TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 421.415 | Formula: C17H26F3N5O4
H donors: 1 H acceptors: 5 LogP: -1.95 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(F)(F)F.COCC(=O)N1CCCn2c(C1)nnc2CN1CCCCC1
InChi: 1S/C15H25N5O2.C2HF3O2/c1-22-12-15(21)19-8-5-9-20-13(16-17-14(20)11-19)10-18-6-3-2-4-7-18;3-2(4,5)1(6)7/h2-12H2,1H3;(H,6,7)
InChiKey: PECBYNMSOBIEQA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	laminin-like protein K08C7.3 precursor	0.0055	0.0253	0.0933
Brugia malayi	Thioredoxin reductase	0.0051	0.0219	0.0801
Onchocerca volvulus		0.0043	0.0155	0.0785
Schistosoma mansoni	lipoxygenase	0.0142	0.0989	0.2288
Brugia malayi	nuclear receptor NHR-88	0.0051	0.0215	0.0787
Loa Loa (eye worm)	abnormal epIthelia family member	0.0055	0.0253	0.0933
Echinococcus multilocularis	carbonic anhydrase	0.0028	0.0022	0.0017
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.0875	0.3368
Mycobacterium ulcerans	transmembrane carbonic anhydrase, SulP	0.0032	0.0061	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0155	0.0552
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0099	0.0331
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0051	0.0215	0.0472
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0093	0.057	0.6803
Schistosoma mansoni	lipoxygenase	0.01	0.0628	0.1441
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0116	0.077	0.079
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0022	0.0029
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0155	0.0155
Echinococcus granulosus	geminin	0.0532	0.4272	1
Schistosoma mansoni	single-minded	0.0042	0.0139	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0215	0.0787
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0116	0.077	0.079
Schistosoma mansoni	hypothetical protein	0.0028	0.0022	0.0017
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0129	0.0879	0.1874
Loa Loa (eye worm)	phosphofructokinase	0.0093	0.057	0.2177
Trichomonas vaginalis	glutaminase, putative	0.033	0.257	0.257
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0121	0.081	0.3113
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0155	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0215	0.0787
Echinococcus granulosus	6 phosphofructokinase	0.0093	0.057	0.1306
Leishmania major	carbonic anhydrase-like protein	0.0121	0.081	0.1694
Trypanosoma cruzi	trypanothione reductase, putative	0.0051	0.0219	0.2106
Schistosoma mansoni	carbonic anhydrase-related	0.0028	0.0022	0.0017
Loa Loa (eye worm)	glutaminase 2	0.033	0.257	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0051	0.0215	0.0787
Mycobacterium ulcerans	lipase LipD	0.0043	0.0155	0.0108
Echinococcus multilocularis	transfer RNA-Lys	0.0031	0.0048	0.0079
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0142	0.0989	0.2288
Brugia malayi	beta-lactamase family protein	0.0043	0.0155	0.0552
Schistosoma mansoni	RAR-like nuclear receptor	0.0051	0.0215	0.0472
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.046	0.5332
Plasmodium vivax	glutathione reductase, putative	0.0051	0.0219	1
Toxoplasma gondii	inorganic anion transporter, sulfate permease (SulP) family protein	0.0032	0.0061	0.2801
Echinococcus multilocularis	6 phosphofructokinase	0.0093	0.057	0.1306
Onchocerca volvulus		0.0031	0.0048	0.0049
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0028	0.0022	0.0029
Plasmodium falciparum	carbonic anhydrase	0.0028	0.0022	0.0985
Echinococcus multilocularis	FTZ F1 alpha	0.0051	0.0215	0.0472
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0051	0.0215	0.0787
Onchocerca volvulus		0.0051	0.0215	0.1198
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0155	0.0108
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0038	0.0109	0.0224
Echinococcus granulosus	ecdysone induced protein 78C	0.0051	0.0215	0.0472
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0051	0.0215	0.0472
Plasmodium falciparum	inorganic anion exchanger, inorganic anion antiporter	0.0032	0.0061	0.2801
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0155	0.0552
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0051	0.0215	0.0787
Echinococcus granulosus	jun protein	0.0038	0.0109	0.0224
Schistosoma mansoni	carbonic anhydrase	0.0502	0.402	0.9408
Echinococcus multilocularis	jun protein	0.0038	0.0109	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0253	0.0933
Loa Loa (eye worm)	glutaminase	0.033	0.257	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0051	0.0219	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0101	0.0338
Entamoeba histolytica	carbonic anhydrase, putative	0.0502	0.402	1
Trichomonas vaginalis	conserved hypothetical protein	0.1212	1	1
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0028	0.0022	0.0029
Loa Loa (eye worm)	6-phosphofructokinase	0.0093	0.057	0.2177
Schistosoma mansoni	hypothetical protein	0.0532	0.4272	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0155	0.0552
Schistosoma mansoni	carbonic anhydrase-related	0.0028	0.0022	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0051	0.0215	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0962	0.3711
Mycobacterium tuberculosis	Beta-carbonic anhydrase	0.0967	0.7936	1
Brugia malayi	hypoxia-induced factor 1	0.0129	0.0871	0.3355
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0235	0.1765	0.2068
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0121	0.081	0.1868
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.0875	0.3368
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0121	0.081	0.3113
Schistosoma mansoni	hypothetical protein	0.0532	0.4272	1
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.008	0.046	0.079
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0155	0.7084
Entamoeba histolytica	phosphofructokinase, putative	0.0093	0.057	0.1419
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0215	0.0787
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0051	0.0215	0.0472
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0155	0.1253
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0155	0.0331
Schistosoma mansoni	hypothetical protein	0.0031	0.0049	0.0083
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0051	0.0215	0.0787
Schistosoma mansoni	6-phosphofructokinase	0.0093	0.057	0.1306
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0038	0.0109	0.0224
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.008	0.046	0.1145
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.046	0.5332
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0155	0.1253
Echinococcus granulosus	thioredoxin glutathione reductase	0.0051	0.0219	0.0481
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0155	0.0155
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.046	0.5332
Entamoeba histolytica	phosphofructokinase, putative	0.0093	0.057	0.1419
Loa Loa (eye worm)	glutathione reductase	0.0051	0.0219	0.0801
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0051	0.0219	0.0481
Loa Loa (eye worm)	6-phosphofructokinase	0.0093	0.057	0.2177
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0155	0.0331
Loa Loa (eye worm)	carbonic anhydrase 3	0.0121	0.081	0.3113
Onchocerca volvulus		0.0203	0.1499	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0093	0.057	0.057
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0051	0.0215	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0253	0.0933
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0051	0.0215	0.0472
Brugia malayi	phosphofructokinase	0.0093	0.057	0.2177
Brugia malayi	EGF-like domain containing protein	0.0055	0.0253	0.0933
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.008	0.046	0.1746
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0215	0.0787
Brugia malayi	bHLH-PAS transcription factor	0.0031	0.0048	0.0131
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0129	0.0871	0.3355
Echinococcus granulosus	carbonic anhydrase	0.0028	0.0022	0.0017
Brugia malayi	MH2 domain containing protein	0.0129	0.0875	0.3368
Brugia malayi	PAS domain containing protein	0.0042	0.0139	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0215	0.0787
Schistosoma mansoni	jun-related protein	0.0031	0.0049	0.0083
Echinococcus multilocularis	slit 2 protein	0.0055	0.0253	0.056
Brugia malayi	6-phosphofructokinase	0.0093	0.057	0.2177
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0116	0.077	0.1591
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0155	0.0155
Brugia malayi	glutaminase DH11.1	0.033	0.257	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0051	0.0215	0.0472
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0155	0.0108
Echinococcus multilocularis	geminin	0.0532	0.4272	1
Trichomonas vaginalis	esterase, putative	0.0043	0.0155	0.0155
Brugia malayi	ecdysteroid receptor	0.0051	0.0215	0.0787
Trypanosoma brucei	carbonic anhydrase-like protein	0.0121	0.081	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0155	0.0155
Echinococcus multilocularis	carbonic anhydrase	0.0028	0.0022	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0215	0.0787
Echinococcus granulosus	expressed protein	0.0403	0.3184	0.7444
Echinococcus granulosus	FTZ F1 alpha	0.0051	0.0215	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0215	0.0787
Trichomonas vaginalis	phosphofructokinase, putative	0.0093	0.057	0.057
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0051	0.0215	0.0472
Mycobacterium ulcerans	transmembrane carbonic anhydrase, SulP	0.0032	0.0061	0.0014
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0051	0.0215	0.0787
Brugia malayi	steroid hormone receptor	0.0051	0.0215	0.0787
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.008	0.046	0.1048
Mycobacterium tuberculosis	Probable oxidoreductase	0.0129	0.0879	0.0931
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0121	0.081	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0093	0.057	0.057
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0051	0.0215	0.0472
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0242	0.0893
Onchocerca volvulus		0.0043	0.0155	0.0785
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0242	0.0893
Entamoeba histolytica	phosphofructokinase, putative	0.0093	0.057	0.1419
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0028	0.0022	0.0029
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0051	0.0215	0.0472
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0155	0.0155
Mycobacterium ulcerans	6-phosphofructokinase	0.0093	0.057	0.0525
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0093	0.057	0.1075
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0155	0.0552
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0051	0.0215	0.0472
Plasmodium vivax	thioredoxin reductase, putative	0.0051	0.0219	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0051	0.0215	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0155	0.0552
Onchocerca volvulus	Protein ultraspiracle homolog	0.0051	0.0215	0.1198
Schistosoma mansoni	6-phosphofructokinase	0.0093	0.057	0.1306
Brugia malayi	beta-lactamase	0.0043	0.0155	0.0552
Loa Loa (eye worm)	thioredoxin reductase	0.0051	0.0219	0.0801
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0051	0.0215	0.0472
Toxoplasma gondii	thioredoxin reductase	0.0051	0.0219	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0028	0.0022	0.0029
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0028	0.0022	0.0029
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0051	0.0215	0.0787
Mycobacterium ulcerans	integral membrane transporter	0.0032	0.0061	0.0014
Trypanosoma brucei	trypanothione reductase	0.0051	0.0219	0.2106
Trichomonas vaginalis	conserved hypothetical protein	0.1212	1	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0155	0.0552
Echinococcus multilocularis	carbonic anhydrase	0.0028	0.0022	0.0017
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.2129	0.2537
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0155	0.1253
Toxoplasma gondii	hypothetical protein	0.0028	0.0022	0.0985
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0121	0.081	0.1868
Mycobacterium tuberculosis	Beta-carbonic anhydrase CanB	0.0257	0.1956	0.2315
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0093	0.057	0.0534
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0051	0.0215	0.0787
Schistosoma mansoni	coup transcription factor	0.0051	0.0215	0.0472
Leishmania major	carbonic anhydrase family protein, putative	0.0502	0.402	1
Toxoplasma gondii	ABC1 family protein	0.0043	0.0155	0.7084
Mycobacterium ulcerans	glutaminase	0.033	0.257	0.2534
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0022	0.0029
Schistosoma mansoni	glutaminase	0.033	0.257	0.6001
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0121	0.081	0.3113
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0051	0.0215	0.0787
Brugia malayi	beta-lactamase family protein	0.0043	0.0155	0.0552
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0051	0.0215	0.0472
Brugia malayi	glutathione reductase	0.0051	0.0219	0.0801
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0121	0.081	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0155	0.0552
Brugia malayi	Steroid receptor seven-up type 2	0.0051	0.0215	0.0787
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0051	0.0215	0.0472
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0051	0.0215	0.0472
Mycobacterium leprae	Probable transmembrane transport protein	0.0235	0.1765	0.4164
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.008	0.046	0.1746
Schistosoma mansoni	carbonic anhydrase-related	0.0028	0.0022	0.0017
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0051	0.0215	0.0472
Schistosoma mansoni	carbonic anhydrase	0.0028	0.0022	0.0017
Onchocerca volvulus		0.0043	0.0155	0.0785
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0022	0.0029
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0025	0	0.5
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0155	0.0331
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0051	0.0215	0.0472
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0242	0.0893
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0051	0.0215	0.0787
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0116	0.077	0.079
Brugia malayi	Nuclear hormone receptor-like 1	0.0051	0.0215	0.0787
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.008	0.046	0.1048
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.008	0.046	0.1048
Plasmodium vivax	sulfate transporter, putative	0.0032	0.0061	0.2801
Plasmodium falciparum	thioredoxin reductase	0.0051	0.0219	1
Schistosoma mansoni	laminin gamma-3 chain	0.0055	0.0253	0.056
Leishmania major	ATP-dependent phosphofructokinase	0.0093	0.057	0.1075
Brugia malayi	bZIP transcription factor family protein	0.0038	0.0109	0.0372
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0051	0.0215	0.0787
Echinococcus multilocularis	transcription factor Dp 1	0.0046	0.0178	0.0384
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0051	0.0215	0.0787
Echinococcus granulosus	carbonic anhydrase	0.0028	0.0022	0.0017
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0116	0.077	0.079
Echinococcus multilocularis	neurogenic locus notch protein	0.0055	0.0253	0.056
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0051	0.0215	0.0472
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0051	0.0215	0.0787
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0051	0.0215	0.0472
Mycobacterium leprae	CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)	0.0502	0.402	1
Mycobacterium tuberculosis	Probable reductase	0.0116	0.077	0.079
Chlamydia trachomatis	sulfate transporter	0.0032	0.0061	1
Brugia malayi	hypothetical protein	0.0139	0.0962	0.3711
Schistosoma mansoni	chondroitin sulfate proteoglycan-related	0.0055	0.0253	0.056
Schistosoma mansoni	slit	0.0055	0.0253	0.056
Echinococcus multilocularis	expressed protein	0.0403	0.3184	0.7444
Onchocerca volvulus	Putative sulfate transporter	0.0203	0.1499	1
Echinococcus granulosus	neurogenic locus notch protein	0.0055	0.0253	0.056
Schistosoma mansoni	retinoic acid receptor RXR	0.0051	0.0215	0.0472
Onchocerca volvulus	Bile acid receptor homolog	0.0051	0.0215	0.1198
Mycobacterium tuberculosis	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)	0.048	0.3829	0.4721
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0051	0.0215	0.0787
Schistosoma mansoni	thyroid hormone receptor	0.0051	0.0215	0.0472
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0129	0.0879	0.0931
Schistosoma mansoni	cell polarity protein	0.0055	0.0253	0.056
Echinococcus granulosus	carbonic anhydrase	0.0028	0.0022	0.0017
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0051	0.0215	0.1198
Echinococcus granulosus	pikachurin	0.0055	0.0253	0.056
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0129	0.0879	0.0931
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0051	0.0215	0.0787
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0051	0.0215	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0242	0.0893
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0051	0.0215	0.0787
Mycobacterium ulcerans	carbonic anhydrase	0.0502	0.402	0.3991
Echinococcus multilocularis	ecdysone induced protein 78C	0.0051	0.0215	0.0472
Echinococcus granulosus	single minded 2	0.0031	0.0048	0.0079
Schistosoma mansoni	aryl hydrocarbon receptor	0.0042	0.0139	0.0292
Leishmania major	trypanothione reductase	0.0051	0.0219	0.0165
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0051	0.0215	0.0472
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0093	0.057	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0051	0.0215	0.0787
Loa Loa (eye worm)	steroid hormone receptor	0.0051	0.0215	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0215	0.0787
Brugia malayi	6-phosphofructokinase	0.0093	0.057	0.2177
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0155	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0155	0.0552
Plasmodium falciparum	glutathione reductase	0.0051	0.0219	1
Echinococcus granulosus	carbonic anhydrase II	0.0121	0.081	0.1868
Echinococcus granulosus	transcription factor Dp 1	0.0046	0.0178	0.0384
Echinococcus granulosus	slit 2 protein	0.0055	0.0253	0.056
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0155	0.0552
Brugia malayi	laminin alpha chain	0.0055	0.0253	0.0933
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0028	0.0022	0.0029
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0051	0.0215	0.0787
Brugia malayi	Thrombospondin N-terminal -like domain containing protein	0.0055	0.0253	0.0933
Echinococcus multilocularis	carbonic anhydrase II	0.0121	0.081	0.1868
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0253	0.0933
Schistosoma mansoni	thyroid hormone receptor	0.0051	0.0215	0.0472
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0051	0.0215	0.0787
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0142	0.0989	0.2288
Mycobacterium tuberculosis	Probable dehydrogenase	0.0116	0.077	0.079
Brugia malayi	photoreceptor-specific nuclear receptor	0.0051	0.0215	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0099	0.0331
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0093	0.057	0.6803
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0051	0.0215	0.0787
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0155	0.0108
Schistosoma mansoni	hypothetical protein	0.0037	0.0099	0.0199
Trichomonas vaginalis	phosphofructokinase, putative	0.0093	0.057	0.057
Echinococcus multilocularis	pikachurin	0.0055	0.0253	0.056
Brugia malayi	hypothetical protein	0.003	0.0041	0.0103
Brugia malayi	nuclear hormone receptor	0.0051	0.0215	0.0787
Schistosoma mansoni	nuclear hormone receptor	0.0051	0.0215	0.0472

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3500923

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2077961