Detailed information for compound 222821

Basic information

Technical information
  • TDR Targets ID: 222821
  • Name: [(E)-[4-(2,3-dimethylphenoxy)phenyl]methylide neamino]urea
  • MW: 283.325 | Formula: C16H17N3O2
  • H donors: 2 H acceptors: 1 LogP: 2.86 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)N/N=C/c1ccc(cc1)Oc1cccc(c1C)C
  • InChi: 1S/C16H17N3O2/c1-11-4-3-5-15(12(11)2)21-14-8-6-13(7-9-14)10-18-19-16(17)20/h3-10H,1-2H3,(H3,17,19,20)/b18-10+
  • InChiKey: XYZOAVPBMOMPMV-VCHYOVAHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(E)-[4-(2,3-dimethylphenoxy)phenyl]methyleneamino]urea
  • 1-[(E)-[4-(2,3-dimethylphenoxy)phenyl]methylideneamino]urea
  • [(E)-[4-(2,3-dimethylphenoxy)benzylidene]amino]urea
  • [[4-(2,3-dimethylphenoxy)phenyl]methylideneamino]urea
  • [[4-(2,3-dimethylphenoxy)phenyl]methyleneamino]urea
  • [[4-(2,3-dimethylphenoxy)benzylidene]amino]urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.2588 0.9827
Onchocerca volvulus 0.0091 0.1321 0.4796
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0112 0.0424
Loa Loa (eye worm) hypothetical protein 0.0091 0.1321 0.4796
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0349 0.1326
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.2588 0.9827
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.1616 0.5807
Trichomonas vaginalis penicillin-binding protein, putative 0.0091 0.1321 0.5016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0112 0.0424
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0349 0.1326
Echinococcus multilocularis peregrin 0.0033 0.0286 0.1086
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0091 0.1321 0.5016
Echinococcus granulosus eukaryotic initiation factor 4A 0.0165 0.2634 1
Brugia malayi latrophilin 2 splice variant baaae 0.0024 0.0134 0.0509
Brugia malayi Cathepsin L-like precursor 0.0023 0.0112 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0112 0.0424
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0091 0.1321 0.1321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0424
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0112 0.0424
Brugia malayi Bromodomain containing protein 0.0033 0.0286 0.1086
Loa Loa (eye worm) MH2 domain-containing protein 0.0083 0.1186 0.4261
Mycobacterium ulcerans lipase LipD 0.0091 0.1321 1
Leishmania major cathepsin L-like protease 0.0023 0.0112 0.0424
Loa Loa (eye worm) hypothetical protein 0.003 0.0238 0.05
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0112 0.0424
Plasmodium falciparum eukaryotic initiation factor 4A 0.0165 0.2634 1
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0286 0.1086
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0112 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0424
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0546 0.2072
Leishmania major DNA polymerase eta, putative 0.0021 0.0081 0.0308
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0023 0.0112 0.0424
Brugia malayi Calcitonin receptor-like protein seb-1 0.0035 0.033 0.1254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0424
Echinococcus granulosus cathepsin l cysteine peptidase 0.0023 0.0112 0.0424
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0112 0.0424
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.1616 0.1616
Leishmania major cysteine peptidase A (CPA) 0.0023 0.0112 0.0424
Trichomonas vaginalis D-aminoacylase, putative 0.0091 0.1321 0.5016
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0349 0.0942
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0112 0.0424
Brugia malayi Cathepsin L-like precursor 0.0023 0.0112 0.0424
Leishmania major cathepsin L-like protease 0.0023 0.0112 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0112 0.0424
Giardia lamblia PHD finger protein 15 0.0033 0.0286 0.1086
Brugia malayi Cathepsin L-like precursor 0.0023 0.0112 0.0424
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.1616 0.1616
Plasmodium falciparum thioredoxin reductase 0.0047 0.0546 0.2072
Brugia malayi eukaryotic initiation factor 4A 0.0165 0.2634 1
Schistosoma mansoni hypothetical protein 0.0033 0.0286 0.1086
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0091 0.1321 1
Schistosoma mansoni alpha glucosidase 0.0036 0.0349 0.1326
Mycobacterium tuberculosis Conserved protein 0.0091 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.0692
Schistosoma mansoni jumonji domain containing protein 0.0085 0.1208 0.4587
Onchocerca volvulus 0.0091 0.1321 0.4796
Trypanosoma brucei hypothetical protein, conserved 0.0091 0.1321 0.5016
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0165 0.2634 1
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0165 0.2634 0.2634
Plasmodium falciparum cysteine proteinase falcipain 3 0.0023 0.0112 0.0424
Loa Loa (eye worm) hypothetical protein 0.0056 0.0697 0.2322
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.1596 0.6058
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0023 0.0112 0.0424
Schistosoma mansoni alpha-glucosidase 0.014 0.2187 0.8305
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0035 0.033 0.1254
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0238 0.0903
Echinococcus multilocularis beta LACTamase domain containing family member 0.0091 0.1321 0.5016
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0546 0.2072
Trypanosoma brucei glucosidase, putative 0.0036 0.0349 0.1326
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0165 0.2634 1
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.1828 0.1828
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0081 0.0308
Brugia malayi glutathione reductase 0.0047 0.0546 0.2072
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0286 0.1086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0112 0.0424
Onchocerca volvulus 0.0091 0.1321 0.4796
Loa Loa (eye worm) hypothetical protein 0.0035 0.033 0.0866
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0112 0.0424
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0112 0.0424
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0349 0.1326
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0407 0.1546
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0349 0.0942
Mycobacterium ulcerans esterase/lipase LipP 0.0091 0.1321 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0349 0.1326
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0349 0.0942
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0112 0.0424
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.0112 0.0424
Leishmania major eukaryotic initiation factor 4a, putative 0.0165 0.2634 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0349 0.1326
Trichomonas vaginalis penicillin-binding protein, putative 0.0091 0.1321 0.5016
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0165 0.2634 1
Brugia malayi PHD-finger family protein 0.0033 0.0286 0.1086
Brugia malayi Cathepsin L-like precursor 0.0023 0.0112 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0424
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0165 0.2634 1
Brugia malayi Cathepsin L-like precursor 0.0023 0.0112 0.0424
Trichomonas vaginalis D-aminoacylase, putative 0.0091 0.1321 0.5016
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0165 0.2634 1
Echinococcus granulosus cathepsin l1 0.0023 0.0112 0.0424
Leishmania major cathepsin L-like protease 0.0023 0.0112 0.0424
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0286 0.1086
Loa Loa (eye worm) hypothetical protein 0.0165 0.2634 1
Mycobacterium tuberculosis Probable reductase 0.0108 0.1616 0.1616
Loa Loa (eye worm) beta-lactamase 0.0091 0.1321 0.4796
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0112 0.0424
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.1616 0.1616
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.2588 0.9827
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0349 0.1326
Echinococcus granulosus cathepsin L cysteine proteinase 0.0023 0.0112 0.0424
Toxoplasma gondii thioredoxin reductase 0.0047 0.0546 0.2072
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0165 0.2634 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0021 0.0081 0.0308
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0349 0.1326
Mycobacterium tuberculosis Probable esterase LipL 0.0091 0.1321 0.1321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0424
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.2588 0.9819
Plasmodium falciparum glutathione reductase 0.0047 0.0546 0.2072
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.0112 0.0424
Loa Loa (eye worm) hypothetical protein 0.0024 0.0134 0.0089
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0349 0.1326
Echinococcus granulosus beta LACTamase domain containing family member 0.0091 0.1321 0.5016
Brugia malayi Cathepsin L-like precursor 0.0023 0.0112 0.0424
Plasmodium vivax RNA helicase-1, putative 0.0165 0.2634 1
Brugia malayi Thioredoxin reductase 0.0047 0.0546 0.2072
Leishmania major cathepsin L-like protease 0.0023 0.0112 0.0424
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0112 0.0424
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0546 0.0546
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.1616 0.1616
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0112 0.0424
Mycobacterium tuberculosis Conserved protein 0.0091 0.1321 0.1321
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0112 0.0424
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0112 0.0424
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0165 0.2634 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0424
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.1828 0.1828
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0091 0.1321 0.5016
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0349 0.1326
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0165 0.2634 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0424
Loa Loa (eye worm) transcription factor SMAD2 0.0083 0.1186 0.4261
Echinococcus granulosus peregrin 0.0033 0.0286 0.1086
Echinococcus granulosus dna polymerase eta 0.003 0.0238 0.0903
Schistosoma mansoni alpha-glucosidase 0.014 0.2187 0.8305
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0165 0.2634 1
Plasmodium vivax vivapain-2 0.0023 0.0112 0.0424
Loa Loa (eye worm) hypothetical protein 0.0091 0.1321 0.4796
Leishmania major cathepsin L-like protease 0.0023 0.0112 0.0424
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0407 0.1546
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0112 0.0424
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0112 0.0424
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.0112 0.0424
Loa Loa (eye worm) hypothetical protein 0.0091 0.1321 0.4796
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0349 0.1326
Plasmodium falciparum phd finger protein, putative 0.0033 0.0286 0.1086
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0899 0.3122
Leishmania major cathepsin L-like protease 0.0023 0.0112 0.0424
Brugia malayi MH2 domain containing protein 0.0083 0.1186 0.4504
Plasmodium vivax vivapain-2 0.0023 0.0112 0.0424
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.2588 0.9827
Mycobacterium tuberculosis Probable lipase LipE 0.0091 0.1321 0.1321
Schistosoma mansoni DNA polymerase eta 0.003 0.0238 0.0903
Leishmania major DNA polymerase eta, putative 0.003 0.0238 0.0903
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0286 0.1086
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0286 0.1086
Loa Loa (eye worm) hypothetical protein 0.0091 0.1321 0.4796
Trypanosoma cruzi hypothetical protein, conserved 0.0091 0.1321 0.5016
Leishmania major trypanothione reductase 0.0047 0.0546 0.2072
Echinococcus multilocularis dna polymerase eta 0.003 0.0238 0.0903
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0349 0.1326
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0091 0.1321 0.1321
Toxoplasma gondii cathepsin CPL 0.0023 0.0112 0.0424
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0091 0.1321 0.5016
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0546 0.2072
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0165 0.2634 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.1828 0.1828
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.1596 0.6058
Toxoplasma gondii ABC1 family protein 0.0091 0.1321 0.5016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0035 0.033 0.0866
Trichomonas vaginalis D-aminoacylase, putative 0.0091 0.1321 0.5016
Brugia malayi jmjC domain containing protein 0.0107 0.1596 0.6058
Leishmania major hypothetical protein, conserved 0.0091 0.1321 0.5016
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0165 0.2634 1
Trypanosoma cruzi cruzipain precursor, putative 0.0023 0.0112 0.0424
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0407 0.1172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0424
Trypanosoma cruzi hypothetical protein, conserved 0.0091 0.1321 0.5016
Leishmania major cathepsin L-like protease 0.0023 0.0112 0.0424
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0 0.5
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0407 0.1546
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0091 0.1321 0.1321
Trichomonas vaginalis esterase, putative 0.0091 0.1321 0.5016
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0286 0.0692
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0112 0.0424
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.0112 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0424
Schistosoma mansoni hypothetical protein 0.0024 0.0134 0.0509
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0112 0.0424
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0165 0.2634 1
Leishmania major cathepsin L-like protease 0.0023 0.0112 0.0424
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0349 0.1326
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0 0.5
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.1828 1
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0165 0.2634 1
Brugia malayi beta-lactamase family protein 0.0091 0.1321 0.5016
Mycobacterium ulcerans beta-lactamase 0.0091 0.1321 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.1321 0.4796
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0091 0.1321 0.4796
Loa Loa (eye worm) hypothetical protein 0.0091 0.1321 0.4796
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0546 0.1721
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.1616 0.1616
Mycobacterium ulcerans hypothetical protein 0.0091 0.1321 1
Brugia malayi jmjC domain containing protein 0.0039 0.0407 0.1546
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0112 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0112 0.0424
Mycobacterium tuberculosis Conserved protein 0.0091 0.1321 0.1321
Leishmania major eukaryotic initiation factor 4a, putative 0.0165 0.2634 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0349 0.1326
Treponema pallidum ATP-dependent RNA helicase 0.0165 0.2634 1
Mycobacterium tuberculosis Probable hydrolase 0.0091 0.1321 0.1321
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0349 0.1326
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0407 0.1546
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0512 0.1942
Loa Loa (eye worm) glutathione reductase 0.0047 0.0546 0.1721
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0349 0.1326
Mycobacterium tuberculosis Probable lipase LipD 0.0091 0.1321 0.1321
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0238 0.0903
Trypanosoma brucei DNA polymerase eta, putative 0.003 0.0238 0.0903
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0112 0.0424
Brugia malayi beta-lactamase family protein 0.0091 0.1321 0.5016
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0286 0.1086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0112 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0112 0.0424
Plasmodium vivax glutathione reductase, putative 0.0047 0.0546 0.2072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0112 0.0424
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0512 0.1942
Onchocerca volvulus Alhambra homolog 0.0033 0.0286 0.0692
Echinococcus multilocularis cysteine protease 0.0023 0.0112 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0112 0.0424
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0165 0.2634 1
Trypanosoma brucei trypanothione reductase 0.0047 0.0546 0.2072
Plasmodium vivax hypothetical protein, conserved 0.0091 0.1321 0.5016
Brugia malayi beta-lactamase 0.0091 0.1321 0.5016
Echinococcus multilocularis cysteine protease 0.0023 0.0112 0.0424
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0165 0.2634 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0349 0.1326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0112 0.0424
Onchocerca volvulus 0.0094 0.1375 0.5009
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0546 0.2072

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NT 0 Compound was tested for anticonvulsant activity after Oral Administration into Rats by using MES screen test after 0.25h,dose 12.5 mg/kg; No activity was demonstrated ChEMBL. 8831764
Activity (functional) NT 0 Compound was tested for anticonvulsant activity after Oral Administration into Rats by using MES screen test after 0.5h,dose 12.5 mg/kg; No activity was demonstrated ChEMBL. 8831764
Activity (functional) NT 0 Compound was tested for anticonvulsant activity after Oral Administration into Rats by using MES screen test after 2h,dose 12.5 mg/kg; No activity was demonstrated ChEMBL. 8831764
Activity (functional) = 1 Compound was tested for anticonvulsant activity after Oral Administration into Rats by using MES screen test after 1h,dose 12.5 mg/kg; number of rats out of four which were protected ChEMBL. 8831764
Activity (functional) = 1 Compound was tested for anticonvulsant activity after Oral Administration into Rats by using MES screen test after 4h,dose 12.50 mg/kg; number of rats out of four which were protected ChEMBL. 8831764
Dose (functional) = 100 mg kg-1 Anticonvulsant activity after intraperitoneal injection into mice measured in a maximal electroshock scree (MES) screen ChEMBL. 8831764
Dose (functional) = 100 mg kg-1 Anticonvulsant activity after intraperitoneal injection into mice measured in a maximal electroshock scree (MES) screen ChEMBL. 8831764

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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