Detailed information for compound 208137

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 624.812 | Formula: C33H45FN6O3S
  • H donors: 4 H acceptors: 4 LogP: 5.12 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCNC[C@@H](Nc1ccncc1S(=O)(=O)N[C@H](C(=O)N1CCC(CC1)CCF)Cc1ccc(cc1)N)Cc1ccccc1
  • InChi: 1S/C33H45FN6O3S/c1-2-17-36-23-29(21-26-6-4-3-5-7-26)38-30-13-18-37-24-32(30)44(42,43)39-31(22-27-8-10-28(35)11-9-27)33(41)40-19-14-25(12-16-34)15-20-40/h3-11,13,18,24-25,29,31,36,39H,2,12,14-17,19-23,35H2,1H3,(H,37,38)/t29-,31-/m0/s1
  • InChiKey: XYRUNBCIDWUSPO-SMCANUKXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.019 0.3767 0.4497
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0051 0.0594 0.0594
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.0044 0.0434 0.0434
Brugia malayi isocitrate dehydrogenase 0.0056 0.0714 0.0809
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0056 0.0714 0.2935
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0953 0.5997
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus granulosus neuropeptide FF receptor 2 0.019 0.3767 0.3767
Schistosoma mansoni glutamate receptor AMPA 0.0042 0.0403 0.0345
Brugia malayi Calcitonin receptor-like protein seb-1 0.0383 0.8137 1
Echinococcus granulosus g protein coupled receptor 0.019 0.3767 0.3767
Brugia malayi putative neuropeptide receptor NPR1 0.019 0.3767 0.4589
Echinococcus multilocularis rhodopsin orphan GPCR 0.019 0.3767 0.3767
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.019 0.3767 0.3729
Schistosoma mansoni biogenic amine receptor 0.019 0.3767 0.3729
Toxoplasma gondii isocitrate dehydrogenase 0.0056 0.0714 0.4386
Echinococcus multilocularis GPCR, family 2 0.0121 0.2196 0.2196
Schistosoma mansoni glutamate receptor NMDA 0.0216 0.4348 0.4314
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0125 0.2286 0.2239
Echinococcus granulosus glutamate receptor 2 0.0035 0.0231 0.0231
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0263 0.0246
Echinococcus multilocularis neuropeptide s receptor 0.019 0.3767 0.3767
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.019 0.3767 0.3729
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0263 0.0246
Echinococcus multilocularis rhodopsin orphan GPCR 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus multilocularis neuropeptide receptor 0.019 0.3767 0.3767
Loa Loa (eye worm) latrophilin receptor protein 2 0.0121 0.2196 0.2196
Toxoplasma gondii LsmAD domain-containing protein 0.0043 0.0433 0.2504
Echinococcus multilocularis fmrfamide receptor 0.019 0.3767 0.3767
Schistosoma mansoni amine GPCR 0.019 0.3767 0.3729
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0178 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0562 0.0562
Echinococcus multilocularis musashi 0.0051 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0061
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.019 0.3767 0.3767
Brugia malayi G-protein coupled receptor 0.019 0.3767 0.4589
Loa Loa (eye worm) hypothetical protein 0.0125 0.2286 0.2286
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.019 0.3767 0.3729
Schistosoma mansoni rhodopsin-like orphan GPCR 0.019 0.3767 0.3729
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0263 0.1361
Brugia malayi Intermediate filament tail domain containing protein 0.0051 0.0594 0.0661
Echinococcus granulosus importin subunit beta 1 0.0044 0.0434 0.0434
Echinococcus multilocularis serotonin receptor 0.019 0.3767 0.3767
Echinococcus granulosus somatostatin receptor 0.019 0.3767 0.3767
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0034 0.0227 0.0167
Schistosoma mansoni neuropeptide f receptor 76f 0.019 0.3767 0.3729
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Schistosoma mansoni biogenic amine (dopamine) receptor 0.019 0.3767 0.3729
Schistosoma mansoni opsin-like receptor 0.019 0.3767 0.3729
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0562 0.0504
Toxoplasma gondii isocitrate dehydrogenase 0.0056 0.0714 0.4386
Plasmodium vivax importin-beta 2, putative 0.0044 0.0434 0.1679
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0953 0.2134
Brugia malayi hypothetical protein 0.0043 0.0433 0.0461
Onchocerca volvulus 0.019 0.3767 0.4497
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0121 0.2196 0.2196
Brugia malayi hypothetical protein 0.021 0.4227 0.5159
Loa Loa (eye worm) glutamate receptor 2 0.0042 0.0403 0.0403
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0032 0.0173 0.0173
Schistosoma mansoni ran 0.0032 0.0173 0.0113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0034 0.0227 0.0227
Schistosoma mansoni hypothetical protein 0.0121 0.2196 0.2148
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.019 0.3767 0.4589
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0056 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Schistosoma mansoni rhodopsin-like orphan GPCR 0.019 0.3767 0.3729
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0125 0.2286 0.2286
Schistosoma mansoni hypothetical protein 0.0261 0.5387 0.5359
Echinococcus multilocularis g protein coupled receptor 0.019 0.3767 0.3767
Echinococcus multilocularis alpha 1A adrenergic receptor 0.019 0.3767 0.3767
Onchocerca volvulus Neuropeptide F receptor homolog 0.019 0.3767 0.4497
Echinococcus granulosus 7TM GPCR rhodopsin 0.019 0.3767 0.3767
Echinococcus granulosus lamin 0.0051 0.0594 0.0594
Loa Loa (eye worm) inositol-1 0.0036 0.0263 0.0263
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0953 0.2694
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0182 0.1858
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0034 0.0227 0.0227
Plasmodium falciparum ataxin-2 like protein, putative 0.0043 0.0433 0.1231
Schistosoma mansoni glutamate receptor kainate 0.0042 0.0403 0.0345
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0125 0.2286 1
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0032 0.0182 0.0182
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0034 0.0227 0.0227
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0056 0.0714 1
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0125 0.2286 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0056 0.0714 0.0714
Schistosoma mansoni rhodopsin-like orphan GPCR 0.019 0.3767 0.3729
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0559 0.0617
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0093 0.1549 0.1807
Schistosoma mansoni neuropeptide F-like receptor 0.019 0.3767 0.3729
Echinococcus granulosus nmda type glutamate receptor 0.0181 0.3564 0.3564
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0263 0.3103
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0032 0.0182 0.0147
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0032 0.0182 0.1359
Echinococcus granulosus rhodopsin orphan GPCR 0.019 0.3767 0.3767
Brugia malayi Isocitrate dehydrogenase 0.0056 0.0714 0.0809
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus multilocularis somatostatin receptor 0.019 0.3767 0.3767
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0034 0.0227 0.0167
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0121 0.2196 0.2196
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0032 0.0182 0.1858
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0032 0.0182 0.0182
Echinococcus multilocularis rhodopsin orphan GPCR 0.019 0.3767 0.3767
Onchocerca volvulus 0.019 0.3767 0.4497
Trypanosoma cruzi PAB1-binding protein , putative 0.0043 0.0433 0.5708
Schistosoma mansoni ATP-binding cassette transporter 0.0042 0.0403 0.0345
Schistosoma mansoni hypothetical protein 0.0465 1 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0585 0.0585
Echinococcus granulosus biogenic amine 5HT receptor 0.019 0.3767 0.3767
Echinococcus granulosus hypothetical protein 0.019 0.3767 0.3767
Loa Loa (eye worm) G-protein coupled receptor 0.019 0.3767 0.3767
Trichomonas vaginalis glutaminase, putative 0.0211 0.4244 0.5076
Schistosoma mansoni lipoxygenase 0.0129 0.2374 0.2328
Schistosoma mansoni inositol monophosphatase 0.0036 0.0263 0.0204
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0056 0.0714 0.197
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.019 0.3767 0.3729
Onchocerca volvulus 0.019 0.3767 0.4497
Schistosoma mansoni neuropeptide receptor 0.019 0.3767 0.3729
Echinococcus multilocularis biogenic amine (5HT) receptor 0.019 0.3767 0.3767
Toxoplasma gondii hypothetical protein 0.0032 0.0182 0.0815
Schistosoma mansoni adenoreceptor 0.019 0.3767 0.3729
Brugia malayi MH2 domain containing protein 0.0208 0.418 0.5101
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0034 0.0227 0.0227
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0953 0.0898
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.019 0.3767 0.3729
Brugia malayi follicle stimulating hormone receptor 0.019 0.3767 0.4589
Schistosoma mansoni opsin-like receptor 0.019 0.3767 0.3729
Leishmania major GTP-binding protein, putative 0.0032 0.0173 0.1262
Echinococcus granulosus rhodopsin orphan GPCR 0.019 0.3767 0.3767
Giardia lamblia Rab geranylgeranyltransferase 0.0032 0.0182 0.0041
Onchocerca volvulus 0.019 0.3767 0.4497
Schistosoma mansoni rhodopsin-like orphan GPCR 0.019 0.3767 0.3729
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus granulosus intermediate filament protein 0.0051 0.0594 0.0594
Echinococcus granulosus allatostatin A receptor 0.019 0.3767 0.3767
Echinococcus granulosus lamin dm0 0.0051 0.0594 0.0594
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.019 0.3767 0.3729
Brugia malayi Glutamate receptor 1 precursor 0.0042 0.0403 0.0424
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0032 0.0182 0.1858
Echinococcus multilocularis nmda type glutamate receptor 0.0181 0.3564 0.3564
Echinococcus granulosus biogenic amine 5HT receptor 0.019 0.3767 0.3767
Brugia malayi G protein-coupled receptor F59B2.13 0.019 0.3767 0.4589
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Brugia malayi ORL1-like opioid receptor 0.019 0.3767 0.4589
Loa Loa (eye worm) hypothetical protein 0.024 0.4903 0.4903
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0263 0.0246
Schistosoma mansoni rhodopsin-like orphan GPCR 0.019 0.3767 0.3729
Loa Loa (eye worm) G-protein coupled receptor 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.0121 0.2196 0.2196
Schistosoma mansoni glutamate receptor kainate 0.0042 0.0403 0.0345
Onchocerca volvulus 0.019 0.3767 0.4497
Schistosoma mansoni glutaminase 0.0211 0.4244 0.4209
Brugia malayi Importin beta-1 subunit 0.0044 0.0434 0.0463
Schistosoma mansoni hypothetical protein 0.0464 0.9996 0.9996
Brugia malayi hypothetical protein 0.019 0.3767 0.4589
Echinococcus multilocularis isocitrate dehydrogenase 0.0056 0.0714 0.0714
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0585 0.0585
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.019 0.3767 0.3767
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0121 0.2196 0.2196
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.019 0.3767 0.4589
Echinococcus multilocularis lamin dm0 0.0051 0.0594 0.0594
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.019 0.3767 0.3729
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0032 0.0173 0.1725
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0263 0.0426
Loa Loa (eye worm) intermediate filament protein 0.0051 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0049 0.0562 0.0504
Brugia malayi Melatonin receptor type 1A 0.019 0.3767 0.4589
Onchocerca volvulus 0.019 0.3767 0.4497
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0125 0.2286 0.2286
Schistosoma mansoni hypothetical protein 0.0121 0.2196 0.2148
Trichomonas vaginalis set domain proteins, putative 0.039 0.8302 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0049 0.0562 0.0562
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Schistosoma mansoni neuropeptide receptor 0.019 0.3767 0.3729
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0121 0.2196 0.2196
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus multilocularis neuropeptide receptor 0.019 0.3767 0.3767
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0953 0.0898
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.019 0.3767 0.3729
Onchocerca volvulus 0.019 0.3767 0.4497
Echinococcus multilocularis lamin 0.0051 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus granulosus nmda type glutamate receptor 0.0174 0.3391 0.3391
Echinococcus multilocularis neuropeptides capa receptor 0.019 0.3767 0.3767
Toxoplasma gondii hypothetical protein 0.0093 0.1549 1
Brugia malayi hypothetical protein 0.019 0.3767 0.4589
Echinococcus multilocularis geminin 0.0464 0.9996 0.9996
Echinococcus multilocularis G-protein coupled receptor, putative 0.019 0.3767 0.3767
Echinococcus granulosus glutamate NMDA receptor subunit 0.0042 0.0403 0.0403
Echinococcus granulosus dro:myosuppressin receptor 0.019 0.3767 0.3767
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0032 0.0182 0.0182
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0034 0.0227 0.0206
Brugia malayi Pre-SET motif family protein 0.0342 0.7227 0.8873
Onchocerca volvulus Huntingtin homolog 0.021 0.4227 0.5056
Brugia malayi neuropeptide F receptor 0.019 0.3767 0.4589
Schistosoma mansoni importin beta-1 0.0044 0.0434 0.0376
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.019 0.3767 0.3767
Echinococcus multilocularis orexin receptor type 2 0.019 0.3767 0.3767
Brugia malayi hypothetical protein 0.019 0.3767 0.4589
Schistosoma mansoni lamin 0.0051 0.0594 0.0537
Schistosoma mansoni opsin-like receptor 0.019 0.3767 0.3729
Schistosoma mansoni biogenic amine receptor 0.019 0.3767 0.3729
Schistosoma mansoni peptide (allatostatin)-like receptor 0.019 0.3767 0.3729
Echinococcus granulosus g protein coupled receptor 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.019 0.3767 0.3767
Echinococcus granulosus neuropeptide receptor A26 0.019 0.3767 0.3767
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus granulosus tm gpcr rhodopsin 0.019 0.3767 0.3767
Echinococcus multilocularis neuropeptides capa receptor 0.019 0.3767 0.3767
Brugia malayi hypothetical protein 0.019 0.3767 0.4589
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0056 0.0714 0.0714
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0173 0.3375 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.019 0.3767 0.3767
Echinococcus granulosus GTP binding nuclear protein Ran 0.0032 0.0173 0.0173
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0056 0.0714 1
Brugia malayi Dopamine receptor protein 2 0.019 0.3767 0.4589
Schistosoma mansoni amine GPCR 0.019 0.3767 0.3729
Schistosoma mansoni biogenic amine (dopamine) receptor 0.019 0.3767 0.3729
Schistosoma mansoni hypothetical protein 0.0049 0.0559 0.0501
Echinococcus multilocularis tachykinin peptides receptor 99D 0.019 0.3767 0.3767
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0034 0.0227 0.0167
Brugia malayi larval opioid receptor 0.019 0.3767 0.4589
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0178 0.0353
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0953 0.2134
Mycobacterium ulcerans glutaminase 0.0211 0.4244 1
Echinococcus multilocularis serotonin receptor 0.019 0.3767 0.3767
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0032 0.0173 0.0173
Echinococcus granulosus survival motor neuron protein 1 0.024 0.4903 0.4903
Onchocerca volvulus 0.019 0.3767 0.4497
Echinococcus multilocularis neuropeptide FF receptor 2 0.019 0.3767 0.3767
Brugia malayi G-protein coupled receptor 0.019 0.3767 0.4589
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0953 1
Brugia malayi hypothetical protein 0.019 0.3767 0.4589
Onchocerca volvulus 0.019 0.3767 0.4497
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0562 0.0562
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0032 0.0182 0.1858
Loa Loa (eye worm) TYRA-2 protein 0.019 0.3767 0.3767
Plasmodium falciparum ataxin-2 like protein, putative 0.0043 0.0433 0.1231
Schistosoma mansoni alpha-1 adrenergic receptor 0.019 0.3767 0.3729
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0032 0.0182 0.0122
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0465 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0953 0.0953
Brugia malayi RE15519p 0.019 0.3767 0.4589
Schistosoma mansoni biogenic amine (5HT) receptor 0.019 0.3767 0.3729
Echinococcus multilocularis snurportin 1 0.0465 1 1
Echinococcus multilocularis glutamate receptor 2 0.005 0.0585 0.0585
Onchocerca volvulus 0.019 0.3767 0.4497
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0047 0.0521 0.0521
Echinococcus multilocularis g protein coupled receptor 0.019 0.3767 0.3767
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Onchocerca volvulus 0.0049 0.0559 0.0605
Schistosoma mansoni intermediate filament proteins 0.0051 0.0594 0.0537
Brugia malayi glutaminase DH11.1 0.0211 0.4244 0.5179
Echinococcus multilocularis neuropeptide receptor A26 0.019 0.3767 0.3767
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0056 0.0714 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.019 0.3767 0.4589
Brugia malayi Glutamate receptor 2 precursor 0.0042 0.0403 0.0424
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0056 0.0714 0.7314
Brugia malayi Pre-SET motif family protein 0.0049 0.0562 0.062
Echinococcus multilocularis glutamate receptor NMDA 0.0166 0.3209 0.3209
Schistosoma mansoni survival motor neuron protein 0.0049 0.0559 0.0501
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Trypanosoma brucei PAB1-binding protein , putative 0.0043 0.0433 0.5708
Schistosoma mansoni glutamate receptor NMDA 0.0042 0.0403 0.0345
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0032 0.0182 0.0545
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.005 0.0585 0.0585
Echinococcus granulosus neuropeptide receptor 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0383 0.8137 0.8137
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0056 0.0714 0.0714
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.019 0.3767 0.3767
Schistosoma mansoni hypothetical protein 0.019 0.3767 0.3729
Echinococcus multilocularis dro:myosuppressin receptor 0.019 0.3767 0.3767
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0032 0.0173 0.0506
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0061
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.019 0.3767 0.3767
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0182 0.1858
Schistosoma mansoni hypothetical protein 0.0121 0.2196 0.2148
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus multilocularis neuropeptide Y receptor 0.019 0.3767 0.3767
Echinococcus multilocularis importin subunit beta 1 0.0044 0.0434 0.0434
Echinococcus granulosus fmrfamide receptor 0.019 0.3767 0.3767
Trypanosoma brucei importin beta-1 subunit, putative 0.0044 0.0434 0.5722
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.0051 0.0594 0.0594
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0129 0.2374 0.2374
Echinococcus granulosus neuropeptide Y receptor 0.019 0.3767 0.3767
Brugia malayi neuropeptide F receptor 0.019 0.3767 0.4589
Echinococcus multilocularis glutamate receptor 2 0.0035 0.0231 0.0231
Echinococcus multilocularis rhodopsin orphan GPCR 0.019 0.3767 0.3767
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0129 0.2374 0.2374
Brugia malayi hypothetical protein 0.0028 0.0083 0.0028
Schistosoma mansoni lipoxygenase 0.009 0.1493 0.1441
Schistosoma mansoni hypothetical protein 0.0464 0.9996 0.9996
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0056 0.0714 1
Echinococcus granulosus G protein coupled receptor 139 0.019 0.3767 0.3767
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0562 0.0504
Schistosoma mansoni rhodopsin-like orphan GPCR 0.019 0.3767 0.3729
Echinococcus multilocularis beta LACTamase domain containing family member 0.0027 0.0061 0.0061
Echinococcus granulosus beta LACTamase domain containing family member 0.0027 0.0061 0.0061
Echinococcus granulosus GPCR family 2 0.0121 0.2196 0.2196
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0585 0.0585
Onchocerca volvulus Huntingtin homolog 0.021 0.4227 0.5056
Echinococcus granulosus g protein coupled receptor 0.019 0.3767 0.3767
Echinococcus granulosus neuropeptide s receptor 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.0043 0.0433 0.0433
Brugia malayi Inositol-1 0.0036 0.0263 0.0251
Plasmodium vivax SET domain protein, putative 0.0049 0.0562 0.2252
Echinococcus multilocularis nmda type glutamate receptor 0.0174 0.3391 0.3391
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.019 0.3767 0.3729
Echinococcus multilocularis g-protein coupled receptor 0.019 0.3767 0.3767
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.019 0.3767 0.3767
Loa Loa (eye worm) melatonin receptor type 1A 0.019 0.3767 0.3767
Brugia malayi intermediate filament protein 0.0051 0.0594 0.0661
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0032 0.0173 0.1725
Trypanosoma cruzi importin beta-1 subunit, putative 0.0035 0.0247 0.2859
Schistosoma mansoni amine GPCR 0.019 0.3767 0.3729
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0056 0.0714 0.0714
Schistosoma mansoni lamin 0.0051 0.0594 0.0537
Schistosoma mansoni ran 0.0032 0.0173 0.0113
Onchocerca volvulus 0.019 0.3767 0.4497
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.019 0.3767 0.3767
Echinococcus multilocularis G protein coupled receptor 139 0.019 0.3767 0.3767
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0562 0.0562
Loa Loa (eye worm) glutaminase 0.0211 0.4244 0.4244
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.019 0.3767 0.3767
Trichomonas vaginalis importin beta-1, putative 0.0035 0.0247 0.0227
Echinococcus multilocularis fmrfamide receptor 0.019 0.3767 0.3767
Onchocerca volvulus 0.0049 0.0562 0.0608
Schistosoma mansoni amine GPCR 0.019 0.3767 0.3729
Loa Loa (eye worm) hypothetical protein 0.021 0.4227 0.4227
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0585 0.0585
Schistosoma mansoni glutamate receptor AMPA 0.0042 0.0403 0.0345
Echinococcus granulosus sex peptide receptor 0.019 0.3767 0.3767
Schistosoma mansoni rhodopsin-like orphan GPCR 0.019 0.3767 0.3729
Schistosoma mansoni rhodopsin-like orphan GPCR 0.019 0.3767 0.3729
Loa Loa (eye worm) transcription factor SMAD2 0.0208 0.418 0.418
Giardia lamblia Rab geranylgeranyltransferase 0.0125 0.2286 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0034 0.0227 0.0227
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0042 0.0403 0.0403
Onchocerca volvulus 0.019 0.3767 0.4497
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0027 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Loa Loa (eye worm) neuropeptide F receptor 0.019 0.3767 0.3767
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0263 0.3103
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0121 0.2196 0.2644
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0125 0.2286 0.27
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0032 0.0182 0.1858
Echinococcus granulosus 7tm_1 domain containing protein 0.019 0.3767 0.3767
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0125 0.2286 0.27
Echinococcus granulosus geminin 0.0464 0.9996 0.9996
Trypanosoma brucei importin beta-1 subunit, putative 0.0044 0.0434 0.5722
Schistosoma mansoni rhodopsin-like orphan GPCR 0.019 0.3767 0.3729
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.019 0.3767 0.3767
Brugia malayi hypothetical protein 0.024 0.4903 0.5996
Brugia malayi RNA, U transporter 1 0.0124 0.2257 0.272
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Schistosoma mansoni biogenic amine (5HT) receptor 0.019 0.3767 0.3729
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus multilocularis rhodopsin orphan GPCR 0.019 0.3767 0.3767
Brugia malayi Dopamine receptor protein 1 0.019 0.3767 0.4589
Echinococcus multilocularis sex peptide receptor 0.019 0.3767 0.3767
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0342 0.7227 0.7227
Loa Loa (eye worm) glutaminase 2 0.0211 0.4244 0.4244
Brugia malayi hypothetical protein 0.019 0.3767 0.4589
Schistosoma mansoni glutamate receptor kainate 0.0042 0.0403 0.0345
Onchocerca volvulus 0.039 0.8302 1
Loa Loa (eye worm) glutamate receptor 1 0.0042 0.0403 0.0403
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0032 0.0182 0.0182
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0049 0.0562 0.3365
Loa Loa (eye worm) MH2 domain-containing protein 0.0208 0.418 0.418
Brugia malayi hypothetical protein 0.019 0.3767 0.4589
Trichomonas vaginalis ran, putative 0.0032 0.0173 0.0137
Schistosoma mansoni neuropeptide F-like receptor 0.019 0.3767 0.3729
Echinococcus granulosus neuropeptides capa receptor 0.019 0.3767 0.3767
Echinococcus granulosus neuropeptides capa receptor 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus granulosus rhodopsin orphan GPCR 0.019 0.3767 0.3767
Brugia malayi hypothetical protein 0.019 0.3767 0.4589
Echinococcus multilocularis glutamate receptor 2 0.0042 0.0403 0.0403
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.019 0.3767 0.3767
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0032 0.0173 0.0757
Onchocerca volvulus 0.019 0.3767 0.4497
Brugia malayi Tachykinin-like peptides receptor 99D 0.019 0.3767 0.4589
Loa Loa (eye worm) hypothetical protein 0.0261 0.5387 0.5387
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0032 0.0182 0.015
Onchocerca volvulus 0.0051 0.0594 0.0648
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus granulosus glutamate receptor NMDA 0.0166 0.3209 0.3209
Schistosoma mansoni hypothetical protein 0.019 0.3767 0.3729
Echinococcus granulosus rhodopsin orphan GPCR 0.019 0.3767 0.3767
Schistosoma mansoni neuropeptide receptor 0.019 0.3767 0.3729
Brugia malayi Latrophilin receptor protein 2 0.0121 0.2196 0.2644
Echinococcus granulosus tm gpcr rhodopsin 0.019 0.3767 0.3767
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0263 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0585 0.0585
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.019 0.3767 0.3767
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0032 0.0173 0.0139
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Brugia malayi Dopamine receptor 0.019 0.3767 0.4589
Schistosoma mansoni biogenic amine (dopamine) receptor 0.019 0.3767 0.3729
Echinococcus granulosus peptide allatostatin:somatostatin 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.0383 0.8137 0.8137
Brugia malayi GnHR receptor homolog 0.019 0.3767 0.4589
Echinococcus granulosus thyrotropin releasing hormone receptor 0.019 0.3767 0.3767
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0953 0.0953
Leishmania major importin beta-1 subunit, putative 0.0035 0.0247 0.2091
Echinococcus granulosus orexin receptor type 2 0.019 0.3767 0.3767
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0263 0.0484
Schistosoma mansoni inositol monophosphatase 0.0036 0.0263 0.0204
Schistosoma mansoni hypothetical protein 0.0121 0.2196 0.2148
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Brugia malayi latrophilin 2 splice variant baaae 0.0261 0.5387 0.6595
Schistosoma mansoni biogenic amine receptor 0.019 0.3767 0.3729
Brugia malayi G protein-coupled receptor 0.019 0.3767 0.4589
Echinococcus multilocularis neuropeptide Y receptor 0.019 0.3767 0.3767
Plasmodium vivax ataxin-2 like protein, putative 0.0043 0.0433 0.1675
Onchocerca volvulus 0.019 0.3767 0.4497
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0125 0.2286 0.2286
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Schistosoma mansoni histamine h1 receptor 0.019 0.3767 0.3729
Echinococcus granulosus tachykinin peptides receptor 99D 0.019 0.3767 0.3767
Brugia malayi Serotonin/octopamine receptor family protein 7 0.019 0.3767 0.4589
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0125 0.2286 1
Echinococcus multilocularis g protein coupled receptor 0.019 0.3767 0.3767
Echinococcus granulosus rhodopsin orphan GPCR 0.019 0.3767 0.3767
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0383 0.8137 1
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0032 0.0182 0.0041
Onchocerca volvulus 0.0051 0.0594 0.0648
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0027 0.0061 0.0061
Schistosoma mansoni growth hormone secretagogue receptor 0.019 0.3767 0.3729
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Brugia malayi Serotonin receptor 0.019 0.3767 0.4589
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.4903 0.4903
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0032 0.0182 0.1858
Brugia malayi AKH receptor 0.019 0.3767 0.4589
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0032 0.0173 0.1725
Loa Loa (eye worm) neuropeptide F receptor 0.019 0.3767 0.3767
Loa Loa (eye worm) beta-lactamase 0.0027 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.019 0.3767 0.4497
Echinococcus granulosus neuropeptide Y receptor 0.019 0.3767 0.3767
Entamoeba histolytica hypothetical protein 0.0035 0.0247 0.0351
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0182 0.1858
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0032 0.0182 0.1858
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0061
Brugia malayi gonadotropin-releasing hormone receptor 2 0.019 0.3767 0.4589
Echinococcus multilocularis allatostatin A receptor 0.019 0.3767 0.3767
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0562 0.0504
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus granulosus neuropeptide receptor 0.019 0.3767 0.3767
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0263 0.3103
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0953 0.2134
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0032 0.0182 0.0041
Loa Loa (eye worm) follicle stimulating hormone receptor 0.019 0.3767 0.3767
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0056 0.0714 0.0657
Brugia malayi hypothetical protein 0.019 0.3767 0.4589
Brugia malayi hypothetical protein 0.019 0.3767 0.4589
Echinococcus granulosus serotonin receptor 0.019 0.3767 0.3767
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.019 0.3767 0.3767
Echinococcus granulosus tm gpcr rhodopsin 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0061
Brugia malayi Serotonin receptor 0.019 0.3767 0.4589
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.021 0.4227 0.4227
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0125 0.2286 0.2755
Trypanosoma cruzi PAB1-binding protein , putative 0.0043 0.0433 0.5708
Schistosoma mansoni amine GPCR 0.019 0.3767 0.3729
Echinococcus multilocularis rhodopsin orphan GPCR 0.019 0.3767 0.3767
Schistosoma mansoni hypothetical protein 0.019 0.3767 0.3729
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0056 0.0714 0.2558
Schistosoma mansoni myosin xvIII 0.019 0.3767 0.3729
Echinococcus granulosus alpha 1A adrenergic receptor 0.019 0.3767 0.3767
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0056 0.0714 0.0714
Schistosoma mansoni neuropeptide receptor 0.019 0.3767 0.3729
Echinococcus granulosus rhodopsin orphan GPCR 0.019 0.3767 0.3767
Loa Loa (eye worm) hypothetical protein 0.005 0.0573 0.0573
Schistosoma mansoni hypothetical protein 0.019 0.3767 0.3729
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Leishmania major hypothetical protein, conserved 0.0043 0.0433 0.4175
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0061
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.019 0.3767 0.3767
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0125 0.2286 0.27
Plasmodium falciparum importin beta, putative 0.0044 0.0434 0.1236
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0035 0.0247 0.0227
Onchocerca volvulus 0.019 0.3767 0.4497
Echinococcus multilocularis rhodopsin orphan GPCR 0.019 0.3767 0.3767
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0263 0.2269
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0032 0.0182 0.0182
Brugia malayi putative neuropeptide receptor 0.019 0.3767 0.4589
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.005 0.0585 0.0585
Onchocerca volvulus 0.0032 0.0182 0.0147
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus multilocularis rhodopsin orphan GPCR 0.019 0.3767 0.3767
Onchocerca volvulus 0.019 0.3767 0.4497
Brugia malayi sulfakinin receptor protein 0.019 0.3767 0.4589
Toxoplasma gondii HEAT repeat-containing protein 0.0044 0.0434 0.251
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0035 0.0247 0.0227
Loa Loa (eye worm) hypothetical protein 0.019 0.3767 0.3767
Echinococcus granulosus glutamate receptor 2 0.005 0.0585 0.0585
Echinococcus granulosus g-protein coupled receptor 0.019 0.3767 0.3767
Echinococcus granulosus rhodopsin orphan GPCR 0.019 0.3767 0.3767

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 3.3 uM Activated partial thromboplastin time (APTT) was determined by the influence of the compound on doubling of a human clotting time assay ChEMBL. 9934475
Activity (functional) = 3.3 uM Activated partial thromboplastin time (APTT) was determined by the influence of the compound on doubling of a human clotting time assay ChEMBL. 9934475
AUC (ADMET) = 2 Area under curve(carotid artery) was determined by the availability of the compound in blood ChEMBL. 9934475
AUC (ADMET) = 43 Area under curve(portal vein) was determined by the availability of the compound in blood ChEMBL. 9934475
Ki (binding) = 47 nM In vitro binding affinity for human thrombin. ChEMBL. 9934475
Ki (binding) = 47 nM In vitro binding affinity for human thrombin. ChEMBL. 9934475

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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