Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0049 | 0.063 | 0.0886 |
Onchocerca volvulus | 0.0217 | 0.5225 | 1 | |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.3948 | 0.3948 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.7105 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0805 | 0.1134 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.4082 | 0.5745 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0049 | 0.063 | 0.0882 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0049 | 0.063 | 0.0886 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0049 | 0.063 | 0.0886 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.4082 | 0.5745 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0805 | 0.1542 |
Brugia malayi | ecdysteroid receptor | 0.0049 | 0.063 | 0.0886 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0029 | 0.0089 | 0.017 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.0585 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0049 | 0.063 | 0.1206 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0185 | 0.0261 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0185 | 0.0261 |
Schistosoma mansoni | thyroid hormone receptor | 0.0201 | 0.4788 | 0.9164 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0049 | 0.063 | 0.0886 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0217 | 0.5225 | 0.7353 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.3453 | 0.6609 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0049 | 0.063 | 0.0882 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0185 | 0.0261 |
Brugia malayi | nuclear receptor NHR-88 | 0.0049 | 0.063 | 0.0886 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0089 | 0.0125 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0805 | 0.1134 |
Brugia malayi | nuclear hormone receptor | 0.0049 | 0.063 | 0.0886 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0049 | 0.063 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0089 | 0.0125 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.063 | 0.0886 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0049 | 0.063 | 0.0886 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0049 | 0.063 | 0.063 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.0585 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.063 | 0.0886 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0049 | 0.063 | 0.0886 |
Echinococcus granulosus | lamin | 0.0033 | 0.0185 | 0.0185 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0888 | 0.1249 |
Echinococcus granulosus | slit 2 protein | 0.0029 | 0.0089 | 0.0089 |
Brugia malayi | PAS domain containing protein | 0.0059 | 0.0901 | 0.1269 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.063 | 0.0886 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0049 | 0.063 | 0.063 |
Brugia malayi | hypoxia-induced factor 1 | 0.0182 | 0.4268 | 0.6006 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0049 | 0.063 | 0.0886 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0194 | 0.4613 | 0.4613 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0049 | 0.063 | 0.0886 |
Brugia malayi | hypothetical protein | 0.0286 | 0.7105 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0888 | 0.1699 |
Schistosoma mansoni | lamin | 0.0033 | 0.0185 | 0.0355 |
Brugia malayi | hypothetical protein | 0.0153 | 0.3471 | 0.4886 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0049 | 0.063 | 0.0886 |
Brugia malayi | bHLH-PAS transcription factor | 0.0043 | 0.0484 | 0.0681 |
Schistosoma mansoni | single-minded | 0.0059 | 0.0901 | 0.1725 |
Onchocerca volvulus | 0.0217 | 0.5225 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5225 | 0.7353 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0089 | 0.0125 |
Brugia malayi | ShTK domain containing protein | 0.0217 | 0.5225 | 0.7353 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.063 | 0.0886 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0049 | 0.063 | 0.0886 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0049 | 0.063 | 0.1206 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.3617 | 0.6923 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0805 | 0.1134 |
Onchocerca volvulus | 0.0043 | 0.0484 | 0.0592 | |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0049 | 0.063 | 0.063 |
Brugia malayi | laminin alpha chain | 0.0029 | 0.0089 | 0.0125 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0049 | 0.063 | 0.0882 |
Schistosoma mansoni | tyrosinase precursor | 0.0217 | 0.5225 | 1 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0185 | 0.0261 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.3453 | 0.3453 |
Schistosoma mansoni | jun-related protein | 0.0158 | 0.3617 | 0.6923 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0049 | 0.063 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0169 | 0.0238 |
Echinococcus multilocularis | geminin | 0.0205 | 0.4891 | 0.6884 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4891 | 0.9362 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.0702 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.4468 | 0.6288 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0805 | 0.1542 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.0702 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0217 | 0.5225 | 0.7353 |
Echinococcus granulosus | pikachurin | 0.0029 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.063 | 0.0886 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0217 | 0.5225 | 0.7353 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0049 | 0.063 | 0.0886 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0049 | 0.063 | 0.0886 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0185 | 0.0261 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0217 | 0.5225 | 0.7353 |
Brugia malayi | steroid hormone receptor | 0.0049 | 0.063 | 0.0886 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0049 | 0.063 | 0.0886 |
Echinococcus granulosus | jun protein | 0.0194 | 0.4613 | 0.4613 |
Loa Loa (eye worm) | abnormal epIthelia family member | 0.0029 | 0.0089 | 0.0125 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.0702 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0049 | 0.063 | 0.0886 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.0042 | 0.0059 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4891 | 0.9362 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0049 | 0.063 | 0.0886 |
Schistosoma mansoni | cell polarity protein | 0.0029 | 0.0089 | 0.017 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0049 | 0.063 | 0.063 |
Echinococcus granulosus | FTZ F1 alpha | 0.0049 | 0.063 | 0.063 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0049 | 0.063 | 0.1206 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0805 | 0.0805 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.0702 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0805 | 0.1542 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0049 | 0.063 | 0.0886 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0029 | 0.0089 | 0.0125 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0049 | 0.063 | 0.0886 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0043 | 0.0484 | 0.0681 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.4685 | 0.6594 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0049 | 0.063 | 0.1206 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0185 | 0.0185 |
Schistosoma mansoni | slit | 0.0029 | 0.0089 | 0.017 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0182 | 0.4268 | 0.6006 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0049 | 0.063 | 0.0886 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.063 | 0.0886 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0217 | 0.5225 | 0.7353 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0049 | 0.063 | 0.1206 |
Schistosoma mansoni | coup transcription factor | 0.0049 | 0.063 | 0.1206 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.7105 | 0.7105 |
Echinococcus multilocularis | jun protein | 0.0194 | 0.4613 | 0.6493 |
Onchocerca volvulus | 0.0217 | 0.5225 | 1 | |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0049 | 0.063 | 0.063 |
Schistosoma mansoni | nuclear hormone receptor | 0.0049 | 0.063 | 0.1206 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0049 | 0.063 | 0.0886 |
Onchocerca volvulus | 0.0153 | 0.3471 | 0.6521 | |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.0042 | 0.0059 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0049 | 0.063 | 0.0886 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0049 | 0.063 | 0.1206 |
Schistosoma mansoni | tyrosinase precursor | 0.0217 | 0.5225 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0043 | 0.0484 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.3453 | 0.486 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0059 | 0.0901 | 0.1725 |
Brugia malayi | follicle stimulating hormone receptor | 0.0283 | 0.7023 | 0.9885 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0049 | 0.063 | 0.0886 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.0702 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0049 | 0.063 | 0.0886 |
Echinococcus granulosus | geminin | 0.0205 | 0.4891 | 0.4891 |
Onchocerca volvulus | 0.0217 | 0.5225 | 1 | |
Schistosoma mansoni | lamin | 0.0033 | 0.0185 | 0.0355 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0201 | 0.4788 | 0.6739 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5225 | 0.7353 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0185 | 0.0261 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0049 | 0.063 | 0.0886 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0049 | 0.063 | 0.0886 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0185 | 0.0355 |
Echinococcus granulosus | single minded 2 | 0.0043 | 0.0484 | 0.0484 |
Brugia malayi | hypothetical protein | 0.0197 | 0.4685 | 0.6594 |
Onchocerca volvulus | 0.0049 | 0.063 | 0.0882 | |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0049 | 0.063 | 0.0886 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0049 | 0.063 | 0.0886 |
Brugia malayi | laminin-like protein K08C7.3 precursor | 0.0029 | 0.0089 | 0.0125 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0049 | 0.063 | 0.0886 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0805 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.063 | 0.0886 |
Onchocerca volvulus | 0.0058 | 0.0888 | 0.1394 | |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0049 | 0.063 | 0.1206 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0049 | 0.063 | 0.0886 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0049 | 0.063 | 0.063 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.0585 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0049 | 0.063 | 0.1206 |
Schistosoma mansoni | thyroid hormone receptor | 0.0201 | 0.4788 | 0.9164 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.063 | 0.0886 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0217 | 0.5225 | 0.7353 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0283 | 0.7023 | 0.9885 |
Brugia malayi | bZIP transcription factor family protein | 0.0194 | 0.4613 | 0.6493 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.4082 | 0.7813 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0185 | 0.0261 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0217 | 0.5225 | 0.7353 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0194 | 0.4613 | 0.6493 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0049 | 0.063 | 0.1206 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0049 | 0.063 | 0.0886 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0049 | 0.063 | 0.0886 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0049 | 0.063 | 0.0886 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0888 | 0.1699 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.0702 | 0.0702 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0049 | 0.063 | 0.0886 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.7105 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0029 | 0.0089 | 0.0089 |
Echinococcus multilocularis | slit 2 protein | 0.0029 | 0.0089 | 0.0125 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0805 | 0.0805 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0185 | 0.0185 |
Brugia malayi | Thrombospondin N-terminal -like domain containing protein | 0.0029 | 0.0089 | 0.0125 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.4082 | 0.5745 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0217 | 0.5225 | 0.7353 |
Brugia malayi | EGF-like domain containing protein | 0.0029 | 0.0089 | 0.0125 |
Echinococcus multilocularis | pikachurin | 0.0029 | 0.0089 | 0.0125 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0185 | 0.0261 |
Schistosoma mansoni | chondroitin sulfate proteoglycan-related | 0.0029 | 0.0089 | 0.017 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.