TDR Targets

Basic information

Technical information

TDR Targets ID: 210841
Name: 1-methyl-5-(phenethylamino)-5,6,7,8-tetrahydr oquinolin-2-one
MW: 282.38 | Formula: C18H22N2O
H donors: 1 H acceptors: 1 LogP: 2.06 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cn1c(=O)ccc2c1CCCC2NCCc1ccccc1
InChi: 1S/C18H22N2O/c1-20-17-9-5-8-16(15(17)10-11-18(20)21)19-13-12-14-6-3-2-4-7-14/h2-4,6-7,10-11,16,19H,5,8-9,12-13H2,1H3
InChiKey: UUEOIKHPDJSEIS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-methyl-5-(2-phenylethylamino)-5,6,7,8-tetrahydroquinolin-2-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Acetylcholinesterase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Brugia malayi	Carboxylesterase family protein	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	carboxylesterase 5A	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	carboxylesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	acetylcholinesterase 1	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma japonicum	Acetylcholinesterase 1 precursor, putative	Get druggable targets OG5_126875	All targets in OG5_126875
Brugia malayi	Carboxylesterase family protein	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma japonicum	ko:K01049 acetylcholinesterase [EC3.1.1.7], putative	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	carboxylesterase 5A	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus	Carnitine O-palmitoyltransferase 2, mitochondrial homolog	Acetylcholinesterase	614 aa	531 aa	39.7 %
Brugia malayi	Carboxylesterase family protein	Acetylcholinesterase	614 aa	573 aa	30.5 %
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	Acetylcholinesterase	614 aa	602 aa	24.3 %
Loa Loa (eye worm)	hypothetical protein	Acetylcholinesterase	614 aa	574 aa	24.0 %
Loa Loa (eye worm)	hypothetical protein	Acetylcholinesterase	614 aa	570 aa	25.4 %
Echinococcus granulosus	BC026374 protein S09 family	Acetylcholinesterase	614 aa	642 aa	34.1 %
Echinococcus multilocularis	neuroligin	Acetylcholinesterase	614 aa	496 aa	24.0 %
Echinococcus multilocularis	BC026374 protein (S09 family)	Acetylcholinesterase	614 aa	642 aa	34.0 %
Drosophila melanogaster	CG10175 gene product from transcript CG10175-RE	Acetylcholinesterase	614 aa	547 aa	32.5 %
Onchocerca volvulus	Putative nuclear protein	Acetylcholinesterase	614 aa	577 aa	40.7 %
Onchocerca volvulus		Acetylcholinesterase	614 aa	583 aa	30.7 %
Onchocerca volvulus		Acetylcholinesterase	614 aa	581 aa	27.0 %
Brugia malayi	Carboxylesterase family protein	Acetylcholinesterase	614 aa	507 aa	26.4 %
Onchocerca volvulus		Acetylcholinesterase	614 aa	632 aa	25.6 %
Onchocerca volvulus	Molybdopterin synthase catalytic subunit homolog	Acetylcholinesterase	614 aa	564 aa	29.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0015	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0212	0.0212
Brugia malayi	Cache domain containing protein	0.0072	0.0615	0.0615
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0191	0.0619
Onchocerca volvulus		0.0045	0.033	0.033
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0191	0.0191
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0019	0.0056	0.0371
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0335	0.2228
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.0941	0.2589
Plasmodium vivax	hexose transporter	0.0103	0.0941	1
Onchocerca volvulus		0.0964	1	1
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0615	0.0615
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0007	0.0011
Schistosoma mansoni	hypothetical protein	0.0084	0.0742	0.4938
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.0941	0.2589
Schistosoma mansoni	glucose transporter	0.0015	0.0007	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Brugia malayi	Carboxylesterase family protein	0.0082	0.0716	0.0716
Toxoplasma gondii	facilitative glucose transporter GT1	0.0103	0.0941	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0964	1	1
Onchocerca volvulus		0.0015	0.0007	0.0007
Schistosoma mansoni	sugar transporter	0.0015	0.0007	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0045	0.033	0.033
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0335	0.0335
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Onchocerca volvulus		0.0015	0.0007	0.0007
Onchocerca volvulus		0.0015	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0015	0.0007	0.0007
Leishmania major	glucose transporter, lmgt3	0.0032	0.0191	0.0619
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0191	0.0619
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0056	0.0163
Echinococcus multilocularis	carboxylesterase 5A	0.0082	0.0716	0.197
Brugia malayi	calpain 5	0.0019	0.0056	0.0056
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Onchocerca volvulus		0.0015	0.0007	0.0007
Loa Loa (eye worm)	acetylcholinesterase 1	0.0082	0.0716	0.0716
Echinococcus granulosus	acetylcholinesterase	0.0082	0.0716	0.197
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0191	0.0619
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0297	0.2982	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0191	0.0619
Leishmania major	glucose transporter, lmgt2	0.0032	0.0191	0.0619
Echinococcus granulosus	General substrate transporter	0.0089	0.0788	0.2169
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Trypanosoma brucei	antigen, putative	0.0019	0.0056	0.0163
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0359	0.3634	1
Echinococcus multilocularis	calpain family protein 1, d	0.0045	0.033	0.0907
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0007	0.5
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0964	1	1
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0359	0.3634	1
Brugia malayi	Sugar transporter family protein	0.0015	0.0007	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0016	0.002	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0016	0.002	0.002
Schistosoma mansoni	sugar transporter	0.0015	0.0007	0.0048
Echinococcus granulosus	solute carrier family 22	0.0015	0.0007	0.002
Echinococcus granulosus	calpain A	0.0068	0.0566	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0964	1	1
Echinococcus granulosus	acetylcholinesterase	0.0082	0.0716	0.197
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0007	0.0007
Loa Loa (eye worm)	calpain family protein 1	0.0064	0.0531	0.0531
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0007	0.0007
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.002	0.002
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0191	0.0619
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.002	0.002
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Brugia malayi	Sugar transporter family protein	0.0015	0.0007	0.0007
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.0941	0.2589
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0056	0.0163
Trypanosoma cruzi	hypothetical protein, conserved	0.0297	0.2982	1
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0191	0.0191
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.0941	0.2589
Onchocerca volvulus		0.0015	0.0007	0.0007
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0212	0.0212
Schistosoma mansoni	hypothetical protein	0.0016	0.002	0.0134
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0964	1	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0297	0.2982	0.2982
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0335	0.0335
Loa Loa (eye worm)	calpain family protein 1	0.0045	0.033	0.033
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0378	0.0378
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0039	0.0106
Echinococcus multilocularis	hypothetical protein	0.0019	0.0056	0.0154
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.0941	0.2589
Echinococcus multilocularis	calpain A	0.0068	0.0566	0.1556
Echinococcus granulosus	solute carrier family 22	0.0015	0.0007	0.002
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0064	0.0531	0.3532
Loa Loa (eye worm)	hypothetical protein	0.0045	0.033	0.033
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0056	0.0163
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Onchocerca volvulus		0.0015	0.0007	0.0007
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0007	0.002
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0079	0.0686	0.4561
Trypanosoma cruzi	hypothetical protein, conserved	0.0297	0.2982	1
Echinococcus multilocularis	GPCR, family 2	0.0016	0.002	0.0055
Echinococcus granulosus	solute carrier family 22	0.0015	0.0007	0.002
Schistosoma mansoni	calpain-7 (C02 family)	0.0019	0.0056	0.0371
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.002	0.0055
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.002	0.0055
Leishmania major	glucose transporter, lmgt1	0.0032	0.0191	0.0619
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0015	0.0007	0.0007
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0335	0.0921
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0964	1	1
Loa Loa (eye worm)	sugar transporter	0.0103	0.0941	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.0941	0.2589
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0056	0.0163
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0007	0.0048
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0056	0.0163
Brugia malayi	major facilitator superfamily protein	0.0015	0.0007	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0007	0.0007
Mycobacterium ulcerans	sugar transporter	0.0015	0.0007	0.0007
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0007	0.0007
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0191	0.0191
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0191	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Loa Loa (eye worm)	calpain 5	0.0019	0.0056	0.0056
Brugia malayi	N-terminal motif family protein	0.018	0.175	0.175
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0191	0.0619
Echinococcus multilocularis	calpain 7 (C02 family)	0.0019	0.0056	0.0154
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0007	0.0007
Brugia malayi	major facilitator superfamily protein	0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Trypanosoma cruzi	kinesin, putative	0.0019	0.0056	0.0163
Onchocerca volvulus		0.0015	0.0007	0.0007
Echinococcus granulosus	calpain 5	0.0019	0.0056	0.0154
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0007	0.002
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0964	1	1
Schistosoma mansoni	serine-rich repeat protein	0.0084	0.0742	0.4938
Onchocerca volvulus		0.0015	0.0007	0.0007
Trypanosoma cruzi	hexose transporter	0.0032	0.0191	0.0619
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0007	0.0007
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0019	0.0056	0.0163
Brugia malayi	calpain family protein 1	0.0064	0.0531	0.0531
Echinococcus multilocularis	General substrate transporter	0.0089	0.0788	0.2169
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0007	0.0007
Onchocerca volvulus		0.0015	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0034	0.0212	0.1413
Brugia malayi	calpain 7	0.0019	0.0056	0.0056
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0191	0.0619
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0019	0.0056	0.0163
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0056	0.0163
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0056	0.0163
Schistosoma mansoni	glucose transport protein	0.0103	0.0941	0.6259
Echinococcus granulosus	calpain A	0.0019	0.0056	0.0154
Echinococcus multilocularis	calpain	0.0019	0.0056	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0716	0.0716
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0082	0.0716	0.4762
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0191	0.0191
Onchocerca volvulus		0.0015	0.0007	0.0007
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0007	0.0007
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0667	0.6873	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0056	0.0163
Schistosoma mansoni	glucose transport protein	0.0103	0.0941	0.6259
Schistosoma mansoni	calpain (C02 family)	0.0019	0.0056	0.0371
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0056	0.0163
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0007	0.002
Onchocerca volvulus		0.0015	0.0007	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0007	0.0007
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0191	0.0619
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.002	0.0055
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0378	0.0378
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0964	1	1
Loa Loa (eye worm)	calpain	0.0019	0.0056	0.0056
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0191	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0191	0.0191
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Schistosoma mansoni	calpain C (C02 family)	0.0019	0.0056	0.0371
Onchocerca volvulus		0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0016	0.002	0.0134
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0378	0.0378
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.002	0.0055
Onchocerca volvulus		0.0015	0.0007	0.0007
Trypanosoma cruzi	kinesin, putative	0.0019	0.0056	0.0163
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0007	0.002
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0191	0.0619
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0007	0.0007
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0335	0.0921
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0335	0.0921
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.0941	0.0941
Schistosoma mansoni	hypothetical protein	0.0016	0.002	0.0134
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0335	0.2228
Echinococcus granulosus	calpain	0.0019	0.0056	0.0154
Echinococcus multilocularis	acetylcholinesterase	0.0082	0.0716	0.197
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0191	0.0619
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0531	0.0531
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0964	1	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0716	0.0716
Schistosoma mansoni	hypothetical protein	0.0103	0.0941	0.6259
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0191	0.0619
Echinococcus granulosus	solute carrier family 22	0.0015	0.0007	0.002
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0335	0.2228
Trypanosoma brucei	kinesin, putative	0.0019	0.0056	0.0163
Loa Loa (eye worm)	hypothetical protein	0.018	0.175	0.175
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0191	0.0619
Schistosoma mansoni	sugar transporter	0.0015	0.0007	0.0048
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0103	0.0941	0.2589
Brugia malayi	calpain family protein 1	0.0064	0.0531	0.0531
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0191	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0007	0.002
Loa Loa (eye worm)	sugar transporter	0.0015	0.0007	0.0007
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0068	0.0566	0.1556
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0056	0.0163
Onchocerca volvulus		0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0335	0.0921
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0056	0.0163
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0007	0.0007
Schistosoma mansoni	calpain-7 (C02 family)	0.0019	0.0056	0.0371
Echinococcus multilocularis	calpain 5	0.0019	0.0056	0.0154
Schistosoma mansoni	glucose transport protein	0.0103	0.0941	0.6259
Plasmodium falciparum	hexose transporter	0.0103	0.0941	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Loa Loa (eye worm)	carboxylesterase	0.0082	0.0716	0.0716
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0056	0.0163
Echinococcus multilocularis	acetylcholinesterase	0.0082	0.0716	0.197
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0007	0.002
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0157	0.1503	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0068	0.0566	0.3762
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0163	0.1573	0.433
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0068	0.0566	0.1556
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0056	0.0163
Leishmania major	kinesin, putative	0.0019	0.0056	0.0163
Loa Loa (eye worm)	hypothetical protein	0.005	0.0378	0.0378
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Onchocerca volvulus	Putative transporter	0.0015	0.0007	0.0007
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0056	0.0163
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0297	0.2982	0.2982
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Plasmodium vivax	calpain, putative	0.0019	0.0056	0.052
Echinococcus granulosus	GPCR family 2	0.0016	0.002	0.0055
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.0941	0.2589
Brugia malayi	Carboxylesterase family protein	0.0082	0.0716	0.0716
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0007	0.0007
Leishmania major	hypothetical protein, conserved	0.0297	0.2982	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0191	0.0619
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0191	0.0619
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0191	0.0191
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0007	0.002
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.018	0.175	0.175
Onchocerca volvulus		0.0015	0.0007	0.0007
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0068	0.0566	0.3762
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.002	0.002
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0056	0.0163
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0163	0.1573	0.433
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0007	0.0011
Brugia malayi	Sugar transporter family protein	0.0103	0.0941	0.0941
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0191	0.0619
Echinococcus granulosus	carboxylesterase 5A	0.0082	0.0716	0.197
Echinococcus granulosus	calpain 7 C02 family	0.0019	0.0056	0.0154
Schistosoma mansoni	sugar transporter	0.0015	0.0007	0.0048
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0964	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0056	0.0163
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0056	0.0163
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0007	0.002
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0964	1	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0964	1	1
Onchocerca volvulus		0.0015	0.0007	0.0007

Activities

Activity type	Activity value	Assay description	Source	Reference
Active dose (functional)	= 1 mg kg-1	Active dose for reversal of scopolamine dementia activity in mouse following s.c. administration.	ChEMBL.	7658452
Active dose (functional)	= 1 mg kg-1	Active dose for reversal of scopolamine dementia activity in mouse following s.c. administration.	ChEMBL.	7658452
IC50 (binding)	= 18.6 uM	Acetylcholinesterase inhibitory activity in rat striatal homogenates	ChEMBL.	7658452
IC50 (binding)	= 18.6 uM	Acetylcholinesterase inhibitory activity in rat striatal homogenates	ChEMBL.	7658452

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL121344
PubChem: 10107833

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 210841