TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 372.385 | Formula: C17H23F3N4O2
H donors: 1 H acceptors: 4 LogP: 1.25 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(F)(F)F.CCCN1CCC(CC1)c1nn2c(n1)ccc(c2)C
InChi: 1S/C15H22N4.C2HF3O2/c1-3-8-18-9-6-13(7-10-18)15-16-14-5-4-12(2)11-19(14)17-15;3-2(4,5)1(6)7/h4-5,11,13H,3,6-10H2,1-2H3;(H,6,7)
InChiKey: LVAVCCNSZIMEIJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Cathepsin B precursor	0.0571	0.351	1
Onchocerca volvulus	Cathepsin F homolog	0.0581	0.3582	1
Schistosoma mansoni	cathepsin D (A01 family)	0.0179	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0478	0.0478
Giardia lamblia	Cathepsin B precursor	0.0571	0.351	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0114	0.0412	0.0237
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0323	0.1832	0.1832
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0581	0.3582	0.3582
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0142	0.0603	0.1568
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0142	0.0603	0.1568
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0142	0.0603	0.0603
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0581	0.3582	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0142	0.0603	0.1568
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0142	0.0603	0.1568
Onchocerca volvulus		0.0188	0.0915	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0222	0.1148	0.1148
Echinococcus granulosus	cathepsin L	0.0142	0.0603	0.0603
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0603	0.1246
Echinococcus granulosus	calpain A	0.0114	0.0412	0.0412
Trypanosoma cruzi	cysteine peptidase, putative	0.0178	0.0846	0.0679
Schistosoma mansoni	cathepsin C	0.0142	0.0603	0.0603
Echinococcus granulosus	calpain 5	0.0114	0.0412	0.0412
Plasmodium vivax	serine-repeat antigen (SERA)	0.0142	0.0603	0.1568
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.3582	1
Echinococcus granulosus	cathepsin b	0.1528	1	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0061	0.0049	0.0049
Brugia malayi	calpain 7	0.0114	0.0412	0.0412
Entamoeba histolytica	cysteine proteinase, putative	0.032	0.1811	0.4795
Trypanosoma brucei	calpain-like protein, putative	0.0114	0.0412	0.0241
Schistosoma mansoni	calpain-7 (C02 family)	0.0114	0.0412	0.0412
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0581	0.3582	0.3582
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0581	0.3582	0.3582
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1502	0.9822	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0603	0.0603
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1502	0.9822	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0142	0.0603	0.0603
Brugia malayi	Cathepsin L-like precursor	0.0403	0.2374	0.2374
Brugia malayi	Cathepsin L-like precursor	0.0581	0.3582	0.3582
Loa Loa (eye worm)	cathepsin B	0.0571	0.351	0.351
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.3582	1
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0063	0.0065	0.0065
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1502	0.9822	1
Echinococcus multilocularis	hypothetical protein	0.0114	0.0412	0.0412
Plasmodium falciparum	serine repeat antigen 8	0.0142	0.0603	0.1568
Echinococcus granulosus	cysteine protease	0.032	0.1811	0.1811
Schistosoma mansoni	cathepsin B (C01 family)	0.0142	0.0603	0.0603
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0142	0.0603	0.1568
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0323	0.1832	0.1832
Entamoeba histolytica	cysteine protease, putative	0.032	0.1811	0.4795
Echinococcus multilocularis	cysteine protease	0.0581	0.3582	0.3582
Schistosoma mansoni	calpain (C02 family)	0.0114	0.0412	0.0412
Plasmodium vivax	vivapain-2	0.0581	0.3582	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0846	0.0846
Toxoplasma gondii	cathepsin CPC1	0.0142	0.0603	0.1568
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.032	0.1811	0.1811
Entamoeba histolytica	cysteine protease, putative	0.032	0.1811	0.4795
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0412	0.0241
Entamoeba histolytica	cysteine protease, putative	0.032	0.1811	0.4795
Echinococcus granulosus	growth factor receptor bound protein 2	0.0536	0.3272	0.3272
Loa Loa (eye worm)	calpain family protein 1	0.0302	0.1689	0.1689
Loa Loa (eye worm)	hypothetical protein	0.0188	0.0915	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0268	0.1456	0.1456
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.0603	0.0603
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.032	0.1811	0.1661
Echinococcus multilocularis	calpain	0.0114	0.0412	0.0412
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0323	0.1832	0.1832
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0061	0.0049	0.0049
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1502	0.9822	1
Leishmania major	cathepsin L-like protease	0.0581	0.3582	0.3528
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0571	0.351	0.3453
Echinococcus granulosus	cathepsin l1	0.0403	0.2374	0.2374
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0142	0.0603	0.1568
Onchocerca volvulus		0.0581	0.3582	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.0603	0.0603
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0114	0.0412	0.0237
Entamoeba histolytica	cysteine proteinase, putative	0.0581	0.3582	1
Loa Loa (eye worm)	hypothetical protein	0.0302	0.1689	0.1689
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.3582	1
Brugia malayi	calpain family protein 1	0.0302	0.1689	0.1689
Echinococcus granulosus	cathepsin l1	0.0581	0.3582	0.3582
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.032	0.1811	0.1692
Brugia malayi	Sex muscle abnormal protein 5	0.0536	0.3272	0.3272
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0412	0.0241
Echinococcus granulosus	calpain	0.0114	0.0412	0.0412
Giardia lamblia	Cathepsin B precursor	0.0571	0.351	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0142	0.0603	0.1568
Leishmania major	cathepsin L-like protease	0.0581	0.3582	0.3528
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0603	0.1246
Entamoeba histolytica	cysteine protease, putative	0.032	0.1811	0.4795
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.032	0.1811	0.4987
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0142	0.0603	0.1246
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0581	0.3582	1
Echinococcus granulosus	calpain 7 C02 family	0.0114	0.0412	0.0412
Entamoeba histolytica	cysteine protease, putative	0.032	0.1811	0.4795
Leishmania major	cathepsin L-like protease	0.1502	0.9822	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0142	0.0603	0.1568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0403	0.2374	0.6582
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0603	0.0603
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.0233	0.1218	0.1218
Entamoeba histolytica	cysteine proteinase, putative	0.032	0.1811	0.4795
Brugia malayi	Papain family cysteine protease containing protein	0.0142	0.0603	0.0603
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1502	0.9822	1
Plasmodium vivax	unspecified product	0.0178	0.0846	0.2256
Echinococcus granulosus	calpain A	0.0324	0.1836	0.1836
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1528	1	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0142	0.0603	0.1568
Trypanosoma brucei	calpain-like protein, putative	0.0114	0.0412	0.0241
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1528	1	1
Brugia malayi	Cathepsin L-like precursor	0.0581	0.3582	0.3582
Onchocerca volvulus		0.0581	0.3582	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.0603	0.0603
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1502	0.9822	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.3582	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0142	0.0603	0.1568
Schistosoma mansoni	growth factor receptor-bound protein	0.0536	0.3272	0.3272
Brugia malayi	calpain family protein 1	0.0302	0.1689	0.1689
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.3582	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1502	0.9822	0.9819
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0114	0.0412	0.0241
Echinococcus multilocularis	calpain 7 (C02 family)	0.0114	0.0412	0.0412
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0536	0.3272	0.3272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.0603	0.1568
Trypanosoma cruzi	cysteine peptidase, putative	0.1502	0.9822	0.9819
Loa Loa (eye worm)	hypothetical protein	0.0233	0.1218	0.1218
Entamoeba histolytica	cysteine proteinase, putative	0.0581	0.3582	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0142	0.0603	0.1568
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0061	0.0052	0.0052
Entamoeba histolytica	cysteine protease, putative	0.032	0.1811	0.4795
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0233	0.1218	0.1218
Loa Loa (eye worm)	calpain family protein 1	0.0222	0.1148	0.1148
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0412	0.0237
Echinococcus multilocularis	cathepsin L cysteine protease	0.0581	0.3582	0.3582
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0142	0.0603	0.1568
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.3582	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.3582	1
Trypanosoma cruzi	cysteine protease, putative	0.032	0.1811	0.1661
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.0603	0.0603
Plasmodium falciparum	serine repeat antigen 1	0.0142	0.0603	0.1568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.3582	1
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0061	0.0049	0.0049
Schistosoma mansoni	calpain C (C02 family)	0.0114	0.0412	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0846	0.0846
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1502	0.9822	1
Brugia malayi	cathepsin L-like precursor	0.0403	0.2374	0.2374
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0412	0.0237
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0581	0.3582	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0603	0.0603
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0061	0.0049	0.0049
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0142	0.0603	0.0603
Trypanosoma cruzi	major cysteine proteinase, putative	0.0142	0.0603	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0846	0.0846
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0403	0.2374	0.2374
Entamoeba histolytica	cysteine proteinase, putative	0.032	0.1811	0.4795
Schistosoma mansoni	cathepsin F (C01 family)	0.0581	0.3582	0.3582
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0412	0.0241
Loa Loa (eye worm)	calpain 5	0.008	0.018	0.018
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0142	0.0603	0.1568
Entamoeba histolytica	cysteine protease, putative	0.032	0.1811	0.4795
Plasmodium falciparum	serine repeat antigen 6	0.0142	0.0603	0.1568
Brugia malayi	Cathepsin L-like precursor	0.0581	0.3582	0.3582
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0124	0.0478	0.0478
Trypanosoma cruzi	cruzipain precursor, putative	0.1502	0.9822	0.9819
Trypanosoma cruzi	cruzipain precursor, putative	0.0178	0.0846	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0603	0.0603
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0302	0.1689	0.1689
Leishmania major	cathepsin L-like protease	0.0581	0.3582	0.3528
Plasmodium falciparum	serine repeat antigen 2	0.0142	0.0603	0.1568
Echinococcus multilocularis	cathepsin L cysteine protease	0.0581	0.3582	0.3582
Entamoeba histolytica	cysteine protease, putative	0.032	0.1811	0.4795
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.3582	1
Echinococcus multilocularis	cathepsin L	0.032	0.1811	0.1811
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1324	0.8615	0.8589
Brugia malayi	Papain family cysteine protease containing protein	0.0142	0.0603	0.0603
Onchocerca volvulus	Cathepsin L homolog	0.0581	0.3582	1
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0114	0.0412	0.0237
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0114	0.0412	0.0412
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0114	0.0412	0.0237
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.3582	1
Echinococcus multilocularis	cathepsin b	0.1528	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.0603	0.1568
Onchocerca volvulus		0.0581	0.3582	1
Loa Loa (eye worm)	fibroinase	0.0581	0.3582	0.3582
Trypanosoma brucei	calpain-like protein, putative	0.0114	0.0412	0.0241
Plasmodium falciparum	serine repeat antigen 9	0.0142	0.0603	0.1568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0142	0.0603	0.1568
Schistosoma mansoni	growth factor receptor-bound protein	0.0536	0.3272	0.3272
Plasmodium vivax	calpain, putative	0.0114	0.0412	0.1027
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0142	0.0603	0.0603
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.032	0.1811	0.1692
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0581	0.3582	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1502	0.9822	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.3582	1
Onchocerca volvulus		0.0403	0.2374	0.5946
Entamoeba histolytica	cysteine proteinase, putative	0.032	0.1811	0.4795
Brugia malayi	Papain family cysteine protease containing protein	0.032	0.1811	0.1811
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1528	1	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0142	0.0603	0.1568
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0412	0.0241
Echinococcus multilocularis	calpain A	0.0324	0.1836	0.1836
Echinococcus granulosus	cathepsin b	0.1528	1	1
Onchocerca volvulus		0.0581	0.3582	1
Entamoeba histolytica	hypothetical protein	0.0142	0.0603	0.1246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.032	0.1811	0.4987
Loa Loa (eye worm)	calpain	0.0114	0.0412	0.0412
Schistosoma mansoni	dopamine-beta-monooxygenase	0.0124	0.0478	0.0478
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0412	0.0237
Plasmodium falciparum	serine repeat antigen 7	0.0142	0.0603	0.1568
Plasmodium vivax	vivapain-2	0.0581	0.3582	1
Plasmodium vivax	vivapain-1	0.032	0.1811	0.4987
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1528	1	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0142	0.0603	0.0603
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.0233	0.1218	0.1218
Trypanosoma brucei	antigen, putative	0.0114	0.0412	0.0241
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.032	0.1811	0.1811
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0603	0.0603
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0571	0.351	0.351
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0142	0.0603	0.1568
Entamoeba histolytica	cysteine protease, putative	0.032	0.1811	0.4795
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0142	0.0603	0.0603
Leishmania major	cathepsin L-like protease	0.1502	0.9822	1
Echinococcus granulosus	cathepsin L cysteine protease	0.032	0.1811	0.1811
Loa Loa (eye worm)	hypothetical protein	0.0403	0.2374	0.2374
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.3582	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0178	0.0846	0.0846
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.3582	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0142	0.0603	0.0603
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.3582	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1528	1	1
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0603	0.1246
Leishmania major	cathepsin L-like protease	0.0581	0.3582	0.3528
Brugia malayi	calpain 5	0.008	0.018	0.018
Trypanosoma cruzi	cysteine peptidase, putative	0.0581	0.3582	0.3464
Plasmodium vivax	vivapain-3	0.032	0.1811	0.4987
Plasmodium falciparum	serine repeat antigen 5	0.0142	0.0603	0.1568
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0142	0.0603	0.1246
Brugia malayi	Cathepsin L-like precursor	0.0581	0.3582	0.3582
Entamoeba histolytica	cysteine protease, putative	0.0581	0.3582	1
Brugia malayi	Cathepsin L-like precursor	0.0178	0.0846	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0581	0.3582	0.3582
Trypanosoma cruzi	cysteine peptidase, putative	0.032	0.1811	0.1661
Brugia malayi	Cathepsin L-like precursor	0.0581	0.3582	0.3582
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0142	0.0603	0.1568
Entamoeba histolytica	cysteine protease, putative	0.032	0.1811	0.4795
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1502	0.9822	1
Onchocerca volvulus		0.0581	0.3582	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1502	0.9822	0.9819
Leishmania major	cysteine peptidase A (CPA)	0.0581	0.3582	0.3528
Brugia malayi	Papain family cysteine protease containing protein	0.0142	0.0603	0.0603
Plasmodium vivax	unspecified product	0.0142	0.0603	0.1568
Plasmodium falciparum	serine repeat antigen 4	0.0142	0.0603	0.1568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.3582	1
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0603	0.1568
Trypanosoma cruzi	cysteine proteinase, putative	0.032	0.1811	0.1661
Toxoplasma gondii	cathepsin B	0.0571	0.351	0.9796
Echinococcus multilocularis	calpain 5	0.0114	0.0412	0.0412
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0142	0.0603	0.1568
Echinococcus multilocularis	cathepsin L	0.0142	0.0603	0.0603
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0571	0.351	0.3453
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.0603	0.1568
Schistosoma mansoni	cathepsin F (C01 family)	0.0403	0.2374	0.2374
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0142	0.0603	0.1568
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0581	0.3582	0.3582
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0142	0.0603	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0403	0.2374	0.2374
Echinococcus granulosus	cathepsin L	0.032	0.1811	0.1811
Entamoeba histolytica	cysteine protease, putative	0.032	0.1811	0.4795
Echinococcus multilocularis	calpain family protein 1, d	0.0222	0.1148	0.1148
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1502	0.9822	1
Leishmania major	cathepsin L-like protease	0.0581	0.3582	0.3528
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.3582	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0142	0.0603	0.1568
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1502	0.9822	1
Trypanosoma brucei	calpain-like protein, putative	0.0114	0.0412	0.0241
Schistosoma mansoni	cathepsin s	0.0178	0.0846	0.0846
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0114	0.0412	0.0237
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0142	0.0603	0.0603
Trypanosoma cruzi	cysteine proteinase, putative	0.032	0.1811	0.1661
Plasmodium falciparum	cysteine proteinase falcipain 1	0.032	0.1811	0.4987
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.0603	0.1568
Schistosoma mansoni	cathepsin F (C01 family)	0.0581	0.3582	0.3582
Echinococcus multilocularis	cathepsin b	0.1528	1	1
Echinococcus multilocularis	cysteine protease	0.0581	0.3582	0.3582
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0412	0.0237
Loa Loa (eye worm)	hypothetical protein	0.1528	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0142	0.0603	0.1568
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0114	0.0412	0.0237
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0323	0.1832	0.1832
Schistosoma mansoni	cathepsin S (C01 family)	0.0142	0.0603	0.0603
Brugia malayi	Cathepsin L-like precursor	0.0403	0.2374	0.2374
Entamoeba histolytica	cysteine proteinase 1, putative	0.032	0.1811	0.4795
Toxoplasma gondii	cathepsin CPC2	0.0142	0.0603	0.1568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.0603	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0603	0.0603
Entamoeba histolytica	cysteine protease, putative	0.032	0.1811	0.4795
Entamoeba histolytica	cysteine protease, putative	0.032	0.1811	0.4795
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0142	0.0603	0.1568
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0142	0.0603	0.1568
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.0603	0.0603
Schistosoma mansoni	calpain-7 (C02 family)	0.0114	0.0412	0.0412
Onchocerca volvulus	Cathepsin L homolog	0.0581	0.3582	1
Entamoeba histolytica	cysteine proteinase 2	0.032	0.1811	0.4795
Plasmodium vivax	unspecified product	0.032	0.1811	0.4987
Toxoplasma gondii	cathepsin CPL	0.0581	0.3582	1
Leishmania major	cathepsin L-like protease	0.1502	0.9822	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.3582	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0571	0.351	0.9796
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.3582	1
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0603	0.1246
Schistosoma mansoni	cathepsin D (A01 family)	0.0179	0.0849	0.0849
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.3582	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0571	0.351	0.3391
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.032	0.1811	0.1811
Brugia malayi	fibroinase precursor	0.0142	0.0603	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0403	0.2374	0.2374
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0403	0.2374	0.6582
Brugia malayi	cathepsin L precursor	0.0142	0.0603	0.0603
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0142	0.0603	0.1568
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0142	0.0603	0.0603
Brugia malayi	Papain family cysteine protease containing protein	0.032	0.1811	0.1811
Trypanosoma cruzi	major cysteine proteinase, putative	0.1062	0.6844	0.6786
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0603	0.1246
Schistosoma mansoni	peptidylglycine monooxygenase	0.0124	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0049	0.0049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.0603	0.1568
Brugia malayi	Papain family cysteine protease containing protein	0.0581	0.3582	0.3582
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0142	0.0603	0.0603
Loa Loa (eye worm)	cysteine protease	0.0581	0.3582	0.3582
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0142	0.0603	0.0603
Plasmodium falciparum	serine repeat antigen 3	0.0142	0.0603	0.1568
Onchocerca volvulus		0.0581	0.3582	1
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0603	0.1568
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0536	0.3272	0.3272
Entamoeba histolytica	cysteine proteinase, putative	0.0403	0.2374	0.6451
Brugia malayi	cathepsin F-like cysteine proteinase	0.0142	0.0603	0.0603
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0178	0.0846	0.0846
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0603	0.1246
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.3582	1
Onchocerca volvulus		0.0581	0.3582	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0581	0.3582	0.3582
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0581	0.3582	0.3582
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0581	0.3582	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.3582	1
Brugia malayi	Cathepsin L-like precursor	0.0581	0.3582	0.3582
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.0233	0.1218	0.1218
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.3582	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0142	0.0603	0.1568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.3582	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0178	0.0846	0.0846
Loa Loa (eye worm)	ctsf protein	0.0581	0.3582	0.3582

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3501478

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2077481