Detailed information for compound 2138443

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 360.22 | Formula: C24H28N2O
  • H donors: 1 H acceptors: 0 LogP: 4.22 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 0
  • SMILES: CN(C1(CCC2(CC1)OCCc1c2[nH]c2c1cccc2)c1ccccc1)C
  • InChi: InChI=1S/C24H28N2O/c1-26(2)23(18-8-4-3-5-9-18)13-15-24(16-14-23)22-20(12-17-27-24)19-10-6-7-11-21(19)25-22/h3-11,25H,12-17H2,1-2H3
  • InChiKey: PICPCIFZWHBKPD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid growth factor receptor-like 1 No references
Homo sapiens opioid receptor, mu 1 No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0323 0.4303 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0111 0.1293 0.2158
Brugia malayi hypothetical protein 0.0111 0.1293 0.2332
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0066
Echinococcus granulosus cyclin dependent kinase 5 0.0039 0.0267 0.043
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0054 0.0478 0.0892
Brugia malayi CHE-14 protein 0.0038 0.0248 0.0431
Brugia malayi intermediate filament protein 0.0024 0.0054 0.0078
Echinococcus multilocularis sex peptide receptor 0.0111 0.1293 0.1283
Schistosoma mansoni hypothetical protein 0.0036 0.0229 0.0366
Brugia malayi Protein kinase domain containing protein 0.0039 0.0267 0.0465
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Echinococcus multilocularis cyclin dependent kinase 1 0.0039 0.0267 0.0256
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0408 0.5506 1
Entamoeba histolytica hypothetical protein 0.0093 0.1036 0.1745
Brugia malayi isocitrate dehydrogenase 0.0041 0.0293 0.0514
Loa Loa (eye worm) TYRA-2 protein 0.0111 0.1293 0.2332
Echinococcus multilocularis dro:myosuppressin receptor 0.0111 0.1293 0.1283
Echinococcus multilocularis neuropeptides capa receptor 0.0111 0.1293 0.1283
Echinococcus granulosus cyclins 0.0027 0.0092 0.0135
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Onchocerca volvulus 0.0043 0.0324 0.0495
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0054 0.0478 0.042
Onchocerca volvulus 0.0073 0.0747 0.1272
Echinococcus multilocularis neuropeptide s receptor 0.0111 0.1293 0.1283
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0323 0.4303 0.4355
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0103 0.0092
Brugia malayi hypothetical protein 0.0111 0.1293 0.2332
Schistosoma mansoni adenosine kinase 0.0082 0.088 0.1464
Onchocerca volvulus 0.0228 0.2943 0.53
Entamoeba histolytica cyclin, putative 0.0045 0.0357 0.0491
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0103 0.0155
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0041 0.0293 0.0282
Brugia malayi cell division control protein 2 homolog 0.0039 0.0267 0.0465
Trypanosoma brucei mitotic cyclin 6 0.0045 0.0357 0.0224
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0323 0.4303 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0054 0.0478 0.0523
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0088 0.0962 0.1607
Echinococcus granulosus peptide allatostatin:somatostatin 0.0111 0.1293 0.2158
Loa Loa (eye worm) hypothetical protein 0.0109 0.1266 0.2284
Brugia malayi hypoxia-induced factor 1 0.013 0.1555 0.2809
Schistosoma mansoni lamin 0.0024 0.0054 0.0072
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0054 0.0478 0.0917
Echinococcus multilocularis cyclins 0.0027 0.0092 0.008
Echinococcus multilocularis g protein coupled receptor 0.0111 0.1293 0.1283
Schistosoma mansoni hypothetical protein 0.0439 0.595 1
Onchocerca volvulus Alhambra homolog 0.0028 0.0103 0.009
Brugia malayi Isocitrate dehydrogenase 0.0041 0.0293 0.0514
Trichomonas vaginalis cyclins, putative 0.0045 0.0357 0.0296
Echinococcus multilocularis somatostatin receptor 0.0111 0.1293 0.1283
Echinococcus granulosus geminin 0.0439 0.595 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0088 0.0962 0.173
Echinococcus multilocularis cyclins 0.0027 0.0092 0.008
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0088 0.0962 0.1601
Brugia malayi Dopamine receptor protein 2 0.0111 0.1293 0.2332
Schistosoma mansoni cyclin B 0.0045 0.0357 0.0582
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0038 0.0245 0.0426
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0103 0.024
Echinococcus granulosus Niemann Pick C1 protein 0.0088 0.0961 0.1599
Loa Loa (eye worm) hypoxia-induced factor 1 0.013 0.1555 0.2809
Echinococcus multilocularis cyclin dependent kinase 1 0.0039 0.0267 0.0256
Loa Loa (eye worm) hypothetical protein 0.0065 0.064 0.1144
Schistosoma mansoni opsin-like receptor 0.0111 0.1293 0.2158
Echinococcus granulosus tm gpcr rhodopsin 0.0111 0.1293 0.2158
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0323 0.4303 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0111 0.1293 0.2158
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0111 0.1293 0.2158
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0124 0.1466 0.3093
Trichomonas vaginalis cyclins, putative 0.0045 0.0357 0.0296
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0323 0.4303 0.7812
Onchocerca volvulus 0.0111 0.1293 0.2272
Echinococcus multilocularis cyclin B3 1 0.0027 0.0092 0.008
Loa Loa (eye worm) hypothetical protein 0.0034 0.0196 0.0336
Echinococcus multilocularis sterol regulatory element binding protein 0.0038 0.0248 0.0237
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0408 0.5506 1
Echinococcus multilocularis g protein coupled receptor 0.0111 0.1293 0.1283
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0267 0.043
Trichomonas vaginalis cyclin B, putative 0.0045 0.0357 0.0296
Brugia malayi Cyclin, N-terminal domain containing protein 0.0027 0.0092 0.0146
Echinococcus multilocularis adenosine kinase 0.0082 0.088 0.087
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0478 0.1111
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0039 0.0267 0.062
Echinococcus multilocularis isocitrate dehydrogenase 0.0041 0.0293 0.0282
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.1293 0.2158
Echinococcus multilocularis geminin 0.0439 0.595 0.5945
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Onchocerca volvulus 0.0045 0.0357 0.0556
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0039 0.0267 0.0465
Schistosoma mansoni hypothetical protein 0.0111 0.1293 0.2158
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.1293 0.1283
Onchocerca volvulus 0.0111 0.1293 0.2272
Brugia malayi hypothetical protein 0.0065 0.064 0.1144
Entamoeba histolytica cell division protein kinase 2, putative 0.0039 0.0267 0.0323
Echinococcus granulosus Protein patched homolog 1 0.0038 0.0248 0.0398
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0054 0.0478 0.042
Trypanosoma cruzi adenosine kinase, putative 0.0082 0.088 0.1667
Giardia lamblia PHD finger protein 15 0.0028 0.0103 0.0022
Echinococcus multilocularis jumonji domain containing protein 0.0038 0.0257 0.0246
Onchocerca volvulus 0.0111 0.1293 0.2272
Trichomonas vaginalis cyclins, putative 0.0045 0.0357 0.0296
Loa Loa (eye worm) hypothetical protein 0.0141 0.1709 0.309
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.1293 0.1283
Trypanosoma brucei hypothetical protein, conserved 0.0124 0.1466 0.2971
Schistosoma mansoni amine GPCR 0.0111 0.1293 0.2158
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Toxoplasma gondii kinase, pfkB family protein 0.0082 0.088 0.2046
Echinococcus granulosus hypothetical protein 0.0111 0.1293 0.2158
Entamoeba histolytica hypothetical protein 0.0235 0.3041 0.5448
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Onchocerca volvulus 0.0111 0.1293 0.2272
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0045 0.0357 0.0224
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.1293 0.1283
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0111 0.1293 0.2332
Brugia malayi G protein-coupled receptor 0.0111 0.1293 0.2332
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.1293 0.2158
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0088 0.0962 0.0952
Schistosoma mansoni myosin xvIII 0.0111 0.1293 0.2158
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0408 0.5506 0.5592
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0089 0.098 0.1632
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0323 0.4303 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Brugia malayi hypothetical protein 0.0111 0.1293 0.2332
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.1293 0.2158
Echinococcus granulosus g protein coupled receptor 0.0111 0.1293 0.2158
Echinococcus granulosus neuropeptide s receptor 0.0111 0.1293 0.2158
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0111 0.1293 0.2158
Schistosoma mansoni hypothetical protein 0.0036 0.0229 0.0366
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0054 0.0078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.1293 0.2158
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.1293 0.2158
Trichomonas vaginalis cyclin B, putative 0.0027 0.0092 0.0023
Onchocerca volvulus 0.0111 0.1293 0.2272
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0111 0.1293 0.2332
Echinococcus multilocularis neuropeptide receptor 0.0111 0.1293 0.1283
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0111 0.1293 0.2332
Echinococcus multilocularis G protein coupled receptor 139 0.0111 0.1293 0.1283
Onchocerca volvulus 0.0111 0.1293 0.2272
Brugia malayi jmjC domain containing protein 0.0033 0.0186 0.0317
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Loa Loa (eye worm) transcription factor SMAD2 0.031 0.4107 0.7454
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Echinococcus multilocularis g protein coupled receptor 0.0111 0.1293 0.1283
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0111 0.1293 0.2332
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Schistosoma mansoni neuropeptide F-like receptor 0.0111 0.1293 0.2158
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0124 0.1466 0.3093
Brugia malayi Dopamine receptor protein 1 0.0111 0.1293 0.2332
Echinococcus multilocularis orexin receptor type 2 0.0111 0.1293 0.1283
Brugia malayi PAS domain containing protein 0.0042 0.0307 0.0539
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0088 0.0962 0.1722
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0248 0.0184
Echinococcus multilocularis neuropeptide Y receptor 0.0111 0.1293 0.1283
Echinococcus granulosus g protein coupled receptor 0.0111 0.1293 0.2158
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0103 0.0155
Echinococcus granulosus neuropeptide receptor A26 0.0111 0.1293 0.2158
Onchocerca volvulus 0.0111 0.1293 0.2272
Echinococcus granulosus cyclin dependent kinase 1 0.0039 0.0267 0.043
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0111 0.1293 0.2158
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Brugia malayi MH2 domain containing protein 0.031 0.4107 0.7454
Loa Loa (eye worm) neuropeptide F receptor 0.0111 0.1293 0.2332
Brugia malayi follicle stimulating hormone receptor 0.0111 0.1293 0.2332
Trypanosoma cruzi PAB1-binding protein , putative 0.0065 0.064 0.1081
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.1293 0.2158
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0323 0.4303 0.7779
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0111 0.1293 0.2158
Entamoeba histolytica hypothetical protein 0.0093 0.1036 0.1745
Trypanosoma cruzi cyclin, putative 0.0045 0.0357 0.0393
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0408 0.5506 0.5592
Onchocerca volvulus 0.0408 0.5506 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Brugia malayi Bromodomain containing protein 0.0028 0.0103 0.0167
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Onchocerca volvulus 0.0111 0.1293 0.2272
Brugia malayi Serotonin receptor 0.0111 0.1293 0.2332
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0111 0.1293 0.2158
Echinococcus granulosus 7tm_1 domain containing protein 0.0111 0.1293 0.2158
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0323 0.4303 0.7228
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0041 0.0293 0.0282
Trichomonas vaginalis cyclin D, putative 0.0027 0.0092 0.0023
Loa Loa (eye worm) G-protein coupled receptor 0.0111 0.1293 0.2332
Plasmodium falciparum ataxin-2 like protein, putative 0.0065 0.064 0.1301
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0111 0.1293 0.1283
Plasmodium vivax ataxin-2 like protein, putative 0.0065 0.064 0.1277
Schistosoma mansoni neuropeptide receptor 0.0111 0.1293 0.2158
Trichomonas vaginalis conserved hypothetical protein 0.071 0.9791 1
Echinococcus granulosus single minded 2 0.0031 0.0153 0.0238
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0054 0.0478 0.0467
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0054 0.0478 0.042
Onchocerca volvulus 0.0111 0.1293 0.2272
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0041 0.0293 0.0066
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Echinococcus multilocularis expressed conserved protein 0.0083 0.0885 0.0875
Loa Loa (eye worm) hypothetical protein 0.0229 0.2959 0.5365
Echinococcus multilocularis lamin 0.0024 0.0054 0.0043
Schistosoma mansoni jumonji/arid domain-containing protein 0.0033 0.0186 0.0294
Echinococcus multilocularis fmrfamide receptor 0.0111 0.1293 0.1283
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0408 0.5506 0.5592
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0034 0.0201 0.0346
Schistosoma mansoni alpha-1 adrenergic receptor 0.0111 0.1293 0.2158
Brugia malayi larval opioid receptor 0.0111 0.1293 0.2332
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0323 0.4303 1
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0267 0.0203
Echinococcus granulosus tm gpcr rhodopsin 0.0111 0.1293 0.2158
Trichomonas vaginalis cyclins, putative 0.0045 0.0357 0.0296
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0111 0.1293 0.1283
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0029 0.0128 0.0197
Schistosoma mansoni histamine h1 receptor 0.0111 0.1293 0.2158
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0111 0.1293 0.2158
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Trypanosoma cruzi cdc2-related kinase 1 0.0039 0.0267 0.0173
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.052 0.0926
Brugia malayi PHD-finger family protein 0.0028 0.0103 0.0167
Plasmodium falciparum ataxin-2 like protein, putative 0.0065 0.064 0.1301
Leishmania major hypothetical protein, conserved 0.0065 0.064 0.0924
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0111 0.1293 0.2158
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0111 0.1293 0.2158
Brugia malayi jmjC domain containing protein 0.009 0.0994 0.1788
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0088 0.0962 0.0918
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0034 0.0201 0.032
Schistosoma mansoni jumonji/arid domain-containing protein 0.0033 0.0186 0.0294
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0038 0.0248 0.0431
Echinococcus granulosus lysine specific demethylase 5A 0.0033 0.0186 0.0294
Plasmodium falciparum protein kinase 5 0.0039 0.0267 0.0416
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.1293 0.2158
Echinococcus granulosus jumonji domain containing protein 0.0038 0.0257 0.0413
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0111 0.1293 0.1283
Brugia malayi Calcitonin receptor-like protein seb-1 0.0038 0.0245 0.0426
Trichomonas vaginalis cyclin D, putative 0.0027 0.0092 0.0023
Loa Loa (eye worm) neuropeptide F receptor 0.0111 0.1293 0.2332
Brugia malayi Adenosine kinase-like 0.0082 0.088 0.1582
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0078
Toxoplasma gondii LsmAD domain-containing protein 0.0065 0.064 0.1487
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0478 0.0849
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0124 0.1466 0.3093
Echinococcus multilocularis protein patched 0.0038 0.0248 0.0237
Echinococcus multilocularis cyclins 0.0027 0.0092 0.008
Schistosoma mansoni cyclins 0.0027 0.0092 0.0135
Echinococcus granulosus alpha 1A adrenergic receptor 0.0111 0.1293 0.2158
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0111 0.1293 0.2158
Echinococcus granulosus sex peptide receptor 0.0111 0.1293 0.2158
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0111 0.1293 0.2332
Echinococcus multilocularis transfer RNA-Lys 0.0031 0.0153 0.0141
Trypanosoma cruzi hypothetical protein, conserved 0.0235 0.3041 0.6927
Loa Loa (eye worm) hypothetical protein 0.0109 0.1266 0.2284
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0478 0.0714
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0323 0.4303 0.7812
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0041 0.0293 0.0066
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0041 0.0293 0.0238
Schistosoma mansoni lamin 0.0024 0.0054 0.0072
Echinococcus multilocularis serotonin receptor 0.0111 0.1293 0.1283
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0054 0.0478 0.042
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0111 0.1293 0.2332
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0408 0.5506 0.5592
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0088 0.0962 0.0918
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.1293 0.1283
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0111 0.1293 0.1283
Schistosoma mansoni amine GPCR 0.0111 0.1293 0.2158
Echinococcus granulosus sterol regulatory element binding protein 0.0038 0.0248 0.0398
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0054 0.0478 0.0786
Schistosoma mansoni neuropeptide receptor 0.0111 0.1293 0.2158
Brugia malayi hypothetical protein 0.0111 0.1293 0.2332
Trichomonas vaginalis Sialidase-1 precursor, putative 0.071 0.9791 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0228 0.2943 0.5336
Trypanosoma cruzi adenosine kinase, putative 0.0082 0.088 0.1667
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0041 0.0293 0.0475
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0478 0.0714
Echinococcus multilocularis lamin dm0 0.0024 0.0054 0.0043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.1293 0.1283
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0111 0.1293 0.2158
Echinococcus multilocularis lysine specific demethylase 5A 0.0033 0.0186 0.0175
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0111 0.1293 0.2158
Schistosoma mansoni adenosine kinase 0.0082 0.088 0.1464
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.009 0.0994 0.0984
Brugia malayi hypothetical protein 0.0111 0.1293 0.2332
Brugia malayi latrophilin 2 splice variant baaae 0.0026 0.0076 0.0119
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0111 0.1293 0.2332
Loa Loa (eye worm) isocitrate dehydrogenase 0.0041 0.0293 0.0514
Schistosoma mansoni amine GPCR 0.0111 0.1293 0.2158
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0408 0.5506 0.5592
Echinococcus granulosus g-protein coupled receptor 0.0111 0.1293 0.2158
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0229 0.2959 0.4964
Brugia malayi AKH receptor 0.0111 0.1293 0.2332
Trichomonas vaginalis cyclin B, putative 0.0045 0.0357 0.0296
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0408 0.5506 1
Plasmodium vivax protein kinase Crk2 0.0039 0.0267 0.0389
Schistosoma mansoni biogenic amine receptor 0.0111 0.1293 0.2158
Schistosoma mansoni biogenic amine (5HT) receptor 0.0111 0.1293 0.2158
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0323 0.4303 0.4297
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0124 0.1466 0.3093
Trypanosoma cruzi cyclin, putative 0.0045 0.0357 0.0393
Plasmodium falciparum phd finger protein, putative 0.0028 0.0103 0.0028
Echinococcus granulosus cyclin B 0.0045 0.0357 0.0582
Echinococcus granulosus neuropeptides capa receptor 0.0111 0.1293 0.2158
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Schistosoma mansoni amine GPCR 0.0111 0.1293 0.2158
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.1293 0.1283
Trypanosoma cruzi cdc2-related kinase 3 0.0039 0.0267 0.0173
Schistosoma mansoni neuropeptide F-like receptor 0.0111 0.1293 0.2158
Trypanosoma brucei hypothetical protein, conserved 0.0124 0.1466 0.2971
Echinococcus granulosus expressed conserved protein 0.0083 0.0885 0.1472
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Schistosoma mansoni growth hormone secretagogue receptor 0.0111 0.1293 0.2158
Echinococcus multilocularis g-protein coupled receptor 0.0111 0.1293 0.1283
Echinococcus multilocularis cyclins 0.0027 0.0092 0.008
Trichomonas vaginalis cyclin B, putative 0.0045 0.0357 0.0296
Echinococcus multilocularis serotonin receptor 0.0111 0.1293 0.1283
Loa Loa (eye worm) hypothetical protein 0.0038 0.0253 0.0441
Loa Loa (eye worm) hypothetical protein 0.0045 0.0357 0.063
Brugia malayi neuropeptide F receptor 0.0111 0.1293 0.2332
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0229 0.2959 0.2951
Brugia malayi hypothetical protein 0.0211 0.2712 0.4915
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0111 0.1293 0.1283
Schistosoma mansoni biogenic amine receptor 0.0111 0.1293 0.2158
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0054 0.0478 0.0687
Trichomonas vaginalis cyclin A, putative 0.0045 0.0357 0.0296
Brugia malayi bHLH-PAS transcription factor 0.0031 0.0153 0.0257
Trypanosoma cruzi CYC2-like cyclin, putative 0.0045 0.0357 0.0393
Schistosoma mansoni neuropeptide receptor 0.0111 0.1293 0.2158
Onchocerca volvulus Neuropeptide F receptor homolog 0.0111 0.1293 0.2272
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0034 0.0201 0.019
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0054 0.0478 0.042
Schistosoma mansoni hypothetical protein 0.0093 0.1036 0.1726
Echinococcus granulosus allatostatin A receptor 0.0111 0.1293 0.2158
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0088 0.0962 0.1865
Echinococcus multilocularis cyclins 0.0027 0.0092 0.008
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0408 0.5506 0.5592
Brugia malayi Cyclin, N-terminal domain containing protein 0.0045 0.0357 0.063
Echinococcus multilocularis neuropeptide Y receptor 0.0111 0.1293 0.1283
Schistosoma mansoni jumonji domain containing protein 0.0072 0.073 0.1211
Brugia malayi ORL1-like opioid receptor 0.0111 0.1293 0.2332
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0088 0.0962 0.1865
Loa Loa (eye worm) hypothetical protein 0.0028 0.0103 0.0167
Loa Loa (eye worm) hypothetical protein 0.0046 0.0369 0.065
Entamoeba histolytica cell division protein kinase 2, putative 0.0039 0.0267 0.0323
Loa Loa (eye worm) hypothetical protein 0.0088 0.0961 0.1728
Brugia malayi Melatonin receptor type 1A 0.0111 0.1293 0.2332
Echinococcus multilocularis neuropeptide FF receptor 2 0.0111 0.1293 0.1283
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0111 0.1293 0.1283
Schistosoma mansoni opsin-like receptor 0.0111 0.1293 0.2158
Trypanosoma cruzi PAB1-binding protein , putative 0.0065 0.064 0.1081
Loa Loa (eye worm) MH2 domain-containing protein 0.031 0.4107 0.7454
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0088 0.0962 0.1722
Loa Loa (eye worm) hypothetical protein 0.0034 0.0196 0.0336
Brugia malayi sulfakinin receptor protein 0.0111 0.1293 0.2332
Trichomonas vaginalis cyclins, putative 0.0027 0.0092 0.0023
Schistosoma mansoni biogenic amine receptor 0.0111 0.1293 0.2158
Trichomonas vaginalis cyclin B3, putative 0.0027 0.0092 0.0023
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0408 0.5506 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0119
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Echinococcus granulosus neuropeptides capa receptor 0.0111 0.1293 0.2158
Schistosoma mansoni hypothetical protein 0.0028 0.0103 0.0155
Loa Loa (eye worm) hypothetical protein 0.0038 0.0245 0.0426
Echinococcus granulosus cyclins 0.0027 0.0092 0.0135
Echinococcus granulosus neuropeptide Y receptor 0.0111 0.1293 0.2158
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0111 0.1293 0.2332
Schistosoma mansoni survival motor neuron protein 0.0043 0.0324 0.0526
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0054 0.0478 0.0714
Loa Loa (eye worm) G-protein coupled receptor 0.0111 0.1293 0.2332
Brugia malayi hypothetical protein 0.0109 0.1266 0.2284
Schistosoma mansoni amine GPCR 0.0111 0.1293 0.2158
Brugia malayi hypothetical protein 0.0111 0.1293 0.2332
Echinococcus granulosus cyclins 0.0027 0.0092 0.0135
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0478 0.0714
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0323 0.4303 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0111 0.1293 0.1283
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0111 0.1293 0.1283
Toxoplasma gondii isocitrate dehydrogenase 0.0041 0.0293 0.0682
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Onchocerca volvulus 0.0111 0.1293 0.2272
Schistosoma mansoni hypothetical protein 0.0029 0.0128 0.0197
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.009 0.0994 0.1655
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0478 0.0849
Echinococcus granulosus orexin receptor type 2 0.0111 0.1293 0.2158
Schistosoma mansoni hypothetical protein 0.0111 0.1293 0.2158
Echinococcus multilocularis peregrin 0.0028 0.0103 0.0092
Schistosoma mansoni transcription factor LCR-F1 0.0093 0.1036 0.1726
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0092 0.0023
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Echinococcus granulosus fmrfamide receptor 0.0111 0.1293 0.2158
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0478 0.0714
Entamoeba histolytica hypothetical protein 0.0093 0.1036 0.1745
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0054 0.0478 0.042
Echinococcus granulosus G protein coupled receptor 139 0.0111 0.1293 0.2158
Echinococcus granulosus cyclins 0.0027 0.0092 0.0135
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0111 0.1293 0.2272
Brugia malayi putative neuropeptide receptor 0.0111 0.1293 0.2332
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0034 0.0201 0.0346
Leishmania major cyclin 0.0045 0.0357 0.0224
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0111 0.1293 0.1283
Schistosoma mansoni intermediate filament proteins 0.0024 0.0054 0.0072
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0323 0.4303 0.7812
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0054 0.0478 0.0467
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0088 0.0961 0.1606
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0054 0.0478 0.0786
Loa Loa (eye worm) hypothetical protein 0.0054 0.0478 0.0849
Brugia malayi hypothetical protein 0.0111 0.1293 0.2332
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0054 0.0478 0.042
Echinococcus granulosus tachykinin peptides receptor 99D 0.0111 0.1293 0.2158
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0054 0.0478 0.0786
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0054 0.0478 0.0687
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Brugia malayi G protein-coupled receptor F59B2.13 0.0111 0.1293 0.2332
Schistosoma mansoni adenoreceptor 0.0111 0.1293 0.2158
Loa Loa (eye worm) melatonin receptor type 1A 0.0111 0.1293 0.2332
Brugia malayi G-protein coupled receptor 0.0111 0.1293 0.2332
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0041 0.0293 0.0282
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0029 0.0128 0.0117
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0111 0.1293 0.2158
Echinococcus multilocularis survival motor neuron protein 1 0.0211 0.2712 0.2704
Brugia malayi GnHR receptor homolog 0.0111 0.1293 0.2332
Echinococcus multilocularis protein dispatched 1 0.0043 0.0324 0.0313
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.1293 0.2158
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0478 0.0849
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0323 0.4303 0.4355
Echinococcus granulosus survival motor neuron protein 1 0.0211 0.2712 0.4548
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0041 0.0293 0.0066
Schistosoma mansoni hypothetical protein 0.0111 0.1293 0.2158
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.1293 0.2158
Echinococcus multilocularis allatostatin A receptor 0.0111 0.1293 0.1283
Echinococcus granulosus tm gpcr rhodopsin 0.0111 0.1293 0.2158
Echinococcus granulosus serotonin receptor 0.0111 0.1293 0.2158
Echinococcus granulosus peregrin 0.0028 0.0103 0.0155
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0323 0.4303 0.7228
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0054 0.0478 0.0687
Brugia malayi Serotonin receptor 0.0111 0.1293 0.2332
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0043 0.0324 0.0569
Onchocerca volvulus 0.0111 0.1293 0.2272
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0111 0.1293 0.1283
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0111 0.1293 0.2158
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0046 0.037 0.086
Brugia malayi Tachykinin-like peptides receptor 99D 0.0111 0.1293 0.2332
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0478 0.1111
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0041 0.0293 0.0475
Loa Loa (eye worm) hypothetical protein 0.0047 0.0383 0.0676
Echinococcus multilocularis cyclins 0.0027 0.0092 0.008
Echinococcus multilocularis cyclin B 0.0045 0.0357 0.0346
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0088 0.0962 0.173
Schistosoma mansoni opsin-like receptor 0.0111 0.1293 0.2158
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0039 0.0267 0.0465
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0103 0.024
Trypanosoma brucei adenosine kinase, putative 0.0082 0.088 0.152
Brugia malayi G-protein coupled receptor 0.0111 0.1293 0.2332
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.0124 0.1466 0.2971
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.0304 0.0532
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0111 0.1293 0.1283
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.1293 0.2158
Schistosoma mansoni hypothetical protein 0.0111 0.1293 0.2158
Schistosoma mansoni cyclin B3 0.0027 0.0092 0.0135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.1293 0.2158
Echinococcus multilocularis fmrfamide receptor 0.0111 0.1293 0.1283
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0093 0.1036 0.1026
Onchocerca volvulus 0.0111 0.1293 0.2272
Brugia malayi Cyclin, N-terminal domain containing protein 0.0045 0.0357 0.063
Onchocerca volvulus 0.0111 0.1293 0.2272
Loa Loa (eye worm) hypothetical protein 0.0082 0.088 0.1582
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0041 0.0293 0.0282
Mycobacterium tuberculosis Probable enoyl-CoA hydratase EchA14 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) 0.0352 0.4709 0.8472
Schistosoma mansoni patched 1 0.0038 0.0248 0.0398
Onchocerca volvulus 0.0111 0.1293 0.2272
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0034 0.0201 0.019
Brugia malayi hypothetical protein 0.0042 0.0311 0.0545
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0041 0.0293 0.0453
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0111 0.1293 0.2332
Toxoplasma gondii isocitrate dehydrogenase 0.0041 0.0293 0.0682
Echinococcus granulosus cyclin B3 1 0.0027 0.0092 0.0135
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0054 0.0478 0.0523
Onchocerca volvulus 0.0111 0.1293 0.2272
Echinococcus multilocularis neuropeptide receptor A26 0.0111 0.1293 0.1283
Schistosoma mansoni biogenic amine (5HT) receptor 0.0111 0.1293 0.2158
Echinococcus multilocularis cyclin b3 0.0027 0.0092 0.008
Echinococcus granulosus adenosine kinase 0.0082 0.088 0.1464
Trypanosoma brucei adenosine kinase, putative 0.0082 0.088 0.152
Trypanosoma cruzi cyclin 6, putative 0.0045 0.0357 0.0393
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0039 0.0267 0.0465
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0408 0.5506 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0054 0.0478 0.042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0034 0.0201 0.032
Onchocerca volvulus 0.0111 0.1293 0.2272
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0111 0.1293 0.2158
Trypanosoma cruzi cdc2-related kinase 3 0.0039 0.0267 0.0173
Loa Loa (eye worm) hypothetical protein 0.0045 0.0357 0.063
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0478 0.0849
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0054 0.0478 0.0786
Brugia malayi putative neuropeptide receptor NPR1 0.0111 0.1293 0.2332
Echinococcus granulosus dro:myosuppressin receptor 0.0111 0.1293 0.2158
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0267 0.0203
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0111 0.1293 0.2158
Brugia malayi hypothetical protein 0.0111 0.1293 0.2332
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0267 0.043
Echinococcus granulosus neuropeptide FF receptor 2 0.0111 0.1293 0.2158
Echinococcus multilocularis neuropeptide receptor 0.0111 0.1293 0.1283
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0027 0.0092 0.0135
Echinococcus granulosus cyclin b3 0.0027 0.0092 0.0135
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.1293 0.1283
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0111 0.1293 0.1283
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0229 0.2959 0.4964
Echinococcus granulosus biogenic amine 5HT receptor 0.0111 0.1293 0.2158
Schistosoma mansoni hypothetical protein 0.0036 0.0229 0.0366
Echinococcus granulosus neuropeptide Y receptor 0.0111 0.1293 0.2158
Echinococcus multilocularis Zinc finger, PHD finger 0.0054 0.0478 0.0467
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0054 0.0478 0.0786
Echinococcus granulosus intermediate filament protein 0.0024 0.0054 0.0072
Echinococcus multilocularis cyclins 0.0027 0.0092 0.008
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0186 0.0317
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0034 0.0201 0.032
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0093 0.1036 0.1726
Trypanosoma cruzi hypothetical protein, conserved 0.0235 0.3041 0.6927
Schistosoma mansoni neuropeptide f receptor 76f 0.0111 0.1293 0.2158
Trichomonas vaginalis cyclin B, putative 0.0045 0.0357 0.0296
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.1293 0.2158
Echinococcus granulosus somatostatin receptor 0.0111 0.1293 0.2158
Giardia lamblia Kinase, CMGC CDK 0.0039 0.0267 0.0323
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0267 0.0203
Loa Loa (eye worm) cyclin domain-containing protein 0.0027 0.0092 0.0146
Brugia malayi Niemann-Pick C1 protein precursor 0.0088 0.0961 0.1728
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0041 0.0293 0.0479
Brugia malayi hypothetical protein 0.0111 0.1293 0.2332
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Echinococcus granulosus neuropeptide receptor 0.0111 0.1293 0.2158
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.1293 0.2158
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0111 0.1293 0.2332
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0111 0.1293 0.1283
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0323 0.4303 0.7812
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.1293 0.2158
Brugia malayi Pax transcription factor protein 2 0.0228 0.2943 0.5336
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0111 0.1293 0.2158
Echinococcus granulosus Niemann Pick C1 protein 0.0126 0.1497 0.2502
Schistosoma mansoni hypothetical protein 0.0439 0.595 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0323 0.4303 1
Echinococcus granulosus lamin dm0 0.0024 0.0054 0.0072
Schistosoma mansoni neuropeptide receptor 0.0111 0.1293 0.2158
Onchocerca volvulus 0.0031 0.0153 0.0181
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0041 0.0293 0.0238
Schistosoma mansoni single-minded 0.0042 0.0307 0.0498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0034 0.0201 0.032
Giardia lamblia Kinase, CMGC CDK 0.0039 0.0267 0.0323
Schistosoma mansoni hypothetical protein 0.0036 0.0229 0.0366
Entamoeba histolytica hypothetical protein 0.0054 0.0478 0.0714
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.1293 0.2158
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0027 0.0092 0.008
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0054 0.0478 0.0786
Brugia malayi Dopamine receptor 0.0111 0.1293 0.2332
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0111 0.1293 0.1283
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0088 0.0962 0.1601
Echinococcus granulosus g protein coupled receptor 0.0111 0.1293 0.2158
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Trypanosoma brucei PAB1-binding protein , putative 0.0065 0.064 0.0924
Schistosoma mansoni aryl hydrocarbon receptor 0.0042 0.0307 0.0498
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0042 0.0304 0.0392
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0054 0.0478 0.0714
Schistosoma mansoni hypothetical protein 0.0043 0.0324 0.0526
Entamoeba histolytica hypothetical protein 0.0093 0.1036 0.1745
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0042 0.0304 0.0263
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0039 0.0267 0.043
Echinococcus granulosus cyclins 0.0027 0.0092 0.0135
Echinococcus granulosus cyclin dependent kinase 0.0039 0.0267 0.043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.1293 0.1283
Brugia malayi hypothetical protein 0.0093 0.1036 0.1865
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0478 0.0714
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0408 0.5506 1
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0124 0.1466 0.3093
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0054 0.0478 0.042
Brugia malayi hypothetical protein 0.0034 0.0196 0.0336
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0034 0.0201 0.032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0111 0.1293 0.2158
Schistosoma mansoni hypothetical protein 0.0034 0.0196 0.0311
Echinococcus multilocularis Niemann Pick C1 protein 0.0088 0.0961 0.0951
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0408 0.5506 1
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0054 0.0078
Schistosoma mansoni hypothetical protein 0.0026 0.0076 0.011
Onchocerca volvulus 0.0111 0.1293 0.2272
Brugia malayi neuropeptide F receptor 0.0111 0.1293 0.2332
Loa Loa (eye worm) hypothetical protein 0.0038 0.0248 0.0431
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Brugia malayi RE15519p 0.0111 0.1293 0.2332
Echinococcus multilocularis cyclin dependent kinase 5 0.0039 0.0267 0.0256
Echinococcus multilocularis musashi 0.0024 0.0054 0.0043
Echinococcus multilocularis neuropeptides capa receptor 0.0111 0.1293 0.1283
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0038 0.0245 0.0426
Giardia lamblia G2/mitotic-specific cyclin B 0.0045 0.0357 0.0491
Echinococcus granulosus biogenic amine 5HT receptor 0.0111 0.1293 0.2158
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0103 0.0167
Trypanosoma cruzi cdc2-related kinase 1 0.0039 0.0267 0.0173
Echinococcus multilocularis Niemann Pick C1 protein 0.0126 0.1497 0.1487
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0111 0.1293 0.1283
Brugia malayi hypothetical protein 0.0141 0.1709 0.309
Loa Loa (eye worm) hypothetical protein 0.0211 0.2712 0.4915
Loa Loa (eye worm) hypothetical protein 0.0111 0.1293 0.2332
Leishmania major adenosine kinase, putative 0.0082 0.088 0.152
Echinococcus granulosus lamin 0.0024 0.0054 0.0072
Echinococcus granulosus 7TM GPCR rhodopsin 0.0111 0.1293 0.2158
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.1293 0.2158
Echinococcus granulosus neuropeptide receptor 0.0111 0.1293 0.2158
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0054 0.0078
Brugia malayi hypothetical protein 0.0111 0.1293 0.2332
Echinococcus multilocularis cyclin dependent kinase 0.0039 0.0267 0.0256

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.3 nM Binding Assay BINDINGDB. No reference
Ki (binding) = 0.6 nM Binding Assay BINDINGDB. No reference
Ki (binding) = 0.6 nM Binding Assay BINDINGDB. No reference
Ki (binding) = 1.3 nM Binding Assay BINDINGDB. No reference
Ki (binding) = 310 nM Binding Assay BINDINGDB. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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