Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Oxytocin receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Vasopressin V1 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Vasopressin V2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | orexin receptor type 2 | Oxytocin receptor | 388 aa | 332 aa | 23.2 % |
Echinococcus granulosus | neuropeptide receptor | Oxytocin receptor | 388 aa | 324 aa | 21.9 % |
Onchocerca volvulus | Oxytocin receptor | 388 aa | 327 aa | 23.9 % | |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | Vasopressin V2 receptor | 371 aa | 382 aa | 22.5 % |
Echinococcus multilocularis | neuropeptide receptor | Oxytocin receptor | 388 aa | 324 aa | 21.6 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Oxytocin receptor | 388 aa | 323 aa | 21.7 % |
Onchocerca volvulus | Phospholipase d-related homolog | Oxytocin receptor | 388 aa | 330 aa | 20.0 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Vasopressin V2 receptor | 371 aa | 310 aa | 20.3 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Vasopressin V2 receptor | 371 aa | 357 aa | 21.6 % |
Echinococcus granulosus | orexin receptor type 2 | Oxytocin receptor | 388 aa | 338 aa | 24.3 % |
Onchocerca volvulus | Vasopressin V2 receptor | 371 aa | 331 aa | 21.4 % | |
Schistosoma mansoni | adenoreceptor | Vasopressin V2 receptor | 371 aa | 317 aa | 26.2 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Oxytocin receptor | 388 aa | 346 aa | 24.0 % |
Onchocerca volvulus | Vasopressin V2 receptor | 371 aa | 315 aa | 22.5 % | |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Oxytocin receptor | 388 aa | 349 aa | 22.9 % |
Loa Loa (eye worm) | hypothetical protein | Vasopressin V1 receptor | 425 aa | 370 aa | 24.3 % |
Echinococcus granulosus | allatostatin A receptor | Oxytocin receptor | 388 aa | 313 aa | 23.6 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Oxytocin receptor | 388 aa | 327 aa | 19.3 % |
Echinococcus multilocularis | allatostatin A receptor | Oxytocin receptor | 388 aa | 311 aa | 21.9 % |
Brugia malayi | GnHR receptor homolog | Vasopressin V2 receptor | 371 aa | 304 aa | 22.4 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Vasopressin V2 receptor | 371 aa | 314 aa | 21.3 % |
Onchocerca volvulus | Vasopressin V1 receptor | 425 aa | 392 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.01 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0591 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0591 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.01 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0591 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0591 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0591 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0591 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0591 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.01 | 0 | 0.5 |
Onchocerca volvulus | 0.01 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.01 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0591 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.01 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0591 | 1 | 1 |
Onchocerca volvulus | 0.01 | 0 | 0.5 | |
Onchocerca volvulus | 0.01 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.01 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.01 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0591 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0591 | 1 | 1 |
Onchocerca volvulus | 0.01 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0591 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 45 nM | Inhibition of radioligand [3H]-oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue | ChEMBL. | 8258821 |
IC50 (binding) | = 45 nM | Inhibition of radioligand [3H]-oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue | ChEMBL. | 8258821 |
IC50 (binding) | > 300 nM | Inhibition of radioligand [3H]-AVP binding to the vasopressin V1 receptor in rat liver tissue | ChEMBL. | 8258821 |
IC50 (binding) | > 300 nM | Inhibition of radioligand [3H]-AVP binding to the vasopressin V1 receptor in rat liver tissue | ChEMBL. | 8258821 |
IC50 (binding) | > 3000 nM | Inhibition of radioligand [3H]-AVP binding to the vasopressin V2 receptor in rat kidney tissue | ChEMBL. | 8258821 |
IC50 (binding) | > 3000 nM | Inhibition of radioligand [3H]-AVP binding to the vasopressin V2 receptor in rat kidney tissue | ChEMBL. | 8258821 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.