Detailed information for compound 207486

Basic information

Technical information
  • TDR Targets ID: 207486
  • Name: N-(3-bromophenyl)cinnolin-4-amine
  • MW: 300.153 | Formula: C14H10BrN3
  • H donors: 1 H acceptors: 2 LogP: 3.42 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cccc(c1)Nc1cnnc2c1cccc2
  • InChi: 1S/C14H10BrN3/c15-10-4-3-5-11(8-10)17-14-9-16-18-13-7-2-1-6-12(13)14/h1-9H,(H,17,18)
  • InChiKey: WVNAAWCVKNMCCQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-bromophenyl)-4-cinnolinamine
  • (3-bromophenyl)-cinnolin-4-yl-amine
  • cinnoline deriv. 22

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1544 0.2998
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.01 0.1004 0.0965
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.0324 0.4054
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.0096
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0132 0.0132
Plasmodium vivax vivapain-1 0.0047 0.0324 0.4322
Echinococcus multilocularis neuropeptide Y receptor 0.01 0.1004 0.0965
Brugia malayi Tachykinin-like peptides receptor 99D 0.01 0.1004 0.1109
Brugia malayi Pre-SET motif family protein 0.0032 0.0132 0.0146
Trypanosoma cruzi cysteine protease, putative 0.0047 0.0324 0.0615
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0393 0.4734 0.4712
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0177 0.0463
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1544 0.425
Echinococcus granulosus tm gpcr rhodopsin 0.0621 0.7634 0.7624
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.0324 0.0283
Loa Loa (eye worm) matrixin family protein 0.0052 0.0386 0.0427
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0324 0.0615
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0737 0.1955
Brugia malayi hypothetical protein 0.01 0.1004 0.1109
Schistosoma mansoni opsin-like receptor 0.01 0.1004 0.1004
Echinococcus granulosus 7tm_1 domain containing protein 0.01 0.1004 0.0965
Echinococcus granulosus rhodopsin orphan GPCR 0.01 0.1004 0.0965
Brugia malayi ORL1-like opioid receptor 0.01 0.1004 0.1109
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.1004 0.0965
Brugia malayi RNA binding protein 0.0125 0.132 0.1459
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0177 0.0697
Onchocerca volvulus 0.0025 0.0042 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0324 0.101
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.01 0.1004 0.0965
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.1004 0.1004
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0042 0.0064
Echinococcus granulosus cathepsin b 0.0424 0.5129 0.5108
Echinococcus granulosus somatostatin receptor 0.01 0.1004 0.0965
Echinococcus multilocularis neuropeptide receptor 0.01 0.1004 0.0965
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Entamoeba histolytica cysteine protease, putative 0.0079 0.0737 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0177 0.0328
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.1004 0.0965
Loa Loa (eye worm) cathepsin B 0.0148 0.1615 0.1786
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0531 0.0491
Schistosoma mansoni amine GPCR 0.01 0.1004 0.1004
Schistosoma mansoni hypothetical protein 0.0073 0.0655 0.0655
Entamoeba histolytica hypothetical protein 0.0073 0.0655 0.8813
Brugia malayi cathepsin L precursor 0.0025 0.0042 0.0047
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0177 0.0136
Onchocerca volvulus 0.0035 0.0177 0.0626
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.01 0.1004 0.1109
Echinococcus granulosus peptide allatostatin:somatostatin 0.01 0.1004 0.0965
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0918 0.1015
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0042 0.0047
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0424 0.5129 0.5129
Schistosoma mansoni peptide (allatostatin)-like receptor 0.01 0.1004 0.1004
Schistosoma mansoni biogenic amine (5HT) receptor 0.01 0.1004 0.1004
Echinococcus multilocularis biogenic amine (5HT) receptor 0.01 0.1004 0.0965
Entamoeba histolytica cysteine protease, putative 0.0047 0.0324 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0148 0.1615 0.1615
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0531 0.0587
Brugia malayi Cathepsin L-like precursor 0.0079 0.0737 0.0815
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0025 0.0042 0.0451
Echinococcus granulosus g protein coupled receptor 0.01 0.1004 0.0965
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0324 0.0324
Plasmodium vivax SET domain protein, putative 0.0032 0.0132 0.1692
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.132 0.1459
Loa Loa (eye worm) RNA binding protein 0.0125 0.132 0.1459
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0026 0.0059 0.0066
Schistosoma mansoni alpha-1 adrenergic receptor 0.01 0.1004 0.1004
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.01 0.1004 0.1004
Brugia malayi Melatonin receptor type 1A 0.01 0.1004 0.1109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0047
Entamoeba histolytica cysteine proteinase 2 0.0047 0.0324 0.4054
Echinococcus multilocularis cathepsin b 0.0424 0.5129 0.5108
Onchocerca volvulus Cathepsin L homolog 0.0079 0.0737 0.2603
Schistosoma mansoni neuropeptide receptor 0.01 0.1004 0.1004
Loa Loa (eye worm) hypothetical protein 0.0136 0.1464 0.1618
Echinococcus granulosus G protein coupled receptor 139 0.01 0.1004 0.0965
Entamoeba histolytica cysteine protease, putative 0.0047 0.0324 0.4054
Echinococcus multilocularis fmrfamide receptor 0.01 0.1004 0.0965
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.01 0.1004 0.0965
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Brugia malayi Serotonin receptor 0.01 0.1004 0.1109
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.1544 0.425
Echinococcus granulosus orexin receptor type 2 0.01 0.1004 0.0965
Brugia malayi Cathepsin L-like precursor 0.0079 0.0737 0.0815
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0148 0.1615 0.3137
Echinococcus granulosus neuropeptide FF receptor 2 0.01 0.1004 0.0965
Echinococcus granulosus cathepsin l1 0.0057 0.0455 0.0415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.1004 0.1004
Brugia malayi Pre-SET motif family protein 0.0214 0.2457 0.2716
Brugia malayi larval opioid receptor 0.01 0.1004 0.1109
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0621 0.7634 0.7624
Echinococcus granulosus cathepsin l1 0.0079 0.0737 0.0698
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.0324 0.4054
Loa Loa (eye worm) ctsf protein 0.0079 0.0737 0.0815
Mycobacterium leprae Probable lipase LipE 0.0035 0.0177 1
Echinococcus granulosus g protein coupled receptor 0.01 0.1004 0.0965
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0177 1
Schistosoma mansoni tar DNA-binding protein 0.0125 0.132 0.132
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0087 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0737 0.1955
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0102 0.0061
Echinococcus granulosus cpg binding protein 0.006 0.049 0.045
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.1004 0.0965
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.01 0.1004 0.1004
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Onchocerca volvulus 0.01 0.1004 0.3543
Loa Loa (eye worm) beta-lactamase 0.0035 0.0177 0.0196
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0079 0.0737 1
Brugia malayi hypothetical protein 0.01 0.1004 0.1109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0737 0.1955
Brugia malayi cathepsin L-like precursor 0.0057 0.0455 0.0504
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0655 0.0655
Entamoeba histolytica cysteine protease, putative 0.0047 0.0324 0.4054
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.01 0.1004 0.1109
Echinococcus granulosus neuropeptide receptor A26 0.01 0.1004 0.0965
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0132 0.0091
Toxoplasma gondii cathepsin CPL 0.0079 0.0737 0.4419
Schistosoma mansoni cpg binding protein 0.006 0.049 0.049
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.01 0.1004 0.1004
Echinococcus granulosus biogenic amine 5HT receptor 0.01 0.1004 0.0965
Echinococcus granulosus rhodopsin orphan GPCR 0.01 0.1004 0.0965
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.0737 0.0815
Toxoplasma gondii cathepsin B 0.0148 0.1615 1
Echinococcus multilocularis cathepsin L 0.0047 0.0324 0.0283
Echinococcus granulosus cysteine protease 0.0047 0.0324 0.0283
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0079 0.0737 0.0815
Echinococcus granulosus serotonin receptor 0.01 0.1004 0.0965
Brugia malayi AKH receptor 0.01 0.1004 0.1109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0737 0.2492
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.1108 0.6777
Echinococcus multilocularis cysteine protease 0.0079 0.0737 0.0698
Brugia malayi hypothetical protein 0.01 0.1004 0.1109
Trichomonas vaginalis esterase, putative 0.0035 0.0177 0.0484
Schistosoma mansoni histamine h1 receptor 0.01 0.1004 0.1004
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0737 0.2492
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0531 0.0587
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.3566 1
Loa Loa (eye worm) neuropeptide F receptor 0.01 0.1004 0.1109
Schistosoma mansoni neuropeptide receptor 0.01 0.1004 0.1004
Loa Loa (eye worm) matrixin family protein 0.0047 0.0332 0.0367
Schistosoma mansoni cathepsin B (C01 family) 0.0025 0.0042 0.0042
Brugia malayi G-protein coupled receptor 0.01 0.1004 0.1109
Plasmodium vivax unspecified product 0.0047 0.0324 0.4322
Brugia malayi Calcitonin receptor-like protein seb-1 0.02 0.2268 0.2507
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0177 0.0196
Giardia lamblia Cathepsin B precursor 0.0148 0.1615 1
Echinococcus granulosus neuropeptides capa receptor 0.01 0.1004 0.0965
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.01 0.1004 0.0965
Echinococcus granulosus neuropeptide receptor 0.01 0.1004 0.0965
Brugia malayi RE15519p 0.01 0.1004 0.1109
Schistosoma mansoni tar DNA-binding protein 0.0125 0.132 0.132
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0025 0.0042 0.0451
Schistosoma mansoni cathepsin s 0.0022 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0737 0.2492
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0918 0.1015
Loa Loa (eye worm) hypothetical protein 0.0057 0.0455 0.0504
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Schistosoma mansoni hypothetical protein 0.0063 0.0531 0.0531
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0177 0.0484
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.01 0.1004 0.0965
Leishmania major cathepsin L-like protease 0.0079 0.0737 0.1955
Loa Loa (eye worm) TK/EGFR protein kinase 0.018 0.202 0.2233
Schistosoma mansoni biogenic amine (dopamine) receptor 0.01 0.1004 0.1004
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0324 0.4054
Plasmodium vivax vivapain-3 0.0047 0.0324 0.4322
Brugia malayi G-protein coupled receptor 0.01 0.1004 0.1109
Entamoeba histolytica cysteine protease, putative 0.0047 0.0324 0.4054
Brugia malayi beta-lactamase family protein 0.0035 0.0177 0.0196
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0025 0.0042 0.0451
Trypanosoma brucei cysteine peptidase C (CPC) 0.0148 0.1615 0.4452
Echinococcus granulosus tar DNA binding protein 0.0125 0.132 0.1283
Echinococcus multilocularis GPCR, family 2 0.0063 0.0531 0.0491
Leishmania major cathepsin L-like protease 0.0079 0.0737 0.1955
Entamoeba histolytica cysteine protease, putative 0.0047 0.0324 0.4054
Onchocerca volvulus Neuropeptide F receptor homolog 0.01 0.1004 0.3543
Brugia malayi Serotonin receptor 0.01 0.1004 0.1109
Entamoeba histolytica cysteine protease, putative 0.0047 0.0324 0.4054
Onchocerca volvulus 0.0079 0.0737 0.2603
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.01 0.1004 0.1004
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0042 0.0047
Brugia malayi hypothetical protein 0.0732 0.9046 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0737 0.2492
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0324 0.0358
Schistosoma mansoni tyrosine kinase 0.0096 0.0946 0.0946
Schistosoma mansoni lamin 0.0028 0.0087 0.0087
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.01 0.1004 0.0965
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0267 0.0504
Brugia malayi G protein-coupled receptor F59B2.13 0.01 0.1004 0.1109
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0058 0.046 0.042
Echinococcus granulosus alpha 1A adrenergic receptor 0.01 0.1004 0.0965
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0042 0.0047
Leishmania major cathepsin L-like protease 0.0079 0.0737 0.1955
Onchocerca volvulus 0.0079 0.0737 0.2603
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.132 0.1459
Echinococcus granulosus g protein coupled receptor 0.01 0.1004 0.0965
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.01 0.1004 0.0965
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0737 0.1955
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.1004 0.1004
Schistosoma mansoni hypothetical protein 0.01 0.1004 0.1004
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.01 0.1004 0.0965
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.005 0.0079
Echinococcus multilocularis epidermal growth factor receptor 0.018 0.202 0.1987
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0385 0.0734
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0324 0.0779
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.01 0.1004 0.0965
Echinococcus granulosus lamin 0.0028 0.0087 0.0045
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.005 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0455 0.1482
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.01 0.1004 0.1109
Brugia malayi Dopamine receptor protein 2 0.01 0.1004 0.1109
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.01 0.1004 0.1004
Loa Loa (eye worm) hypothetical protein 0.0424 0.5129 0.567
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0737 0.2492
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.01 0.1004 0.1004
Echinococcus granulosus fmrfamide receptor 0.01 0.1004 0.0965
Schistosoma mansoni cathepsin F (C01 family) 0.0079 0.0737 0.0737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0455 0.1482
Brugia malayi Cathepsin L-like precursor 0.0079 0.0737 0.0815
Loa Loa (eye worm) hypothetical protein 0.0079 0.0737 0.0815
Mycobacterium ulcerans lipase LipD 0.0035 0.0177 0.0697
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0737 0.2492
Onchocerca volvulus Cathepsin L homolog 0.0079 0.0737 0.2603
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.1004 0.1004
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0737 0.1422
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0737 0.2492
Onchocerca volvulus 0.01 0.1004 0.3543
Onchocerca volvulus 0.0079 0.0737 0.2603
Echinococcus multilocularis cathepsin L cysteine protease 0.0079 0.0737 0.0698
Onchocerca volvulus 0.0079 0.0737 0.2603
Schistosoma mansoni hypothetical protein 0.0351 0.4195 0.4195
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0177 0.0177
Giardia lamblia Cathepsin B precursor 0.0148 0.1615 1
Echinococcus granulosus biogenic amine 5HT receptor 0.01 0.1004 0.0965
Onchocerca volvulus 0.0035 0.0177 0.0626
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0737 0.1955
Echinococcus granulosus allatostatin A receptor 0.01 0.1004 0.0965
Loa Loa (eye worm) hypothetical protein 0.0035 0.0177 0.0196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0737 0.1955
Plasmodium vivax unspecified product 0.0025 0.0042 0.0451
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Schistosoma mansoni hypothetical protein 0.0351 0.4195 0.4195
Echinococcus granulosus rhodopsin orphan GPCR 0.01 0.1004 0.0965
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0042 0.0451
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0655 0.0615
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0424 0.5129 0.5129
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Schistosoma mansoni amine GPCR 0.01 0.1004 0.1004
Loa Loa (eye worm) hypothetical protein 0.0025 0.005 0.0055
Loa Loa (eye worm) hypothetical protein 0.02 0.2268 0.2507
Brugia malayi putative neuropeptide receptor 0.01 0.1004 0.1109
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.1004 0.0965
Brugia malayi cathepsin B-like cysteine proteinase 0.0424 0.5129 0.567
Entamoeba histolytica hypothetical protein 0.0073 0.0655 0.8813
Schistosoma mansoni biogenic amine (dopamine) receptor 0.01 0.1004 0.1004
Brugia malayi Cathepsin L-like precursor 0.0079 0.0737 0.0815
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.1004 0.0965
Echinococcus granulosus sex peptide receptor 0.01 0.1004 0.0965
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0025 0.0042 0.0451
Schistosoma mansoni growth hormone secretagogue receptor 0.01 0.1004 0.1004
Entamoeba histolytica cysteine protease, putative 0.0047 0.0324 0.4054
Loa Loa (eye worm) hypothetical protein 0.0732 0.9046 1
Leishmania major hypothetical protein, conserved 0.0035 0.0177 0.0362
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.1004 0.0965
Brugia malayi cathepsin F-like cysteine proteinase 0.0025 0.0042 0.0047
Echinococcus multilocularis 0.0056 0.0437 0.0397
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.1004 0.0965
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Schistosoma mansoni hypothetical protein 0.0063 0.0531 0.0531
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.1464 0.1618
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Onchocerca volvulus 0.0079 0.0737 0.2603
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0324 0.0615
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Brugia malayi Serotonin/octopamine receptor family protein 7 0.01 0.1004 0.1109
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0177 0.0463
Loa Loa (eye worm) pigment dispersing factor receptor c 0.02 0.2268 0.2507
Schistosoma mansoni biogenic amine receptor 0.01 0.1004 0.1004
Schistosoma mansoni tyrosine kinase 0.0058 0.046 0.046
Echinococcus multilocularis lamin dm0 0.0028 0.0087 0.0045
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.0737 1
Echinococcus granulosus rhodopsin orphan GPCR 0.01 0.1004 0.0965
Echinococcus multilocularis neuropeptide Y receptor 0.01 0.1004 0.0965
Onchocerca volvulus 0.0244 0.2832 1
Leishmania major cathepsin L-like protease 0.0079 0.0737 0.1955
Trypanosoma cruzi cruzipain precursor, putative 0.0079 0.0737 0.1422
Brugia malayi hypothetical protein 0.01 0.1004 0.1109
Trypanosoma cruzi major cysteine proteinase, putative 0.0025 0.0042 0.0064
Schistosoma mansoni cpg binding protein 0.006 0.049 0.049
Echinococcus multilocularis neuropeptides capa receptor 0.01 0.1004 0.0965
Echinococcus multilocularis geminin 0.0351 0.4195 0.417
Schistosoma mansoni biogenic amine (5HT) receptor 0.01 0.1004 0.1004
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0737 0.1422
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.001
Echinococcus granulosus neuropeptide Y receptor 0.01 0.1004 0.0965
Echinococcus granulosus neuropeptide s receptor 0.01 0.1004 0.0965
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Onchocerca volvulus 0.01 0.1004 0.3543
Leishmania major cathepsin L-like protease 0.0079 0.0737 0.1955
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0737 0.2492
Toxoplasma gondii hypothetical protein 0.0049 0.0347 0.1935
Plasmodium falciparum cysteine proteinase falcipain 3 0.0079 0.0737 1
Echinococcus granulosus lamin dm0 0.0028 0.0087 0.0045
Loa Loa (eye worm) hypothetical protein 0.0057 0.0455 0.0504
Echinococcus granulosus GPCR family 2 0.0063 0.0531 0.0491
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0025 0.0042 0.0042
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0132 0.0091
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0087 0.0096
Echinococcus multilocularis neuropeptide s receptor 0.01 0.1004 0.0965
Loa Loa (eye worm) melatonin receptor type 1A 0.01 0.1004 0.1109
Echinococcus granulosus thyrotropin releasing hormone receptor 0.01 0.1004 0.0965
Giardia lamblia Cathepsin B precursor 0.0148 0.1615 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.01 0.1004 0.1004
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0148 0.1615 0.4452
Loa Loa (eye worm) hypothetical protein 0.0063 0.0531 0.0587
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0087 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0737 0.1955
Echinococcus granulosus neuropeptide receptor 0.01 0.1004 0.0965
Schistosoma mansoni cathepsin F (C01 family) 0.0079 0.0737 0.0737
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0025 0.0042 0.0042
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.3566 1
Schistosoma mansoni tar DNA-binding protein 0.0125 0.132 0.132
Schistosoma mansoni amine GPCR 0.01 0.1004 0.1004
Echinococcus multilocularis dro:myosuppressin receptor 0.01 0.1004 0.0965
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.8232 0.8224
Onchocerca volvulus 0.003 0.0114 0.0402
Echinococcus multilocularis serotonin receptor 0.01 0.1004 0.0965
Schistosoma mansoni hypothetical protein 0.01 0.1004 0.1004
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0097 0.0959 0.0921
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0042 0.0149
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.01 0.1004 0.0965
Onchocerca volvulus 0.0079 0.0737 0.2603
Schistosoma mansoni hypothetical protein 0.0136 0.1464 0.1464
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0042 0.0042
Schistosoma mansoni lamin 0.0028 0.0087 0.0087
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0918 0.088
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Loa Loa (eye worm) neuropeptide F receptor 0.01 0.1004 0.1109
Echinococcus granulosus dro:myosuppressin receptor 0.01 0.1004 0.0965
Loa Loa (eye worm) G-protein coupled receptor 0.01 0.1004 0.1109
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.0959 0.0921
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0025 0.0042 0.0047
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0177 0.0463
Echinococcus granulosus microtubule associated protein 2 0.0668 0.8232 0.8224
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0737 0.1422
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0324 0.0358
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.0959 0.0921
Onchocerca volvulus 0.01 0.1004 0.3543
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0079 0.0737 0.0698
Brugia malayi Dopamine receptor protein 1 0.01 0.1004 0.1109
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.005 0.0557
Leishmania major cathepsin L-like protease 0.0079 0.0737 0.1955
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0531 0.0587
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0148 0.1615 0.5639
Echinococcus multilocularis neuropeptide FF receptor 2 0.01 0.1004 0.0965
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.01 0.1004 0.0965
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0079 0.0737 0.2492
Brugia malayi Matrixin family protein 0.0052 0.0386 0.0427
Brugia malayi TAR-binding protein 0.0125 0.132 0.1459
Schistosoma mansoni hypothetical protein 0.003 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0032 0.0132 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0737 0.2492
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.8232 0.8232
Onchocerca volvulus 0.01 0.1004 0.3543
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.1272 0.1272
Leishmania major cysteine peptidase A (CPA) 0.0079 0.0737 0.1955
Brugia malayi Hemopexin family protein 0.003 0.0114 0.0126
Brugia malayi fibroinase precursor 0.0025 0.0042 0.0047
Onchocerca volvulus 0.01 0.1004 0.3543
Loa Loa (eye worm) G-protein coupled receptor 0.01 0.1004 0.1109
Onchocerca volvulus 0.0028 0.0087 0.0306
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.3566 0.6948
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0737 0.1955
Mycobacterium ulcerans hypothetical protein 0.0035 0.0177 0.0697
Schistosoma mansoni intermediate filament proteins 0.0028 0.0087 0.0087
Mycobacterium tuberculosis Conserved protein 0.0035 0.0177 0.0463
Schistosoma mansoni tyrosine kinase 0.0097 0.0959 0.0959
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0737 0.2492
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0424 0.5129 0.5129
Echinococcus granulosus cathepsin L 0.0047 0.0324 0.0283
Schistosoma mansoni hypothetical protein 0.0063 0.0531 0.0531
Onchocerca volvulus 0.01 0.1004 0.3543
Loa Loa (eye worm) TYRA-2 protein 0.01 0.1004 0.1109
Echinococcus multilocularis neuropeptide receptor A26 0.01 0.1004 0.0965
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.1004 0.1004
Brugia malayi gonadotropin-releasing hormone receptor 2 0.01 0.1004 0.1109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0737 0.2492
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0079 0.0737 0.0698
Echinococcus granulosus rhodopsin orphan GPCR 0.01 0.1004 0.0965
Brugia malayi follicle stimulating hormone receptor 0.01 0.1004 0.1109
Entamoeba histolytica cysteine protease, putative 0.0047 0.0324 0.4054
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.01 0.1004 0.1109
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Leishmania major cathepsin L-like protease 0.0079 0.0737 0.1955
Schistosoma mansoni hypothetical protein 0.01 0.1004 0.1004
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0267 0.0504
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Brugia malayi Cathepsin L-like cysteine proteinase 0.0057 0.0455 0.0504
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0009 0.001
Onchocerca volvulus 0.0057 0.0455 0.1608
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0042 0.0451
Schistosoma mansoni neuropeptide receptor 0.01 0.1004 0.1004
Brugia malayi hypothetical protein 0.01 0.1004 0.1109
Echinococcus multilocularis orexin receptor type 2 0.01 0.1004 0.0965
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0918 0.088
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Loa Loa (eye worm) hypothetical protein 0.0035 0.0177 0.0196
Schistosoma mansoni tyrosine kinase 0.0058 0.046 0.046
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.2457 0.2716
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0324 0.4054
Brugia malayi hypothetical protein 0.01 0.1004 0.1109
Onchocerca volvulus 0.0032 0.0132 0.0468
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Schistosoma mansoni hypothetical protein 0.0807 1 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.0324 0.4054
Echinococcus multilocularis dnaJ subfamily B 0.0807 1 1
Schistosoma mansoni tyrosine kinase 0.0096 0.0946 0.0946
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0177 0.0463
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.01 0.1004 0.1109
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0042 0.0047
Onchocerca volvulus 0.01 0.1004 0.3543
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0177 0.0697
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0025 0.0042 0.0047
Echinococcus granulosus cathepsin l cysteine peptidase 0.0079 0.0737 0.0698
Plasmodium vivax serine-repeat antigen (SERA) 0.0025 0.0042 0.0451
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0042 0.0042
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0455 0.0871
Echinococcus multilocularis cysteine protease 0.0079 0.0737 0.0698
Brugia malayi GnHR receptor homolog 0.01 0.1004 0.1109
Echinococcus multilocularis allatostatin A receptor 0.01 0.1004 0.0965
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0918 0.088
Echinococcus granulosus g-protein coupled receptor 0.01 0.1004 0.0965
Echinococcus multilocularis neuropeptide receptor 0.01 0.1004 0.0965
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Brugia malayi beta-lactamase 0.0035 0.0177 0.0196
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0424 0.5129 1
Brugia malayi hypothetical protein 0.0025 0.005 0.0055
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0025 0.0042 0.0451
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0132 0.0091
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0042 0.0042
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0042 0.0042
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.01 0.1004 0.1004
Entamoeba histolytica cysteine protease, putative 0.0047 0.0324 0.4054
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.3566 0.6948
Schistosoma mansoni cathepsin F (C01 family) 0.0057 0.0455 0.0455
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0918 0.0918
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Loa Loa (eye worm) TK/INSR protein kinase 0.0058 0.046 0.0509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0737 0.1955
Schistosoma mansoni opsin-like receptor 0.01 0.1004 0.1004
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0177 0.0362
Onchocerca volvulus 0.0035 0.0177 0.0626
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0737 0.2492
Onchocerca volvulus 0.01 0.1004 0.3543
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0267 0.0504
Echinococcus multilocularis alpha 1A adrenergic receptor 0.01 0.1004 0.0965
Onchocerca volvulus 0.01 0.1004 0.3543
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0737 0.2492
Schistosoma mansoni myosin xvIII 0.01 0.1004 0.1004
Schistosoma mansoni tar DNA-binding protein 0.0125 0.132 0.132
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0324 0.0324
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.2268 0.2507
Echinococcus granulosus rhodopsin orphan GPCR 0.01 0.1004 0.0965
Brugia malayi hypothetical protein 0.01 0.1004 0.1109
Schistosoma mansoni tar DNA-binding protein 0.0125 0.132 0.132
Echinococcus granulosus tm gpcr rhodopsin 0.01 0.1004 0.0965
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0025 0.0042 0.0451
Echinococcus granulosus epidermal growth factor receptor 0.018 0.202 0.1987
Loa Loa (eye worm) hypothetical protein 0.0028 0.008 0.0089
Loa Loa (eye worm) TAR-binding protein 0.0125 0.132 0.1459
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.01 0.1004 0.0965
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.01 0.1004 0.0965
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.005 0.0112
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.01 0.1004 0.1109
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0177 0.0328
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.01 0.1004 0.1109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0737 0.2492
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.001
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.0737 1
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0047
Echinococcus multilocularis G protein coupled receptor 139 0.01 0.1004 0.0965
Brugia malayi Cathepsin L-like precursor 0.0022 0.0009 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.01 0.1004 0.1004
Brugia malayi Protein kinase domain containing protein 0.0058 0.046 0.0509
Echinococcus multilocularis cathepsin b 0.0424 0.5129 0.5108
Trichomonas vaginalis set domain proteins, putative 0.0244 0.2832 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0078 0.0718 0.0679
Echinococcus multilocularis G-protein coupled receptor, putative 0.01 0.1004 0.0965
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0324 0.4054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0132 0.0132
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0324 0.0324
Entamoeba histolytica cysteine protease, putative 0.0047 0.0324 0.4054
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0177 0.0463
Brugia malayi intermediate filament protein 0.0028 0.0087 0.0096
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2601 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0078 0.0718 0.0679
Echinococcus granulosus cathepsin L cysteine proteinase 0.0079 0.0737 0.0698
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0066
Schistosoma mansoni tyrosine kinase 0.0097 0.0959 0.0959
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0918 0.0918
Mycobacterium tuberculosis Conserved protein 0.0035 0.0177 0.0463
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.0324 0.0615
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0132 0.0574
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0737 0.2492
Echinococcus multilocularis cathepsin L cysteine protease 0.0079 0.0737 0.0698
Onchocerca volvulus 0.01 0.1004 0.3543
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1749 0.665
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.01 0.1004 0.3543
Brugia malayi cathepsin L-like cysteine proteinase 0.0025 0.0042 0.0047
Onchocerca volvulus 0.01 0.1004 0.3543
Onchocerca volvulus Cathepsin F homolog 0.0079 0.0737 0.2603
Echinococcus multilocularis insulin receptor 0.0058 0.046 0.042
Schistosoma mansoni opsin-like receptor 0.01 0.1004 0.1004
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.005 0.0112
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0177 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0737 0.1955
Echinococcus multilocularis g protein coupled receptor 0.01 0.1004 0.0965
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0042 0.0047
Brugia malayi putative neuropeptide receptor NPR1 0.01 0.1004 0.1109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0737 0.2492
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0531 0.0491
Schistosoma mansoni cathepsin C 0.0025 0.0042 0.0042
Onchocerca volvulus 0.01 0.1004 0.3543
Onchocerca volvulus 0.01 0.1004 0.3543
Schistosoma mansoni neuropeptide F-like receptor 0.01 0.1004 0.1004
Brugia malayi Cathepsin L-like precursor 0.0057 0.0455 0.0504
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0737 0.1422
Leishmania major cathepsin L-like protease 0.0079 0.0737 0.1955
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0324 0.4054
Echinococcus multilocularis fmrfamide receptor 0.01 0.1004 0.0965
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0737 0.2492
Echinococcus granulosus rhodopsin orphan GPCR 0.01 0.1004 0.0965
Brugia malayi hypothetical protein 0.01 0.1004 0.1109
Loa Loa (eye worm) follicle stimulating hormone receptor 0.01 0.1004 0.1109
Echinococcus multilocularis serotonin receptor 0.01 0.1004 0.0965
Echinococcus multilocularis sex peptide receptor 0.01 0.1004 0.0965
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0324 0.0779
Schistosoma mansoni biogenic amine receptor 0.01 0.1004 0.1004
Schistosoma mansoni hypothetical protein 0.01 0.1004 0.1004
Echinococcus multilocularis g protein coupled receptor 0.01 0.1004 0.0965
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0531 0.0491
Schistosoma mansoni hypothetical protein 0.0063 0.0531 0.0531
Echinococcus multilocularis cpg binding protein 0.006 0.049 0.045
Schistosoma mansoni neuropeptide f receptor 76f 0.01 0.1004 0.1004
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0079 0.0737 0.2492
Echinococcus granulosus tachykinin peptides receptor 99D 0.0393 0.4734 0.4712
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.01 0.1004 0.1004
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0655 0.0615
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0424 0.5129 0.5129
Echinococcus multilocularis g protein coupled receptor 0.01 0.1004 0.0965
Brugia malayi Dopamine receptor 0.01 0.1004 0.1109
Echinococcus granulosus neuropeptides capa receptor 0.01 0.1004 0.0965
Brugia malayi hypothetical protein 0.01 0.1004 0.1109
Schistosoma mansoni tyrosine kinase 0.018 0.202 0.202
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0177 0.0484
Echinococcus multilocularis musashi 0.0028 0.0087 0.0045
Schistosoma mansoni adenoreceptor 0.01 0.1004 0.1004
Brugia malayi Cathepsin L-like precursor 0.0079 0.0737 0.0815
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0267 0.0618
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0737 0.2492
Loa Loa (eye worm) hypothetical protein 0.0035 0.0177 0.0196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0918 0.0918
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0737 0.2492
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0025 0.0042 0.0451
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0177 0.0484
Echinococcus multilocularis tar DNA binding protein 0.0125 0.132 0.1283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0737 0.1955
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.1004 0.1004
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0324 0.0615
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0079 0.0737 0.0815
Echinococcus multilocularis lamin 0.0028 0.0087 0.0045
Echinococcus multilocularis neuropeptides capa receptor 0.01 0.1004 0.0965
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.1004 0.0965
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Onchocerca volvulus 0.01 0.1004 0.3543
Echinococcus granulosus intermediate filament protein 0.0028 0.0087 0.0045
Entamoeba histolytica cysteine protease, putative 0.0047 0.0324 0.4054
Onchocerca volvulus 0.0028 0.0087 0.0306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0737 0.2492
Entamoeba histolytica hypothetical protein 0.0073 0.0655 0.8813
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0042 0.0042
Brugia malayi Furin-like cysteine rich region family protein 0.018 0.202 0.2233
Echinococcus granulosus tm gpcr rhodopsin 0.01 0.1004 0.0965
Echinococcus granulosus geminin 0.0351 0.4195 0.417
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0177 0.0484
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.1004 0.1004
Schistosoma mansoni biogenic amine receptor 0.01 0.1004 0.1004
Loa Loa (eye worm) cysteine protease 0.0079 0.0737 0.0815
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.005 0.0049
Onchocerca volvulus 0.0079 0.0737 0.2603
Brugia malayi sulfakinin receptor protein 0.0732 0.9046 1
Plasmodium vivax vivapain-2 0.0079 0.0737 1
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Schistosoma mansoni neuropeptide receptor 0.01 0.1004 0.1004
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0047
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.01 0.1004 0.0965
Brugia malayi neuropeptide F receptor 0.01 0.1004 0.1109
Schistosoma mansoni amine GPCR 0.01 0.1004 0.1004
Brugia malayi Cathepsin L-like precursor 0.0057 0.0455 0.0504
Onchocerca volvulus Matrilysin homolog 0.0047 0.0332 0.1172
Entamoeba histolytica cysteine protease, putative 0.0047 0.0324 0.4054
Mycobacterium ulcerans hypothetical protein 0.0159 0.1749 1
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Loa Loa (eye worm) hypothetical protein 0.0057 0.0455 0.0504
Loa Loa (eye worm) hypothetical protein 0.0035 0.0177 0.0196
Loa Loa (eye worm) hypothetical protein 0.0035 0.0177 0.0196
Loa Loa (eye worm) fibroinase 0.0079 0.0737 0.0815
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0022 0.0009 0.001
Onchocerca volvulus 0.0057 0.0449 0.1584
Echinococcus granulosus 7TM GPCR rhodopsin 0.01 0.1004 0.0965
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.1004 0.1004
Schistosoma mansoni cpg binding protein 0.0057 0.0449 0.0449
Entamoeba histolytica hypothetical protein 0.0073 0.0655 0.8813
Schistosoma mansoni tyrosine kinase 0.0096 0.0946 0.0946
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0177 0.0196
Brugia malayi G protein-coupled receptor 0.01 0.1004 0.1109
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0177 0.0484
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0737 0.2492
Brugia malayi neuropeptide F receptor 0.01 0.1004 0.1109
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0177 0.0463
Brugia malayi Cathepsin L-like precursor 0.0079 0.0737 0.0815
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0079 0.0737 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0177 0.0859
Loa Loa (eye worm) hypothetical protein 0.0035 0.0177 0.0196
Echinococcus multilocularis g-protein coupled receptor 0.01 0.1004 0.0965
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0449 0.0496
Brugia malayi CXXC zinc finger family protein 0.0057 0.0449 0.0496
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0025 0.0042 0.0451
Entamoeba histolytica cysteine proteinase, putative 0.0057 0.0455 0.5946
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0058 0.046 0.042
Plasmodium vivax vivapain-2 0.0079 0.0737 1
Brugia malayi hypothetical protein 0.0073 0.0655 0.0724
Onchocerca volvulus 0.01 0.1004 0.3543
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0918 0.088
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0042 0.0047
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0531 0.0491
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0177 0.0177
Schistosoma mansoni neuropeptide F-like receptor 0.01 0.1004 0.1004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.0737 0.2492
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0177 0.0463
Mycobacterium tuberculosis Conserved protein 0.0035 0.0177 0.0463
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.01 0.1004 0.0965
Echinococcus granulosus hypothetical protein 0.01 0.1004 0.0965
Brugia malayi beta-lactamase family protein 0.0035 0.0177 0.0196
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0042 0.0047
Echinococcus granulosus neuropeptide Y receptor 0.01 0.1004 0.0965
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0132 0.0132
Schistosoma mansoni cathepsin S (C01 family) 0.0025 0.0042 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.1004 0.1004
Echinococcus granulosus cathepsin b 0.0424 0.5129 0.5108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0324 0.101
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.01 0.1004 0.1109
Echinococcus multilocularis somatostatin receptor 0.01 0.1004 0.0965
Brugia malayi cathepsin F-like cysteine proteinase 0.0022 0.0009 0.001
Mycobacterium ulcerans beta-lactamase 0.0035 0.0177 0.0697
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0025 0.0042 0.0451
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0079 0.0737 0.2492
Schistosoma mansoni amine GPCR 0.01 0.1004 0.1004
Onchocerca volvulus 0.01 0.1004 0.3543
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0177 0.2306
Echinococcus granulosus insulin receptor 0.0058 0.046 0.042
Onchocerca volvulus Matrix metalloproteinase homolog 0.0047 0.0332 0.1172

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10000 nM Evaluation of inhibitory activity against phospholipase C-gamma1 phosphorylation by Epidermal growth factor receptor enzyme isolated from A431 cells. ChEMBL. 7658435
IC50 (binding) > 10000 nM Evaluation of inhibitory activity against phospholipase C-gamma1 phosphorylation by Epidermal growth factor receptor enzyme isolated from A431 cells. ChEMBL. 7658435

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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