Detailed information for compound 222720

Basic information

Technical information
  • TDR Targets ID: 222720
  • Name: 4-amino-1-[(1S,4R)-2-fluoro-4-(hydroxymethyl) cyclopent-2-en-1-yl]pyrimidin-2-one
  • MW: 225.22 | Formula: C10H12FN3O2
  • H donors: 2 H acceptors: 2 LogP: -1.1 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccn(c(=O)n1)[C@H]1C[C@H](C=C1F)CO
  • InChi: 1S/C10H12FN3O2/c11-7-3-6(5-15)4-8(7)14-2-1-9(12)13-10(14)16/h1-3,6,8,15H,4-5H2,(H2,12,13,16)/t6-,8-/m0/s1
  • InChiKey: GWTRSVUDRSVUFO-XPUUQOCRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-amino-1-[(1S,4R)-2-fluoro-4-(hydroxymethyl)-1-cyclopent-2-enyl]-2-pyrimidinone
  • 4-azanyl-1-[(1S,4R)-2-fluoro-4-(hydroxymethyl)cyclopent-2-en-1-yl]pyrimidin-2-one
  • 4-amino-1-[(1S,4R)-2-fluoro-4-methylol-cyclopent-2-en-1-yl]pyrimidin-2-one
  • 4-amino-1-[(1S,4R)-2-fluoro-4-(hydroxymethyl)-1-cyclopent-2-enyl]pyrimidin-2-one
  • 4-amino-1-[(1S,4R)-2-fluoro-4-methylol-1-cyclopent-2-enyl]pyrimidin-2-one
  • ( + )-2(1H)-Pyrimidinone, 4-amino-1-[(1S,4R)-2-fluoro-4-(hydroxymethyl)-2-cyclopenten-1-yl]-
  • AIDS-292554
  • AIDS292554
  • L-2'F-C-d4C

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nAChR subunit 0.0076 0.0303 0.0303
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Entamoeba histolytica protein kinase domain containing protein 0.0087 0.0384 0.2315
Onchocerca volvulus Cathepsin F homolog 0.0238 0.1515 1
Giardia lamblia Cathepsin L-like protease 0.0077 0.0312 0.0429
Schistosoma mansoni hypothetical protein 0.0671 0.4738 0.4738
Onchocerca volvulus 0.0238 0.1515 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0076 0.0303 0.0303
Echinococcus granulosus nAChR subunit 0.0076 0.0303 0.0303
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0076 0.0303 0.0303
Brugia malayi cathepsin F-like cysteine proteinase 0.0077 0.0312 0.0312
Plasmodium vivax histone deacetylase 2, putative 0.0054 0.014 0.0859
Plasmodium vivax vivapain-3 0.0142 0.08 0.5245
Schistosoma mansoni cathepsin B (C01 family) 0.0077 0.0312 0.0312
Giardia lamblia Cathepsin L precursor 0.0077 0.0312 0.0429
Plasmodium falciparum serine repeat antigen 4 0.0077 0.0312 0.1525
Entamoeba histolytica cysteine protease, putative 0.0077 0.0312 0.1824
Trypanosoma cruzi histone deacetylase 1, putative 0.0097 0.0465 0.0454
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0077 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0173 0.1027 0.1027
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0077 0.0312 0.2003
Entamoeba histolytica cysteine protease, putative 0.0077 0.0312 0.1824
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0479 0.3308 0.3301
Onchocerca volvulus 0.0041 0.0044 0.0288
Brugia malayi Cathepsin L-like precursor 0.0238 0.1515 0.1515
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Echinococcus multilocularis histone deacetylase 6 0.0054 0.014 0.014
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0142 0.08 0.08
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0077 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0077 0.0312 0.0312
Brugia malayi cathepsin L-like precursor 0.0173 0.1027 0.1027
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0077 0.0312 0.2003
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0178 0.0178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0077 0.0312 0.0914
Echinococcus granulosus histone deacetylase 1 0.0097 0.0465 0.0465
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0178 0.0506
Entamoeba histolytica hypothetical protein 0.0077 0.0312 0.1824
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Loa Loa (eye worm) hypothetical protein 0.1378 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0077 0.0312 0.0312
Leishmania major protein kinase, putative 0.0059 0.0178 0.0506
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0312
Leishmania major histone deacetylase, putative 0.0054 0.014 0.0392
Giardia lamblia Cathepsin L precursor 0.0077 0.0312 0.0429
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0076 0.0303 0.0303
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0465 0.1376
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Echinococcus granulosus cathepsin L 0.0142 0.08 0.08
Plasmodium falciparum serine repeat antigen 9 0.0077 0.0312 0.1525
Schistosoma mansoni cathepsin F (C01 family) 0.0238 0.1515 0.1515
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0076 0.0303 0.0303
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0312
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0077 0.0312 0.2003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0312 0.0914
Brugia malayi Cathepsin L-like precursor 0.0238 0.1515 0.1515
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0221 0.1384 0.1384
Loa Loa (eye worm) ACC-1 protein 0.0076 0.0303 0.0303
Plasmodium falciparum protein serine/threonine kinase-1 0.0059 0.0178 0.0578
Echinococcus multilocularis cathepsin L 0.0142 0.08 0.08
Loa Loa (eye worm) glutaminase 0.0301 0.1978 0.1978
Trypanosoma cruzi major cysteine proteinase, putative 0.0077 0.0312 0.0302
Entamoeba histolytica cysteine protease, putative 0.0077 0.0312 0.1824
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0111 0.0566 0.0566
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0142 0.08 0.08
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0076 0.0303 0.0303
Onchocerca volvulus Cathepsin L homolog 0.0238 0.1515 1
Loa Loa (eye worm) hypothetical protein 0.0351 0.2349 0.2349
Plasmodium falciparum serine repeat antigen 5 0.0077 0.0312 0.1525
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Onchocerca volvulus Cathepsin L homolog 0.0238 0.1515 1
Entamoeba histolytica cysteine proteinase, putative 0.0173 0.1027 0.6685
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0312
Plasmodium vivax serine-repeat antigen (SERA) 0.0077 0.0312 0.2003
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0551 0.3704
Schistosoma mansoni nAChR subunit 0.0076 0.0303 0.0303
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0077 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0036 0.0011 0.0011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0011 0.0011
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0694 0.0694
Trypanosoma cruzi cruzipain precursor, putative 0.0238 0.1515 0.1506
Brugia malayi Cathepsin L-like precursor 0.0238 0.1515 0.1515
Plasmodium falciparum cysteine proteinase falcipain 1 0.0142 0.08 0.4961
Loa Loa (eye worm) hypothetical protein 0.0086 0.0378 0.0378
Brugia malayi Papain family cysteine protease containing protein 0.0238 0.1515 0.1515
Entamoeba histolytica cysteine protease, putative 0.0077 0.0312 0.1824
Onchocerca volvulus 0.0076 0.0303 0.2003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0303 0.0303
Brugia malayi glutaminase DH11.1 0.0301 0.1978 0.1978
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0479 0.3308 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0076 0.0303 0.0303
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Schistosoma mansoni hypothetical protein 0.0671 0.4738 0.4738
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0694 0.0694
Trypanosoma cruzi cysteine peptidase, putative 0.0238 0.1515 0.1506
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0465 0.1376
Loa Loa (eye worm) hypothetical protein 0.024 0.1524 0.1524
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Trypanosoma cruzi cysteine peptidase, putative 0.0238 0.1515 0.1506
Giardia lamblia Cathepsin B precursor 0.0479 0.3308 1
Onchocerca volvulus 0.0076 0.0303 0.2003
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0077 0.0312 0.0914
Echinococcus multilocularis histone deacetylase 3 0.0097 0.0465 0.0465
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0221 0.1384 0.1384
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0077 0.0312 0.0914
Loa Loa (eye worm) glutathione reductase 0.0048 0.0096 0.0096
Leishmania major histone deacetylase, putative 0.0054 0.014 0.0392
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1378 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0077 0.0312 0.0914
Giardia lamblia Cathepsin L precursor 0.0077 0.0312 0.0429
Schistosoma mansoni nAChR subunit 0.0076 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Trypanosoma cruzi cysteine protease, putative 0.0142 0.08 0.079
Schistosoma mansoni cathepsin F (C01 family) 0.0173 0.1027 0.1027
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.0817 0.0817
Leishmania major protein kinase, putative 0.0059 0.0178 0.0506
Brugia malayi latrophilin 2 splice variant baaae 0.024 0.1524 0.1524
Brugia malayi Histone deacetylase family protein 0.0054 0.014 0.014
Loa Loa (eye worm) histone deacetylase 1 0.0097 0.0465 0.0465
Onchocerca volvulus 0.0076 0.0303 0.2003
Giardia lamblia Cathepsin B precursor 0.0077 0.0312 0.0429
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0076 0.0303 0.0303
Brugia malayi histone deacetylase 1 (HD1) 0.0097 0.0465 0.0465
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Entamoeba histolytica cysteine proteinase, putative 0.0238 0.1515 1
Echinococcus granulosus geminin 0.0671 0.4738 0.4738
Brugia malayi RNA binding protein 0.0128 0.0694 0.0694
Plasmodium vivax vivapain-2 0.0238 0.1515 1
Echinococcus multilocularis dual specificity protein kinase clk2 0.0059 0.0178 0.0178
Echinococcus multilocularis cathepsin L cysteine protease 0.0238 0.1515 0.1515
Plasmodium falciparum serine repeat antigen 6 0.0077 0.0312 0.1525
Onchocerca volvulus 0.0076 0.0303 0.2003
Brugia malayi Cathepsin L-like precursor 0.0066 0.0228 0.0228
Onchocerca volvulus 0.0229 0.1441 0.9511
Brugia malayi beta-lactamase family protein 0.0036 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0641 0.4324
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0312 0.0914
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0312
Loa Loa (eye worm) latrophilin receptor protein 2 0.0111 0.0566 0.0566
Toxoplasma gondii cathepsin B 0.0479 0.3308 1
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0228 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Plasmodium falciparum cysteine proteinase falcipain 3 0.0238 0.1515 1
Brugia malayi Papain family cysteine protease containing protein 0.0077 0.0312 0.0312
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Brugia malayi cathepsin F-like cysteine proteinase 0.0066 0.0228 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.1027 0.3083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Brugia malayi Cation transporter family protein 0.0076 0.0303 0.0303
Brugia malayi Cathepsin L-like precursor 0.0238 0.1515 0.1515
Entamoeba histolytica cysteine proteinase 2 0.0142 0.08 0.5139
Echinococcus multilocularis histone deacetylase 1 0.0097 0.0465 0.0465
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0076 0.0303 0.0303
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Loa Loa (eye worm) glutaminase 2 0.0301 0.1978 0.1978
Entamoeba histolytica hypothetical protein 0.0087 0.0384 0.2315
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0059 0.0178 0.0506
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Echinococcus multilocularis cathepsin b 0.1378 1 1
Plasmodium falciparum serine repeat antigen 2 0.0077 0.0312 0.1525
Echinococcus granulosus cathepsin l cysteine peptidase 0.0238 0.1515 0.1515
Brugia malayi Cathepsin L-like precursor 0.0173 0.1027 0.1027
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.08 0.5139
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0059 0.0178 0.0167
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0059 0.0178 0.0178
Onchocerca volvulus 0.0036 0.0011 0.0071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0111 0.0566 0.0566
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0551 0.3704
Brugia malayi beta-lactamase family protein 0.0036 0.0011 0.0011
Giardia lamblia Cathepsin B precursor 0.0479 0.3308 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0059 0.0178 0.0167
Plasmodium vivax histone deacetylase, putative 0.0054 0.014 0.0859
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0076 0.0303 0.0303
Brugia malayi Histone deacetylase family protein 0.0054 0.014 0.014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1378 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0111 0.0566 0.0566
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0077 0.0312 0.2003
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0059 0.0178 0.0167
Giardia lamblia Cathepsin B precursor 0.0077 0.0312 0.0429
Onchocerca volvulus 0.0238 0.1515 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0221 0.1384 0.1384
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0097 0.0465 0.1376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0238 0.1515 0.4561
Schistosoma mansoni histone deacetylase 4 5 0.0054 0.014 0.014
Trypanosoma cruzi histone deacetylase, putative 0.0054 0.014 0.0129
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0817 0.0817
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0221 0.1384 0.1384
Onchocerca volvulus 0.0077 0.0312 0.206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.08 0.2392
Loa Loa (eye worm) cathepsin B 0.0479 0.3308 0.3308
Trypanosoma cruzi cysteine proteinase, putative 0.0142 0.08 0.079
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0076 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.0111 0.0566 0.0566
Loa Loa (eye worm) cysteine protease 0.0238 0.1515 0.1515
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0312 0.0914
Brugia malayi glutathione reductase 0.0048 0.0096 0.0096
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0076 0.0303 0.0303
Echinococcus multilocularis glycine receptor subunit beta 0.0076 0.0303 0.0303
Echinococcus multilocularis glycine receptor subunit beta 0.0076 0.0303 0.0303
Leishmania major cysteine peptidase A (CPA) 0.0238 0.1515 0.4561
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0694 0.0694
Loa Loa (eye worm) histone deacetylase 7A 0.0054 0.014 0.014
Leishmania major trypanothione reductase 0.0048 0.0096 0.0257
Giardia lamblia Cysteine protease 0.0077 0.0312 0.0429
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Echinococcus granulosus GPCR family 2 0.0111 0.0566 0.0566
Brugia malayi cathepsin L-like cysteine proteinase 0.0077 0.0312 0.0312
Onchocerca volvulus 0.0238 0.1515 1
Brugia malayi Latrophilin receptor protein 2 0.0111 0.0566 0.0566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0096 0.0564
Echinococcus multilocularis cysteine protease 0.0238 0.1515 0.1515
Brugia malayi Protein kinase domain containing protein 0.0087 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Loa Loa (eye worm) RNA binding protein 0.0128 0.0694 0.0694
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0077 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Giardia lamblia Cathepsin B precursor 0.0077 0.0312 0.0429
Mycobacterium ulcerans glutaminase 0.0301 0.1978 1
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.08 0.5139
Plasmodium vivax serine/threonine kinase-1, putative 0.0059 0.0178 0.1109
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0551 0.3704
Echinococcus granulosus histone deacetylase 6 0.0054 0.014 0.014
Echinococcus multilocularis cysteine protease 0.0238 0.1515 0.1515
Loa Loa (eye worm) ctsf protein 0.0238 0.1515 0.1515
Schistosoma mansoni neurotransmitter gated ion channel 0.0041 0.0044 0.0044
Echinococcus multilocularis cathepsin L cysteine protease 0.0238 0.1515 0.1515
Brugia malayi Papain family cysteine protease containing protein 0.0142 0.08 0.08
Brugia malayi Histone deacetylase 1 0.0097 0.0465 0.0465
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.08 0.2392
Brugia malayi Cathepsin L-like precursor 0.0238 0.1515 0.1515
Brugia malayi Papain family cysteine protease containing protein 0.0077 0.0312 0.0312
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0076 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0077 0.0312 0.0914
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.0817 0.0817
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0077 0.0312 0.0312
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Loa Loa (eye worm) hypothetical protein 0.0066 0.0228 0.0228
Plasmodium vivax unspecified product 0.0142 0.08 0.5245
Entamoeba histolytica protein kinase, putative 0.0087 0.0384 0.2315
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0178 0.0178
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0096 0.0096
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0238 0.1515 0.1515
Schistosoma mansoni cathepsin s 0.0066 0.0228 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Toxoplasma gondii cathepsin CPL 0.0238 0.1515 0.4561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0011 0.0011
Echinococcus granulosus cathepsin L 0.0077 0.0312 0.0312
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0303 0.0303
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.08 0.5139
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.1234 0.1234
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0238 0.1515 1
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0096 0.0096
Brugia malayi cathepsin Z-like cysteine proteinase 0.0077 0.0312 0.0312
Entamoeba histolytica protein kinase, putative 0.0087 0.0384 0.2315
Trypanosoma brucei histone deacetylase 1 0.0097 0.0465 0.1376
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0817 0.0817
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0077 0.0312 0.2003
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Onchocerca volvulus 0.0076 0.0303 0.2003
Echinococcus granulosus glycine receptor subunit alpha 1 0.0076 0.0303 0.0303
Brugia malayi Pre-SET motif family protein 0.0201 0.1234 0.1234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.08 0.2392
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0011 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0303 0.0303
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0076 0.0303 0.0303
Onchocerca volvulus Cathepsin L homolog 0.0077 0.0312 0.206
Trypanosoma cruzi cysteine peptidase, putative 0.0142 0.08 0.079
Echinococcus granulosus cathepsin l1 0.0238 0.1515 0.1515
Trypanosoma brucei histone deacetylase 3 0.0054 0.014 0.0392
Echinococcus granulosus dual specificity protein kinase clk2 0.0059 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0238 0.1515 0.1515
Toxoplasma gondii preprocathepsin c precursor, putative 0.0077 0.0312 0.0914
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0077 0.0312 0.0312
Plasmodium falciparum serine repeat antigen 3 0.0077 0.0312 0.1525
Echinococcus granulosus glycine receptor subunit alpha 1 0.0076 0.0303 0.0303
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Brugia malayi Protein kinase domain containing protein 0.0059 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Toxoplasma gondii histone deacetylase HDAC2 0.0097 0.0465 0.1376
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Echinococcus granulosus cathepsin l1 0.0173 0.1027 0.1027
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0312 0.0914
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0817 0.0817
Echinococcus granulosus histone deacetylase 6 0.0054 0.014 0.014
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0221 0.1384 0.1384
Brugia malayi Cation transporter family protein 0.0076 0.0303 0.0303
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0641 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0238 0.1515 0.1515
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0076 0.0303 0.0303
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0076 0.0303 0.0303
Plasmodium falciparum serine repeat antigen 8 0.0077 0.0312 0.1525
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0077 0.0312 0.0914
Giardia lamblia Cathepsin B precursor 0.0479 0.3308 1
Giardia lamblia Encystation-specific protease 0.0077 0.0312 0.0429
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0694 0.0694
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0819 0.5834 0.5834
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0076 0.0303 0.0303
Onchocerca volvulus 0.0238 0.1515 1
Leishmania major histone deacetylase, putative 0.0097 0.0465 0.1376
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0551 0.3704
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0096 0.0096
Entamoeba histolytica cysteine proteinase, putative 0.0238 0.1515 1
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Echinococcus granulosus nAChR subunit 0.0041 0.0044 0.0044
Toxoplasma gondii cathepsin CPC1 0.0077 0.0312 0.0914
Plasmodium falciparum histone deacetylase, putative 0.0054 0.014 0.0313
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0077 0.0312 0.1525
Schistosoma mansoni cathepsin S (C01 family) 0.0077 0.0312 0.0312
Giardia lamblia Cathepsin L precursor 0.0077 0.0312 0.0429
Plasmodium vivax glutathione reductase, putative 0.0048 0.0096 0.0564
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0077 0.0312 0.2003
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0221 0.1384 0.1384
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0077 0.0312 0.2003
Echinococcus granulosus hypothetical protein 0.0058 0.0171 0.0171
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0041 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0066 0.0228 0.0228
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0066 0.0228 0.0228
Onchocerca volvulus 0.0036 0.0011 0.0071
Brugia malayi excitatory GABA receptor EXP-1A 0.0076 0.0303 0.0303
Schistosoma mansoni glutaminase 0.0301 0.1978 0.1978
Onchocerca volvulus 0.0173 0.1027 0.6781
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0312 0.0914
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0077 0.0312 0.0312
Echinococcus granulosus histone deacetylase 7 0.0054 0.014 0.014
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0059 0.0178 0.0506
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0076 0.0303 0.0303
Giardia lamblia Cysteine protease 0.0077 0.0312 0.0429
Loa Loa (eye worm) hypothetical protein 0.0036 0.0011 0.0011
Entamoeba histolytica histone deacetylase, putative 0.0097 0.0465 0.2861
Echinococcus granulosus dual specificity 0.0087 0.0384 0.0384
Entamoeba histolytica cysteine protease, putative 0.0077 0.0312 0.1824
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0238 0.1515 0.1515
Schistosoma mansoni histone deacetylase 0.0097 0.0465 0.0465
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Echinococcus granulosus histone deacetylase 0.0054 0.014 0.014
Trypanosoma cruzi major cysteine proteinase, putative 0.0077 0.0312 0.0302
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Plasmodium vivax unspecified product 0.0077 0.0312 0.2003
Echinococcus granulosus histone deacetylase 3 0.0097 0.0465 0.0465
Brugia malayi Cation transporter family protein 0.0076 0.0303 0.0303
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0465 0.1376
Loa Loa (eye worm) hypothetical protein 0.0097 0.0465 0.0465
Giardia lamblia Hypothetical protein 0.0077 0.0312 0.0429
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0077 0.0312 0.0914
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0551 0.3704
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0384 0.0384
Trypanosoma brucei trypanothione reductase 0.0048 0.0096 0.0257
Giardia lamblia Cathepsin L-like protease 0.0077 0.0312 0.0429
Entamoeba histolytica cysteine protease, putative 0.0077 0.0312 0.1824
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0041 0.0044 0.0044
Echinococcus multilocularis cathepsin L 0.0077 0.0312 0.0312
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0041 0.0044 0.0044
Plasmodium vivax serine-repeat antigen (SERA) 0.0077 0.0312 0.2003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Schistosoma mansoni nAChR subunit 0.0076 0.0303 0.0303
Echinococcus granulosus glycine receptor subunit beta 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Giardia lamblia Cysteine protease 0.0077 0.0312 0.0429
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0076 0.0303 0.0303
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0077 0.0312 0.0312
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0076 0.0303 0.0303
Loa Loa (eye worm) histone deacetylase 0.0054 0.014 0.014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0077 0.0312 0.0312
Plasmodium falciparum histone deacetylase 2 0.0054 0.014 0.0313
Brugia malayi Cathepsin L-like cysteine proteinase 0.0173 0.1027 0.1027
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0041 0.0044 0.0044
Entamoeba histolytica cysteine proteinase 1, putative 0.0142 0.08 0.5139
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Brugia malayi Papain family cysteine protease containing protein 0.0142 0.08 0.08
Onchocerca volvulus 0.0036 0.0011 0.0071
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0312
Trypanosoma cruzi histone deacetylase, putative 0.0054 0.014 0.0129
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0479 0.3308 0.3308
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0111 0.0566 0.0566
Echinococcus granulosus cysteine protease 0.0142 0.08 0.08
Schistosoma mansoni histone deacetylase hda2 0.0054 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0312 0.0914
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0077 0.0312 0.0914
Onchocerca volvulus 0.0041 0.0044 0.0288
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0097 0.0465 0.1376
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0076 0.0303 0.0303
Echinococcus multilocularis 0.0058 0.0171 0.0171
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0641 0.4324
Loa Loa (eye worm) hypothetical protein 0.0036 0.0011 0.0011
Plasmodium vivax vivapain-1 0.0142 0.08 0.5245
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0221 0.1384 0.1384
Leishmania major histone deacetylase, putative 0.0097 0.0465 0.1376
Loa Loa (eye worm) hypothetical protein 0.0036 0.0011 0.0011
Echinococcus granulosus histone deacetylase 6 0.0054 0.014 0.014
Echinococcus multilocularis nAChR subunit 0.0076 0.0303 0.0303
Giardia lamblia Cathepsin L precursor 0.0077 0.0312 0.0429
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Loa Loa (eye worm) hypothetical protein 0.0238 0.1515 0.1515
Brugia malayi Calcitonin receptor-like protein seb-1 0.0351 0.2349 0.2349
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0077 0.0312 0.0429
Toxoplasma gondii thioredoxin reductase 0.0048 0.0096 0.0257
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Brugia malayi Papain family cysteine protease containing protein 0.0077 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1378 1 1
Loa Loa (eye worm) ACC-1 protein 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0173 0.1027 0.1027
Onchocerca volvulus 0.0238 0.1515 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0077 0.0312 0.0914
Schistosoma mansoni histone deacetylase 0.0097 0.0465 0.0465
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0076 0.0303 0.0303
Brugia malayi Cathepsin L-like precursor 0.0238 0.1515 0.1515
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0058 0.0171 0.0171
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0142 0.08 0.079
Loa Loa (eye worm) LGC-31 protein 0.0076 0.0303 0.0303
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0041 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0077 0.0312 0.2003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0817 0.0817
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0076 0.0303 0.0303
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Echinococcus multilocularis dual specificity 0.0087 0.0384 0.0384
Echinococcus granulosus glycine receptor subunit beta 0.0076 0.0303 0.0303
Onchocerca volvulus 0.0076 0.0303 0.2003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0817 0.0817
Echinococcus multilocularis histone deacetylase 0.0054 0.014 0.014
Trypanosoma brucei cysteine peptidase C (CPC) 0.0479 0.3308 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.0384 0.0374
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0076 0.0303 0.0303
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.08 0.5139
Trypanosoma cruzi histone deacetylase 1, putative 0.0097 0.0465 0.0454
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Plasmodium falciparum histone deacetylase 1 0.0097 0.0465 0.26
Toxoplasma gondii cathepsin CPC2 0.0077 0.0312 0.0914
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0087 0.0384 0.1133
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0059 0.0178 0.0506
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0694 0.0694
Loa Loa (eye worm) hypothetical protein 0.0076 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.0111 0.0566 0.0566
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0077 0.0312 0.2003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Echinococcus granulosus cathepsin L cysteine protease 0.0142 0.08 0.08
Brugia malayi Cathepsin L-like precursor 0.0173 0.1027 0.1027
Echinococcus multilocularis histone deacetylase 6 0.0054 0.014 0.014
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0076 0.0303 0.0303
Schistosoma mansoni nAChR subunit 0.0076 0.0303 0.0303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0087 0.0384 0.0384
Giardia lamblia Histone deacetylase 0.0097 0.0465 0.0917
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0096 0.0085
Schistosoma mansoni hypothetical protein 0.0111 0.0566 0.0566
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0077 0.0312 0.0429
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0076 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.024 0.1524 0.1524
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0059 0.0178 0.0167
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0465 0.1376
Trichomonas vaginalis set domain proteins, putative 0.0229 0.1441 0.4337
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0111 0.0566 0.0566
Echinococcus granulosus cathepsin b 0.1378 1 1
Brugia malayi beta-lactamase 0.0036 0.0011 0.0011
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0077 0.0312 0.1525
Loa Loa (eye worm) hypothetical protein 0.0086 0.0378 0.0378
Onchocerca volvulus 0.0238 0.1515 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0077 0.0312 0.0312
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0221 0.1384 0.1384
Loa Loa (eye worm) hypothetical protein 0.0036 0.0011 0.0011
Giardia lamblia Cathepsin B precursor 0.0077 0.0312 0.0429
Echinococcus multilocularis GPCR, family 2 0.0111 0.0566 0.0566
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0641 0.4324
Entamoeba histolytica cysteine protease, putative 0.0142 0.08 0.5139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0817 0.0817
Trypanosoma cruzi cysteine proteinase, putative 0.0142 0.08 0.079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.0312 0.0914
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0041 0.0044 0.0044
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0077 0.0312 0.0429
Echinococcus multilocularis histone deacetylase 7 0.0054 0.014 0.014
Echinococcus multilocularis cathepsin b 0.1378 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0173 0.1027 0.1018
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0011 0.0011
Giardia lamblia Cathepsin B precursor 0.0077 0.0312 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0312 0.0914
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0077 0.0312 0.1525
Mycobacterium tuberculosis Probable reductase 0.0109 0.0551 0.3704
Loa Loa (eye worm) fibroinase 0.0238 0.1515 0.1515
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0077 0.0312 0.2003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0303 0.0303
Schistosoma mansoni nAChR subunit 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0111 0.0566 0.0566
Schistosoma mansoni cathepsin C 0.0077 0.0312 0.0312
Plasmodium vivax histone deacetylase 1, putative 0.0097 0.0465 0.3017
Schistosoma mansoni cathepsin F (C01 family) 0.0238 0.1515 0.1515
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0011 0.0011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1378 1 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.0384 0.0374
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0077 0.0312 0.0312
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0077 0.0312 0.0914
Giardia lamblia Hypothetical protein 0.0077 0.0312 0.0429
Plasmodium vivax vivapain-2 0.0238 0.1515 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0351 0.2349 0.2349
Loa Loa (eye worm) hypothetical protein 0.0173 0.1027 0.1027
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0077 0.0312 0.1824
Schistosoma mansoni histone deacetylase 4 5 0.0054 0.014 0.014
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0076 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0077 0.0312 0.0914
Echinococcus multilocularis histone deacetylase 6 0.0054 0.014 0.014
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0076 0.0303 0.0303
Trypanosoma cruzi cysteine peptidase, putative 0.0238 0.1515 0.1506
Plasmodium falciparum serine repeat antigen 7 0.0077 0.0312 0.1525
Trypanosoma brucei histone deacetylase 4 0.0054 0.014 0.0392
Trypanosoma cruzi histone deacetylase, putative 0.0054 0.014 0.0129
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0694 0.0694
Brugia malayi histone deacetylase 3 (HD3) 0.0097 0.0465 0.0465
Brugia malayi fibroinase precursor 0.0077 0.0312 0.0312
Toxoplasma gondii histone deacetylase HDAC1 0.0054 0.014 0.0392
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0097 0.0465 0.1376
Giardia lamblia Cathepsin L precursor 0.0077 0.0312 0.0429
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0228 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.1515 0.4561
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0077 0.0312 0.0312
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0465 0.1376
Echinococcus granulosus cathepsin L cysteine proteinase 0.0238 0.1515 0.1515
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.08 0.2392
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0238 0.1515 0.4561
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Onchocerca volvulus 0.0238 0.1515 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.1515 0.4561
Entamoeba histolytica cysteine protease, putative 0.0238 0.1515 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.1515 0.4561
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0817 0.0817
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0694 0.0694
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0694 0.0694
Brugia malayi Thioredoxin reductase 0.0048 0.0096 0.0096
Loa Loa (eye worm) histone deacetylase 3 0.0097 0.0465 0.0465
Toxoplasma gondii histone deacetylase HDAC3 0.0097 0.0465 0.1376
Brugia malayi cathepsin L precursor 0.0077 0.0312 0.0312
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0694 0.0694
Plasmodium falciparum serine repeat antigen 1 0.0077 0.0312 0.1525
Trypanosoma cruzi cysteine peptidase, putative 0.0238 0.1515 0.1506
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.1469 1
Schistosoma mansoni nAChR subunit 0.0076 0.0303 0.0303
Trichomonas vaginalis glutaminase, putative 0.0301 0.1978 0.5966
Echinococcus multilocularis geminin 0.0671 0.4738 0.4738
Loa Loa (eye worm) hypothetical protein 0.0066 0.0228 0.0228
Leishmania major cathepsin L-like protease 0.0238 0.1515 0.4561
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0044
Loa Loa (eye worm) beta-lactamase 0.0036 0.0011 0.0011
Brugia malayi TAR-binding protein 0.0128 0.0694 0.0694
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1378 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0066 0.0228 0.0228
Loa Loa (eye worm) GABA receptor subunit 0.0041 0.0044 0.0044
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0087 0.0384 0.1133
Giardia lamblia Cysteine protease 0.0077 0.0312 0.0429
Echinococcus granulosus cathepsin b 0.1378 1 1
Trypanosoma brucei histone deacetylase, putative 0.0054 0.014 0.0392
Schistosoma mansoni hypothetical protein 0.0111 0.0566 0.0566
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0076 0.0303 0.0303
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0142 0.08 0.08
Echinococcus granulosus glycine receptor subunit alpha 1 0.0076 0.0303 0.0303
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0077 0.0312 0.1824
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0551 0.8565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.1027 0.3083
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0077 0.0312 0.0429
Onchocerca volvulus Putative nachr subunit 0.0221 0.1384 0.9136
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0465 0.1376
Loa Loa (eye worm) hypothetical protein 0.0221 0.1384 0.1384
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0096 0.0581
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0479 0.3308 1
Echinococcus multilocularis nAChR subunit 0.0041 0.0044 0.0044
Plasmodium vivax unspecified product 0.0066 0.0228 0.1443
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0238 0.1515 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0351 0.2349 0.2349
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0076 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0312
Echinococcus granulosus tar DNA binding protein 0.0128 0.0694 0.0694

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 37.7 uM Effective concentration to inhibit HIV-1 activity in human peripheral blood mononuclear cells ChEMBL. 15916425
EC50 (functional) = 37.7 uM Effective concentration to inhibit HIV-1 activity in human peripheral blood mononuclear cells ChEMBL. 15916425
EC90 (functional) = 1.8 uM Antiviral activity was determined against lamivudine-resistant mutant M184V strain ChEMBL. 12540238
EC90 (functional) = 2.1 uM Antiviral activity was determined against WT (HIV-1xxBRU) ChEMBL. 12540238
EC90 (functional) = 8 uM Antiviral activity was determined against WT (HIV-1xxBRU) ChEMBL. 12540238
EC90 (functional) > 100 uM Antiviral activity was determined against lamivudine-resistant mutant M184V strain ChEMBL. 12540238
FI (functional) = 0.2 Fold increase was determined from the ratio of EC90(HIV-1M184V)/EC90(HIV-1xxBRU) ChEMBL. 12540238
FI (functional) > 100 Fold increase was determined from the ratio of EC90(HIV-1M184V)/EC90(HIV-1xxBRU) ChEMBL. 12540238
IC50 (functional) > 100 uM Inhibitory concentration was determined against PHA stimulated human peripheral blood mononuclear cells ChEMBL. 15916425
IC50 (functional) > 100 uM Inhibitory concentration of the compound was determined against CEM cell line ChEMBL. 15916425
IC50 (functional) > 100 uM Inhibitory concentration of the compound was determined against uninfected Vero cells ChEMBL. 15916425
IC50 (functional) > 100 uM Inhibitory concentration was determined against PHA stimulated human peripheral blood mononuclear cells ChEMBL. 15916425
IC50 (functional) > 100 uM Inhibitory concentration of the compound was determined against CEM cell line ChEMBL. 15916425

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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