Detailed information for compound 215273

Basic information

Technical information
  • TDR Targets ID: 215273
  • Name: (2S)-3-(4-fluorophenoxy)-2-hydroxy-2-methyl-N -[4-nitro-3-(trifluoromethyl)phenyl]propanami de
  • MW: 402.297 | Formula: C17H14F4N2O5
  • H donors: 2 H acceptors: 4 LogP: 3.15 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)OC[C@@](C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+](=O)[O-])(O)C
  • InChi: 1S/C17H14F4N2O5/c1-16(25,9-28-12-5-2-10(18)3-6-12)15(24)22-11-4-7-14(23(26)27)13(8-11)17(19,20)21/h2-8,25H,9H2,1H3,(H,22,24)/t16-/m0/s1
  • InChiKey: KJMFOTCDISOHDX-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-3-(4-fluorophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide
  • FHM
  • S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens androgen receptor Starlite/ChEMBL References
Rattus norvegicus Androgen Receptor No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0278 0.1014 0.2751
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0154 0.0528 0.1114
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0002 0.0004
Entamoeba histolytica hypothetical protein 0.0073 0.0215 0.6552
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0048 0.0132
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0035 0.0067 0.0221
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0002 0.0004
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0154 0.0528 0.1434
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0002 0.0005
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0002 0.0002
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.0276 1
Schistosoma mansoni intermediate filament proteins 0.0031 0.0048 0.0082
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0176 0.0615 0.1047
Loa Loa (eye worm) MIR domain-containing protein 0.0102 0.0327 0.0887
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0002 0.0004
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0035 0.0067 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.0512 0.1389
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0002 0.0004
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0067 0.0188 0.5735
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0035 0.0067 0.1402
Trypanosoma brucei monoglyceride lipase, putative 0.0067 0.0188 0.0814
Brugia malayi Protein kinase domain containing protein 0.0154 0.0528 0.0899
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0067 0.0188 0.5735
Echinococcus multilocularis muscleblind protein 1 0.0165 0.0571 0.0571
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0113 0.0239
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.0528 0.0899
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0089 0.0276 1
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0188 0.5735
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.0512 0.0871
Mycobacterium ulcerans hypothetical protein 0.0067 0.0188 0.6402
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0002 0.0002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0035 0.0067 0.0221
Loa Loa (eye worm) hypothetical protein 0.0964 0.3685 1
Schistosoma mansoni lamin 0.0031 0.0048 0.0082
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0002 0.0002
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0002 0.0004
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0276 1
Schistosoma mansoni hypothetical protein 0.0102 0.0327 0.0557
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0089 0.0276 0.0749
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0186 0.0653 0.1111
Mycobacterium ulcerans lysophospholipase 0.0067 0.0188 0.6402
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0006
Trichomonas vaginalis ap endonuclease, putative 0.0035 0.0067 0.1987
Brugia malayi hypothetical protein 0.0019 0.0002 0.0004
Plasmodium falciparum esterase, putative 0.0067 0.0188 0.6559
Loa Loa (eye worm) hypothetical protein 0.0115 0.0377 0.1024
Leishmania major monoglyceride lipase, putative 0.0067 0.0188 0.1224
Echinococcus granulosus muscleblind protein 0.0165 0.0571 0.1203
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0126
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0328 0.0559
Schistosoma mansoni ryanodine receptor related 0.1526 0.5876 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0004 0.0008
Echinococcus multilocularis lamin 0.0031 0.0048 0.0048
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0089 0.0276 1
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.0048 0.0649
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0467 0.1747 0.2973
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0002 0.0004
Trypanosoma cruzi monoglyceride lipase, putative 0.0067 0.0188 0.0814
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0033 0.0438
Schistosoma mansoni lamin 0.0031 0.0048 0.0082
Plasmodium vivax PST-A protein 0.0067 0.0188 0.6559
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0053 0.0136 0.0231
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0188 0.5735
Echinococcus granulosus lamin 0.0031 0.0048 0.0102
Echinococcus multilocularis expressed protein 0.0367 0.136 0.136
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0033 0.0054
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0002 0.0004
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.2574 0.2574
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.0945 0.1992
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0002 0.0005
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0156 0.7943
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0002 0.0004
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0154 0.0528 1
Echinococcus multilocularis musashi 0.0031 0.0048 0.0048
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0002 0.0006
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0002 0.0005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0035 0.0067 0.0141
Brugia malayi PXA domain containing protein 0.0019 0.0002 0.0004
Brugia malayi hypothetical protein 0.0115 0.0377 0.0642
Brugia malayi MIR domain containing protein 0.0102 0.0327 0.0557
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0048 0.0132
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0033 0.0438
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0113 0.0113
Echinococcus granulosus ryanodine receptor 44f 0.0964 0.3685 0.7767
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0035 0.0067 0.0332
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0102 0.0327 0.0557
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0002 0.0005
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0035 0.0067 0.0067
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0154 0.0528 0.0528
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0215 0.0366
Loa Loa (eye worm) hypothetical protein 0.0047 0.0113 0.0307
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0067 0.0188 0.5735
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.0276 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.0276 1
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0002 0.0004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0095 0.0298 0.0809
Onchocerca volvulus 0.0095 0.0298 0.564
Echinococcus multilocularis muscleblind protein 0.0165 0.0571 0.0571
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0276 1
Onchocerca volvulus Huntingtin homolog 0.0115 0.0377 0.7138
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0035 0.0067 0.1779
Entamoeba histolytica hypothetical protein 0.0073 0.0215 0.6552
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0002 0.0002
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0067 0.0188 0.6402
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0067 0.0188 0.5735
Entamoeba histolytica hypothetical protein 0.0027 0.0033 0.0936
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.1526 0.5876 1
Schistosoma mansoni hypothetical protein 0.0073 0.0215 0.0366
Schistosoma mansoni hypothetical protein 0.0376 0.1396 0.2375
Loa Loa (eye worm) hypothetical protein 0.0165 0.0571 0.1549
Onchocerca volvulus 0.0031 0.0048 0.0917
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0215 0.0453
Echinococcus multilocularis lamin dm0 0.0031 0.0048 0.0048
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0089 0.0276 0.0276
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0002 0.0004
Echinococcus multilocularis GPCR, family 2 0.0047 0.0113 0.0113
Brugia malayi intermediate filament protein 0.0031 0.0048 0.0082
Onchocerca volvulus 0.0053 0.0136 0.2573
Schistosoma mansoni hypothetical protein 0.0047 0.0113 0.0193
Brugia malayi cation channel family protein 0.0652 0.2472 0.4206
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0035 0.0067 0.0221
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0154 0.0528 0.0899
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0047 0.0113 0.0193
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0328 0.0559
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0327 0.0557
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.0945 0.0945
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.0328 0.0692
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0276 1
Toxoplasma gondii exonuclease III APE 0.0035 0.0067 0.1779
Echinococcus multilocularis geminin 0.0193 0.0681 0.0681
Schistosoma mansoni ap endonuclease 0.0035 0.0067 0.0113
Trichomonas vaginalis ap endonuclease, putative 0.0035 0.0067 0.1987
Brugia malayi Probable ClpP-like protease 0.0089 0.0276 0.047
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0095 0.0298 0.0507
Brugia malayi hypothetical protein 0.0073 0.0215 0.0366
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0067 0.0188 0.5735
Entamoeba histolytica hypothetical protein 0.0073 0.0215 0.6552
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0261 0.0945 0.2564
Brugia malayi PXA domain containing protein 0.0019 0.0002 0.0004
Brugia malayi hypothetical protein 0.0024 0.0021 0.0036
Echinococcus granulosus ryanodine receptor 44f 0.1236 0.4745 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0132
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0048 0.1059
Loa Loa (eye worm) hypothetical protein 0.0102 0.0327 0.0889
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0004 0.0011
Brugia malayi hypothetical protein 0.0019 0.0002 0.0004
Onchocerca volvulus Huntingtin homolog 0.0115 0.0377 0.7138
Echinococcus multilocularis stromal cell derived factor 2 0.0102 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0186 0.0653 0.1772
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.0328 0.0328
Trichomonas vaginalis mannosyltransferase 1, putative 0.0102 0.0327 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0035 0.0067 0.1987
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0004 0.0007
Echinococcus granulosus microtubule associated protein 2 0.0679 0.2574 0.5426
Mycobacterium tuberculosis Possible lysophospholipase 0.0067 0.0188 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0113 0.0239
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0006
Treponema pallidum exodeoxyribonuclease (exoA) 0.0035 0.0067 0.1402
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0004 0.0007
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0002 0.0006
Brugia malayi exodeoxyribonuclease III family protein 0.0035 0.0067 0.0113
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0002 0.0005
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0002 0.0002
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0048 0.0649
Trypanosoma brucei monoglyceride lipase, putative 0.0067 0.0188 0.0814
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0165 0.0571 0.1549
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0089 0.0276 1
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0113 0.0193
Echinococcus granulosus GPCR family 2 0.0047 0.0113 0.0239
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0156 0.0156
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0103 0.0328 0.0559
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0067 0.0188 0.5735
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0113 0.0307
Loa Loa (eye worm) hypothetical protein 0.015 0.0512 0.1389
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0002 0.0006
Schistosoma mansoni hypothetical protein 0.0193 0.0681 0.116
Echinococcus granulosus lamin dm0 0.0031 0.0048 0.0102
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0067 0.0188 0.5735
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0033 0.0438
Brugia malayi hypothetical protein 0.0261 0.0945 0.1608
Plasmodium falciparum lysophospholipase, putative 0.0067 0.0188 0.6559
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0215 0.0215
Echinococcus granulosus intermediate filament protein 0.0031 0.0048 0.0102
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0006
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0035 0.0067 0.1402
Entamoeba histolytica hypothetical protein 0.0073 0.0215 0.6552
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0002 0.0002
Echinococcus granulosus geminin 0.0193 0.0681 0.1436
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0002 0.0005
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0067 0.0188 0.5735
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0328 0.0559
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0002 0.0004
Onchocerca volvulus 0.0031 0.0048 0.0917
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.0512 0.0871
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0035 0.0067 0.1779
Schistosoma mansoni hypothetical protein 0.0047 0.0113 0.0193
Echinococcus multilocularis ryanodine receptor 44f 0.0964 0.3685 0.3685
Brugia malayi Muscleblind-like protein 0.0165 0.0571 0.0971
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0033 0.0082
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0002 0.0004
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0035 0.0067 0.0181
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.2574 0.4381
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.0328 0.0692
Echinococcus granulosus L aminoadipate semialdehyde 0.0095 0.0298 0.0628
Echinococcus multilocularis L aminoadipate semialdehyde 0.0095 0.0298 0.0298
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0048 0.1059
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0033 0.0438
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.0276 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0154 0.0528 0.1434
Onchocerca volvulus 0.0102 0.0327 0.6189
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0103 0.0328 0.0891
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0006
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0002 0.0005
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.029 0.106 0.2878
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0095 0.0298 0.0507
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.055 0.2073 1
Echinococcus multilocularis ryanodine receptor 44f 0.1236 0.4745 0.4745
Schistosoma mansoni peptidase Clp (S14 family) 0.0089 0.0276 0.047
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0048 0.0082
Schistosoma mansoni survival motor neuron protein 0.0053 0.0136 0.0231
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0089 0.0276 0.0582
Toxoplasma gondii hypothetical protein 0.0031 0.0048 0.1059
Entamoeba histolytica MIR domain protein 0.0102 0.0327 1
Schistosoma mansoni hypothetical protein 0.0193 0.0681 0.116
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0035 0.0067 0.2191
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0002 0.0004
Echinococcus granulosus expressed protein 0.0367 0.136 0.2866
Loa Loa (eye worm) hypothetical protein 0.0115 0.0377 0.1024
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0156 0.7943
Loa Loa (eye worm) ryanodine receptor 0.036 0.1332 0.3616
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0113 0.0193
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0002 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0004 0.0007
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0136 0.0231
Plasmodium falciparum lysophospholipase, putative 0.0067 0.0188 0.6559
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0002 0.0002
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0156 0.5085
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0002 0.0004
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.055 0.2073 1
Schistosoma mansoni hypothetical protein 0.0047 0.0113 0.0193
Loa Loa (eye worm) ryanodine receptor 0.057 0.215 0.5835
Echinococcus granulosus stromal cell derived factor 2 0.0102 0.0327 0.0689
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.0328 0.0328
Schistosoma mansoni ap endonuclease 0.0035 0.0067 0.0113
Leishmania major hypothetical protein, conserved 0.0374 0.1387 1
Plasmodium falciparum lysophospholipase, putative 0.0067 0.0188 0.6559
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0276 1
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0156 0.033

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 43 % Agonist activity at androgen receptor assessed as receptor transactivation at 1 nM by reporter gene assay relative to 5-alpha-dihydrotestosterone ChEMBL. 19432422
Efficacy (binding) = 43.4 % Transactivation of intact rat androgen receptor in ventral prostate cytosol at 10 nM relative to dihydrotestosterone PATENT. No reference
Ki (binding) = 2.3 nM Displacement of [3H]mibolerone from androgen receptor in intact rat ventral prostate cytosol by competitive binding assay PATENT. No reference
Ki (functional) = 6.1 nM Agonist activity at androgen receptor ChEMBL. 19432422
RBA (binding) = 26.4 % Ratio of dihydrotestosterone Ki to compound Ki for rat androgen receptor in ventral prostate cytosol relative to control PATENT. No reference
Relative binding affinity (binding) = 1.35 Binding affinity against cytosolic androgen receptor from ventral prostate of rats using [3H]-MIB competitive binding assay (relative to dihydro testosterone) ChEMBL. 15239655
Relative binding affinity (binding) = 1.35 Binding affinity against cytosolic androgen receptor from ventral prostate of rats using [3H]-MIB competitive binding assay (relative to dihydro testosterone) ChEMBL. 15239655

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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