Detailed information for compound 2075831

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 263.207 | Formula: C12H20Cl2N2
  • H donors: 2 H acceptors: 0 LogP: 4 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1NC1CCNCC1.Cl.Cl
  • InChi: 1S/C12H18N2.2ClH/c1-10-4-2-3-5-12(10)14-11-6-8-13-9-7-11;;/h2-5,11,13-14H,6-9H2,1H3;2*1H
  • InChiKey: WLTMPXAIVSBZEQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0347 0.0631
Brugia malayi Cathepsin L-like precursor 0.0018 0.0074 0.0074
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0347 0.1976
Schistosoma mansoni lamin 0.0029 0.0401 0.0382
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.1083 0.1083
Echinococcus granulosus lamin dm0 0.0029 0.0401 0.0382
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0025 0.0279 0.0251
Echinococcus multilocularis Aminotransferase class III 0.0023 0.023 0.0199
Loa Loa (eye worm) DR-78 0.0025 0.0279 0.0279
Mycobacterium ulcerans putative regulatory protein 0.0076 0.1845 0.3864
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0286 0.158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1582 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0279 0.1157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.0018 0.0074 0.0074
Onchocerca volvulus 0.0029 0.0401 0.185
Echinococcus multilocularis snurportin 1 0.0327 0.9405 1
Loa Loa (eye worm) CYP4Cod1 0.003 0.0439 0.0439
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0043 0.0043
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0345 0.196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1582 1
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.1109 0.1139
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0074 0.0074
Brugia malayi hypothetical protein 0.0017 0.0059 0.0059
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0025 0.0279 0.0251
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0074 0.0032
Schistosoma mansoni hypothetical protein 0.0327 0.9405 1
Leishmania major protein kinase, putative 0.0027 0.0347 0.1976
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.1404 0.8847
Echinococcus granulosus importin subunit beta 1 0.0031 0.0461 0.0446
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0074 0.0032
Schistosoma mansoni intermediate filament proteins 0.0029 0.0401 0.0382
Loa Loa (eye worm) hypothetical protein 0.0052 0.1109 0.1109
Plasmodium falciparum ornithine aminotransferase 0.0023 0.023 0.446
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0461 0.0446
Onchocerca volvulus 0.0029 0.0401 0.185
Loa Loa (eye worm) hypothetical protein 0.0027 0.0368 0.0368
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0401 0.0401
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.1109 0.5846
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1582 1
Onchocerca volvulus 0.0076 0.1845 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.1144 0.7155
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0345 0.7217
Loa Loa (eye worm) hypothetical protein 0.0025 0.0279 0.0279
Echinococcus granulosus ornithine aminotransferase 0.0023 0.023 0.0199
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.1109 0.1139
Loa Loa (eye worm) nuclear hormone receptor 0.0025 0.0279 0.0279
Brugia malayi Importin beta-1 subunit 0.0031 0.0461 0.0461
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.1109 0.1139
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0217 0.416
Schistosoma mansoni nuclear receptor 0.0025 0.0279 0.0251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1582 1
Brugia malayi nuclear receptor RXR 0.0027 0.0368 0.0368
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0279 0.0251
Echinococcus granulosus single minded 2 0.0076 0.1845 0.1925
Loa Loa (eye worm) hypothetical protein 0.0025 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0028 0.0386 0.0386
Onchocerca volvulus 0.0025 0.0279 0.1157
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.1109 0.1109
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0217 0.113
Loa Loa (eye worm) hypothetical protein 0.0346 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.1109 0.1109
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0217 0.5
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0025 0.0279 0.0279
Brugia malayi hypothetical protein 0.0025 0.0279 0.0279
Brugia malayi nuclear hormone receptor family member nhr-6 0.0025 0.0279 0.0279
Leishmania major cytochrome p450-like protein 0.003 0.0439 0.2571
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0345 0.2094
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.1109 0.1139
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0461 0.2902
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.1109 0.1109
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0023 0.023 0.0427
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0439 0.0439
Brugia malayi Cathepsin L-like precursor 0.0018 0.0074 0.0074
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.1109 0.1139
Loa Loa (eye worm) hypothetical protein 0.0251 0.7117 0.7117
Echinococcus granulosus thyroid hormone receptor alpha 0.0025 0.0279 0.0251
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0279 0.0251
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.1109 0.1139
Loa Loa (eye worm) hypothetical protein 0.0027 0.0368 0.0368
Schistosoma mansoni thyroid hormone receptor 0.0052 0.1109 0.1139
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0347 0.0631
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0027 0.0347 0.0631
Mycobacterium leprae Possible regulatory protein 0.0027 0.0347 0.0282
Loa Loa (eye worm) hypothetical protein 0.0031 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0025 0.0279 0.0279
Leishmania major importin beta-1 subunit, putative 0.0025 0.0286 0.158
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0023 0.023 0.0427
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.1109 0.1109
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0025 0.0279 0.0251
Plasmodium vivax importin-beta 2, putative 0.0031 0.0461 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0401 0.0401
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.1109 0.1139
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1582 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0025 0.0279 0.0279
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0027 0.0347 0.0347
Leishmania major cathepsin L-like protease 0.0018 0.0074 0.0197
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0074 0.0032
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0345 0.196
Loa Loa (eye worm) nuclear receptor NHR-67 0.0025 0.0279 0.0279
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0074 0.0074
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.1109 0.5846
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0217 0.113
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.1109 0.1109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1582 1
Brugia malayi Cytochrome P450 family protein 0.003 0.0439 0.0439
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0401 0.0401
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0074 0.0032
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.0347 1
Plasmodium vivax vivapain-2 0.0018 0.0074 0.0726
Mycobacterium ulcerans hypothetical protein 0.0161 0.441 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.1483 0.9359
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.1109 0.1139
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.1109 0.1109
Schistosoma mansoni nuclear receptor 0.0025 0.0279 0.0251
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.1843 0.1923
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0043 0.0043
Brugia malayi nuclear receptor RXR 0.0025 0.0279 0.0279
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0461 0.2716
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1483 0.2999
Brugia malayi hypothetical protein 0.0027 0.0345 0.0345
Brugia malayi nuclear receptor NHR-88 0.0052 0.1109 0.1109
Leishmania major cathepsin L-like protease 0.0068 0.1582 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0217 0.0217
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.1109 0.1139
Onchocerca volvulus 0.0051 0.1083 0.5698
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.1109 0.1139
Echinococcus granulosus FTZ F1 alpha 0.0052 0.1109 0.1139
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.1109 0.1139
Echinococcus granulosus lamin 0.0029 0.0401 0.0382
Trichomonas vaginalis adenylate cyclase, putative 0.0027 0.0347 0.0631
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0286 0.0491
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.1109 0.1109
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0161 0.441 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0217 0.0186
Echinococcus multilocularis nuclear receptor nhr 48 0.0025 0.0279 0.0251
Loa Loa (eye worm) hypothetical protein 0.0025 0.0279 0.0279
Brugia malayi bHLH-PAS transcription factor 0.0076 0.1845 0.1845
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0217 0.1207
Brugia malayi hypothetical protein 0.0027 0.0368 0.0368
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0027 0.0347 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.1109 0.1109
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.1582 1
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0074 0.0197
Schistosoma mansoni ran 0.0023 0.0217 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1582 1
Schistosoma mansoni ran 0.0023 0.0217 0.0186
Leishmania major cathepsin L-like protease 0.0068 0.1582 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.1109 0.1109
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0286 0.0491
Brugia malayi nuclear hormone receptor family member odr-7 0.0025 0.0279 0.0279
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0027 0.0347 0.0631
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1483 0.2999
Brugia malayi hypothetical protein 0.0025 0.0279 0.0279
Echinococcus multilocularis transfer RNA-Lys 0.0076 0.1845 0.1925
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.023 0.0199
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0439 0.2571
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.0052 0.1109 0.1109
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0027 0.0347 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.0052 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.0027 0.0368 0.0368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1582 1
Brugia malayi nuclear receptor NHR-88 0.0025 0.0279 0.0279
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0279 0.0251
Loa Loa (eye worm) hypothetical protein 0.0025 0.0279 0.0279
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.1109 0.1139
Schistosoma mansoni hypothetical protein 0.0051 0.1083 0.1111
Brugia malayi conserved hypotetical protein 0.0025 0.0279 0.0279
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0217 0.416
Loa Loa (eye worm) hypothetical protein 0.0025 0.0279 0.0279
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.1109 0.1139
Brugia malayi hypothetical protein 0.0076 0.1843 0.1843
Echinococcus granulosus geminin 0.018 0.4968 0.5261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1582 1
Brugia malayi steroid hormone receptor 0.0052 0.1109 0.1109
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0217 0.0186
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0347 0.1976
Schistosoma mansoni aryl hydrocarbon receptor 0.0103 0.2656 0.2791
Trypanosoma brucei cytochrome P450, putative 0.003 0.0439 0.2571
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.1109 0.1109
Echinococcus granulosus snurportin 1 0.0327 0.9405 1
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.1843 0.1923
Brugia malayi Cathepsin L-like precursor 0.0018 0.0074 0.0074
Plasmodium falciparum importin beta, putative 0.0031 0.0461 1
Onchocerca volvulus 0.0027 0.0347 0.1545
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0279 0.0251
Onchocerca volvulus 0.0025 0.0279 0.1157
Brugia malayi hypothetical protein 0.0027 0.0368 0.0368
Leishmania major cathepsin L-like protease 0.0018 0.0074 0.0197
Schistosoma mansoni hypothetical protein 0.0076 0.1843 0.1923
Leishmania major cathepsin L-like protease 0.0018 0.0074 0.0197
Brugia malayi tailless protein 0.0025 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0099
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0074 0.0197
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0074 0.0074
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0023 0.023 0.1294
Brugia malayi nuclear hormone receptor 0.0025 0.0279 0.0279
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.023 0.0199
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0074 0.0032
Schistosoma mansoni survival motor neuron protein 0.0051 0.1083 0.1111
Leishmania major GTP-binding protein, putative 0.0023 0.0217 0.113
Brugia malayi hypothetical protein 0.0251 0.7117 0.7117
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0279 0.0251
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.1483 0.1538
Schistosoma mansoni nuclear hormone receptor 0.0052 0.1109 0.1139
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0439 0.0439
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0279 0.0251
Schistosoma mansoni thyroid hormone receptor 0.0052 0.1109 0.1139
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.1109 0.1109
Trichomonas vaginalis ran, putative 0.0023 0.0217 0.0331
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0368 0.0368
Schistosoma mansoni hypothetical protein 0.018 0.4968 0.5261
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.1109 0.5846
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.1109 0.1139
Entamoeba histolytica hypothetical protein 0.0025 0.0286 0.1202
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0461 0.2716
Echinococcus multilocularis lamin 0.0029 0.0401 0.0382
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0023 0.023 0.0427
Brugia malayi isocitrate dehydrogenase 0.0017 0.0043 0.0043
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0279 0.0279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.1109 0.1109
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.1109 0.1139
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0327 0.9405 0.9405
Loa Loa (eye worm) fibroinase 0.0018 0.0074 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.1109 0.1109
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0074 0.0726
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.1109 0.1139
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0074 0.0726
Brugia malayi nuclear hormone receptor 0.0052 0.1109 0.1109
Echinococcus granulosus cathepsin l1 0.0018 0.0074 0.0032
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0025 0.0279 0.0251
Loa Loa (eye worm) hypothetical protein 0.0025 0.0279 0.0279
Entamoeba histolytica hypothetical protein 0.0076 0.1843 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0279 0.0279
Entamoeba histolytica hypothetical protein 0.0076 0.1843 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1582 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0347 0.0631
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0025 0.0279 0.0251
Loa Loa (eye worm) hypothetical protein 0.0025 0.0279 0.0279
Leishmania major hypothetical protein, conserved 0.0027 0.0345 0.196
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0368 0.0346
Loa Loa (eye worm) hypothetical protein 0.0052 0.1109 0.1109
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0345 0.7217
Loa Loa (eye worm) hypoxia-induced factor 1 0.0319 0.9189 0.9189
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1483 0.2999
Toxoplasma gondii cathepsin CPL 0.0018 0.0074 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1582 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.0439 0.0501
Echinococcus multilocularis aryl hydrocarbon receptor 0.0027 0.0347 0.0325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1582 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.1109 0.1109
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0347 0.0631
Loa Loa (eye worm) hypothetical protein 0.0052 0.1109 0.1109
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0074 0.0032
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0347 0.0631
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.1109 0.1109
Echinococcus multilocularis musashi 0.0029 0.0401 0.0382
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0161 0.441 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0347 0.1976
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0217 0.113
Entamoeba histolytica hypothetical protein 0.0076 0.1843 1
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.7117 0.7557
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.1109 0.1139
Brugia malayi RNA, U transporter 1 0.0087 0.2165 0.2165
Loa Loa (eye worm) hypothetical protein 0.0025 0.0279 0.0279
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0439 0.2571
Loa Loa (eye worm) hypothetical protein 0.0027 0.0345 0.0345
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0368 0.0346
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.1109 0.1139
Schistosoma mansoni zinc finger protein 0.0025 0.0279 0.0251
Loa Loa (eye worm) cysteine protease 0.0018 0.0074 0.0074
Echinococcus multilocularis cysteine protease 0.0018 0.0074 0.0032
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0074 0.0032
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1483 0.1538
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1582 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0279 0.0279
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.7117 0.7557
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.1109 0.1139
Loa Loa (eye worm) hypothetical protein 0.0052 0.1109 0.1109
Brugia malayi ecdysteroid receptor 0.0052 0.1109 0.1109
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0286 0.0491
Echinococcus multilocularis geminin 0.018 0.4968 0.5261
Leishmania major cathepsin L-like protease 0.0068 0.1582 1
Brugia malayi hypoxia-induced factor 1 0.0319 0.9189 0.9189
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0368 0.0346
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0279 0.0251
Brugia malayi Cathepsin L-like precursor 0.0018 0.0074 0.0074
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.1109 0.1139
Loa Loa (eye worm) hypothetical protein 0.0052 0.1109 0.1109
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1582 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.1483 0.3298
Schistosoma mansoni lamin 0.0029 0.0401 0.0382
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0279 0.0279
Mycobacterium tuberculosis Probable aminotransferase 0.0161 0.441 1
Schistosoma mansoni single-minded 0.0103 0.2656 0.2791
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.1109 0.1109
Schistosoma mansoni nuclear receptor nhr-48 0.0025 0.0279 0.0251
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0347 0.0631
Brugia malayi Cathepsin L-like precursor 0.0018 0.0074 0.0074
Plasmodium vivax ornithine aminotransferase, putative 0.0023 0.023 0.446
Brugia malayi nuclear receptor NHR-67 0.0025 0.0279 0.0279
Loa Loa (eye worm) ctsf protein 0.0018 0.0074 0.0074
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0347 0.1976
Echinococcus granulosus aryl hydrocarbon receptor 0.0027 0.0347 0.0325
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.1843 0.1923
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0074 0.0726
Leishmania major protein kinase, putative 0.0027 0.0347 0.1976
Brugia malayi Cytochrome P450 family protein 0.003 0.0439 0.0439
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0027 0.0368 0.0368
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.1483 1
Echinococcus multilocularis lamin dm0 0.0029 0.0401 0.0382
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0074 0.0032
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0345 0.7217
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1483 0.1538
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0023 0.023 0.0427
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0368 0.0368
Brugia malayi intermediate filament protein 0.0029 0.0401 0.0401
Brugia malayi Cathepsin L-like precursor 0.0018 0.0074 0.0074
Brugia malayi PAS domain containing protein 0.0103 0.2656 0.2656
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.1109 0.1139
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.1109 0.1109
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0025 0.0279 0.0279
Entamoeba histolytica hypothetical protein 0.0076 0.1843 1
Brugia malayi orphan nuclear receptor NR2E1 0.0025 0.0279 0.0279
Entamoeba histolytica Ran family GTPase 0.0023 0.0217 0.0811
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0347 0.0631
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0161 0.441 1
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0368 0.0368
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.1109 0.1139
Leishmania major cathepsin L-like protease 0.0018 0.0074 0.0197
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.1483 0.1538
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0345 0.196
Leishmania major cathepsin L-like protease 0.0018 0.0074 0.0197
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0161 0.441 1
Echinococcus granulosus Aminotransferase class III 0.0023 0.023 0.0199
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0279 0.1157
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.1109 0.1109
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.1109 0.1139
Brugia malayi ecdysone receptor 0.0025 0.0279 0.0279
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0023 0.023 0.5
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0347 0.1976
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0347 0.1976
Echinococcus granulosus nuclear receptor nhr 48 0.0025 0.0279 0.0251
Loa Loa (eye worm) hypothetical protein 0.0027 0.0368 0.0368
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.023 0.0199
Schistosoma mansoni coup transcription factor 0.0052 0.1109 0.1139
Echinococcus multilocularis cysteine protease 0.0018 0.0074 0.0032
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0023 0.023 0.023
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0347 0.1976
Onchocerca volvulus 0.0052 0.1109 0.5846
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.1109 0.1139
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.1109 0.1109
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.1109 0.1109
Schistosoma mansoni importin beta-1 0.0031 0.0461 0.0446
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.1109 0.1139
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0279 0.0251
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.0347 0.0347
Echinococcus granulosus intermediate filament protein 0.0029 0.0401 0.0382
Plasmodium vivax vivapain-2 0.0018 0.0074 0.0726
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0368 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0347 0.0631
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.1109 0.1139
Schistosoma mansoni hypothetical protein 0.018 0.4968 0.5261

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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