Detailed information for compound 218542

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 287.293 | Formula: C11H24Cl2N2S--
  • H donors: 2 H acceptors: 0 LogP: 3.27 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCCNCCSC1CCCCC1.[Cl-].[Cl-]
  • InChi: 1S/C11H24N2S.2ClH/c12-7-4-8-13-9-10-14-11-5-2-1-3-6-11;;/h11,13H,1-10,12H2;2*1H/p-2
  • InChiKey: LAMACCNBYAOXOQ-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0052 0.0551 0.2147
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0017 0.0095 0.0368
Schistosoma mansoni phosphoglucomutase 0.0203 0.2568 0.2568
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0089 0.1056 0.1202
Trypanosoma brucei ingi protein (ORF1) 0.022 0.2797 0.279
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0681 0.211
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0203 0.2568 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0039 0.0114
Echinococcus granulosus RNA directed DNA polymerase 0.0017 0.0095 0.0108
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0011 0.001 0.0011
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.1971 0.2244
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0224 0.0835
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0017 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0253 0.3229 1
Schistosoma mansoni alpha-glucosidase 0.0136 0.1678 0.1678
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0039 0.0114
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0764 0.2365
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.3229 0.3676
Loa Loa (eye worm) PDE1B protein 0.0011 0.001 0.0031
Schistosoma mansoni cpg binding protein 0.0028 0.0235 0.0235
Echinococcus multilocularis GPCR, family 2 0.0031 0.0281 0.032
Brugia malayi hypothetical protein 0.0017 0.0095 0.0293
Brugia malayi RNase H family protein 0.0203 0.2568 0.7951
Onchocerca volvulus 0.0029 0.0249 0.0968
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0332 0.126
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.001 0.0011
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0332 0.126
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0095 0.0108
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0011 0.001 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0224 0.0835
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0095 0.0108
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0281 0.032
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0332 0.126
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0332 0.126
Echinococcus multilocularis microtubule associated protein 2 0.067 0.8785 1
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0681 0.0776
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0681 0.0681
Trypanosoma brucei ribonuclease H1 0.0203 0.2568 0.256
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0011 0.001 0.001
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.001 0.0011
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0281 0.032
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0095 0.0293
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.146 0.4522
Trypanosoma cruzi ribonuclease H1, putative 0.0203 0.2568 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.001 0.0031
Schistosoma mansoni survival motor neuron protein 0.0052 0.0551 0.0551
Brugia malayi hypothetical protein 0.0253 0.3229 1
Schistosoma mansoni cpg binding protein 0.0029 0.0256 0.0256
Brugia malayi reverse transcriptase 0.0017 0.0095 0.0293
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0039 0.0152
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.001 0.001
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0095 0.0293
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0681 0.0681
Schistosoma mansoni hypothetical protein 0.0031 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0099 0.118 0.3654
Brugia malayi hypothetical protein 0.0017 0.0095 0.0293
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0079 0.0911 0.2822
Brugia malayi Zinc knuckle family protein 0.0017 0.0095 0.0293
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0224 0.0835
Brugia malayi MH2 domain containing protein 0.012 0.146 0.4522
Echinococcus multilocularis ribonuclease H1 0.0203 0.2568 0.2923
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0017 0.0095 0.0108
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0095 0.0293
Schistosoma mansoni alpha glucosidase 0.0035 0.0332 0.0332
Trypanosoma cruzi ribonuclease H1, putative 0.0203 0.2568 1
Trypanosoma brucei ingi protein (ORF1) 0.022 0.2797 0.279
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0039 0.0121
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0681 0.211
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0095 0.0293
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0039 0.0114
Trichomonas vaginalis reverse transcriptases, putative 0.0017 0.0095 0.0331
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0011 0.001 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0332 0.126
Treponema pallidum ribonuclease H (rnhA) 0.0203 0.2568 0.5
Onchocerca volvulus 0.0091 0.1083 0.4218
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0089 0.1056 0.1202
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0681 0.0681
Schistosoma mansoni intermediate filament proteins 0.0029 0.0249 0.0249
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0332 0.0378
Trypanosoma brucei hypothetical protein, conserved 0.022 0.2797 0.279
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0039 0.0114
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0011 0.001 0.0011
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0017 0.0095 0.0331
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.3229 0.3676
Brugia malayi RNase H family protein 0.0203 0.2568 0.7951
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0089 0.1056 0.1202
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0281 0.032
Echinococcus granulosus intermediate filament protein 0.0029 0.0249 0.0283
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0011 0.001 0.001
Schistosoma mansoni phosphoglucomutase 0.0203 0.2568 0.2568
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0095 0.0293
Brugia malayi intermediate filament protein 0.0029 0.0249 0.077
Schistosoma mansoni alpha-glucosidase 0.0136 0.1678 0.1678
Schistosoma mansoni hypothetical protein 0.0068 0.0764 0.0764
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0095 0.0293
Trichomonas vaginalis ribonuclease H1, putative 0.0203 0.2568 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0566 0.2175
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0133
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.0155
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0121
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0095 0.0293
Brugia malayi reverse transcriptase 0.0017 0.0095 0.0293
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0089 0.1056 0.1202
Echinococcus multilocularis RNA directed DNA polymerase 0.0017 0.0095 0.0108
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0039 0.0114
Schistosoma mansoni thyroid hormone receptor 0.0136 0.1682 0.1682
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0039 0.0114
Mycobacterium tuberculosis Possible maturase 0.0017 0.0095 0.5
Loa Loa (eye worm) hypothetical protein 0.0068 0.0764 0.2365
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0039 0.0114
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0095 0.0108
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.001 0.0011
Giardia lamblia Ribonuclease H 0.0203 0.2568 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0332 0.126
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0681 0.0681
Leishmania major ribonuclease H1, putative 0.0203 0.2568 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0281 0.087
Echinococcus granulosus ribonuclease H1 0.0203 0.2568 0.2923
Giardia lamblia Reverse transcriptase/endonuclease 0.0017 0.0095 0.0331
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0095 0.0293
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0017 0.0095 0.0331
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0079 0.0911 0.1037
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0095 0.0293
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0039 0.0114
Echinococcus granulosus lamin 0.0029 0.0249 0.0283
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0249 0.077
Toxoplasma gondii ribonuclease HI protein 0.0203 0.2568 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0011 0.001 0.0011
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0332 0.1029
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0017 0.0095 0.0108
Brugia malayi hypothetical protein 0.0017 0.0095 0.0293
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0281 0.032
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.007 0.0218
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0332 0.126
Schistosoma mansoni hypothetical protein 0.0031 0.0281 0.0281
Onchocerca volvulus 0.0028 0.0235 0.0916
Schistosoma mansoni hypothetical protein 0.0031 0.0281 0.0281
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0332 0.126
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0281 0.087
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.022 0.2797 0.279
Brugia malayi hypothetical protein 0.0017 0.0095 0.0293
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0017 0.0095 0.0331
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0017 0.0095 0.0108
Schistosoma mansoni protein kinase 0.0017 0.0095 0.0095
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0017 0.0095 0.0108
Onchocerca volvulus 0.0017 0.0095 0.0368
Brugia malayi reverse transcriptase 0.0017 0.0095 0.0293
Schistosoma mansoni lamin 0.0029 0.0249 0.0249
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0017 0.0095 0.0085
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0332 0.1029
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.001 0.001
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.1547 0.1761
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.1971 0.6103
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0011 0.001 0.0011
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0011 0.001 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0095 0.0331
Echinococcus granulosus microtubule associated protein 2 0.067 0.8785 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.001 0.001
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0089 0.1056 0.1056
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0039 0.0114
Trypanosoma brucei glucosidase, putative 0.0035 0.0332 0.0323
Schistosoma mansoni microtubule-associated protein tau 0.067 0.8785 0.8785
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0095 0.0108
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0681 0.0681
Leishmania major hypothetical protein, conserved 0.0027 0.0224 0.0835
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.005 0.0057
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0095 0.0293
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0224 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0095 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0332 0.126
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0095 0.0293
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.005 0.0057
Loa Loa (eye worm) RNA binding protein 0.0061 0.0681 0.211
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0095 0.0293
Loa Loa (eye worm) hypothetical protein 0.0029 0.0249 0.077
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.1547 0.1761
Schistosoma mansoni thyroid hormone receptor 0.0136 0.1682 0.1682
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0031
Brugia malayi RNA binding protein 0.0061 0.0681 0.211
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.118 0.3654
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0017 0.0095 0.0331
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0332 0.126
Loa Loa (eye worm) hypothetical protein 0.0027 0.0224 0.0692
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0026 0.0029
Trypanosoma brucei RNA helicase, putative 0.0761 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0681 0.211
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0011 0.001 0.0031
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.065 0.065
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0095 0.0293
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0031
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1971 0.2244
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0039 0.0114
Trichomonas vaginalis reverse transcriptases, putative 0.0017 0.0095 0.0331
Echinococcus granulosus KRAB A domain containing protein 0.0017 0.0095 0.0108
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0011 0.001 0.0031
Onchocerca volvulus 0.0017 0.0095 0.0368
Echinococcus granulosus GPCR family 2 0.0031 0.0281 0.032
Echinococcus multilocularis lamin dm0 0.0029 0.0249 0.0283
Echinococcus granulosus cpg binding protein 0.0029 0.0256 0.0292
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0224 0.0214
Schistosoma mansoni hypothetical protein 0.0017 0.0095 0.0095
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0281 0.087
Trypanosoma brucei unspecified product 0.022 0.2797 0.279
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.001 0.0011
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.001 0.001
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0095 0.0293
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0017 0.0095 0.0331
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0017 0.0095 0.0095
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0332 0.0378
Schistosoma mansoni cpg binding protein 0.0029 0.0256 0.0256
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0011 0.001 0.0031
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0011 0.001 0.001
Brugia malayi CXXC zinc finger family protein 0.0028 0.0235 0.0728
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0095 0.0108
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0224 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0011 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0133
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0011 0.001 0.0031
Schistosoma mansoni hypothetical protein 0.0017 0.0095 0.0095
Echinococcus multilocularis thyroid hormone receptor alpha 0.0136 0.1682 0.1915
Echinococcus granulosus tar DNA binding protein 0.0061 0.0681 0.0776
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0017 0.0095 0.0108
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0095 0.0108
Echinococcus multilocularis cpg binding protein 0.0029 0.0256 0.0292
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.146 0.4522
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0095 0.0108
Echinococcus multilocularis lamin 0.0029 0.0249 0.0283
Onchocerca volvulus Ribonuclease H1 homolog 0.0203 0.2568 1
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0079 0.0911 0.2822
Loa Loa (eye worm) hypothetical protein 0.0031 0.0281 0.087
Echinococcus multilocularis musashi 0.0029 0.0249 0.0283
Brugia malayi RNase H family protein 0.0203 0.2568 0.7951
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0017 0.0095 0.0085
Schistosoma mansoni hypothetical protein 0.0031 0.0281 0.0281
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0089 0.1056 0.4091
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0017 0.0095 0.0331
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0079 0.0911 0.1037
Brugia malayi hypothetical protein 0.0027 0.0224 0.0692
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.001 0.0031
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0332 0.126
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0249 0.077
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0235 0.0728
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0332 0.126
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0332 1
Schistosoma mansoni hypothetical protein 0.0052 0.0551 0.0551
Brugia malayi hypothetical protein 0.0017 0.0096 0.0299
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0095 0.0108
Brugia malayi TAR-binding protein 0.0061 0.0681 0.211
Schistosoma mansoni hypothetical protein 0.0126 0.1547 0.1547
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.007 0.0218
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0039 0.0114
Schistosoma mansoni phosphoglucomutase 0.0203 0.2568 0.2568
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0011 0.001 0.0011
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1971 0.2244
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0031
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.001 0.001
Echinococcus granulosus lamin dm0 0.0029 0.0249 0.0283
Loa Loa (eye worm) hypothetical protein 0.0089 0.1056 0.3271
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.118 0.3654
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0551 0.1707
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0224 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.1971 0.6103
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0039 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0089 0.1056 0.4091
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.118 0.3654
Brugia malayi Zinc knuckle family protein 0.0017 0.0095 0.0293
Schistosoma mansoni lamin 0.0029 0.0249 0.0249
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0332 0.126
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0095 0.0095
Onchocerca volvulus 0.0029 0.0249 0.0968
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.001 0.001
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.001 0.0031
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0332 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0026 0.0029
Schistosoma mansoni hypothetical protein 0.0012 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0242 0.0748
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0249 0.077

Activities

Activity type Activity value Assay description Source Reference
LD50 (functional) = 1131 mg kg-1 LD50 following oral dosing. ChEMBL. 15239660
Survival (functional) = 75 % Percent survival against percutaneously administered sulfur mustard in mice (38.7 mg/kg) after 14 days. ChEMBL. 15239660
Survival (functional) = 100 % Percent survival against percutaneously administered sulfur mustard in mice (38.7 mg/kg) after 7 days. ChEMBL. 15239660

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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