Detailed information for compound 2073313

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 614.73 | Formula: C32H46N4O8
  • H donors: 3 H acceptors: 5 LogP: 1.73 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: CO[C@H]1C[C@H](C)CC2=C(/N=C/CN(C)C)C(=O)C=C(C2=O)NC(=O)/C(=C/C=C\[C@@H]([C@H](/C(=C/[C@@H]([C@H]1O)C)/C)OC(=O)N)OC)/C
  • InChi: 1S/C32H46N4O8/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8/h9-12,16-18,20,25-26,28,30,38H,13-15H2,1-8H3,(H2,33,41)(H,35,40)/b11-9-,19-10+,21-16+,34-12+/t18-,20+,25+,26+,28-,30+/m1/s1
  • InChiKey: UFHFXFGYYAHGIY-OKSFYDSZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus phosphoglycerate kinase 1 0.0074 0.0463 0.0438
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0042 0.0169 0.0143
Schistosoma mansoni phosphoglycerate kinase 0.0074 0.0463 0.0438
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0425 0.3604 0.3587
Echinococcus multilocularis geminin 0.0258 0.2114 0.2093
Echinococcus granulosus uridine 5' monophosphate synthase 0.006 0.0333 0.0308
Mycobacterium ulcerans hypothetical protein 0.0472 0.4034 0.3946
Brugia malayi Phospholipase A2 family protein 0.004 0.0156 0.0141
Schistosoma mansoni hypothetical protein 0.0258 0.2114 0.2093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0241 0.0216
Echinococcus multilocularis hypothetical protein 0.0146 0.1102 0.1079
Echinococcus granulosus ribonuclease H1 0.0045 0.02 0.0174
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0383 0.3232 0.3132
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0126 0.0927 0.0903
Loa Loa (eye worm) hypothetical protein 0.0111 0.0791 0.0776
Echinococcus multilocularis thymidylate synthase 0.1137 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0169 0.0143
Trypanosoma brucei phosphoglycerate kinase 0.0074 0.0463 0.0438
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0181 0.142 0.1407
Toxoplasma gondii orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase 0.006 0.0333 0.0167
Brugia malayi Pre-SET motif family protein 0.0042 0.0169 0.0154
Leishmania major phosphoglycerate kinase C, glycosomal 0.0074 0.0463 0.0438
Trypanosoma brucei unspecified product 0.0054 0.0277 0.0252
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0241 0.0226
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0041 0.0163 0.0138
Trypanosoma brucei phosphoglycerate kinase 0.0027 0.004 0.0014
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0035 0.0111 0.0085
Loa Loa (eye worm) hypothetical protein 0.0228 0.1845 0.1832
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1137 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0472 0.4034 0.3745
Loa Loa (eye worm) thymidylate synthase 0.1137 1 1
Brugia malayi Phosphoglycerate kinase 0.0027 0.004 0.0024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0066
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0241 0.5211
Loa Loa (eye worm) hypothetical protein 0.0048 0.0229 0.0214
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0073 0.0446 0.0421
Onchocerca volvulus Phospholipase A2 homolog 0.004 0.0156 0.0075
Trypanosoma brucei RNA helicase, putative 0.057 0.4905 0.4892
Brugia malayi orotate phosphoribosyltransferase family protein 0.006 0.0333 0.0318
Onchocerca volvulus 0.1137 1 1
Schistosoma mansoni phosphoglucomutase 0.0045 0.02 0.0174
Brugia malayi follicle stimulating hormone receptor 0.0181 0.142 0.1407
Schistosoma mansoni ets-related 0.0152 0.1154 0.1131
Mycobacterium ulcerans orotidine 5'-phosphate decarboxylase 0.006 0.0333 0.019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0241 0.0216
Entamoeba histolytica hypothetical protein 0.0055 0.0287 0.6206
Brugia malayi hypothetical protein 0.0541 0.465 0.4641
Giardia lamblia Phosphoglycerate kinase 0.0074 0.0463 1
Echinococcus multilocularis uridine 5' monophosphate synthase 0.006 0.0333 0.0308
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0241 0.5211
Plasmodium vivax phosphoglycerate kinase, putative 0.0074 0.0463 0.0299
Schistosoma mansoni phosphoglucomutase 0.0045 0.02 0.0174
Leishmania major DNA polymerase eta, putative 0.0028 0.0046 0.002
Brugia malayi Ets-domain containing protein 0.005 0.0243 0.0227
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0146 0.012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0241 0.0216
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0383 0.3232 0.2904
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0048 0.0229 0.0439
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1137 1 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.027 0.0244
Entamoeba histolytica hypothetical protein 0.0032 0.0082 0.1764
Onchocerca volvulus 0.0543 0.4671 0.4627
Trypanosoma brucei phosphoglycerate kinase, putative 0.0027 0.004 0.0014
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0041 0.0163 0.0138
Loa Loa (eye worm) hypoxia-induced factor 1 0.0164 0.1265 0.1251
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0074 0.0463 0.0299
Mycobacterium ulcerans thymidylate synthase 0.1137 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0425 0.3604 0.3587
Trypanosoma brucei phosphoglycerate kinase 0.0074 0.0463 0.0438
Schistosoma mansoni phosphoglucomutase 0.0045 0.02 0.0174
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0035 0.0111 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0241 0.0216
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0241 0.0226
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0383 0.3232 0.3132
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0383 0.3232 0.3132
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0073 0.0446 0.0421
Echinococcus granulosus geminin 0.0258 0.2114 0.2093
Echinococcus multilocularis dna polymerase eta 0.0028 0.0046 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0241 0.0216
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0073 0.0446 0.0421
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0042 0.0169 0.0143
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1137 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0055 0.0287 0.0262
Plasmodium vivax DNA polymerase alpha, putative 0.0066 0.0383 0.0217
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0074 0.0463 0.0525
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0126 0.0927 0.0903
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0241 0.0216
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0073 0.0446 0.0421
Schistosoma mansoni single-minded 0.0053 0.027 0.0244
Brugia malayi hypothetical protein 0.0178 0.1388 0.1375
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0031
Echinococcus granulosus GA binding protein alpha chain 0.005 0.0243 0.0217
Echinococcus granulosus thymidylate synthase 0.1137 1 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1137 1 1
Brugia malayi DNA polymerase I family protein 0.0146 0.1102 0.1089
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1137 1 1
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0383 0.3232 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0291 0.2405 0.2393
Brugia malayi RNase H family protein 0.0045 0.02 0.0184
Schistosoma mansoni hypothetical protein 0.0055 0.0287 0.0262
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0081 0.0519 0.0494
Brugia malayi hypothetical protein 0.0088 0.0581 0.0567
Loa Loa (eye worm) hypothetical protein 0.0074 0.0463 0.0448
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0074 0.0463 0.0944
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.003 0.0066 0.004
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0126 0.0927 0.0903
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1137 1 1
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0241 0.5211
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0048 0.0229 0.0203
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0073 0.0446 0.0421
Toxoplasma gondii ribonuclease HI protein 0.0045 0.02 0.0031
Giardia lamblia DNA polymerase alpha subunit A 0.0068 0.0408 0.7927
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0042 0.0169 0.0143
Schistosoma mansoni gabp alpha 0.005 0.0243 0.0217
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0048 0.0229 0.0203
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0041 0.0163 0.0138
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0897 0.7844 0.7838
Onchocerca volvulus 0.0039 0.0146 0.0065
Brugia malayi RNase H family protein 0.0045 0.02 0.0184
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0146 0.0131
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0074 0.0463 0.0134
Toxoplasma gondii melibiase subfamily protein 0.0073 0.0446 0.0282
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0111 0.0791 0.0715
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0074 0.0463 0.0944
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0074 0.0463 0.0438
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0541 0.465 0.4636
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.006 0.0333 0.0308
Brugia malayi Phosphoglycerate kinase 0.0074 0.0463 0.0448
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0425 0.3604 0.3587
Entamoeba histolytica phosphoglycerate kinase, putative 0.0074 0.0463 1
Brugia malayi PAS domain containing protein 0.0053 0.027 0.0254
Loa Loa (eye worm) hypothetical protein 0.0191 0.151 0.1497
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0055 0.0287 0.0262
Loa Loa (eye worm) hypothetical protein 0.0178 0.1388 0.1375
Wolbachia endosymbiont of Brugia malayi orotidine-5'-phosphate decarboxylase 0.0603 0.521 1
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0035 0.0111 0.0184
Brugia malayi Peptidase family C54 containing protein 0.0026 0.0026 0.0011
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0054 0.0277 0.0252
Entamoeba histolytica hypothetical protein 0.0055 0.0287 0.6206
Loa Loa (eye worm) hypothetical protein 0.0146 0.1102 0.1089
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0383 0.3232 0.3116
Leishmania major mitochondrial DNA polymerase beta 0.0897 0.7844 0.7838
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0074 0.0463 0.0299
Brugia malayi Pre-SET motif family protein 0.0291 0.2405 0.2393
Schistosoma mansoni hypothetical protein 0.0037 0.0124 0.0098
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0027 0.004 0.0014
Loa Loa (eye worm) replication-associated protein 0.0032 0.0082 0.0066
Brugia malayi DNA polymerase alpha catalytic subunit 0.0066 0.0383 0.0368
Loa Loa (eye worm) replication-associated protein 0.0032 0.0082 0.0066
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.006 0.0333 0.0308
Onchocerca volvulus Phospholipase A2 homolog 0.0191 0.151 0.144
Onchocerca volvulus 0.0042 0.0169 0.0088
Trypanosoma brucei ingi protein (ORF1) 0.0054 0.0277 0.0252
Treponema pallidum phosphoglycerate kinase 0.0074 0.0463 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0042 0.0169 0.0143
Echinococcus multilocularis phosphoglycerate kinase 1 0.0074 0.0463 0.0438
Leishmania major ribonuclease H1, putative 0.0045 0.02 0.0174
Loa Loa (eye worm) fli-1 protein 0.0152 0.1154 0.114
Trichomonas vaginalis DNA polymerase II, putative 0.0035 0.0111 0.0184
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0027 0.004 0.0014
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.005 0.0243 0.0227
Schistosoma mansoni phosphoglycerate kinase 0.0074 0.0463 0.0438
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0383 0.3232 0.3232
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0035 0.0111 0.0085
Brugia malayi Melibiase family protein 0.0048 0.0229 0.0214
Loa Loa (eye worm) transcription factor SMAD2 0.0052 0.0263 0.0248
Loa Loa (eye worm) hypothetical protein 0.0043 0.0178 0.0162
Trypanosoma brucei hypothetical protein, conserved 0.0054 0.0277 0.0252
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1137 1 1
Leishmania major phosphoglycerate kinase B, cytosolic 0.0074 0.0463 0.0438
Plasmodium vivax orotidine 5'-phosphate decarboxylase, putative 0.006 0.0333 0.0167
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.004 0.0155 0.0129
Plasmodium falciparum orotidine 5'-phosphate decarboxylase 0.006 0.0333 0.0333
Mycobacterium ulcerans phosphoglycerate kinase 0.0074 0.0463 0.0321
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0073 0.0446 0.0421
Loa Loa (eye worm) MH2 domain-containing protein 0.0052 0.0263 0.0248
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0066 0.0383 0.0217
Brugia malayi MH2 domain containing protein 0.0052 0.0263 0.0248
Brugia malayi hypoxia-induced factor 1 0.0164 0.1265 0.1251
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0897 0.7844 0.7838
Entamoeba histolytica hypothetical protein 0.0055 0.0287 0.6206
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1137 1 1
Entamoeba histolytica hypothetical protein 0.0032 0.0082 0.1764
Trichomonas vaginalis ribonuclease H1, putative 0.0045 0.02 0.0375
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0011
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0073 0.0446 0.0421
Trypanosoma brucei ingi protein (ORF1) 0.0054 0.0277 0.0252
Echinococcus multilocularis ribonuclease H1 0.0045 0.02 0.0174
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0074 0.0463 0.0438
Entamoeba histolytica hypothetical protein 0.0032 0.0082 0.1764
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0081 0.0519 0.0494
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1137 1 1
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0081 0.0519 0.0494
Trichomonas vaginalis set domain proteins, putative 0.0331 0.2765 0.5925
Toxoplasma gondii hypothetical protein 0.0145 0.1093 0.094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0042 0.0169 0.0143
Schistosoma mansoni hypothetical protein 0.057 0.4905 0.4892
Entamoeba histolytica peptidase, C54 family 0.0026 0.0026 0.0567
Onchocerca volvulus 0.0331 0.2765 0.2706
Brugia malayi RNase H family protein 0.0045 0.02 0.0184
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.006 0.0333 0.0308
Trypanosoma cruzi ribonuclease H1, putative 0.0045 0.02 0.0174
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.006 0.0333 0.0318
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0241 0.0216
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.006 0.0333 0.0308
Brugia malayi hypothetical protein 0.0055 0.0287 0.0272
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0027 0.004 0.0014
Schistosoma mansoni DNA polymerase eta 0.0028 0.0046 0.002
Trypanosoma brucei ribonuclease H1 0.0045 0.02 0.0174
Brugia malayi ImpB/MucB/SamB family protein 0.0028 0.0046 0.0031
Schistosoma mansoni hypothetical protein 0.0258 0.2114 0.2093
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0241 0.5211
Entamoeba histolytica hypothetical protein 0.0055 0.0287 0.6206
Plasmodium falciparum phosphoglycerate kinase 0.0074 0.0463 0.0463
Mycobacterium tuberculosis Hypothetical protein 0.0541 0.465 0.439
Echinococcus granulosus single minded 2 0.0039 0.0146 0.012
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0141
Loa Loa (eye worm) replication-associated protein 0.0032 0.0082 0.0066
Schistosoma mansoni DNA polymerase gamma 0.0146 0.1102 0.1079
Echinococcus multilocularis GA binding protein alpha chain 0.005 0.0243 0.0217
Brugia malayi Ets-domain containing protein 0.005 0.0243 0.0227
Onchocerca volvulus Ribonuclease H1 homolog 0.0045 0.02 0.0119
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.1174 0.1151
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.006 0.0333 0.0308
Trypanosoma cruzi DNA polymerase eta, putative 0.0028 0.0046 0.002
Echinococcus granulosus dna polymerase eta 0.0028 0.0046 0.002
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0126 0.0927 0.0903
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.006 0.0333 0.0308
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0897 0.7844 0.7838
Echinococcus granulosus DNA polymerase subunit gamma 0.0146 0.1102 0.1079
Trypanosoma brucei DNA polymerase eta, putative 0.0028 0.0046 0.002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0055 0.0287 0.0262
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0383 0.3232 0.6053
Echinococcus granulosus histone lysine methyltransferase setb 0.0042 0.0169 0.0143
Loa Loa (eye worm) hypothetical protein 0.0042 0.0169 0.0154
Brugia malayi Fli-1 protein 0.0152 0.1154 0.114
Trypanosoma cruzi ribonuclease H1, putative 0.0045 0.02 0.0174
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0241 0.5211
Trichomonas vaginalis conserved hypothetical protein 0.0541 0.465 1

Activities

Activity type Activity value Assay description Source Reference
Retention_time (ADMET) = 8.4 min Retention time in human liver microsomes treated with 10 uM 17-DAMG after 2 hrs by liquid chromatography-tandem mass spectrometry ChEMBL. 21177985

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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