Detailed information for compound 224148

Basic information

Technical information
  • TDR Targets ID: 224148
  • Name: 1-[2-hydroxy-3-(propylamino)propyl]-5-methyl- 2-phenyl-4-(3-phenylpropanoyl)pyrazol-3-one
  • MW: 421.532 | Formula: C25H31N3O3
  • H donors: 2 H acceptors: 3 LogP: 3.62 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNCC(Cn1c(C)c(c(=O)n1c1ccccc1)C(=O)CCc1ccccc1)O
  • InChi: 1S/C25H31N3O3/c1-3-16-26-17-22(29)18-27-19(2)24(23(30)15-14-20-10-6-4-7-11-20)25(31)28(27)21-12-8-5-9-13-21/h4-13,22,26,29H,3,14-18H2,1-2H3
  • InChiKey: MVBHWZHXSXDVEV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-hydroxy-3-(propylamino)propyl]-5-methyl-4-(1-oxo-3-phenylpropyl)-2-phenyl-3-pyrazolone
  • 4-hydrocinnamoyl-1-[2-hydroxy-3-(propylamino)propyl]-5-methyl-2-phenyl-3-pyrazolin-3-one
  • 1-(2-hydroxy-3-propylaminopropyl)-5-methyl-2-phenyl-4-(3-phenylpropanoyl)pyrazol-3-one
  • 1-(2-hydroxy-3-propylamino-propyl)-5-methyl-2-phenyl-4-(3-phenylpropanoyl)pyrazol-3-one
  • 1-(2-hydroxy-3-propylaminopropyl)-5-methyl-4-(1-oxo-3-phenylpropyl)-2-phenyl-3-pyrazolone
  • 214603-84-6
  • 3H-Pyrazol-3-one, 1,2-dihydro-1-(2-hydroxy-3-(propylamino)propyl)-5-methyl-4-(1-oxo-3-phenylpropyl)-2-phenyl-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0036 0.1317 0.1317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0008 0.0028 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0028 0.0028
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0007 0.0005 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0008 0.0028 0.0028
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0016 0.0409 0.128
Mycobacterium leprae Probable lipase LipE 0.0016 0.0432 0.1239
Toxoplasma gondii acyltransferase domain-containing protein 0.0076 0.3191 1
Brugia malayi jmjC domain containing protein 0.0027 0.091 0.091
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0008 0.0028 0.0029
Echinococcus multilocularis homeobox 0.0073 0.3046 0.3046
Plasmodium vivax 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0076 0.3191 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0036 0.1317 0.3601
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0023 0.0752 0.1155
Plasmodium falciparum multidrug resistance protein 1 0.0013 0.0262 0.0821
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0262 0.2423
Echinococcus granulosus FTZ F1 alpha 0.0008 0.0028 0.0028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0028 0.0028
Trichomonas vaginalis D-aminoacylase, putative 0.0016 0.0432 0.3992
Brugia malayi ecdysteroid receptor 0.0008 0.0028 0.0028
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.3569 0.3569
Brugia malayi jmjC domain containing protein 0.0007 0.0005 0.0005
Onchocerca volvulus 0.0016 0.0432 0.1493
Schistosoma mansoni DNA topoisomerase II 0.0031 0.1081 0.3388
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.0085 0.0085
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.0085 0.0085
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.0588 0.0646
Loa Loa (eye worm) hypothetical protein 0.0073 0.3046 0.3148
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0025 0.0839 0.7759
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0262 0.2423
Chlamydia trachomatis glycerol-3-phosphate acyltransferase 0.0076 0.3191 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0016 0.0409 0.1789
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0224 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.091 0.094
Mycobacterium ulcerans DNA gyrase subunit B 0.0018 0.0495 0.0312
Mycobacterium ulcerans lipoprotein LpqF 0.0028 0.0962 0.199
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0031 0.1081 0.1081
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0016 0.0432 0.1353
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0016 0.0409 0.3779
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0007 0.0005 0.0017
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0025 0.0839 0.7759
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0025 0.0839 0.2629
Schistosoma mansoni multidrug resistance protein 0.0013 0.0262 0.0821
Toxoplasma gondii hypothetical protein 0.0012 0.0241 0.0757
Schistosoma mansoni jumonji/arid domain-containing protein 0.0027 0.091 0.2852
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0018 0.0488 0.0488
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0016 0.0432 0.0083
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0036 0.1317 0.3264
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0262 0.0262
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0007 0.0005 0.0017
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0013 0.0262 0.0821
Chlamydia trachomatis DNA gyrase subunit B 0.0014 0.0323 0.021
Mycobacterium tuberculosis Probable hydrolase 0.0016 0.0432 0.04
Brugia malayi ABC transporter family protein 0.0013 0.0262 0.0262
Echinococcus granulosus 1 acyl sn glycerol 3 phosphate acyltransferase 0.0076 0.3191 0.3191
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0009 0.0085 0.0787
Echinococcus multilocularis lysine specific demethylase 5A 0.0027 0.091 0.091
Brugia malayi hypothetical protein 0.0066 0.2733 0.2733
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0262 0.0262
Toxoplasma gondii hypothetical protein 0.0018 0.0515 0.1614
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0014 0.0332 0.0922
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0025 0.0839 0.2629
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0008 0.0028 0.0028
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0262 0.2423
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0012 0.0241 0.0757
Leishmania major DNA topoisomerase ii 0.0029 0.1005 0.3151
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0036 0.1317 0.4127
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0262 0.2423
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0262 0.0262
Leishmania major hypothetical protein, conserved 0.0007 0.0005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0432 0.0446
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0008 0.0028 0.0028
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0007 0.0005 0.0017
Brugia malayi bZIP transcription factor family protein 0.0085 0.3569 0.3569
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0515 0.4765
Schistosoma mansoni protein phosphatase 2C 0.0007 0.0005 0.0017
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0432 0.1239
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0016 0.0432 0.04
Mycobacterium tuberculosis 1-acylglycerol-3-phosphate O-acyltransferase 0.0076 0.3191 0.6909
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0023 0.0752 0.1155
Echinococcus multilocularis jumonji domain containing 1A 0.0007 0.0005 0.0005
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0031 0.1081 0.1081
Echinococcus multilocularis 1 acyl sn glycerol 3 phosphate acyltransferase 0.0076 0.3191 0.3191
Echinococcus multilocularis peptidase Clp (S14 family) 0.0023 0.0752 0.0752
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0016 0.0409 0.128
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.002 0.0588 0.077
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0262 0.2423
Leishmania major hypothetical protein, conserved 0.0016 0.0432 0.1353
Echinococcus multilocularis lysine specific demethylase 6a 0.0007 0.0005 0.0005
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0262 0.2423
Loa Loa (eye worm) transcription factor SMAD2 0.0042 0.1599 0.1652
Schistosoma mansoni DNA topoisomerase type I 0.0041 0.1555 0.4873
Loa Loa (eye worm) hypothetical protein 0.0013 0.0262 0.0271
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0432 0.1353
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0008 0.0028 0.0029
Loa Loa (eye worm) DNA topoisomerase I 0.0041 0.1555 0.1607
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0105 0.4501 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0224 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0262 0.2423
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0018 0.0488 0.0488
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0025 0.0839 0.2629
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0007 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0069 0.284 0.8901
Mycobacterium tuberculosis Probable lipase LipE 0.0016 0.0432 0.04
Brugia malayi jmjC domain containing protein 0.0007 0.0005 0.0005
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0262 0.0262
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0262 0.2423
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0008 0.0028 0.0087
Schistosoma mansoni phd/f-box containing protein 0.0007 0.0005 0.0017
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0025 0.0839 0.2629
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0018 0.0488 0.0488
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0008 0.0028 0.0028
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0025 0.0839 0.7759
Echinococcus granulosus 1 acyl sn glycerol 3 phosphate acyltransferase 0.0076 0.3191 0.3191
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0021 0.0626 0.221
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0262 0.2423
Brugia malayi multidrug resistance protein 3 0.0013 0.0262 0.0262
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0018 0.0495 0.0551
Mycobacterium ulcerans bifunctional transmembrane phospholipid biosynthesis enzyme PlsC 0.0076 0.3191 1
Brugia malayi beta-lactamase family protein 0.0016 0.0432 0.0432
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0028 0.0962 0.2924
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0029 0.1005 0.3151
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0018 0.0495 0.1553
Loa Loa (eye worm) hypothetical protein 0.0007 0.0005 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0016 0.0432 0.0446
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0016 0.0432 0.04
Mycobacterium ulcerans lipase LipD 0.0016 0.0432 0.0083
Echinococcus multilocularis ecdysone induced protein 78C 0.0008 0.0028 0.0028
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0021 0.0626 0.221
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0008 0.0028 0.0087
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0016 0.0432 0.1353
Loa Loa (eye worm) hypothetical protein 0.0082 0.3463 0.3579
Loa Loa (eye worm) hypothetical protein 0.0021 0.0627 0.0648
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0008 0.0028 0.0029
Echinococcus granulosus Msx-like 0.0073 0.3046 0.3046
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0021 0.0626 0.221
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.0028 0.0087
Schistosoma mansoni DNA topoisomerase type I 0.0041 0.1555 0.4873
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0023 0.0752 0.2255
Mycobacterium tuberculosis Probable esterase LipL 0.0016 0.0432 0.04
Brugia malayi Inositol-1 0.0016 0.0409 0.0409
Schistosoma mansoni jumonji domain containing protein 0.0027 0.091 0.2852
Plasmodium vivax JmjC domain containing protein 0.0007 0.0005 0.0017
Toxoplasma gondii DNA topoisomerase I, putative 0.0041 0.1555 0.4873
Plasmodium vivax DNA topoisomerase II, putative 0.0031 0.1081 0.3388
Toxoplasma gondii DNA topoisomerase 2, putative 0.0031 0.1081 0.3388
Echinococcus multilocularis Phospholipid glycerol acyltransferase 0.0076 0.3191 0.3191
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0028 0.0028
Toxoplasma gondii acyltransferase domain-containing protein 0.0076 0.3191 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.3569 0.3569
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0262 0.2423
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0036 0.1317 0.4127
Brugia malayi steroid hormone receptor 0.0008 0.0028 0.0028
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Schistosoma mansoni transcription factor 0.0073 0.3046 0.9547
Loa Loa (eye worm) hypothetical protein 0.0007 0.0005 0.0006
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0027 0.091 0.091
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0262 0.0262
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0025 0.0839 0.7759
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0018 0.0488 0.0488
Echinococcus multilocularis beta LACTamase domain containing family member 0.0016 0.0432 0.0432
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0028 0.0028
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0028 0.0087
Loa Loa (eye worm) hypothetical protein 0.0199 0.8838 0.9133
Echinococcus granulosus JmjC domain containing protein 4 0.0007 0.0005 0.0005
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0036 0.1317 0.3264
Toxoplasma gondii hypothetical protein 0.0018 0.0515 0.1614
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0025 0.0839 0.0839
Brugia malayi jmjC domain containing protein 0.0007 0.0005 0.0005
Schistosoma mansoni smdr2 0.0013 0.0262 0.0821
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0016 0.0432 0.04
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0008 0.0028 0.0028
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0018 0.0495 0.0861
Echinococcus multilocularis FTZ F1 alpha 0.0008 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0025 0.0839 0.0867
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0262 0.2423
Chlamydia trachomatis DNA gyrase subunit B 0.0018 0.0495 0.0797
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0008 0.0028 0.0028
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0016 0.0409 0.128
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Plasmodium vivax multidrug resistance protein 1, putative 0.0013 0.0262 0.0821
Echinococcus multilocularis DNA topoisomerase 1 0.0041 0.1555 0.1555
Schistosoma mansoni peptidase Clp (S14 family) 0.0036 0.1317 0.4127
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0515 0.1614
Loa Loa (eye worm) hypothetical protein 0.0217 0.9676 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0515 0.4765
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0262 0.0262
Plasmodium falciparum DNA gyrase subunit B 0.0018 0.0495 0.1553
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0008 0.0028 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0018 0.0488 0.1528
Echinococcus granulosus jun protein 0.0085 0.3569 0.3569
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0262 0.2423
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0031 0.1081 0.1081
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0008 0.0028 0.0028
Loa Loa (eye worm) inositol-1 0.0016 0.0409 0.0422
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0007 0.0005 0.0005
Trichomonas vaginalis abcb9, putative 0.0013 0.0262 0.2423
Echinococcus granulosus peptidase Clp S14 family 0.0023 0.0752 0.0752
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0008 0.0028 0.0087
Echinococcus granulosus ecdysone induced protein 78C 0.0008 0.0028 0.0028
Echinococcus multilocularis phd:f box containing protein 0.0007 0.0005 0.0005
Wolbachia endosymbiont of Brugia malayi 1-acyl-sn-glycerol-3-phosphate acyltransferase 0.0076 0.3191 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0515 0.4765
Treponema pallidum lysophosphatidic acid acyltransferase 0.0076 0.3191 1
Mycobacterium ulcerans putative regulatory protein 0.0018 0.0515 0.0383
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0025 0.0839 0.2629
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Loa Loa (eye worm) hypothetical protein 0.0021 0.0627 0.0648
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0025 0.0839 0.7759
Loa Loa (eye worm) jmjC domain-containing protein 0.0007 0.0005 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0016 0.0432 0.3992
Brugia malayi jmjC domain containing protein 0.0007 0.0005 0.0005
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0036 0.1317 0.3601
Schistosoma mansoni DNA topoisomerase type I 0.0041 0.1555 0.4873
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0028 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0432 0.1353
Plasmodium vivax DNA gyrase subunit B, putative 0.0018 0.0495 0.1553
Schistosoma mansoni phosphatidylserine receptor 0.0007 0.0005 0.0017
Mycobacterium ulcerans hypothetical protein 0.0016 0.0432 0.0083
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0262 0.2423
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0028 0.0087
Echinococcus granulosus Phospholipid glycerol acyltransferase 0.0076 0.3191 0.3191
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0029
Trichomonas vaginalis esterase, putative 0.0016 0.0432 0.3992
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0008 0.0028 0.0028
Trichomonas vaginalis DNA topoisomerase II, putative 0.0031 0.1081 1
Plasmodium falciparum 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0076 0.3191 1
Brugia malayi Probable DNA topoisomerase II 0.0031 0.1081 0.1081
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0432 0.1353
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0007 0.0005 0.0017
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0008 0.0028 0.0087
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0029
Mycobacterium tuberculosis Probable lipase LipD 0.0016 0.0432 0.04
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0262 0.2423
Echinococcus granulosus neuropeptide receptor A26 0.0203 0.9013 0.9013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0432 0.0446
Brugia malayi nuclear receptor NHR-88 0.0008 0.0028 0.0028
Plasmodium falciparum GAF domain-related protein, putative 0.0018 0.0515 0.1614
Giardia lamblia DNA topoisomerase II 0.0029 0.1008 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0018 0.0488 0.1528
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0018 0.0488 0.0488
Echinococcus granulosus phd:f box containing protein 0.0007 0.0005 0.0005
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0036 0.1317 0.3264
Trypanosoma cruzi 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0076 0.3191 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0262 0.0262
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0839 0.7759
Brugia malayi Steroid receptor seven-up type 2 0.0008 0.0028 0.0028
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0034 0.1253 0.3927
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0034 0.1253 0.3927
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0256 0.0256
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0262 0.2423
Onchocerca volvulus 0.0016 0.0432 0.1493
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Echinococcus granulosus lysine specific demethylase 5A 0.0027 0.091 0.091
Mycobacterium ulcerans beta-lactamase 0.0016 0.0432 0.0083
Loa Loa (eye worm) acyltransferase 0.0076 0.3191 0.3297
Mycobacterium leprae conserved hypothetical protein 0.0018 0.0515 0.1504
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0515 0.4765
Schistosoma mansoni multidrug resistance protein 0.0013 0.0262 0.0821
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0016 0.0432 0.0432
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0262 0.0262
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0018 0.0488 0.0504
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0029
Plasmodium vivax topoisomerase I, putative 0.0041 0.1555 0.4873
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0028 0.0962 0.1652
Loa Loa (eye worm) hypothetical protein 0.0076 0.3191 0.3297
Schistosoma mansoni inositol monophosphatase 0.0016 0.0409 0.128
Loa Loa (eye worm) beta-lactamase 0.0016 0.0432 0.0446
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0262 0.2423
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0262 0.0262
Loa Loa (eye worm) jmjC domain-containing protein 0.0007 0.0005 0.0006
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0025 0.0839 0.7759
Brugia malayi beta-lactamase family protein 0.0016 0.0432 0.0432
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0025 0.0839 0.2629
Onchocerca volvulus 0.0016 0.0432 0.1493
Toxoplasma gondii ABC1 family protein 0.0016 0.0432 0.1353
Plasmodium falciparum topoisomerase I 0.0041 0.1555 0.4873
Trichomonas vaginalis D-aminoacylase, putative 0.0016 0.0432 0.3992
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0008 0.0028 0.0028
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0013 0.0262 0.0821
Echinococcus granulosus DNA topoisomerase 1 0.0041 0.1555 0.1555
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.1599 0.1652
Onchocerca volvulus 0.0066 0.2733 1
Trichomonas vaginalis D-aminoacylase, putative 0.0016 0.0432 0.3992
Echinococcus multilocularis 1 acyl sn glycerol 3 phosphate acyltransferase 0.0076 0.3191 0.3191
Echinococcus granulosus neuropeptide s receptor 0.0203 0.9013 0.9013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0028 0.0028
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0016 0.0409 0.128
Mycobacterium tuberculosis Conserved protein 0.0016 0.0432 0.04
Trichomonas vaginalis inositol monophosphatase, putative 0.0016 0.0409 0.3779
Schistosoma mansoni RAR-like nuclear receptor 0.0008 0.0028 0.0087
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0041 0.1555 0.4873
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0008 0.0028 0.0029
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0008 0.0028 0.0028
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0058 0.2355 0.6996
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0028 0.0028
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0262 0.0262
Schistosoma mansoni retinoic acid receptor RXR 0.0008 0.0028 0.0087
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0016 0.0409 0.128
Trypanosoma brucei 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 0.0076 0.3191 1
Mycobacterium tuberculosis Conserved protein 0.0016 0.0432 0.04
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.002 0.0588 0.077
Leishmania major DNA topoisomerase IB, large subunit 0.0041 0.1555 0.4873
Plasmodium falciparum DNA topoisomerase 2 0.0031 0.1081 0.3388
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0012 0.0241 0.0635
Mycobacterium leprae POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI 0.0076 0.3191 1
Echinococcus multilocularis neuropeptide receptor A26 0.0203 0.9013 0.9013
Schistosoma mansoni jumonji domain containing protein 0.0007 0.0005 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0028 0.0028
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0008 0.0028 0.0028
Echinococcus granulosus lysine specific demethylase 6a 0.0007 0.0005 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0028 0.0028
Echinococcus granulosus jumonji domain containing 1A 0.0007 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0029
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0014 0.0332 0.0165
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0013 0.0262 0.0821
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0036 0.1317 0.3646
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0007 0.0005 0.0017
Mycobacterium ulcerans esterase/lipase LipP 0.0016 0.0432 0.0083
Schistosoma mansoni multidrug resistance protein 0.0013 0.0262 0.0821
Leishmania major mitochondrial DNA topoisomerase II 0.0034 0.1253 0.3927
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0058 0.2355 0.4937
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0025 0.0839 0.0839
Schistosoma mansoni jun-related protein 0.0069 0.284 0.8901
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.0256 0.0256
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0262 0.2423
Schistosoma mansoni jumonji/arid domain-containing protein 0.0027 0.091 0.2852
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Loa Loa (eye worm) hypothetical protein 0.0076 0.3191 0.3297
Mycobacterium tuberculosis Conserved protein 0.0016 0.0432 0.04
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0036 0.1317 0.4127
Brugia malayi MH2 domain containing protein 0.0042 0.1599 0.1599
Trypanosoma brucei DNA topoisomerase ii 0.0034 0.1253 0.3927
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0262 0.2423
Loa Loa (eye worm) jmjC domain-containing protein 0.0007 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0432 0.0446
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0028 0.0087
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0012 0.0241 0.0757
Plasmodium falciparum JmjC domain-containing protein, putative 0.0007 0.0005 0.0017
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0262 0.2423
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0018 0.0495 0.0312
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0262 0.0262
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0036 0.1317 0.1317
Echinococcus granulosus beta LACTamase domain containing family member 0.0016 0.0432 0.0432
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0029 0.1005 0.3151
Schistosoma mansoni coup transcription factor 0.0008 0.0028 0.0087
Echinococcus multilocularis thyroid hormone receptor alpha 0.0008 0.0028 0.0028
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0025 0.0839 0.7759
Leishmania major 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative 0.0076 0.3191 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0008 0.0028 0.0028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0028 0.0028
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0262 0.0271
Loa Loa (eye worm) hypothetical protein 0.0036 0.1317 0.1361
Loa Loa (eye worm) hypothetical protein 0.0012 0.0248 0.0256
Echinococcus granulosus inositol monophosphatase 1 0.0016 0.0409 0.0409
Trypanosoma cruzi DNA topoisomerase II, putative 0.0029 0.1005 0.3151
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0262 0.2423
Brugia malayi Acyltransferase family protein 0.0076 0.3191 0.3191
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Loa Loa (eye worm) hypothetical protein 0.0007 0.0005 0.0006
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0262 0.2423
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0008 0.0028 0.0029
Loa Loa (eye worm) steroid hormone receptor 0.0008 0.0028 0.0029
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0262 0.2423
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0008 0.0028 0.0087
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0262 0.2423
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Trichomonas vaginalis abcb9, putative 0.0013 0.0262 0.2423
Trichomonas vaginalis taga, putative 0.0013 0.0262 0.2423
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Schistosoma mansoni inositol monophosphatase 0.0016 0.0409 0.128
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0016 0.0409 0.3779
Brugia malayi nuclear hormone receptor 0.0008 0.0028 0.0028
Mycobacterium ulcerans 1-acylglycerol-3-phosphate O-acyltransferase 0.0076 0.3191 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0262 0.2423
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0025 0.0839 0.7759
Schistosoma mansoni steroid hormone receptor ad4bp 0.0008 0.0028 0.0087
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0016 0.0432 0.0446
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0029
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0036 0.1317 0.4049
Loa Loa (eye worm) hypothetical protein 0.0016 0.0432 0.0446
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0025 0.0839 0.2629
Echinococcus multilocularis jun protein 0.0085 0.3569 0.3569
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0008 0.0028 0.0028
Brugia malayi DNA topoisomerase I 0.0041 0.1555 0.1555
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0016 0.0432 0.0446
Brugia malayi Probable ClpP-like protease 0.0036 0.1317 0.1317
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0008 0.0028 0.0028
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0025 0.0839 0.7759
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0025 0.0839 0.7759
Echinococcus multilocularis multidrug resistance protein 1 0.0009 0.0085 0.0085
Echinococcus multilocularis neuropeptide s receptor 0.0203 0.9013 0.9013
Leishmania major p-glycoprotein 0.0013 0.0262 0.0821
Loa Loa (eye worm) hypothetical protein 0.0013 0.0256 0.0264
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0262 0.0262
Toxoplasma gondii hypothetical protein 0.0018 0.0515 0.1614
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0025 0.0839 0.7759
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0008 0.0028 0.0028
Trichomonas vaginalis penicillin-binding protein, putative 0.0016 0.0432 0.3992
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.0839 0.7759
Loa Loa (eye worm) hypothetical protein 0.0013 0.0262 0.0271
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0432 0.1353
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0029
Onchocerca volvulus 0.0013 0.0262 0.0866
Trichomonas vaginalis abcb9, putative 0.0013 0.0262 0.2423
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0029
Mycobacterium tuberculosis Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoseri 0.0073 0.3046 0.6568
Brugia malayi beta-lactamase 0.0016 0.0432 0.0432
Brugia malayi jmjC domain containing protein 0.0027 0.091 0.091
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0036 0.1317 0.4127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0018 0.0488 0.1528
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0262 0.2423
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0031 0.1081 0.1081
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0027 0.091 0.091
Trypanosoma cruzi DNA topoisomerase II, putative 0.0029 0.1005 0.3151
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0041 0.1555 0.4873
Toxoplasma gondii GAF domain-containing protein 0.0018 0.0515 0.1614
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0262 0.0262
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0025 0.0839 0.0839
Mycobacterium ulcerans putative regulatory protein 0.0018 0.0515 0.0383
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0262 0.2423
Schistosoma mansoni 1-acyl-sn-glycerol-3-phosphate o-acyltransferase 0.0076 0.3191 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0025 0.0839 0.7759
Loa Loa (eye worm) hypothetical protein 0.0012 0.0248 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0008 0.0028 0.0028
Echinococcus multilocularis JmjC domain containing protein 4 0.0007 0.0005 0.0005
Trypanosoma brucei beta lactamase 0.0028 0.0962 0.3015
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0262 0.0271
Brugia malayi photoreceptor-specific nuclear receptor 0.0008 0.0028 0.0028
Entamoeba histolytica DNA topoisomerase II, putative 0.0031 0.1081 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0029
Loa Loa (eye worm) TOPoisomerase family member 0.0031 0.1081 0.1117
Echinococcus multilocularis inositol monophosphatase 1 0.0016 0.0409 0.0409

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 6.31 uM Compound was tested for inhibition of daunomycin efflux in the resistant human T-lymphoblast cell line CEM vcr1000. ChEMBL. 9767638
EC50 (functional) = 6.31 uM Compound was tested for inhibition of daunomycin efflux in the resistant human T-lymphoblast cell line CEM vcr1000. ChEMBL. 9767638
EC50 (functional) = 15.19 uM Compound was tested for inhibition of rhodamine 123 efflux in mdr 1 transfectant L5178Y VMDRI C.06 mouse lymphoma cells ChEMBL. 9767638
EC50 (functional) = 15.19 uM Compound was tested for inhibition of rhodamine 123 efflux in mdr 1 transfectant L5178Y VMDRI C.06 mouse lymphoma cells ChEMBL. 9767638

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 9767638

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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