Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Homo sapiens | sigma non-opioid intracellular receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0267 | 0.3223 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0182 | 0 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0267 | 0.3223 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1708 | 0.1708 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.3223 | 0.3223 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0267 | 0.3223 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0267 | 0.3223 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.3223 | 0.3223 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 11.28 nM | Sigma 2 binding assay was done rat liver membrane,by labelling the binding site with [3H]-DTG (DuPont-NEN) in the presence of [3H]-(+)-pentazocine (100 nM) | ChEMBL. | 9397171 |
Ki (binding) | = 17.49 nM | Sigma-1 binding assay was done in guinea pig membranes by labelling the binding site with [3H]-(+)-pentazocine | ChEMBL. | 9397171 |
Ki (binding) | = 17.49 nM | Sigma-1 binding assay was done in guinea pig membranes by labelling the binding site with [3H]-(+)-pentazocine | ChEMBL. | 9397171 |
Ki (binding) | = 30.05 nM | Binding affinity of the compound for serotonin transporter was determined in rat cortical membrane. | ChEMBL. | 9397171 |
Ki (binding) | = 30.05 nM | Binding affinity of the compound for serotonin transporter was determined in rat cortical membrane. | ChEMBL. | 9397171 |
Ki (binding) | = 73.8 nM | Binding affinity for dopamine transporter was determined in rat striatal membrane. | ChEMBL. | 9397171 |
Ki (binding) | = 73.8 nM | Binding affinity for dopamine transporter was determined in rat striatal membrane. | ChEMBL. | 9397171 |
Ki (binding) | = 144 nM | Binding to vesicular acetylcholine transporter of torpedo synaptic vesicles | ChEMBL. | 9397171 |
Ki (binding) | = 144 nM | Binding to vesicular acetylcholine transporter of torpedo synaptic vesicles | ChEMBL. | 9397171 |
Ki (binding) | = 5092 nM | In vitro binding affinity for D2/D3 receptors in rat striatal homogenates by [125I]-NCQ298 displacement. | ChEMBL. | 9397171 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.