Detailed information for compound 220363

Basic information

Technical information
  • TDR Targets ID: 220363
  • Name: 4-methylbenzenesulfonate; 3-[4-[(4-tetradecyl oxolan-2-yl)methoxy]butyl]-1,3-thiazol-3-ium
  • MW: 609.923 | Formula: C33H55NO5S2
  • H donors: 0 H acceptors: 3 LogP: 10.24 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cc1ccc(cc1)S(=O)(=O)[O-].CCCCCCCCCCCCCCC1COC(C1)COCCCC[n+]1ccsc1
  • InChi: 1S/C26H48NO2S.C7H8O3S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25-21-26(29-22-25)23-28-19-15-14-17-27-18-20-30-24-27;1-6-2-4-7(5-3-6)11(8,9)10/h18,20,24-26H,2-17,19,21-23H2,1H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
  • InChiKey: XDVLSSHGCNXTQX-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • 4-methylbenzenesulfonate; 3-[4-[(4-tetradecyltetrahydrofuran-2-yl)methoxy]butyl]thiazol-3-ium
  • 4-methylbenzenesulfonate; 3-[4-[(4-tetradecyl-2-tetrahydrofuranyl)methoxy]butyl]thiazol-3-ium
  • 3-[4-[(4-myristyltetrahydrofuran-2-yl)methoxy]butyl]thiazol-3-ium tosylate
  • 4-methylbenzenesulfonate; 3-[4-[(4-myristyltetrahydrofuran-2-yl)methoxy]butyl]thiazol-3-ium

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0027 0.0012 0.1972
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.001 0.0162
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0087 0.2902
Echinococcus multilocularis serotonin transporter 0.0061 0.004 0.0698
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0012 0.0389
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0025 0.001 0.0162
Schistosoma mansoni myosin xvIII 0.0019 0.0005 0.0376
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0025 0.001 0.0318
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Brugia malayi sulfakinin receptor protein 0.0019 0.0005 0.0122
Schistosoma mansoni lamin 0.0027 0.0012 0.0914
Schistosoma mansoni intermediate filament proteins 0.0027 0.0012 0.0914
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0061 0.004 0.3133
Echinococcus granulosus geminin 0.0166 0.0127 0.2169
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0022 1
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0005 0.0376
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0005 0.0082
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0005 0.0084
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0025 0.001 0.0162
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0005 0.0084
Schistosoma mansoni nAChR subunit 0.0025 0.001 0.0747
Schistosoma mansoni lamin 0.0027 0.0012 0.0914
Echinococcus granulosus sex peptide receptor 0.0019 0.0005 0.0082
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0025 0.001 0.0167
Loa Loa (eye worm) ACC-1 protein 0.0025 0.001 0.0318
Schistosoma mansoni hypothetical protein 0.0018 0.0004 0.0293
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0005 0.0376
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0005 0.0084
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0005 0.0376
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0023 0.1796
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0009 0.0651
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0009 0.5
Brugia malayi AKH receptor 0.0019 0.0005 0.0122
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0005 0.0082
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0005 0.0376
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0005 0.0376
Echinococcus granulosus lamin dm0 0.0027 0.0012 0.0198
Brugia malayi Cytochrome P450 family protein 0.0056 0.0036 0.0914
Onchocerca volvulus 0.0027 0.0012 0.1972
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0005 0.0084
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0005 0.0084
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0005 0.016
Onchocerca volvulus 0.0019 0.0005 0.0812
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0005 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.001 0.0242
Brugia malayi Cation transporter family protein 0.0025 0.001 0.0242
Onchocerca volvulus 0.0019 0.0005 0.0812
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0025 0.001 0.0167
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.001 0.0747
Echinococcus granulosus neuropeptide receptor 0.0019 0.0005 0.0082
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0009 0.0165
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0005 0.0376
Echinococcus multilocularis nAChR subunit 0.0025 0.001 0.0167
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0005 0.0084
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0005 0.0084
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.001 0.0242
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0005 0.0082
Echinococcus granulosus fmrfamide receptor 0.0019 0.0005 0.0082
Brugia malayi RE15519p 0.0019 0.0005 0.0122
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0005 0.0084
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.001 0.0242
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0005 0.0082
Echinococcus granulosus intermediate filament protein 0.0027 0.0012 0.0198
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0005 0.0082
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0005 0.0084
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Schistosoma mansoni amine GPCR 0.0019 0.0005 0.0376
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.001 0.0162
Schistosoma mansoni hypothetical protein 0.0019 0.0005 0.0376
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Schistosoma mansoni nAChR subunit 0.0025 0.001 0.0747
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0001 0.0036
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0005 0.0376
Brugia malayi intermediate filament protein 0.0027 0.0012 0.0296
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0005 0.0082
Brugia malayi Serotonin receptor 0.0484 0.0393 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0025 0.001 0.0162
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0005 0.0084
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0005 0.0084
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0005 0.0376
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.001 0.0167
Brugia malayi hypothetical protein 0.0019 0.0005 0.0122
Loa Loa (eye worm) hypothetical protein 0.0061 0.004 0.1332
Schistosoma mansoni hypothetical protein 0.0019 0.0005 0.0376
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Echinococcus granulosus g protein coupled receptor 0.0019 0.0005 0.0082
Onchocerca volvulus 0.0019 0.0005 0.0812
Schistosoma mansoni nAChR subunit 0.0025 0.001 0.0747
Echinococcus multilocularis glycine receptor subunit beta 0.0025 0.001 0.0167
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Schistosoma mansoni biogenic amine receptor 0.0019 0.0005 0.0376
Schistosoma mansoni hypothetical protein 0.0166 0.0127 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0005 0.0376
Onchocerca volvulus 0.0019 0.0005 0.0812
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0005 0.016
Echinococcus multilocularis serotonin receptor 0.0019 0.0005 0.0084
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.002 0.0509
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0025 0.001 0.0242
Echinococcus granulosus neuropeptide receptor 0.0019 0.0005 0.0082
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0025 0.001 0.0162
Brugia malayi Cytochrome P450 family protein 0.0035 0.0018 0.0466
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0005 0.0082
Echinococcus granulosus allatostatin A receptor 0.0019 0.0005 0.0082
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.001 0.0747
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0005 0.016
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0005 0.0082
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0005 0.0376
Brugia malayi G-protein coupled receptor 0.0019 0.0005 0.0122
Schistosoma mansoni histamine h1 receptor 0.0019 0.0005 0.0376
Onchocerca volvulus 0.0025 0.001 0.1612
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0005 0.0084
Brugia malayi hypothetical protein 0.0019 0.0005 0.0122
Schistosoma mansoni nAChR subunit 0.0025 0.001 0.0747
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0025 0.001 0.0747
Brugia malayi hypothetical protein 0.0019 0.0005 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0059 0.1034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0005 0.0376
Schistosoma mansoni nAChR subunit 0.0025 0.001 0.0747
Entamoeba histolytica hypothetical protein 0.0024 0.0009 0.3943
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Schistosoma mansoni biogenic amine receptor 0.0019 0.0005 0.0376
Echinococcus granulosus g protein coupled receptor 0.0019 0.0005 0.0082
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.001 0.0242
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0005 0.0122
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0005 0.016
Brugia malayi neuropeptide F receptor 0.0019 0.0005 0.0122
Trypanosoma brucei C-8 sterol isomerase, putative 0.0372 0.03 1
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0005 0.016
Echinococcus multilocularis conserved hypothetical protein 0.0698 0.0572 1
Onchocerca volvulus 0.0019 0.0005 0.0812
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0005 0.0082
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0005 0.0082
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0005 0.0376
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0025 0.001 0.0162
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0372 0.03 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0025 0.001 0.0318
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0005 0.0122
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0005 0.0376
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0005 0.0082
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.002 0.0341
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0005 0.0376
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0005 0.0122
Brugia malayi hypothetical protein 0.0025 0.0009 0.0241
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0005 0.0082
Echinococcus granulosus g protein coupled receptor 0.0019 0.0005 0.0082
Loa Loa (eye worm) solute carrier family 6 member 4 0.0061 0.004 0.1332
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0005 0.0082
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0035 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0316
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0005 0.016
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0087 0.2902
Onchocerca volvulus 0.0019 0.0005 0.0812
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0005 0.0082
Onchocerca volvulus 0.0019 0.0005 0.0812
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0025 0.001 0.0162
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0009 0.0194
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0059 0.1502
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0005 0.0084
Brugia malayi Dopamine receptor 0.0019 0.0005 0.0122
Brugia malayi ORL1-like opioid receptor 0.0019 0.0005 0.0122
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.002 0.0668
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.001 0.0167
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Loa Loa (eye worm) acetyltransferase 0.0147 0.0111 0.3711
Loa Loa (eye worm) serotonin transporter b 0.0061 0.004 0.1332
Brugia malayi hypothetical protein 0.0019 0.0005 0.0122
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0005 0.0082
Schistosoma mansoni biogenic amine receptor 0.0019 0.0005 0.0376
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0005 0.0376
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0025 0.001 0.0242
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.001 0.0242
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0005 0.0084
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0005 0.0122
Schistosoma mansoni opsin-like receptor 0.0019 0.0005 0.0376
Brugia malayi putative neuropeptide receptor 0.0019 0.0005 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0005 0.0376
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0005 0.0084
Onchocerca volvulus 0.0019 0.0005 0.0812
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0111 0.8732
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0009 0.0651
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0012 0.0296
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0005 0.0082
Loa Loa (eye worm) CYP4Cod1 0.0035 0.0018 0.0612
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.001 0.0242
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0005 0.0082
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0005 0.0082
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.0389
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Echinococcus multilocularis serotonin receptor 0.0019 0.0005 0.0084
Onchocerca volvulus 0.0084 0.0059 1
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0005 0.0084
Loa Loa (eye worm) hypothetical protein 0.0084 0.0059 0.1971
Onchocerca volvulus 0.0019 0.0005 0.0812
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0005 0.0082
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0005 0.0082
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0001 0.0027
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0005 0.0082
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0005 0.0084
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0005 0.0376
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0005 0.0082
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0025 1
Onchocerca volvulus 0.0061 0.004 0.6757
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0009 0.0531
Echinococcus multilocularis glycine receptor subunit beta 0.0025 0.001 0.0167
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0005 0.0084
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0023 0.1796
Schistosoma mansoni amine GPCR 0.0019 0.0005 0.0376
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0022 1
Onchocerca volvulus 0.0025 0.001 0.1612
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Brugia malayi Cytochrome P450 family protein 0.0018 0.0004 0.0095
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0025 0.001 0.0747
Onchocerca volvulus 0.0019 0.0005 0.0812
Brugia malayi larval opioid receptor 0.0019 0.0005 0.0122
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0025 0.001 0.0242
Schistosoma mansoni amine GPCR 0.0019 0.0005 0.0376
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0009 0.2311
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0005 0.0122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0005 0.0376
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0018 0.0612
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0005 0.0084
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0005 0.0084
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0025 0.001 0.0242
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Brugia malayi hypothetical protein 0.0019 0.0005 0.0122
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0025 1
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.591 0.4926 1
Echinococcus multilocularis musashi 0.0027 0.0012 0.0204
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0009 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Brugia malayi Cation transporter family protein 0.0025 0.001 0.0242
Loa Loa (eye worm) hypothetical protein 0.0032 0.0016 0.0531
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0005 0.0084
Echinococcus multilocularis sex peptide receptor 0.0019 0.0005 0.0084
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0009 0.0194
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Brugia malayi hypothetical protein 0.0019 0.0005 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Onchocerca volvulus Putative nachr subunit 0.0025 0.001 0.1612
Echinococcus multilocularis geminin 0.0166 0.0127 0.2229
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0005 0.0084
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Onchocerca volvulus 0.0019 0.0005 0.0812
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0025 0.001 0.0318
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Loa Loa (eye worm) hypothetical protein 0.0372 0.03 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0005 0.0122
Schistosoma mansoni neuropeptide receptor 0.0019 0.0005 0.0376
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0025 1
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0005 0.0084
Schistosoma mansoni hypothetical protein 0.0166 0.0127 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0005 0.0082
Schistosoma mansoni hypothetical protein 0.0019 0.0005 0.0376
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Echinococcus multilocularis somatostatin receptor 0.0019 0.0005 0.0084
Brugia malayi Serotonin receptor 0.0019 0.0005 0.0122
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.001 0.0242
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0022 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.002 0.035
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0025 0.001 0.0162
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0111 0.2829
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0005 0.0376
Brugia malayi Melatonin receptor type 1A 0.0019 0.0005 0.0122
Onchocerca volvulus 0.0025 0.001 0.1612
Schistosoma mansoni hypothetical protein 0.0019 0.0005 0.0376
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0005 0.0084
Trypanosoma brucei cytochrome P450, putative 0.0035 0.0018 0.0493
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0005 0.0082
Echinococcus granulosus glycine receptor subunit beta 0.0025 0.001 0.0162
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0025 0.001 0.0318
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0005 0.016
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0025 0.001 0.0747
Brugia malayi neuropeptide F receptor 0.0019 0.0005 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0009 0.0165
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0005 0.0376
Schistosoma mansoni cytochrome P450 0.0018 0.0004 0.0293
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0025 0.001 0.0167
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0005 0.0082
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0005 0.0084
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0018 0.0493
Brugia malayi Dopamine receptor protein 1 0.0019 0.0005 0.0122
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0005 0.0084
Brugia malayi G-protein coupled receptor 0.0019 0.0005 0.0122
Schistosoma mansoni amine GPCR 0.0019 0.0005 0.0376
Treponema pallidum sodium- and chloride- dependent transporter 0.0061 0.004 1
Echinococcus granulosus hypothetical protein 0.0717 0.0588 1
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0005 0.016
Onchocerca volvulus 0.0019 0.0005 0.0812
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0005 0.0376
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0005 0.0084
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0025 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0061 0.004 0.1015
Brugia malayi hypothetical protein 0.0019 0.0005 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Echinococcus granulosus serotonin transporter 0.0061 0.004 0.068
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Loa Loa (eye worm) hypothetical protein 0.019 0.0148 0.493
Schistosoma mansoni amine GPCR 0.0019 0.0005 0.0376
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0036 0.12
Schistosoma mansoni adenoreceptor 0.0019 0.0005 0.0376
Schistosoma mansoni opsin-like receptor 0.0019 0.0005 0.0376
Onchocerca volvulus 0.0019 0.0005 0.0812
Brugia malayi Cytochrome P450 family protein 0.0035 0.0018 0.0466
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0025 0.001 0.0242
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.001 0.0747
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0025 0.001 0.0167
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Loa Loa (eye worm) cytochrome P450 0.0018 0.0004 0.0125
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0018 0.0612
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0005 0.0082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0005 0.0376
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Brugia malayi cytochrome P450 0.0018 0.0004 0.0095
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0005 0.0082
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0009 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0005 0.0376
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0025 0.001 0.0318
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0004 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0005 0.0376
Brugia malayi hypothetical protein 0.0019 0.0005 0.0122
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0025 0.0423
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0005 0.016
Onchocerca volvulus 0.0019 0.0005 0.0812
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0025 1
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0005 0.0082
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0019 0.0005 0.0812
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0025 0.001 0.0167
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 1.1984 1 1
Echinococcus multilocularis lamin 0.0027 0.0012 0.0204
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0005 0.0082
Brugia malayi excitatory GABA receptor EXP-1A 0.0025 0.001 0.0242
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.001 0.0242
Echinococcus granulosus nAChR subunit 0.0025 0.001 0.0162
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0005 0.0122
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0005 0.0084
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0009 0.272
Brugia malayi Dopamine receptor protein 2 0.0019 0.0005 0.0122
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.001 0.0162
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0005 0.0084
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0009 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0005 0.0376
Echinococcus granulosus glycine receptor subunit beta 0.0025 0.001 0.0162
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0005 0.016
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0005 0.0084
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0025 0.001 0.0167
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0005 0.0084
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0059 0.4637
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0005 0.0084
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0009 0.001
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0005 0.0376
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0009 0.2311
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0005 0.0082
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0025 0.001 0.0162
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0005 0.0084
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0005 0.0122
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0005 0.016
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0059 0.1006
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Schistosoma mansoni neuropeptide receptor 0.0019 0.0005 0.0376
Loa Loa (eye worm) norepinephrine transporter 0.0061 0.004 0.1332
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0372 0.03 0.7624
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0005 0.0376
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0012 0.0389
Echinococcus granulosus somatostatin receptor 0.0019 0.0005 0.0082
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0005 0.0084
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0005 0.0084
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0009 0.0194
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Onchocerca volvulus 0.0019 0.0005 0.0812
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0116
Onchocerca volvulus 0.0025 0.001 0.1612
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0005 0.0084
Brugia malayi hypothetical protein 0.0019 0.0005 0.0122
Echinococcus multilocularis 0.0018 0.0004 0.0065
Leishmania major hypothetical protein, conserved 0.0025 0.0009 0.0194
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0005 0.0084
Onchocerca volvulus 0.0019 0.0005 0.0812
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0005 0.0084
Schistosoma mansoni neuropeptide receptor 0.0019 0.0005 0.0376
Loa Loa (eye worm) LGC-31 protein 0.0025 0.001 0.0318
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0005 0.0376
Brugia malayi Cation transporter family protein 0.0025 0.001 0.0242
Leishmania major cytochrome p450-like protein 0.0035 0.0018 0.0493
Brugia malayi MH2 domain containing protein 0.0118 0.0087 0.2212
Brugia malayi hypothetical protein 0.0019 0.0005 0.0122
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.001 0.0167
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0005 0.0082
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0005 0.0084
Schistosoma mansoni nAChR subunit 0.0025 0.001 0.0747
Onchocerca volvulus Neuropeptide F receptor homolog 0.0019 0.0005 0.0812
Onchocerca volvulus 0.0025 0.001 0.1612
Brugia malayi hypothetical protein 0.0016 0.0002 0.0055
Loa Loa (eye worm) hypothetical protein 0.0061 0.004 0.1332
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0018 0.0493
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0005 0.0084
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0375
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Echinococcus granulosus lamin 0.0027 0.0012 0.0198
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0005 0.0082
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0025 0.001 0.0167
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0005 0.0082
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0009 0.0005
Schistosoma mansoni nAChR subunit 0.0025 0.001 0.0747
Onchocerca volvulus 0.0025 0.001 0.1612
Echinococcus granulosus orexin receptor type 2 0.0019 0.0005 0.0082
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0025 0.001 0.0318
Leishmania major C-8 sterol isomerase-like protein 0.0372 0.03 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0111 0.1947
Echinococcus multilocularis lamin dm0 0.0027 0.0012 0.0204
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0108 0.1835
Loa Loa (eye worm) ACC-1 protein 0.0025 0.001 0.0318
Schistosoma mansoni sodium/chloride dependent transporter 0.0061 0.004 0.3133
Echinococcus granulosus serotonin receptor 0.0019 0.0005 0.0082
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Brugia malayi G protein-coupled receptor 0.0019 0.0005 0.0122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0005 0.0376
Brugia malayi GnHR receptor homolog 0.0019 0.0005 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Schistosoma mansoni neuropeptide receptor 0.0019 0.0005 0.0376
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0025 0.001 0.0242
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0318
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0025 0.001 0.0242
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0005 0.0084
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.016
Loa Loa (eye worm) hypothetical protein 0.0061 0.004 0.1332
Onchocerca volvulus 0.0019 0.0005 0.0812
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.001 0.0242
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0005 0.0084
Schistosoma mansoni opsin-like receptor 0.0019 0.0005 0.0376

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 39 uM Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50% ChEMBL. 1992139
IC50 (functional) = 39 uM Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50% ChEMBL. 1992139
ID50 (functional) > 5 mg kg-1 Activity expressed as the dose required to reduce the lowering of the arterial blood pressure caused by PAF by 50% ChEMBL. 1992139
ID50 (functional) > 5 mg kg-1 Activity expressed as the dose required to reduce the lowering of the arterial blood pressure caused by PAF by 50% ChEMBL. 1992139

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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