Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | multidrug resistance protein | 0.0113 | 0.5862 | 0.5862 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0061 | 0.2824 | 0.223 |
Leishmania major | pentamidine resistance protein 1 | 0.0184 | 1 | 1 |
Brugia malayi | ABC transporter | 0.0059 | 0.27 | 0.27 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.5862 | 0.5862 |
Trichomonas vaginalis | abcb9, putative | 0.0113 | 0.5862 | 1 |
Leishmania major | p-glycoprotein e | 0.0184 | 1 | 1 |
Toxoplasma gondii | ABC transporter, putative | 0.0061 | 0.2824 | 0.223 |
Leishmania major | p-glycoprotein | 0.0113 | 0.5862 | 0.552 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.202 | 0.202 |
Mycobacterium leprae | PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER | 0.0061 | 0.2824 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0111 | 0.5739 | 0.5739 |
Mycobacterium tuberculosis | Probable drugs-transport transmembrane ATP-binding protein ABC transporter | 0.0061 | 0.2824 | 0.404 |
Plasmodium falciparum | multidrug resistance protein 1 | 0.0113 | 0.5862 | 1 |
Echinococcus multilocularis | 0.0026 | 0.0764 | 0.0764 | |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0113 | 0.5862 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0113 | 0.5862 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0113 | 0.5862 | 0.5862 |
Loa Loa (eye worm) | ABC transporter | 0.0061 | 0.2824 | 0.2824 |
Entamoeba histolytica | P-glycoprotein 6, putative | 0.0061 | 0.2824 | 0.017 |
Loa Loa (eye worm) | ABC transporter | 0.0061 | 0.2824 | 0.2824 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0054 | 0.2433 | 0.2433 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0089 | 0.4463 | 0.4463 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0113 | 0.5862 | 0.552 |
Trypanosoma brucei | multidrug resistance protein E | 0.0184 | 1 | 1 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0061 | 0.2824 | 0.5569 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2824 | 0.2824 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0059 | 0.27 | 0.2541 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0182 | 0.9876 | 0.983 |
Brugia malayi | ABC transporter family protein | 0.0061 | 0.2824 | 0.2824 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0113 | 0.5862 | 0.5862 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0113 | 0.5862 | 1 |
Plasmodium vivax | multidrug resistance protein 1, putative | 0.0113 | 0.5862 | 1 |
Schistosoma mansoni | ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) | 0.0059 | 0.27 | 0.27 |
Leishmania major | ATP-binding cassette protein subfamily B, member 3, putative | 0.0061 | 0.2824 | 0.223 |
Trypanosoma brucei | cytochrome P450, putative | 0.0089 | 0.4463 | 0.4004 |
Entamoeba histolytica | ABC transporter, putative | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 1 | 1 |
Echinococcus granulosus | 5'partial|ATP binding cassette sub family B | 0.0111 | 0.5739 | 0.5739 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0184 | 1 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0026 | 0.0764 | 0.0764 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0089 | 0.4463 | 1 |
Brugia malayi | ABC transporter family protein | 0.0113 | 0.5862 | 0.5862 |
Wolbachia endosymbiont of Brugia malayi | ABC-type protease secretion system, ATPase and permease component, AprD | 0.0061 | 0.2824 | 0.5 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0113 | 0.5862 | 0.5862 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.202 | 0.202 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0184 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0184 | 1 | 1 |
Mycobacterium ulcerans | component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD | 0.0061 | 0.2824 | 0.5569 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0043 | 0.1788 | 0.1788 |
Leishmania major | ABC-thiol transporter | 0.0184 | 1 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0113 | 0.5862 | 0.5862 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0184 | 1 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.0113 | 0.5862 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0054 | 0.2433 | 0.2433 |
Schistosoma mansoni | ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) | 0.0061 | 0.2824 | 0.2824 |
Entamoeba histolytica | P-glycoprotein-5 | 0.0113 | 0.5862 | 0.4332 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1456 | 0.1456 |
Entamoeba histolytica | P-glycoprotein 5, putative | 0.0113 | 0.5862 | 0.4332 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0184 | 1 | 1 |
Trypanosoma brucei | ABC transporter of the mitochondrion, putative | 0.0061 | 0.2824 | 0.223 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.27 | 0.27 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0061 | 0.2824 | 0.223 |
Schistosoma mansoni | multidrug resistance protein | 0.0113 | 0.5862 | 0.5862 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0113 | 0.5862 | 1 |
Mycobacterium tuberculosis | Probable transmembrane multidrug efflux pump | 0.0113 | 0.5862 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0184 | 1 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0061 | 0.2824 | 0.2824 |
Brugia malayi | ABC transporter | 0.0061 | 0.2824 | 0.2824 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0054 | 0.2433 | 0.1911 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0054 | 0.2433 | 0.2433 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0113 | 0.5862 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0184 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0184 | 1 | 1 |
Brugia malayi | multidrug resistance related protein 1 | 0.0184 | 1 | 1 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0184 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0089 | 0.4463 | 0.4004 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0184 | 1 | 1 |
Mycobacterium ulcerans | drugs-transport transmembrane ATP-binding protein ABC transporter | 0.0061 | 0.2824 | 0.5569 |
Trypanosoma cruzi | hypothetical protein | 0.0123 | 0.6447 | 0.6153 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0043 | 0.1788 | 0.1788 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0113 | 0.5862 | 0.5862 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0764 | 0.0764 |
Trypanosoma brucei | p-glycoprotein | 0.0184 | 1 | 1 |
Echinococcus multilocularis | 0.0061 | 0.2824 | 0.2824 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0089 | 0.4463 | 0.4004 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2969 | 0.2969 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0061 | 0.2824 | 0.5569 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0113 | 0.5862 | 0.5862 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0089 | 0.4463 | 0.4463 |
Trichomonas vaginalis | ABC transporter, putative | 0.0113 | 0.5862 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0113 | 0.5862 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0113 | 0.5862 | 1 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0061 | 0.2824 | 0.223 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0061 | 0.2824 | 0.223 |
Giardia lamblia | ABC transporter, putative | 0.0184 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0061 | 0.2824 | 0.2824 |
Brugia malayi | multidrug Resistance Protein family member (mrp-5), putative | 0.0061 | 0.2824 | 0.2824 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0059 | 0.27 | 0.2541 |
Loa Loa (eye worm) | multidrug resistance-associated protein | 0.0125 | 0.6571 | 0.6571 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.5862 | 0.5862 |
Leishmania major | ATP-binding cassette protein subfamily B, member 1, putative | 0.0061 | 0.2824 | 0.223 |
Brugia malayi | P-glycoprotein-like protein | 0.0061 | 0.2824 | 0.2824 |
Mycobacterium leprae | PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER | 0.0061 | 0.2824 | 1 |
Loa Loa (eye worm) | ATP-binding cassette sub-family B member 2 | 0.0113 | 0.5862 | 0.5862 |
Leishmania major | ATP-binding cassette protein subfamily C, member 8, putative | 0.0061 | 0.2824 | 0.223 |
Toxoplasma gondii | ATP-binding cassette sub-family B member 5 | 0.0061 | 0.2824 | 0.223 |
Entamoeba histolytica | hypothetical protein | 0.0184 | 1 | 1 |
Schistosoma mansoni | smdr2 | 0.0113 | 0.5862 | 0.5862 |
Trichomonas vaginalis | ABC transporter, putative | 0.0113 | 0.5862 | 1 |
Entamoeba histolytica | P-glycoprotein-2, putative | 0.0113 | 0.5862 | 0.4332 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0113 | 0.5862 | 0.5862 |
Echinococcus multilocularis | multidrug resistance associated protein 4 | 0.0123 | 0.6447 | 0.6447 |
Trichomonas vaginalis | abcb9, putative | 0.0113 | 0.5862 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0113 | 0.5862 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0113 | 0.5862 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0113 | 0.5862 | 0.5862 |
Echinococcus granulosus | multidrug resistance associated protein 4 | 0.0123 | 0.6447 | 0.6447 |
Loa Loa (eye worm) | multidrug resistance protein 3 | 0.0113 | 0.5862 | 0.5862 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0184 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0113 | 0.5862 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0184 | 1 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0113 | 0.5862 | 1 |
Brugia malayi | cytochrome P450 | 0.0026 | 0.0764 | 0.0764 |
Entamoeba histolytica | P-glyco protein 6, putative | 0.0113 | 0.5862 | 0.4332 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0113 | 0.5862 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0184 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0089 | 0.4463 | 0.4004 |
Entamoeba histolytica | P-glycoprotein 6, putative | 0.0061 | 0.2824 | 0.017 |
Echinococcus granulosus | ATP binding cassette sub family B | 0.0061 | 0.2824 | 0.2824 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0184 | 1 | 1 |
Echinococcus granulosus | ATP binding cassette sub family B | 0.0061 | 0.2824 | 0.2824 |
Schistosoma mansoni | multidrug resistance protein | 0.0059 | 0.27 | 0.27 |
Echinococcus granulosus | ATP binding cassette sub family B | 0.0059 | 0.27 | 0.27 |
Schistosoma mansoni | smdr1 | 0.0061 | 0.2824 | 0.2824 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0061 | 0.2824 | 0.5569 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0113 | 0.5862 | 1 |
Onchocerca volvulus | 0.0113 | 0.5862 | 0.5 | |
Toxoplasma gondii | ABC transporter family protein | 0.0061 | 0.2824 | 0.223 |
Brugia malayi | Cytochrome P450 family protein | 0.0089 | 0.4463 | 0.4463 |
Schistosoma mansoni | multidrug resistance protein | 0.0113 | 0.5862 | 0.5862 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0113 | 0.5862 | 1 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0113 | 0.5862 | 1 |
Brugia malayi | hypothetical protein | 0.0061 | 0.2824 | 0.2824 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0061 | 0.2824 | 0.2833 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0113 | 0.5862 | 0.5862 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0113 | 0.5862 | 0.5862 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | ABC transporter | 0.0061 | 0.2824 | 0.2824 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0089 | 0.4463 | 0.4463 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.9876 | 0.9876 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0113 | 0.5862 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0043 | 0.1788 | 0.1788 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0113 | 0.5862 | 0.5862 |
Entamoeba histolytica | P-glycoprotein-1 | 0.0113 | 0.5862 | 0.4332 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0061 | 0.2824 | 0.223 |
Trypanosoma brucei | ABC transporter, mitochondrial, putative | 0.0061 | 0.2824 | 0.223 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0113 | 0.5862 | 1 |
Brugia malayi | multidrug resistance protein 3 | 0.0113 | 0.5862 | 0.5862 |
Schistosoma mansoni | multidrug resistance protein | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 1 | 1 |
Entamoeba histolytica | P-glycoprotein-2 | 0.0113 | 0.5862 | 0.4332 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0764 | 0.0764 |
Trichomonas vaginalis | abcb9, putative | 0.0113 | 0.5862 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.0113 | 0.5862 | 1 |
Mycobacterium tuberculosis | Iron-regulated transporter IrtA | 0.0061 | 0.2824 | 0.404 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0061 | 0.2824 | 0.2824 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0184 | 1 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0113 | 0.5862 | 0.5862 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.0764 | 0.0764 |
Leishmania major | ATP-binding cassette protein subfamily B, member 2, putative | 0.0113 | 0.5862 | 0.552 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0059 | 0.27 | 0.27 |
Giardia lamblia | MRP-like ABC transporter | 0.0184 | 1 | 1 |
Trypanosoma cruzi | ABC transporter, mitochondrial, putative | 0.0061 | 0.2824 | 0.223 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0113 | 0.5862 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0061 | 0.2824 | 0.2824 |
Chlamydia trachomatis | ABC transporter ATP binding protein/permease | 0.0113 | 0.5862 | 0.5 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0059 | 0.27 | 0.2541 |
Schistosoma mansoni | cytochrome P450 | 0.0026 | 0.0764 | 0.0764 |
Wolbachia endosymbiont of Brugia malayi | ABC-type multidrug transport system, ATPase and permease component | 0.0061 | 0.2824 | 0.5 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0113 | 0.5862 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0113 | 0.5862 | 1 |
Brugia malayi | ABC transporter family protein | 0.0061 | 0.2824 | 0.2824 |
Schistosoma mansoni | multidrug resistance protein | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.0026 | 0.0764 | 0.0764 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0184 | 1 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0184 | 1 | 1 |
Brugia malayi | ABC transporter family protein | 0.0061 | 0.2824 | 0.2824 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5739 | 0.5739 |
Trichomonas vaginalis | taga, putative | 0.0113 | 0.5862 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0764 | 0.0764 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0061 | 0.2824 | 0.2824 |
Entamoeba histolytica | P-glycoprotein-2 | 0.0113 | 0.5862 | 0.4332 |
Schistosoma mansoni | multidrug resistance protein | 0.0184 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0043 | 0.1788 | 0.1788 |
Trypanosoma cruzi | ABC transporter of the mitochondrion, putative | 0.0061 | 0.2824 | 0.223 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0061 | 0.2824 | 0.2824 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0184 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0113 | 0.5862 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0089 | 0.4463 | 0.4463 |
Toxoplasma gondii | ATP-binding cassette transporter ABC.B1 | 0.0113 | 0.5862 | 0.552 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0059 | 0.27 | 0.2541 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0113 | 0.5862 | 0.5862 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0184 | 1 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0184 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0113 | 0.5862 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0113 | 0.5862 | 0.5862 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 6.11 | Inhibitory activity against human IL-1 beta converting enzyme from monocytic THP-1 cell line, activity expressed as the logarithm of the second order rate constant for inactivation | ChEMBL. | 9986707 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.