TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 610.786 | Formula: C32H43FN6O3S
H donors: 4 H acceptors: 4 LogP: 4.6 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: FCCC1CCN(CC1)C(=O)[C@@H](NS(=O)(=O)c1cnccc1N[C@@H](Cc1ccccc1)CNCC)Cc1ccc(cc1)N
InChi: 1S/C32H43FN6O3S/c1-2-35-22-28(20-25-6-4-3-5-7-25)37-29-13-17-36-23-31(29)43(41,42)38-30(21-26-8-10-27(34)11-9-26)32(40)39-18-14-24(12-16-33)15-19-39/h3-11,13,17,23-24,28,30,35,38H,2,12,14-16,18-22,34H2,1H3,(H,36,37)/t28-,30-/m0/s1
InChiKey: BXWUQWZMFUCDQO-JDXGNMNLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	coagulation factor II (thrombin)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	intermediate filament protein	0.0051	0.0594	0.0594
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0263	0.0426
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Brugia malayi	Melatonin receptor type 1A	0.019	0.3767	0.4589
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0049	0.0562	0.0504
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.019	0.3767	0.4589
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.019	0.3767	0.3729
Echinococcus multilocularis	lamin dm0	0.0051	0.0594	0.0594
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0032	0.0173	0.1725
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.005	0.0585	0.0585
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.019	0.3767	0.3767
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0121	0.2196	0.2196
Schistosoma mansoni	hypothetical protein	0.0464	0.9996	0.9996
Brugia malayi	hypothetical protein	0.019	0.3767	0.4589
Echinococcus multilocularis	isocitrate dehydrogenase	0.0056	0.0714	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0121	0.2196	0.2196
Schistosoma mansoni	glutamate receptor kainate	0.0042	0.0403	0.0345
Brugia malayi	Importin beta-1 subunit	0.0044	0.0434	0.0463
Onchocerca volvulus		0.019	0.3767	0.4497
Schistosoma mansoni	glutaminase	0.0211	0.4244	0.4209
Brugia malayi	hypothetical protein	0.019	0.3767	0.4589
Echinococcus multilocularis	geminin	0.0464	0.9996	0.9996
Echinococcus multilocularis	G-protein coupled receptor, putative	0.019	0.3767	0.3767
Onchocerca volvulus		0.019	0.3767	0.4497
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus multilocularis	lamin	0.0051	0.0594	0.0594
Echinococcus granulosus	nmda type glutamate receptor	0.0174	0.3391	0.3391
Echinococcus multilocularis	neuropeptides capa receptor	0.019	0.3767	0.3767
Toxoplasma gondii	hypothetical protein	0.0093	0.1549	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0121	0.2196	0.2196
Echinococcus multilocularis	neuropeptide receptor	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Schistosoma mansoni	neuropeptide receptor	0.019	0.3767	0.3729
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.019	0.3767	0.3729
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0953	0.0898
Schistosoma mansoni	hypothetical protein	0.0121	0.2196	0.2148
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0125	0.2286	0.2286
Onchocerca volvulus		0.019	0.3767	0.4497
Trichomonas vaginalis	set domain proteins, putative	0.039	0.8302	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0049	0.0562	0.0562
Giardia lamblia	Rab geranylgeranyltransferase	0.0032	0.0182	0.0041
Onchocerca volvulus		0.019	0.3767	0.4497
Schistosoma mansoni	opsin-like receptor	0.019	0.3767	0.3729
Brugia malayi	follicle stimulating hormone receptor	0.019	0.3767	0.4589
Echinococcus granulosus	rhodopsin orphan GPCR	0.019	0.3767	0.3767
Leishmania major	GTP-binding protein, putative	0.0032	0.0173	0.1262
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0034	0.0227	0.0227
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0953	0.0898
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.019	0.3767	0.3729
Schistosoma mansoni	adenoreceptor	0.019	0.3767	0.3729
Toxoplasma gondii	hypothetical protein	0.0032	0.0182	0.0815
Brugia malayi	MH2 domain containing protein	0.0208	0.418	0.5101
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0263	0.0246
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.019	0.3767	0.3729
Loa Loa (eye worm)	hypothetical protein	0.024	0.4903	0.4903
Loa Loa (eye worm)	G-protein coupled receptor	0.019	0.3767	0.3767
Brugia malayi	ORL1-like opioid receptor	0.019	0.3767	0.4589
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.019	0.3767	0.3729
Brugia malayi	Glutamate receptor 1 precursor	0.0042	0.0403	0.0424
Echinococcus multilocularis	nmda type glutamate receptor	0.0181	0.3564	0.3564
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0032	0.0182	0.1858
Echinococcus granulosus	lamin dm0	0.0051	0.0594	0.0594
Brugia malayi	G protein-coupled receptor F59B2.13	0.019	0.3767	0.4589
Echinococcus granulosus	biogenic amine 5HT receptor	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus granulosus	allatostatin A receptor	0.019	0.3767	0.3767
Echinococcus granulosus	intermediate filament protein	0.0051	0.0594	0.0594
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.019	0.3767	0.3729
Echinococcus granulosus	survival motor neuron protein 1	0.024	0.4903	0.4903
Onchocerca volvulus		0.019	0.3767	0.4497
Echinococcus multilocularis	serotonin receptor	0.019	0.3767	0.3767
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0032	0.0173	0.0173
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0953	0.2134
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0178	0.0353
Mycobacterium ulcerans	glutaminase	0.0211	0.4244	1
Brugia malayi	larval opioid receptor	0.019	0.3767	0.4589
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.0953	0.0953
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0465	1	1
Brugia malayi	RE15519p	0.019	0.3767	0.4589
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0032	0.0182	0.0122
Echinococcus multilocularis	snurportin 1	0.0465	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.019	0.3767	0.3729
Loa Loa (eye worm)	TYRA-2 protein	0.019	0.3767	0.3767
Plasmodium falciparum	ataxin-2 like protein, putative	0.0043	0.0433	0.1231
Schistosoma mansoni	alpha-1 adrenergic receptor	0.019	0.3767	0.3729
Onchocerca volvulus		0.019	0.3767	0.4497
Brugia malayi	hypothetical protein	0.019	0.3767	0.4589
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0032	0.0182	0.1858
Echinococcus granulosus	histone lysine methyltransferase setb	0.0049	0.0562	0.0562
Brugia malayi	G-protein coupled receptor	0.019	0.3767	0.4589
Echinococcus multilocularis	neuropeptide FF receptor 2	0.019	0.3767	0.3767
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.0953	1
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus granulosus	g protein coupled receptor	0.019	0.3767	0.3767
Schistosoma mansoni	opsin-like receptor	0.019	0.3767	0.3729
Schistosoma mansoni	biogenic amine receptor	0.019	0.3767	0.3729
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.019	0.3767	0.3729
Echinococcus multilocularis	orexin receptor type 2	0.019	0.3767	0.3767
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.019	0.3767	0.3767
Brugia malayi	neuropeptide F receptor	0.019	0.3767	0.4589
Schistosoma mansoni	importin beta-1	0.0044	0.0434	0.0376
Schistosoma mansoni	lamin	0.0051	0.0594	0.0537
Brugia malayi	hypothetical protein	0.019	0.3767	0.4589
Echinococcus granulosus	dro:myosuppressin receptor	0.019	0.3767	0.3767
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0042	0.0403	0.0403
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0032	0.0182	0.0182
Brugia malayi	Pre-SET motif family protein	0.0342	0.7227	0.8873
Onchocerca volvulus	Huntingtin homolog	0.021	0.4227	0.5056
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0034	0.0227	0.0206
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.019	0.3767	0.3767
Schistosoma mansoni	hypothetical protein	0.0049	0.0559	0.0501
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0034	0.0227	0.0167
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0173	0.3375	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.019	0.3767	0.3767
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0032	0.0173	0.0173
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0056	0.0714	0.0714
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.019	0.3767	0.3729
Brugia malayi	Dopamine receptor protein 2	0.019	0.3767	0.4589
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0056	0.0714	1
Schistosoma mansoni	amine GPCR	0.019	0.3767	0.3729
Echinococcus multilocularis	neuropeptides capa receptor	0.019	0.3767	0.3767
Brugia malayi	hypothetical protein	0.019	0.3767	0.4589
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus granulosus	neuropeptide receptor A26	0.019	0.3767	0.3767
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.019	0.3767	0.3767
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.019	0.3767	0.3767
Echinococcus granulosus	tm gpcr rhodopsin	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0034	0.0227	0.0167
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.019	0.3767	0.3729
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.0562	0.0504
Schistosoma mansoni	opsin-like receptor	0.019	0.3767	0.3729
Schistosoma mansoni	neuropeptide f receptor 76f	0.019	0.3767	0.3729
Echinococcus granulosus	somatostatin receptor	0.019	0.3767	0.3767
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.019	0.3767	0.3729
Brugia malayi	Intermediate filament tail domain containing protein	0.0051	0.0594	0.0661
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0263	0.1361
Echinococcus multilocularis	serotonin receptor	0.019	0.3767	0.3767
Echinococcus granulosus	importin subunit beta 1	0.0044	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0125	0.2286	0.2286
Brugia malayi	G-protein coupled receptor	0.019	0.3767	0.4589
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.019	0.3767	0.3729
Loa Loa (eye worm)	glutamate receptor 2	0.0042	0.0403	0.0403
Brugia malayi	hypothetical protein	0.021	0.4227	0.5159
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0032	0.0173	0.0173
Schistosoma mansoni	ran	0.0032	0.0173	0.0113
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0953	0.2134
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0121	0.2196	0.2196
Brugia malayi	hypothetical protein	0.0043	0.0433	0.0461
Onchocerca volvulus		0.019	0.3767	0.4497
Plasmodium vivax	importin-beta 2, putative	0.0044	0.0434	0.1679
Toxoplasma gondii	isocitrate dehydrogenase	0.0056	0.0714	0.4386
Schistosoma mansoni	biogenic amine receptor	0.019	0.3767	0.3729
Toxoplasma gondii	isocitrate dehydrogenase	0.0056	0.0714	0.4386
Schistosoma mansoni	glutamate receptor NMDA	0.0216	0.4348	0.4314
Echinococcus multilocularis	GPCR, family 2	0.0121	0.2196	0.2196
Echinococcus granulosus	neuropeptide FF receptor 2	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Brugia malayi	putative neuropeptide receptor NPR1	0.019	0.3767	0.4589
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.019	0.3767	0.3729
Echinococcus multilocularis	rhodopsin orphan GPCR	0.019	0.3767	0.3767
Schistosoma mansoni	glutamate receptor AMPA	0.0042	0.0403	0.0345
Echinococcus granulosus	g protein coupled receptor	0.019	0.3767	0.3767
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0383	0.8137	1
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.0953	0.5997
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0056	0.0714	0.2935
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0434	0.0434
Brugia malayi	isocitrate dehydrogenase	0.0056	0.0714	0.0809
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0051	0.0594	0.0594
Onchocerca volvulus		0.019	0.3767	0.4497
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.005	0.0585	0.0585
Echinococcus multilocularis	fmrfamide receptor	0.019	0.3767	0.3767
Schistosoma mansoni	amine GPCR	0.019	0.3767	0.3729
Toxoplasma gondii	LsmAD domain-containing protein	0.0043	0.0433	0.2504
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0061	0.0061
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.019	0.3767	0.3767
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0178	1
Echinococcus multilocularis	musashi	0.0051	0.0594	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0562	0.0562
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0121	0.2196	0.2196
Echinococcus multilocularis	neuropeptide receptor	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus multilocularis	neuropeptide s receptor	0.019	0.3767	0.3767
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.019	0.3767	0.3729
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0263	0.0246
Echinococcus multilocularis	rhodopsin orphan GPCR	0.019	0.3767	0.3767
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0125	0.2286	0.2239
Echinococcus granulosus	glutamate receptor 2	0.0035	0.0231	0.0231
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0263	0.0246
Echinococcus multilocularis	rhodopsin orphan GPCR	0.019	0.3767	0.3767
Onchocerca volvulus		0.019	0.3767	0.4497
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0034	0.0227	0.0167
Echinococcus multilocularis	somatostatin receptor	0.019	0.3767	0.3767
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0032	0.0182	0.1858
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0032	0.0182	0.0182
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0121	0.2196	0.2196
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Brugia malayi	Isocitrate dehydrogenase	0.0056	0.0714	0.0809
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0032	0.0182	0.0147
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0263	0.3103
Echinococcus granulosus	nmda type glutamate receptor	0.0181	0.3564	0.3564
Echinococcus granulosus	rhodopsin orphan GPCR	0.019	0.3767	0.3767
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0032	0.0182	0.1359
Schistosoma mansoni	neuropeptide receptor	0.019	0.3767	0.3729
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.019	0.3767	0.3767
Onchocerca volvulus		0.019	0.3767	0.4497
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.019	0.3767	0.3729
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0056	0.0714	0.197
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0263	0.0204
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.005	0.0585	0.0585
Echinococcus granulosus	biogenic amine 5HT receptor	0.019	0.3767	0.3767
Schistosoma mansoni	lipoxygenase	0.0129	0.2374	0.2328
Trichomonas vaginalis	glutaminase, putative	0.0211	0.4244	0.5076
Echinococcus granulosus	hypothetical protein	0.019	0.3767	0.3767
Loa Loa (eye worm)	G-protein coupled receptor	0.019	0.3767	0.3767
Trypanosoma cruzi	PAB1-binding protein , putative	0.0043	0.0433	0.5708
Schistosoma mansoni	hypothetical protein	0.0465	1	1
Schistosoma mansoni	ATP-binding cassette transporter	0.0042	0.0403	0.0345
Echinococcus multilocularis	g protein coupled receptor	0.019	0.3767	0.3767
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.019	0.3767	0.3767
Onchocerca volvulus	Neuropeptide F receptor homolog	0.019	0.3767	0.4497
Schistosoma mansoni	hypothetical protein	0.0261	0.5387	0.5359
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0125	0.2286	0.2286
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0056	0.0714	0.0714
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.019	0.3767	0.3729
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0034	0.0227	0.0227
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.019	0.3767	0.4589
Schistosoma mansoni	hypothetical protein	0.0121	0.2196	0.2148
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0559	0.0617
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0056	0.0714	0.0714
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.019	0.3767	0.3729
Schistosoma mansoni	neuropeptide F-like receptor	0.019	0.3767	0.3729
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0093	0.1549	0.1807
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0032	0.0182	0.0182
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0034	0.0227	0.0227
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0056	0.0714	1
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0125	0.2286	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.0953	0.2694
Schistosoma mansoni	glutamate receptor kainate	0.0042	0.0403	0.0345
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0125	0.2286	1
Trypanosoma brucei	hypothetical protein, conserved	0.0032	0.0182	0.1858
Plasmodium falciparum	ataxin-2 like protein, putative	0.0043	0.0433	0.1231
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0034	0.0227	0.0227
Echinococcus granulosus	7TM GPCR rhodopsin	0.019	0.3767	0.3767
Echinococcus granulosus	lamin	0.0051	0.0594	0.0594
Loa Loa (eye worm)	inositol-1	0.0036	0.0263	0.0263
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus granulosus	tachykinin peptides receptor 99D	0.019	0.3767	0.3767
Schistosoma mansoni	histamine h1 receptor	0.019	0.3767	0.3729
Brugia malayi	G protein-coupled receptor	0.019	0.3767	0.4589
Echinococcus multilocularis	neuropeptide Y receptor	0.019	0.3767	0.3767
Plasmodium vivax	ataxin-2 like protein, putative	0.0043	0.0433	0.1675
Brugia malayi	latrophilin 2 splice variant baaae	0.0261	0.5387	0.6595
Schistosoma mansoni	biogenic amine receptor	0.019	0.3767	0.3729
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0125	0.2286	0.2286
Onchocerca volvulus		0.019	0.3767	0.4497
Echinococcus granulosus	orexin receptor type 2	0.019	0.3767	0.3767
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0263	0.0204
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0263	0.0484
Leishmania major	importin beta-1 subunit, putative	0.0035	0.0247	0.2091
Schistosoma mansoni	hypothetical protein	0.0121	0.2196	0.2148
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.019	0.3767	0.3767
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.0953	0.0953
Brugia malayi	GnHR receptor homolog	0.019	0.3767	0.4589
Loa Loa (eye worm)	beta-lactamase	0.0027	0.0061	0.0061
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0032	0.0173	0.1725
Loa Loa (eye worm)	neuropeptide F receptor	0.019	0.3767	0.3767
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.019	0.3767	0.4497
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0032	0.0182	0.1858
Echinococcus multilocularis	survival motor neuron protein 1	0.024	0.4903	0.4903
Brugia malayi	Serotonin receptor	0.019	0.3767	0.4589
Brugia malayi	AKH receptor	0.019	0.3767	0.4589
Onchocerca volvulus		0.0051	0.0594	0.0648
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0027	0.0061	0.0061
Schistosoma mansoni	growth hormone secretagogue receptor	0.019	0.3767	0.3729
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0383	0.8137	1
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0032	0.0182	0.0041
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.019	0.3767	0.4589
Echinococcus multilocularis	g protein coupled receptor	0.019	0.3767	0.3767
Echinococcus granulosus	rhodopsin orphan GPCR	0.019	0.3767	0.3767
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0125	0.2286	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.019	0.3767	0.4589
Onchocerca volvulus		0.0051	0.0594	0.0648
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.0261	0.5387	0.5387
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0032	0.0182	0.015
Onchocerca volvulus		0.019	0.3767	0.4497
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0032	0.0173	0.0757
Echinococcus granulosus	neuropeptides capa receptor	0.019	0.3767	0.3767
Trichomonas vaginalis	ran, putative	0.0032	0.0173	0.0137
Schistosoma mansoni	neuropeptide F-like receptor	0.019	0.3767	0.3729
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus granulosus	rhodopsin orphan GPCR	0.019	0.3767	0.3767
Brugia malayi	hypothetical protein	0.019	0.3767	0.4589
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.019	0.3767	0.3767
Echinococcus multilocularis	glutamate receptor 2	0.0042	0.0403	0.0403
Echinococcus granulosus	neuropeptides capa receptor	0.019	0.3767	0.3767
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0049	0.0562	0.3365
Onchocerca volvulus		0.039	0.8302	1
Loa Loa (eye worm)	glutamate receptor 1	0.0042	0.0403	0.0403
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0032	0.0182	0.0182
Brugia malayi	hypothetical protein	0.019	0.3767	0.4589
Loa Loa (eye worm)	MH2 domain-containing protein	0.0208	0.418	0.418
Brugia malayi	Dopamine receptor	0.019	0.3767	0.4589
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.019	0.3767	0.3729
Echinococcus granulosus	peptide allatostatin:somatostatin	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.0383	0.8137	0.8137
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0061	0.0061
Echinococcus granulosus	tm gpcr rhodopsin	0.019	0.3767	0.3767
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.019	0.3767	0.3767
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0032	0.0173	0.0139
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0263	0.5
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.005	0.0585	0.0585
Schistosoma mansoni	hypothetical protein	0.019	0.3767	0.3729
Echinococcus granulosus	glutamate receptor NMDA	0.0166	0.3209	0.3209
Brugia malayi	Latrophilin receptor protein 2	0.0121	0.2196	0.2644
Echinococcus granulosus	rhodopsin orphan GPCR	0.019	0.3767	0.3767
Schistosoma mansoni	neuropeptide receptor	0.019	0.3767	0.3729
Echinococcus multilocularis	rhodopsin orphan GPCR	0.019	0.3767	0.3767
Onchocerca volvulus		0.019	0.3767	0.4497
Plasmodium falciparum	importin beta, putative	0.0044	0.0434	0.1236
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0035	0.0247	0.0227
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.019	0.3767	0.3767
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0125	0.2286	0.27
Loa Loa (eye worm)	hypothetical protein	0.005	0.0573	0.0573
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Leishmania major	hypothetical protein, conserved	0.0043	0.0433	0.4175
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0061	0.0061
Schistosoma mansoni	hypothetical protein	0.019	0.3767	0.3729
Echinococcus granulosus	glutamate receptor 2	0.005	0.0585	0.0585
Echinococcus granulosus	g-protein coupled receptor	0.019	0.3767	0.3767
Echinococcus granulosus	rhodopsin orphan GPCR	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0035	0.0247	0.0227
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.005	0.0585	0.0585
Onchocerca volvulus		0.0032	0.0182	0.0147
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Brugia malayi	putative neuropeptide receptor	0.019	0.3767	0.4589
Brugia malayi	sulfakinin receptor protein	0.019	0.3767	0.4589
Toxoplasma gondii	HEAT repeat-containing protein	0.0044	0.0434	0.251
Echinococcus multilocularis	rhodopsin orphan GPCR	0.019	0.3767	0.3767
Onchocerca volvulus		0.019	0.3767	0.4497
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0032	0.0182	0.0182
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0263	0.2269
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.019	0.3767	0.3767
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0953	0.2134
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0032	0.0182	0.0041
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0056	0.0714	0.0657
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0263	0.3103
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0061	0.0061
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.019	0.3767	0.4589
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0032	0.0182	0.1858
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus granulosus	neuropeptide receptor	0.019	0.3767	0.3767
Echinococcus multilocularis	allatostatin A receptor	0.019	0.3767	0.3767
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.0562	0.0504
Entamoeba histolytica	hypothetical protein	0.0035	0.0247	0.0351
Echinococcus granulosus	neuropeptide Y receptor	0.019	0.3767	0.3767
Trypanosoma cruzi	hypothetical protein, conserved	0.0032	0.0182	0.1858
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Schistosoma mansoni	hypothetical protein	0.019	0.3767	0.3729
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0056	0.0714	0.2558
Trypanosoma cruzi	PAB1-binding protein , putative	0.0043	0.0433	0.5708
Echinococcus multilocularis	rhodopsin orphan GPCR	0.019	0.3767	0.3767
Schistosoma mansoni	amine GPCR	0.019	0.3767	0.3729
Schistosoma mansoni	neuropeptide receptor	0.019	0.3767	0.3729
Echinococcus granulosus	rhodopsin orphan GPCR	0.019	0.3767	0.3767
Echinococcus granulosus	alpha 1A adrenergic receptor	0.019	0.3767	0.3767
Schistosoma mansoni	myosin xvIII	0.019	0.3767	0.3729
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0056	0.0714	0.0714
Brugia malayi	Serotonin receptor	0.019	0.3767	0.4589
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.021	0.4227	0.4227
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0125	0.2286	0.2755
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0263	0.0263
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.019	0.3767	0.3767
Echinococcus granulosus	tm gpcr rhodopsin	0.019	0.3767	0.3767
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus granulosus	serotonin receptor	0.019	0.3767	0.3767
Brugia malayi	hypothetical protein	0.019	0.3767	0.4589
Brugia malayi	hypothetical protein	0.019	0.3767	0.4589
Echinococcus multilocularis	rhodopsin orphan GPCR	0.019	0.3767	0.3767
Brugia malayi	neuropeptide F receptor	0.019	0.3767	0.4589
Echinococcus multilocularis	glutamate receptor 2	0.0035	0.0231	0.0231
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0129	0.2374	0.2374
Echinococcus multilocularis	neuropeptide Y receptor	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Schistosoma mansoni	hypothetical protein	0.0121	0.2196	0.2148
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0594	0.0594
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0129	0.2374	0.2374
Echinococcus granulosus	neuropeptide Y receptor	0.019	0.3767	0.3767
Echinococcus granulosus	fmrfamide receptor	0.019	0.3767	0.3767
Echinococcus multilocularis	importin subunit beta 1	0.0044	0.0434	0.0434
Trypanosoma brucei	importin beta-1 subunit, putative	0.0044	0.0434	0.5722
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.019	0.3767	0.3767
Trypanosoma cruzi	hypothetical protein, conserved	0.0032	0.0182	0.1858
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0061	0.0061
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.005	0.0585	0.0585
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0027	0.0061	0.0061
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.019	0.3767	0.3729
Echinococcus granulosus	beta LACTamase domain containing family member	0.0027	0.0061	0.0061
Echinococcus granulosus	GPCR family 2	0.0121	0.2196	0.2196
Echinococcus granulosus	G protein coupled receptor 139	0.019	0.3767	0.3767
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.0562	0.0504
Schistosoma mansoni	lipoxygenase	0.009	0.1493	0.1441
Brugia malayi	hypothetical protein	0.0028	0.0083	0.0028
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0056	0.0714	1
Schistosoma mansoni	hypothetical protein	0.0464	0.9996	0.9996
Brugia malayi	Glutamate receptor 2 precursor	0.0042	0.0403	0.0424
Echinococcus multilocularis	neuropeptide receptor A26	0.019	0.3767	0.3767
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.019	0.3767	0.4589
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0056	0.0714	1
Brugia malayi	Pre-SET motif family protein	0.0049	0.0562	0.062
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0559	0.0501
Echinococcus multilocularis	glutamate receptor NMDA	0.0166	0.3209	0.3209
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0056	0.0714	0.7314
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Brugia malayi	glutaminase DH11.1	0.0211	0.4244	0.5179
Onchocerca volvulus		0.0049	0.0559	0.0605
Schistosoma mansoni	intermediate filament proteins	0.0051	0.0594	0.0537
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0047	0.0521	0.0521
Echinococcus multilocularis	g protein coupled receptor	0.019	0.3767	0.3767
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.019	0.3767	0.3767
Onchocerca volvulus		0.019	0.3767	0.4497
Echinococcus multilocularis	glutamate receptor 2	0.005	0.0585	0.0585
Echinococcus multilocularis	dro:myosuppressin receptor	0.019	0.3767	0.3767
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0032	0.0173	0.0506
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.019	0.3767	0.3767
Schistosoma mansoni	hypothetical protein	0.019	0.3767	0.3729
Echinococcus granulosus	neuropeptide receptor	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0056	0.0714	0.0714
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0383	0.8137	0.8137
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.005	0.0585	0.0585
Trypanosoma brucei	PAB1-binding protein , putative	0.0043	0.0433	0.5708
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0032	0.0182	0.0545
Schistosoma mansoni	glutamate receptor NMDA	0.0042	0.0403	0.0345
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0032	0.0182	0.1858
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0125	0.2286	0.27
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0121	0.2196	0.2644
Echinococcus granulosus	7tm_1 domain containing protein	0.019	0.3767	0.3767
Loa Loa (eye worm)	neuropeptide F receptor	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0263	0.3103
Giardia lamblia	Rab geranylgeranyltransferase	0.0125	0.2286	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0034	0.0227	0.0227
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.019	0.3767	0.3729
Loa Loa (eye worm)	transcription factor SMAD2	0.0208	0.418	0.418
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0027	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0042	0.0403	0.0403
Onchocerca volvulus		0.019	0.3767	0.4497
Echinococcus granulosus	sex peptide receptor	0.019	0.3767	0.3767
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.019	0.3767	0.3729
Schistosoma mansoni	glutamate receptor AMPA	0.0042	0.0403	0.0345
Brugia malayi	hypothetical protein	0.019	0.3767	0.4589
Schistosoma mansoni	glutamate receptor kainate	0.0042	0.0403	0.0345
Loa Loa (eye worm)	glutaminase 2	0.0211	0.4244	0.4244
Brugia malayi	Dopamine receptor protein 1	0.019	0.3767	0.4589
Echinococcus multilocularis	sex peptide receptor	0.019	0.3767	0.3767
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0342	0.7227	0.7227
Brugia malayi	RNA, U transporter 1	0.0124	0.2257	0.272
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0263	0.0263
Brugia malayi	hypothetical protein	0.024	0.4903	0.5996
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus multilocularis	rhodopsin orphan GPCR	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Schistosoma mansoni	biogenic amine (5HT) receptor	0.019	0.3767	0.3729
Echinococcus granulosus	geminin	0.0464	0.9996	0.9996
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0125	0.2286	0.27
Trypanosoma brucei	importin beta-1 subunit, putative	0.0044	0.0434	0.5722
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.019	0.3767	0.3729
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.019	0.3767	0.3767
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0032	0.0173	0.1725
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0035	0.0247	0.2859
Brugia malayi	intermediate filament protein	0.0051	0.0594	0.0661
Schistosoma mansoni	ran	0.0032	0.0173	0.0113
Schistosoma mansoni	amine GPCR	0.019	0.3767	0.3729
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0056	0.0714	0.0714
Schistosoma mansoni	lamin	0.0051	0.0594	0.0537
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.019	0.3767	0.3767
Loa Loa (eye worm)	melatonin receptor type 1A	0.019	0.3767	0.3767
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.019	0.3767	0.3729
Echinococcus multilocularis	g-protein coupled receptor	0.019	0.3767	0.3767
Brugia malayi	Inositol-1	0.0036	0.0263	0.0251
Plasmodium vivax	SET domain protein, putative	0.0049	0.0562	0.2252
Loa Loa (eye worm)	hypothetical protein	0.019	0.3767	0.3767
Echinococcus multilocularis	nmda type glutamate receptor	0.0174	0.3391	0.3391
Echinococcus granulosus	g protein coupled receptor	0.019	0.3767	0.3767
Onchocerca volvulus	Huntingtin homolog	0.021	0.4227	0.5056
Echinococcus granulosus	neuropeptide s receptor	0.019	0.3767	0.3767
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0433	0.0433
Schistosoma mansoni	amine GPCR	0.019	0.3767	0.3729
Onchocerca volvulus		0.0049	0.0562	0.0608
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.005	0.0585	0.0585
Loa Loa (eye worm)	hypothetical protein	0.021	0.4227	0.4227
Loa Loa (eye worm)	glutaminase	0.0211	0.4244	0.4244
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.019	0.3767	0.3767
Trichomonas vaginalis	importin beta-1, putative	0.0035	0.0247	0.0227
Echinococcus multilocularis	fmrfamide receptor	0.019	0.3767	0.3767
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0049	0.0562	0.0562
Onchocerca volvulus		0.019	0.3767	0.4497
Echinococcus multilocularis	G protein coupled receptor 139	0.019	0.3767	0.3767
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.019	0.3767	0.3767

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 3.2 uM	Activated partial thromboplastin time (APTT) was determined by the influence of the compound on doubling of a human clotting time assay	ChEMBL.	9934475
Activity (functional)	= 3.2 uM	Activated partial thromboplastin time (APTT) was determined by the influence of the compound on doubling of a human clotting time assay	ChEMBL.	9934475
AUC (ADMET)	= 6	Area under curve(portal vein) was determined by the availability of the compound in blood	ChEMBL.	9934475
AUC (ADMET)	= 6	Area under curve(carotid artery) was determined by the availability of the compound in blood	ChEMBL.	9934475
Ki (binding)	= 99 nM	In vitro binding affinity for human thrombin.	ChEMBL.	9934475
Ki (binding)	= 99 nM	In vitro binding affinity for human thrombin.	ChEMBL.	9934475

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL332763

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 210243