Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sigma non-opioid intracellular receptor 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0267 | 0.4699 | 1 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.4699 | 0.4699 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0109 | 0 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0267 | 0.4699 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.3514 | 0.3514 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0267 | 0.4699 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 1 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.4699 | 0.4699 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 1 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0267 | 0.4699 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 15.87 nM | Sigma 2 binding assay was done rat liver membrane,by labelling the binding site with [3H]-DTG (DuPont-NEN) in the presence of [3H]-(+)-pentazocine (100 nM) | ChEMBL. | 9397171 |
Ki (binding) | = 42.05 nM | Binding affinity for dopamine transporter was determined in rat striatal membrane. | ChEMBL. | 9397171 |
Ki (binding) | = 42.05 nM | Binding affinity for dopamine transporter was determined in rat striatal membrane. | ChEMBL. | 9397171 |
Ki (binding) | = 302.4 nM | Sigma-1 binding assay was done in guinea pig membranes by labelling the binding site with [3H]-(+)-pentazocine | ChEMBL. | 9397171 |
Ki (binding) | = 302.4 nM | Sigma-1 binding assay was done in guinea pig membranes by labelling the binding site with [3H]-(+)-pentazocine | ChEMBL. | 9397171 |
Ki (binding) | = 411 nM | Binding to vesicular acetylcholine transporter of torpedo synaptic vesicles | ChEMBL. | 9397171 |
Ki (binding) | = 411 nM | Binding to vesicular acetylcholine transporter of torpedo synaptic vesicles | ChEMBL. | 9397171 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.