Detailed information for compound 2076270

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 573.489 | Formula: C21H29F6N7O5
  • H donors: 3 H acceptors: 7 LogP: -3.13 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.Cn1ncc(c1)CN1CCCC2(C1)COCCN(C2)Cc1c[nH]nn1
  • InChi: 1S/C17H27N7O.2C2HF3O2/c1-22-9-15(7-19-22)10-23-4-2-3-17(12-23)13-24(5-6-25-14-17)11-16-8-18-21-20-16;2*3-2(4,5)1(6)7/h7-9H,2-6,10-14H2,1H3,(H,18,20,21);2*(H,6,7)
  • InChiKey: UNFZCGCXWSTNRQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0078 0.0804 0.0804
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0804 0.077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0019 0.0019
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0294 0.3382 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0019 0.0019
Plasmodium falciparum glutathione reductase 0.0294 0.3382 0.3382
Echinococcus multilocularis protein cereblon 0.0361 0.4186 0.4186
Brugia malayi Animal haem peroxidase family protein 0.0095 0.1011 0.1011
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0216 0.2451 0.2451
Loa Loa (eye worm) animal heme peroxidase 0.0095 0.1011 0.1011
Loa Loa (eye worm) animal heme peroxidase 0.0095 0.1011 0.1011
Echinococcus granulosus protein cereblon 0.0361 0.4186 0.4186
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0181 0.0181
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0078 0.0804 0.0804
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0078 0.0804 0.077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0294 0.3382 0.3357
Toxoplasma gondii NADPH-glutathione reductase 0.0294 0.3382 0.3382
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0294 0.3382 0.3382
Brugia malayi Peroxidasin 0.0095 0.1011 0.1011
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0078 0.0804 0.0804
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0019 0.0019
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0078 0.0804 0.1849
Loa Loa (eye worm) thioredoxin reductase 0.0848 1 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0078 0.0804 0.0804
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0019 0.0019
Loa Loa (eye worm) glutathione reductase 0.0848 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0019 0.0019
Leishmania major trypanothione reductase 0.0848 1 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0078 0.0804 0.0804
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0079 0.0079
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0216 0.2451 0.2451
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0019 0.0019
Brugia malayi ecdysteroid receptor 0.0012 0.0019 0.0019
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0078 0.0804 0.2293
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0019 0.0019
Echinococcus multilocularis glutamate synthase 0.0078 0.0804 0.0804
Schistosoma mansoni peroxidasin 0.0095 0.1011 0.1011
Echinococcus granulosus bloom syndrome protein 0.0026 0.0181 0.0181
Brugia malayi glutamate synthase 0.0078 0.0804 0.0804
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0294 0.3382 0.3357
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0019 0.0019
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0294 0.3382 0.3382
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0078 0.0804 0.0804
Brugia malayi nuclear hormone receptor 0.0012 0.0019 0.0019
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0078 0.0804 0.0804
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0294 0.3382 0.2803
Mycobacterium tuberculosis Probable oxidoreductase 0.0294 0.3382 0.2803
Echinococcus multilocularis geminin 0.0205 0.2317 0.2317
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0019 0.0019
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0294 0.3382 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0294 0.3382 0.3357
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0294 0.3382 0.3382
Trichomonas vaginalis glutamate synthase, putative 0.0078 0.0804 0.2293
Trichomonas vaginalis glutamate synthase, putative 0.0078 0.0804 0.2293
Brugia malayi hypothetical protein 0.0147 0.1629 0.1629
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0019 0.0019
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0181 0.0429
Brugia malayi hypothetical protein 0.0361 0.4186 0.4186
Plasmodium falciparum ferrodoxin reductase-like protein 0.0078 0.0804 0.0804
Onchocerca volvulus 0.0095 0.1011 0.238
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0019 0.0019
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0078 0.0804 0.1849
Echinococcus multilocularis peroxidasin 0.0095 0.1011 0.1011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0019 0.0019
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0078 0.0804 0.0804
Schistosoma mansoni sulfide quinone reductase 0.0078 0.0804 0.0804
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0019 0.0019
Trypanosoma cruzi NADH dehydrogenase, putative 0.0078 0.0804 0.077
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0095 0.1011 0.1011
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0078 0.0804 0.0804
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0078 0.0804 0.077
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0804 0.077
Trypanosoma brucei NADH dehydrogenase 0.0078 0.0804 0.077
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0019 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Giardia lamblia Thioredoxin reductase 0.0078 0.0804 0.2378
Schistosoma mansoni glutamate synthase 0.0078 0.0804 0.0804
Loa Loa (eye worm) animal heme peroxidase 0.0095 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0095 0.1011 0.1011
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0294 0.3382 0.3382
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0019 0.0019
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0078 0.0804 0.0804
Onchocerca volvulus 0.0095 0.1011 0.238
Trypanosoma cruzi NADH dehydrogenase, putative 0.0078 0.0804 0.077
Loa Loa (eye worm) blistered cuticle protein 3 0.0095 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0294 0.3382 0.3357
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.1689 0.1689
Schistosoma mansoni thyroid hormone receptor 0.0164 0.1835 0.1835
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0019 0.0019
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0294 0.3382 0.3357
Brugia malayi Thioredoxin reductase 0.0848 1 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0294 0.3382 1
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0078 0.0804 0.0804
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0095 0.1011 0.1011
Entamoeba histolytica disulphide oxidoreductase, putative 0.0078 0.0804 0.1849
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0294 0.3382 0.3357
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0294 0.3382 0.3328
Onchocerca volvulus Peroxidase homolog 0.0095 0.1011 0.238
Schistosoma mansoni thyroid hormone receptor 0.0164 0.1835 0.1835
Brugia malayi Animal haem peroxidase family protein 0.0095 0.1011 0.1011
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0019 0.0019
Brugia malayi Animal haem peroxidase family protein 0.0095 0.1011 0.1011
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0078 0.0804 0.0804
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0078 0.0804 0.1849
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0078 0.0804 0.077
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0804 0.077
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0078 0.0804 0.0804
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0078 0.0804 0.0804
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0294 0.3382 0.3357
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0078 0.0804 0.0804
Giardia lamblia NADH oxidase lateral transfer candidate 0.0294 0.3382 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0078 0.0804 0.2293
Onchocerca volvulus Peroxidase homolog 0.0095 0.1011 0.238
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0294 0.3382 0.3357
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0181 0.0429
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0019 0.0019
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0078 0.0804 0.2293
Plasmodium falciparum glutathione reductase 0.0848 1 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0294 0.3382 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0019 0.0019
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0078 0.0804 0.0804
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0078 0.0804 0.0804
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0078 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0095 0.1011 0.1011
Echinococcus granulosus thioredoxin glutathione reductase 0.0848 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Brugia malayi Animal haem peroxidase family protein 0.0095 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0078 0.0804 0.077
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0294 0.3382 0.3382
Plasmodium vivax glutathione reductase, putative 0.0848 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0095 0.1011 0.1011
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Trypanosoma cruzi trypanothione reductase, putative 0.0294 0.3382 0.3357
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.0804 0.2293
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0078 0.0804 0.2293
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0019 0.0019
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0078 0.0804 0.2378
Schistosoma mansoni coup transcription factor 0.0012 0.0019 0.0019
Schistosoma mansoni disulfide oxidoreductase 0.0078 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0095 0.1011 0.1011
Brugia malayi steroid hormone receptor 0.0012 0.0019 0.0019
Brugia malayi Animal haem peroxidase family protein 0.0095 0.1011 0.1011
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0019 0.0019
Onchocerca volvulus Dual oxidase homolog 0.0095 0.1011 0.238
Echinococcus granulosus glutamate synthase 0.0078 0.0804 0.0804
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0019 0.0019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0294 0.3382 0.3357
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0019 0.0019
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0078 0.0804 0.2293
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0078 0.0804 0.2293
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Schistosoma mansoni glutamate synthase 0.0078 0.0804 0.0804
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0294 0.3382 0.3357
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0078 0.0804 0.077
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0019 0.0019
Toxoplasma gondii thioredoxin reductase 0.0848 1 1
Schistosoma mansoni hypothetical protein 0.0152 0.1689 0.1689
Leishmania major hypothetical protein, conserved 0.0078 0.0804 0.077
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0078 0.0804 0.0729
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0078 0.0804 0.1849
Onchocerca volvulus 0.0078 0.0804 0.1885
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0294 0.3382 0.2803
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0116 0.0116
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0078 0.0804 0.077
Entamoeba histolytica thioredoxin reductase, putative 0.0078 0.0804 0.1849
Leishmania major hypothetical protein, conserved 0.0078 0.0804 0.077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0294 0.3382 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0118 0.0118
Leishmania major NADH dehydrogenase, putative 0.0078 0.0804 0.077
Onchocerca volvulus 0.0095 0.1011 0.238
Loa Loa (eye worm) hypothetical protein 0.0361 0.4186 0.4186
Trichomonas vaginalis mercuric reductase, putative 0.0294 0.3382 1
Trichomonas vaginalis apoptosis inducing factor, putative 0.0078 0.0804 0.2293
Schistosoma mansoni glutamate synthase 0.0078 0.0804 0.0804
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0078 0.0804 0.0804
Brugia malayi Blistered cuticle protein 3 0.0095 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0095 0.1011 0.1011
Onchocerca volvulus Protein cereblon homolog 0.0361 0.4186 1
Trypanosoma brucei trypanothione reductase 0.0848 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0095 0.1011 0.1011
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.1689 0.1689
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0078 0.0804 0.0804
Echinococcus granulosus geminin 0.0205 0.2317 0.2317
Loa Loa (eye worm) programmed cell death 8 0.0078 0.0804 0.0804
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0294 0.3382 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0205 0.2317 0.2317
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0143 0.0143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0019 0.0019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0095 0.1011 0.1011
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0078 0.0804 0.2293
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0078 0.0804 0.0729
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0294 0.3382 0.3382
Schistosoma mansoni hypothetical protein 0.0361 0.4186 0.4186
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0019 0.0019
Leishmania major hypothetical protein, conserved 0.0078 0.0804 0.077
Loa Loa (eye worm) RecQ helicase 0.0026 0.0181 0.0181
Toxoplasma gondii selenide, water dikinase 0.0078 0.0804 0.0804
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0019 0.0019
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0078 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0095 0.1011 0.1011
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0078 0.0804 0.077
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0019 0.0019
Onchocerca volvulus Chorion peroxidase homolog 0.0095 0.1011 0.238
Giardia lamblia Glutamate synthase 0.0078 0.0804 0.2378
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0078 0.0804 0.0804
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0078 0.0804 0.077
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0294 0.3382 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0019 0.0019
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0078 0.0804 0.077
Plasmodium falciparum thioredoxin reductase 0.0294 0.3382 0.3382
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0294 0.3382 0.3357
Loa Loa (eye worm) hypothetical protein 0.0095 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0095 0.1011 0.1011
Entamoeba histolytica hypothetical protein, conserved 0.0361 0.4186 1
Brugia malayi hypothetical protein 0.0095 0.1011 0.1011
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0294 0.3382 0.3357
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0383 0.4449 0.4449
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0078 0.0804 0.2293
Onchocerca volvulus Peroxidasin homolog 0.0095 0.1011 0.238
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0019 0.0019
Plasmodium vivax thioredoxin reductase, putative 0.0848 1 1
Plasmodium vivax ferrodoxin reductase, putative 0.0078 0.0804 0.0729
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0019 0.0019
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0078 0.0804 0.077
Plasmodium falciparum thioredoxin reductase 0.0848 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0205 0.2317 0.2317
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Treponema pallidum NADH oxidase 0.0294 0.3382 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0848 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.1835 0.1835
Schistosoma mansoni sulfide quinone reductase 0.0078 0.0804 0.0804
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0078 0.0804 0.077
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0078 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0095 0.1011 0.1011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0294 0.3382 0.3357
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0078 0.0804 0.1849
Echinococcus granulosus peroxidasin 0.0095 0.1011 0.1011
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0078 0.0804 0.2293
Loa Loa (eye worm) hypothetical protein 0.0095 0.1011 0.1011
Loa Loa (eye worm) hypothetical protein 0.0095 0.1011 0.1011
Trichomonas vaginalis glutathione reductase, putative 0.0294 0.3382 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0848 1 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0294 0.3382 0.3357
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0019 0.0019
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0294 0.3382 0.3357
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0019 0.0019
Brugia malayi nuclear receptor NHR-88 0.0012 0.0019 0.0019
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0294 0.3382 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0019
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0294 0.3382 0.3328
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.000000000057866 0.000000000057866
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0019 0.0019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0294 0.3382 0.3357
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0019 0.0019
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0294 0.3382 0.3382
Trypanosoma cruzi trypanothione reductase, putative 0.0848 1 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0078 0.0804 0.0804
Onchocerca volvulus Peroxidasin homolog 0.0095 0.1011 0.238
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0019 0.0019
Schistosoma mansoni peroxidasin 0.0095 0.1011 0.1011
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0078 0.0804 0.0804

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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