Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-2 | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Tolloid protein 1 | 0.01 | 0.5811 | 0.5811 |
Schistosoma mansoni | egf-like domain protein | 0.0029 | 0.0992 | 0.0992 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0161 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0032 | 0.1213 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.0032 | 0.1213 | 0.1213 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0029 | 0.0992 | 0.8181 |
Loa Loa (eye worm) | AStacin protease | 0.0062 | 0.3267 | 0.3267 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0992 | 0.0992 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1213 | 0.1213 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1788 | 0.1788 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0992 | 0.0992 |
Onchocerca volvulus | Arrow homolog | 0.0029 | 0.0992 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0032 | 0.1213 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0029 | 0.0992 | 0.0992 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 1 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.01 | 0.5811 | 0.5811 |
Echinococcus multilocularis | serotonin receptor | 0.0161 | 1 | 1 |
Echinococcus granulosus | laminin | 0.0032 | 0.1213 | 0.1213 |
Echinococcus multilocularis | serotonin receptor | 0.0161 | 1 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.01 | 0.5811 | 0.5811 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.01 | 0.5811 | 0.5811 |
Brugia malayi | Fibulin-1 precursor | 0.0032 | 0.1213 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0032 | 0.1213 | 0.1213 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5535 | 0.5535 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0032 | 0.1213 | 0.5 |
Echinococcus multilocularis | laminin | 0.0032 | 0.1213 | 0.1213 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.1 nM | Binding affinity against Alpha-1 adrenergic receptor by displacing [3H]-prazosin radioligand in rat cortex membrane. | ChEMBL. | 12166933 |
Ki (binding) | = 1.1 nM | Binding affinity against Alpha-1 adrenergic receptor by displacing [3H]-prazosin radioligand in rat cortex membrane. | ChEMBL. | 12166933 |
Ki (binding) | = 181 nM | Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane | ChEMBL. | 12166933 |
Ki (binding) | = 181 nM | Binding affinity against 5-hydroxytryptamine 1A receptor by displacing [3H]-8-OH-DPAT radioligand in rat cortex membrane | ChEMBL. | 12166933 |
Ki (binding) | = 306 nM | Binding affinity against Alpha-2 adrenergic receptor by displacing [3H]-rauwolscine radioligand in rat cortex membrane | ChEMBL. | 12166933 |
Ki (binding) | = 306 nM | Binding affinity against Alpha-2 adrenergic receptor by displacing [3H]-rauwolscine radioligand in rat cortex membrane | ChEMBL. | 12166933 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.