0.3724
Schistosoma mansoni single-minded 0.0053 0.0253 0.0199
Loa Loa (eye worm) cytochrome P450 family protein 0.0088 0.0834 0.1127
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0201 0.0177
Echinococcus granulosus nuclear receptor nhr 48 0.009 0.087 0.0848
Brugia malayi Cytochrome P450 family protein 0.0043 0.0091 0.01
Brugia malayi nuclear receptor NHR-88 0.009 0.087 0.127
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0683 0.0898
Loa Loa (eye worm) solute carrier family 6 member 4 0.0441 0.6685 1
Brugia malayi PAS domain containing protein 0.0053 0.0253 0.0343
Loa Loa (eye worm) norepinephrine transporter 0.0441 0.6685 1
Loa Loa (eye worm) serotonin transporter b 0.0441 0.6685 1
Brugia malayi Cytochrome P450 family protein 0.0043 0.0091 0.01
Loa Loa (eye worm) nuclear hormone receptor 0.009 0.087 0.1182
Echinococcus multilocularis sodium and chloride dependent glycine 0.0075 0.0615 0.0592
Loa Loa (eye worm) hypothetical protein 0.009 0.087 0.1182
Echinococcus multilocularis lamin 0.0054 0.0276 0.0252
Leishmania major cytochrome p450-like protein 0.0043 0.0091 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0101 0.105 0.1001
Schistosoma mansoni coup transcription factor 0.0191 0.2547 0.2506
Trichomonas vaginalis aldehyde oxidase, putative 0.0198 0.2655 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0191 0.2547 0.3787
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0075 0.0615 0.0794
Schistosoma mansoni sodium/chloride dependent transporter 0.0441 0.6685 0.6667
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0075 0.0615 0.0886
Schistosoma mansoni thyroid hormone receptor 0.0191 0.2547 0.2506
Echinococcus multilocularis serotonin transporter 0.0441 0.6685 0.6677
Brugia malayi bZIP transcription factor family protein 0.0188 0.2482 0.369
Schistosoma mansoni steroid hormone receptor ad4bp 0.0191 0.2547 0.2506
Schistosoma mansoni jun-related protein 0.0152 0.19 0.1855
Echinococcus multilocularis FTZ F1 alpha 0.0191 0.2547 0.2528
Schistosoma mansoni lamin 0.0054 0.0276 0.0223
Brugia malayi nuclear receptor NHR-67 0.009 0.087 0.127
Schistosoma mansoni zinc finger protein 0.009 0.087 0.082
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0075 0.0615 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0191 0.2547 0.3724
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0063 0.0419 0.0395
Brugia malayi hypoxia-induced factor 1 0.0164 0.2096 0.311
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0519 0.0467
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0201 0.0264
Schistosoma mansoni ets-related 0.024 0.3349 0.3312
Echinococcus granulosus serotonin transporter 0.0441 0.6685 0.6677
Echinococcus multilocularis Nuclear hormone receptor HR96 0.009 0.087 0.0848
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0191 0.2547 0.3787
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0253 0.0199
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0075 0.0615 0.0592
Loa Loa (eye worm) hypothetical protein 0.0178 0.2325 0.3387
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0075 0.0615 0.0794
Echinococcus multilocularis geminin 0.025 0.3515 0.3499
Loa Loa (eye worm) hypothetical protein 0.009 0.087 0.1182
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0025 0.0159
Loa Loa (eye worm) hypothetical protein 0.0075 0.0615 0.0794
Loa Loa (eye worm) hypothetical protein 0.0075 0.0615 0.0794
Schistosoma mansoni nuclear receptor 0.009 0.087 0.082
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0101 0.105 0.1001
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0075 0.0615 0.0563
Loa Loa (eye worm) hypothetical protein 0.009 0.087 0.1182
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0201 0.0177
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0519 0.0467
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0276 0.0281
Echinococcus granulosus nuclear receptor 2DBD gamma 0.009 0.087 0.0848
Loa Loa (eye worm) hypothetical protein 0.009 0.087 0.1182
Loa Loa (eye worm) hypoxia-induced factor 1 0.0164 0.2096 0.3041
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0075 0.0615 0.0563
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.009 0.087 0.0848
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0191 0.2547 0.3724
Loa Loa (eye worm) hypothetical protein 0.0068 0.0493 0.061
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0101 0.105 0.1028
Schistosoma mansoni lipoxygenase 0.0063 0.0419 0.0366
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0276 0.0281
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0075 0.0615 0.5
Brugia malayi hypothetical protein 0.0075 0.0615 0.0886
Schistosoma mansoni microtubule-associated protein tau 0.0641 1 1
Schistosoma mansoni hypothetical protein 0.0152 0.19 0.1855
Brugia malayi hypothetical protein 0.0261 0.3707 0.5528
Schistosoma mansoni sodium/chloride dependent transporter 0.0075 0.0615 0.0563
Schistosoma mansoni sodium-dependent amino acid transporter 0.0075 0.0615 0.0563
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0191 0.2547 0.2528
Echinococcus granulosus lamin 0.0054 0.0276 0.0252
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.009 0.087 0.127
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0191 0.2547 0.2528
Echinococcus multilocularis musashi 0.0054 0.0276 0.0252
Plasmodium falciparum amino acid transporter, putative 0.0075 0.0615 0.5
Brugia malayi RNA binding protein 0.0069 0.0519 0.0742
Schistosoma mansoni hypothetical protein 0.025 0.3515 0.3479
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0131 0.1547 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.2397 0.3497
Schistosoma mansoni hypothetical protein 0.025 0.3515 0.3479
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0075 0.0615 0.0592
Plasmodium falciparum transporter, putative 0.0075 0.0615 0.5
Onchocerca volvulus 0.0075 0.0615 0.0886
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0191 0.2547 0.3787
Brugia malayi hypothetical protein 0.0041 0.0055 0.0045
Echinococcus granulosus sodium and chloride dependent glycine 0.0075 0.0615 0.0592
Onchocerca volvulus 0.0147 0.1815 0.2688
Loa Loa (eye worm) hypothetical protein 0.0191 0.2547 0.3724
Loa Loa (eye worm) hypothetical protein 0.0191 0.2547 0.3724
Schistosoma mansoni sodium/chloride dependent transporter 0.0075 0.0615 0.0563
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0615 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.009 0.087 0.0848
Loa Loa (eye worm) hypothetical protein 0.0075 0.0615 0.0794
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0075 0.0615 0.0592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0201 0.0147
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0191 0.2547 0.2528
Brugia malayi hypothetical protein 0.0101 0.105 0.1539
Echinococcus multilocularis Nuclear hormone receptor HR96 0.009 0.087 0.0848
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0191 0.2547 0.3787
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0191 0.2547 0.3724
Echinococcus granulosus intermediate filament protein 0.0054 0.0276 0.0252
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0055 0.003
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0043 0.0091 0.0587
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0683 0.066
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0191 0.2547 0.2506
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0075 0.0615 0.5
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0075 0.0615 0.0886
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0441 0.6685 0.6667
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0067 0.0481 0.3111
Brugia malayi Nuclear hormone receptor-like 1 0.0191 0.2547 0.3787
Echinococcus multilocularis nuclear receptor nhr 48 0.009 0.087 0.0848
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0191 0.2547 0.3787
Brugia malayi ecdysteroid receptor 0.0191 0.2547 0.3787
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0191 0.2547 0.3787
Loa Loa (eye worm) hypothetical protein 0.0191 0.2547 0.3724
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0191 0.2547 0.2506
Loa Loa (eye worm) RNA binding protein 0.0069 0.0519 0.0649
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0201 0.0147
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0191 0.2547 0.2506
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0191 0.2547 0.3724
Loa Loa (eye worm) hypothetical protein 0.0101 0.105 0.1454
Toxoplasma gondii hypothetical protein 0.0075 0.0615 0.5
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0441 0.6685 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0615 0.0794
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0191 0.2547 0.2528
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0093 0.0921 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0191 0.2547 0.2506
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0191 0.2547 0.3787
Toxoplasma gondii hypothetical protein 0.0075 0.0615 0.5
Onchocerca volvulus 0.009 0.087 0.127
Loa Loa (eye worm) hypothetical protein 0.009 0.087 0.1182
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0075 0.0615 0.0563
Schistosoma mansoni thyroid hormone receptor 0.0191 0.2547 0.2506
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0519 0.0649
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0191 0.2547 0.2506
Echinococcus granulosus jun protein 0.0188 0.2482 0.2464
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0093 0.0921 0.5951
Brugia malayi Nuclear hormone receptor-like 1 0.0101 0.105 0.1539
Brugia malayi ecdysone receptor 0.009 0.087 0.127
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0075 0.0615 0.0592
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0191 0.2547 0.3724
Echinococcus granulosus FTZ F1 alpha 0.0191 0.2547 0.2528
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0191 0.2547 0.2528
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0191 0.2547 0.3787
Loa Loa (eye worm) hypothetical protein 0.009 0.087 0.1182
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0191 0.2547 0.3787
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0091 0.5
Onchocerca volvulus 0.009 0.087 0.127
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0191 0.2547 0.2528
Echinococcus granulosus thyroid hormone receptor alpha 0.009 0.087 0.0848
Brugia malayi TAR-binding protein 0.0069 0.0519 0.0742
Loa Loa (eye worm) fli-1 protein 0.024 0.3349 0.4941
Brugia malayi conserved hypotetical protein 0.009 0.087 0.127
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0045 0.012 1
Loa Loa (eye worm) hypothetical protein 0.009 0.087 0.1182
Loa Loa (eye worm) hypothetical protein 0.0191 0.2547 0.3724
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0201 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0191 0.2547 0.3787
Loa Loa (eye worm) hypothetical protein 0.0111 0.1208 0.1694
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0519 0.0496
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0519 0.0649
Brugia malayi hypothetical protein 0.0101 0.105 0.1539
Loa Loa (eye worm) hypothetical protein 0.0075 0.0615 0.0794
Loa Loa (eye worm) hypothetical protein 0.0101 0.105 0.1454
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0191 0.2547 0.2528
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0188 0.2482 0.2464
Loa Loa (eye worm) hypothetical protein 0.0054 0.0276 0.0281
Loa Loa (eye worm) hypothetical protein 0.0045 0.012 0.0045
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0201 0.0166
Brugia malayi Nuclear hormone receptor E75 0.009 0.087 0.127
Onchocerca volvulus 0.0054 0.0276 0.0378
Onchocerca volvulus Protein ultraspiracle homolog 0.0191 0.2547 0.3787
Plasmodium vivax amine transporter, putative 0.0075 0.0615 0.5
Onchocerca volvulus 0.0191 0.2547 0.3787
Brugia malayi Nuclear hormone receptor E75 0.009 0.087 0.127
Echinococcus multilocularis ecdysone induced protein 78C 0.0191 0.2547 0.2528
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0519 0.0467
Brugia malayi Steroid receptor seven-up type 2 0.0191 0.2547 0.3787
Loa Loa (eye worm) hypothetical protein 0.009 0.087 0.1182
Brugia malayi Ets-domain containing protein 0.0079 0.0683 0.0989
Echinococcus granulosus geminin 0.025 0.3515 0.3499
Echinococcus granulosus Nuclear hormone receptor HR96 0.009 0.087 0.0848
Loa Loa (eye worm) hypothetical protein 0.0101 0.105 0.1454
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.009 0.087 0.0848
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0075 0.0615 0.0563
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0198 0.2655 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0188 0.2482 0.2464
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0075 0.0615 0.0592
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0075 0.0615 0.0886
Schistosoma mansoni nuclear hormone receptor 0.009 0.087 0.082
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0198 0.2655 0.5
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0075 0.0615 0.0563
Loa Loa (eye worm) hypothetical protein 0.009 0.087 0.1182
Loa Loa (eye worm) hypothetical protein 0.0101 0.105 0.1454
Schistosoma mansoni nuclear hormone receptor 0.009 0.087 0.082
Brugia malayi nuclear hormone receptor family member nhr-6 0.009 0.087 0.127
Loa Loa (eye worm) hypothetical protein 0.0191 0.2547 0.3724
Loa Loa (eye worm) nuclear receptor NHR-67 0.009 0.087 0.1182
Loa Loa (eye worm) hypothetical protein 0.009 0.087 0.1182
Brugia malayi nuclear hormone receptor 0.0191 0.2547 0.3787
Echinococcus multilocularis lamin dm0 0.0054 0.0276 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0191 0.2547 0.3787
Loa Loa (eye worm) hypothetical protein 0.0441 0.6685 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0191 0.2547 0.2528
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0091 0.5
Loa Loa (eye worm) hypothetical protein 0.0191 0.2547 0.3724
Schistosoma mansoni nuclear receptor nhr-48 0.009 0.087 0.082
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.009 0.087 0.127
Schistosoma mansoni RAR-like nuclear receptor 0.0191 0.2547 0.2506
Brugia malayi hypothetical protein 0.0178 0.2325 0.3453
Onchocerca volvulus 0.0441 0.6685 1
Brugia malayi steroid hormone receptor 0.0191 0.2547 0.3787
Loa Loa (eye worm) hypothetical protein 0.009 0.087 0.1182
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0075 0.0615 0.0886
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0067 0.0481 0.3111
Onchocerca volvulus 0.0054 0.0276 0.0378
Loa Loa (eye worm) hypothetical protein 0.009 0.087 0.1182
Brugia malayi tailless protein 0.009 0.087 0.127

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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