Detailed information for compound 209644

Basic information

Technical information
  • TDR Targets ID: 209644
  • Name: 1-(4-chlorophenyl)-N-[4-[4-[(4-chlorophenyl)m ethylideneamino]phenyl]disulfanylphenyl]metha nimine
  • MW: 493.471 | Formula: C26H18Cl2N2S2
  • H donors: 0 H acceptors: 0 LogP: 7.88 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C=Nc1ccc(cc1)SSc1ccc(cc1)N=Cc1ccc(cc1)Cl
  • InChi: 1S/C26H18Cl2N2S2/c27-21-5-1-19(2-6-21)17-29-23-9-13-25(14-10-23)31-32-26-15-11-24(12-16-26)30-18-20-3-7-22(28)8-4-20/h1-18H
  • InChiKey: JPSLIIDRSWXSFJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-chlorophenyl)-N-[4-[4-[(4-chlorophenyl)methyleneamino]phenyl]disulfanylphenyl]methanimine
  • (4-chlorobenzylidene)-[4-[4-[(4-chlorobenzylidene)amino]phenyl]disulfanylphenyl]amine
  • NSC677548
  • 4,4'-Dithiobis{N-[(1E)-(4-chlorophenyl)methylene]aniline}-[(1E)-(4-chlorophenyl)methylene]{4-[(4-{[(1E)-(4-chlorophenyl)methylene]amino}phenyl)dithio]phenyl}amine
  • AIDS-032790
  • AIDS032790

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum cysteine repeat modular protein 1 0.0318 0.3352 1
Brugia malayi PAN domain containing protein 0.0075 0.0682 0.065
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0182 0.1858 0.1847
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Toxoplasma gondii microneme protein MIC4 0.0075 0.0682 0.0915
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0407 0.4325 0.4306
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Loa Loa (eye worm) PAN domain-containing protein 0.0075 0.0682 0.065
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0202 0.2076 0.2065
Brugia malayi EGF-like domain containing protein 0.0182 0.1858 0.183
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0408 0.0375
Echinococcus multilocularis fibropellin Ia 0.0182 0.1858 0.2155
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0034 0.0024
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Brugia malayi EGF-like domain containing protein 0.0182 0.1858 0.183
Echinococcus granulosus protein jagged 2 0.0182 0.1858 0.4278
Brugia malayi CXXC zinc finger family protein 0.0056 0.0475 0.0442
Brugia malayi Cadherin domain containing protein 0.0182 0.1858 0.183
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0318 0.3352 1
Echinococcus multilocularis glycoprotein Antigen 5 0.0402 0.4268 0.497
Loa Loa (eye worm) hypothetical protein 0.0202 0.2076 0.2049
Leishmania major hypothetical protein, conserved 0.0318 0.3352 0.5
Schistosoma mansoni hypothetical protein 0.0182 0.1858 0.1847
Loa Loa (eye worm) acetyltransferase 0.0141 0.1405 0.1376
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0202 0.2076 0.241
Onchocerca volvulus 0.0202 0.2076 0.1681
Toxoplasma gondii PAN domain-containing protein 0.0075 0.0682 0.0915
Brugia malayi Muscle positioning protein 4 0.0182 0.1858 0.183
Brugia malayi Trypsin-like protease protein 5 0.0202 0.2076 0.2049
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.2076 0.2065
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0202 0.2076 0.2065
Schistosoma mansoni tar DNA-binding protein 0.0253 0.2636 0.2626
Brugia malayi PAN domain containing protein 0.0075 0.0682 0.065
Echinococcus granulosus slit 2 protein 0.0182 0.1858 0.4278
Toxoplasma gondii hypothetical protein 0.0075 0.0682 0.0915
Brugia malayi EGF-like domain containing protein 0.0182 0.1858 0.183
Onchocerca volvulus 0.0075 0.0682 0.0217
Toxoplasma gondii PAN domain-containing protein 0.0075 0.0682 0.0915
Echinococcus multilocularis tissue type plasminogen activator 0.0318 0.3352 0.39
Loa Loa (eye worm) hypothetical protein 0.0075 0.0682 0.065
Schistosoma mansoni notch 0.0182 0.1858 0.1847
Onchocerca volvulus 0.0202 0.2076 0.1681
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.2076 0.2065
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Echinococcus multilocularis neurogenic locus notch protein 0.0182 0.1858 0.2155
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0034 0.0048
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.2076 0.2065
Toxoplasma gondii PAN domain-containing protein 0.0075 0.0682 0.0915
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0407 0.4325 0.4306
Loa Loa (eye worm) hypothetical protein 0.0407 0.4325 0.4306
Onchocerca volvulus 0.0075 0.0682 0.0217
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0408 0.0375
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1133 0.1103
Schistosoma mansoni hypothetical protein 0.0182 0.1858 0.1847
Toxoplasma gondii PAN domain-containing protein 0.0075 0.0682 0.0915
Loa Loa (eye worm) trypsin family protein 0.0202 0.2076 0.2049
Mycobacterium ulcerans hypothetical protein 0.0202 0.2076 0.5
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0051 0.0017
Echinococcus multilocularis neurogenic locus protein delta 0.0182 0.1858 0.2155
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0048 0.0014
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0021
Echinococcus granulosus protein jagged 1 0.0182 0.1858 0.4278
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.2076 0.2065
Echinococcus multilocularis notch 0.0182 0.1858 0.2155
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.1163 0.1151
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1405 0.1394
Toxoplasma gondii PAN/Apple domain-containing protein 0.0075 0.0682 0.0915
Brugia malayi Calcium binding EGF domain containing protein 0.0182 0.1858 0.183
Onchocerca volvulus 0.0182 0.1858 0.1452
Brugia malayi PAN domain containing protein 0.0075 0.0682 0.065
Onchocerca volvulus Arrow homolog 0.0407 0.4325 0.4042
Loa Loa (eye worm) hypothetical protein 0.0202 0.2076 0.2049
Echinococcus granulosus protein jagged 1 0.0182 0.1858 0.4278
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0202 0.2076 0.2065
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.2076 0.2065
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0034 0.0024
Echinococcus granulosus cpg binding protein 0.0059 0.051 0.1151
Brugia malayi hypothetical protein 0.0202 0.2076 0.2049
Echinococcus multilocularis neurogenic locus notch protein 0.0182 0.1858 0.2155
Echinococcus granulosus fibropellin Ia 0.0182 0.1858 0.4278
Loa Loa (eye worm) hypothetical protein 0.0924 1 1
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0407 0.4325 0.4318
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Loa Loa (eye worm) hypothetical protein 0.0407 0.4325 0.4306
Brugia malayi PAN domain containing protein 0.0075 0.0682 0.065
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0182 0.1858 0.183
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Schistosoma mansoni cpg binding protein 0.0059 0.051 0.0497
Toxoplasma gondii microneme protein MIC17C 0.0075 0.0682 0.0915
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0021
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0402 0.4268 0.426
Loa Loa (eye worm) hypothetical protein 0.005 0.0408 0.0375
Brugia malayi PAN domain containing protein 0.0075 0.0682 0.065
Loa Loa (eye worm) hypothetical protein 0.0034 0.0235 0.0202
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Schistosoma mansoni tar DNA-binding protein 0.0253 0.2636 0.2626
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Loa Loa (eye worm) hypothetical protein 0.0202 0.2076 0.2049
Onchocerca volvulus Slit protein homolog 0.0182 0.1858 0.1452
Loa Loa (eye worm) hypothetical protein 0.0924 1 1
Onchocerca volvulus 0.0182 0.1858 0.1452
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Echinococcus granulosus delta-like protein 1 0.0182 0.1858 0.4278
Schistosoma mansoni tar DNA-binding protein 0.0253 0.2636 0.2626
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0202 0.2076 0.2065
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0794 0.8573 1
Echinococcus granulosus tissue type plasminogen activator 0.0318 0.3352 0.7743
Brugia malayi Calcium binding EGF domain containing protein 0.0407 0.4325 0.4306
Loa Loa (eye worm) PAN domain-containing protein 0.0075 0.0682 0.065
Onchocerca volvulus 0.0075 0.0682 0.0217
Loa Loa (eye worm) PAN domain-containing protein 0.0075 0.0682 0.065
Schistosoma mansoni hypothetical protein 0.0318 0.3352 0.3343
Brugia malayi Fibulin-1 precursor 0.0407 0.4325 0.4306
Schistosoma mansoni tar DNA-binding protein 0.0253 0.2636 0.2626
Schistosoma mansoni hypothetical protein 0.0202 0.2076 0.2065
Echinococcus granulosus neural cadherin 0.0182 0.1858 0.4278
Giardia lamblia High cysteine protein 0.0182 0.1858 1
Schistosoma mansoni hypothetical protein 0.0182 0.1858 0.1847
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0315 1
Brugia malayi Protein kinase domain containing protein 0.0318 0.3352 0.3329
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.1062 0.1862
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Onchocerca volvulus 0.0075 0.0682 0.0217
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1133 0.1103
Echinococcus multilocularis neural cadherin 0.0182 0.1858 0.2155
Loa Loa (eye worm) TAR-binding protein 0.0253 0.2636 0.2611
Loa Loa (eye worm) hypothetical protein 0.0075 0.0682 0.065
Onchocerca volvulus 0.0924 1 1
Echinococcus multilocularis enteropeptidase 0.0402 0.4268 0.497
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0315 0.07
Onchocerca volvulus 0.0075 0.0682 0.0217
Loa Loa (eye worm) hypothetical protein 0.0318 0.3352 0.3329
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0407 0.4325 0.4306
Echinococcus multilocularis fibrillin 1 0.0407 0.4325 0.5038
Toxoplasma gondii subtilisin SUB12 0.0075 0.0682 0.0915
Onchocerca volvulus 0.0075 0.0682 0.0217
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Schistosoma mansoni notch 0.0182 0.1858 0.1847
Echinococcus multilocularis neurogenic locus notch protein 4 0.0182 0.1858 0.2155
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.2076 0.2065
Loa Loa (eye worm) hypothetical protein 0.0075 0.0682 0.065
Brugia malayi Trypsin family protein 0.0202 0.2076 0.2049
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0253 0.2636 0.2611
Brugia malayi RNA recognition motif domain containing protein 0.0253 0.2636 0.2611
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1405 0.1376
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0021
Echinococcus granulosus laminin 0.0407 0.4325 1
Brugia malayi Trypsin family protein 0.0202 0.2076 0.2049
Brugia malayi Delta serrate ligand family protein 0.0182 0.1858 0.183
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Echinococcus granulosus GPCR family 2 0.0016 0.0034 0.0048
Echinococcus granulosus glycoprotein Antigen 5 0.0402 0.4268 0.9867
Toxoplasma gondii microneme protein MIC17A 0.0075 0.0682 0.0915
Toxoplasma gondii EGF family domain-containing protein 0.0182 0.1858 0.3848
Brugia malayi Kringle domain containing protein 0.0318 0.3352 0.3329
Loa Loa (eye worm) notch protein 0.0182 0.1858 0.183
Loa Loa (eye worm) PAN domain-containing protein 0.0075 0.0682 0.065
Echinococcus granulosus neurogenic locus notch protein 4 0.0182 0.1858 0.4278
Echinococcus multilocularis GPCR, family 2 0.0016 0.0034 0.0024
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0021
Brugia malayi PAN domain containing protein 0.0075 0.0682 0.065
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0315 1
Onchocerca volvulus 0.0182 0.1858 0.1452
Schistosoma mansoni cpg binding protein 0.0059 0.051 0.0497
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Brugia malayi PAN domain containing protein 0.0075 0.0682 0.065
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0182 0.1858 0.1452
Loa Loa (eye worm) hypothetical protein 0.0407 0.4325 0.4306
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0202 0.2076 0.4783
Echinococcus granulosus tar DNA binding protein 0.0253 0.2636 0.6083
Echinococcus multilocularis neurogenic locus protein delta 0.0182 0.1858 0.2155
Brugia malayi GCC2 and GCC3 family protein 0.0182 0.1858 0.183
Echinococcus multilocularis transmembrane protease serine 3 0.0202 0.2076 0.241
Loa Loa (eye worm) hypothetical protein 0.0202 0.2076 0.2049
Loa Loa (eye worm) hypothetical protein 0.0075 0.0682 0.065
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Brugia malayi EGF-like domain containing protein 0.0182 0.1858 0.183
Brugia malayi Calcium binding EGF domain containing protein 0.0182 0.1858 0.183
Schistosoma mansoni cpg binding protein 0.0056 0.0475 0.0462
Echinococcus multilocularis protein jagged 1 0.0182 0.1858 0.2155
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Onchocerca volvulus 0.0075 0.0682 0.0217
Echinococcus granulosus enteropeptidase 0.0402 0.4268 0.9867
Brugia malayi notch-like transmembrane receptor 0.0182 0.1858 0.183
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0202 0.2076 0.241
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0924 1 1
Toxoplasma gondii kringle domain-containing protein 0.0318 0.3352 0.7573
Toxoplasma gondii hypothetical protein 0.0075 0.0682 0.0915
Echinococcus granulosus notch 0.0182 0.1858 0.4278
Onchocerca volvulus 0.0075 0.0682 0.0217
Loa Loa (eye worm) PAN domain-containing protein 0.0075 0.0682 0.065
Echinococcus granulosus Tolloid protein 1 0.0407 0.4325 1
Onchocerca volvulus 0.0722 0.7785 0.7675
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0202 0.2076 0.2049
Echinococcus granulosus Mastin 0.0402 0.4268 0.9867
Onchocerca volvulus 0.0202 0.2076 0.1681
Echinococcus granulosus neurogenic locus notch protein 0.0182 0.1858 0.4278
Toxoplasma gondii PAN domain-containing protein 0.0075 0.0682 0.0915
Brugia malayi PAN domain containing protein 0.0075 0.0682 0.065
Schistosoma mansoni notch 0.0182 0.1858 0.1847
Schistosoma mansoni notch 0.0182 0.1858 0.1847
Brugia malayi PAN domain containing protein 0.0075 0.0682 0.065
Onchocerca volvulus 0.0075 0.0682 0.0217
Loa Loa (eye worm) hypothetical protein 0.0407 0.4325 0.4306
Schistosoma mansoni hypothetical protein 0.0034 0.0235 0.0222
Echinococcus granulosus transmembrane protease serine 3 0.0202 0.2076 0.4783
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0407 0.4325 0.4306
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.2076 0.2065
Echinococcus multilocularis slit 2 protein 0.0182 0.1858 0.2155
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0051 0.0087
Echinococcus multilocularis Tolloid protein 1 0.0407 0.4325 0.5038
Echinococcus multilocularis protein jagged 2 0.0182 0.1858 0.2155
Schistosoma mansoni hypothetical protein 0.0202 0.2076 0.2065
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Echinococcus multilocularis laminin 0.0407 0.4325 0.5038
Onchocerca volvulus 0.0318 0.3352 0.302
Loa Loa (eye worm) TK/ROR protein kinase 0.0318 0.3352 0.3329
Brugia malayi RNA binding protein 0.0253 0.2636 0.2611
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0475 0.0442
Schistosoma mansoni hypothetical protein 0.0182 0.1858 0.1847
Brugia malayi EGF-like domain containing protein 0.0182 0.1858 0.183
Schistosoma mansoni egf-like domain protein 0.0407 0.4325 0.4318
Schistosoma mansoni hypothetical protein 0.0182 0.1858 0.1847
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0235 0.0202
Loa Loa (eye worm) hypothetical protein 0.0407 0.4325 0.4306
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.2076 0.2065
Brugia malayi Calcium binding EGF domain containing protein 0.0182 0.1858 0.183
Echinococcus multilocularis tar DNA binding protein 0.0253 0.2636 0.3064
Toxoplasma gondii microneme protein, putative 0.0075 0.0682 0.0915
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.2076 0.2065
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0202 0.2076 0.2065
Toxoplasma gondii PAN domain-containing protein 0.0075 0.0682 0.0915
Schistosoma mansoni tar DNA-binding protein 0.0253 0.2636 0.2626
Loa Loa (eye worm) hypothetical protein 0.0075 0.0682 0.065
Onchocerca volvulus 0.0182 0.1858 0.1452
Brugia malayi PAN domain containing protein 0.0075 0.0682 0.065
Schistosoma mansoni hypothetical protein 0.0182 0.1858 0.1847
Toxoplasma gondii calcium binding egf domain-containing protein 0.0407 0.4325 1
Echinococcus granulosus neurogenic locus notch protein 0.0182 0.1858 0.4278
Echinococcus multilocularis fat cadherin tumor suppressor 0.0182 0.1858 0.2155
Loa Loa (eye worm) hypothetical protein 0.0075 0.0682 0.065
Onchocerca volvulus 0.0182 0.1858 0.1452
Schistosoma mansoni laminin gamma-3 chain 0.0182 0.1858 0.1847
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0051 0.0044
Toxoplasma gondii microneme protein MIC17B 0.0075 0.0682 0.0915
Onchocerca volvulus 0.0202 0.2076 0.1681
Onchocerca volvulus 0.0075 0.0682 0.0217
Schistosoma mansoni cell polarity protein 0.0182 0.1858 0.1847
Brugia malayi Cadherin domain containing protein 0.0182 0.1858 0.183
Brugia malayi EGF-like domain containing protein 0.0182 0.1858 0.183
Toxoplasma gondii calcium binding egf domain-containing protein 0.0407 0.4325 1
Loa Loa (eye worm) hypothetical protein 0.0202 0.2076 0.2049
Onchocerca volvulus Putative cubilin 0.0182 0.1858 0.1452
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0924 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0318 0.3352 0.5
Echinococcus granulosus protein jagged 2 0.0182 0.1858 0.4278
Schistosoma mansoni slit 0.0182 0.1858 0.1847
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.2076 0.2065
Loa Loa (eye worm) Notch2 0.0182 0.1858 0.183
Brugia malayi MH2 domain containing protein 0.0116 0.1133 0.1103
Loa Loa (eye worm) hypothetical protein 0.0075 0.0682 0.065
Schistosoma mansoni septate junction protein 0.0182 0.1858 0.1847
Echinococcus multilocularis protein jagged 1 0.0182 0.1858 0.2155
Brugia malayi Trypsin family protein 0.0202 0.2076 0.2049
Onchocerca volvulus 0.0202 0.2076 0.1681
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1405 0.1626
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.2076 0.2065
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1362 0.3128
Loa Loa (eye worm) RNA binding protein 0.0253 0.2636 0.2611
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0075 0.0682 0.0915
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0408 0.0375
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0034 0.0048
Echinococcus multilocularis cpg binding protein 0.0059 0.051 0.058
Onchocerca volvulus Neurogenic locus notch homolog 0.0182 0.1858 0.1452
Schistosoma mansoni notch 0.0182 0.1858 0.1847
Echinococcus granulosus neurogenic locus protein delta 0.0182 0.1858 0.4278
Schistosoma mansoni notch 0.0182 0.1858 0.1847
Loa Loa (eye worm) hypothetical protein 0.0182 0.1858 0.183
Brugia malayi TAR-binding protein 0.0253 0.2636 0.2611
Schistosoma mansoni hypothetical protein 0.0182 0.1858 0.1847
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0277 0.5
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0202 0.2076 0.4783
Brugia malayi EGF-like domain containing protein 0.0182 0.1858 0.183
Onchocerca volvulus 0.0075 0.0682 0.0217
Echinococcus multilocularis Mastin 0.0402 0.4268 0.497

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Inhibition of HIV-1 replication in human T-cell by using XTT assay; Inactive ChEMBL. 8809151
IC50 (functional) = 23.4 Inhibition of HIV-1 replication in a proliferating human T-cell line assayed using an XTT assay. ChEMBL. 8809151

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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